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Entry version 178 (02 Jun 2021)
Sequence version 2 (27 Apr 2001)
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Protein

Integrin beta-nu

Gene

Itgbn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic elimination of S.aureus by mediating the binding of S.aureus peptidoglycan to larval hemocytes, which probably activates a signaling pathway involving Rac1 and Rac2. Not required for the production of antimicrobial peptides during S.aureus. Upon activation by LanA, integrin alpha-PS3/beta-nu activates Fak in presynapsis to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with LanA, glutamate receptor-modulated NMJ growth.

6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Phagocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-114608, Platelet degranulation
R-DME-1236973, Cross-presentation of particulate exogenous antigens (phagosomes)
R-DME-2129379, Molecules associated with elastic fibres
R-DME-216083, Integrin cell surface interactions
R-DME-3000157, Laminin interactions
R-DME-3000170, Syndecan interactions
R-DME-3000178, ECM proteoglycans
R-DME-354192, Integrin signaling
R-DME-446107, Type I hemidesmosome assembly
R-DME-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin beta-nu
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ItgbnImported
Synonyms:beta-nu, betaInt-nu, ItgbetanuImported
ORF Names:CG1762Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010395, Itgbn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 725ExtracellularSequence analysisAdd BLAST699
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei726 – 746HelicalSequence analysisAdd BLAST21
Topological domaini747 – 799CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Homozygous mutant flies are viable and fertile. Mutant embryos show reduced level of phagocytosis, but normal level of hemocytes or apoptosis. At NMJ, mutant larvae show normal patterns of synaptic proteins but increased branch length, bouton number and quantal content in basal synaptic transmission recording.4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001635727 – 799Integrin beta-nuAdd BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi655N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q27591

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is confined to the developing midgut endoderm and its precursors during embryogenesis. In the larvae, expression is concentrated in the midgut imaginal disks. Expressed in embryonic and larval hemocytes (at protein level).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout development. Highest expression occurs during 12-15 hours of embryonic development (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010395, Expressed in digestive system element and 18 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q27591, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q27591, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit.

Interacts with scb/alpha-PS3.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
61326, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q27591, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080990

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q27591

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini136 – 372VWFAPROSITE-ProRule annotationAdd BLAST237

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1226, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234611

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011772_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q27591

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTDGFMH

Database of Orthologous Groups

More...
OrthoDBi
473040at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q27591

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013111, EGF_extracell
IPR033760, Integrin_beta_N
IPR015812, Integrin_bsu
IPR014836, Integrin_bsu_cyt_dom
IPR002369, Integrin_bsu_VWA
IPR032695, Integrin_dom_sf
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10082, PTHR10082, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974, EGF_2, 1 hit
PF08725, Integrin_b_cyt, 1 hit
PF00362, Integrin_beta, 1 hit
PF17205, PSI_integrin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002512, Integrin_B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01186, INTEGRINB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00187, INB, 1 hit
SM01241, Integrin_b_cyt, 1 hit
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit
SSF69179, SSF69179, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 4 hits
PS00243, INTEGRIN_BETA, 1 hit
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q27591-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLGGRAFL WIYLVFLIAE ISHSDADSID DQCRHADSCE RCLSAHLECA
60 70 80 90 100
WCTDKEYQVG YRCLSRRQLL NYNCSETDIY ENQPVLDVLQ DKPLKDYETS
110 120 130 140 150
DQAVQVTPQR AYLKLVKGNT QRMKLSYRTA RNNPLDLYVL MDLTWTMRDD
160 170 180 190 200
KKTLEELGAQ LSQTLKNLTG NYRLGFGSFA DKPTLPMILP QHRENPCAAE
210 220 230 240 250
RATCEPTYGY RHQLSLTDDI PAFTSAVANS KITGNLDNLE GGLDALMQVI
260 270 280 290 300
VCTKEIGWKE QARKVVILVT DGFMHLAGDG LLAGIIQRND KQCHLNKAGE
310 320 330 340 350
YTGSLNYDYP SLEEIYRELL RRKINVIFAV TEEVVSSYWE LSALMKEISY
360 370 380 390 400
VDILSADSSN ILELIKKSYE SLIKRTQFAD NSPDFIDMAY YTDCGGQFPS
410 420 430 440 450
LQKRNYCNNV TLGKQIDFYV DVTLKKYPDN QVYTHKIRVE ETSLSEFMDL
460 470 480 490 500
DVELQRPCPC QETPDPENEE GRFLCDYKGY LYCGMCECDE GWTGTYCNCP
510 520 530 540 550
TDATNVTSNE ALLQKCRQPF SDKSTSELVC SNHGDCDCGT CLCDPGYTGP
560 570 580 590 600
FCECRECLDC DEKLADCFCG QCVCKYGWSG SKCNCDGDTD ACVGPTGEIC
610 620 630 640 650
SERGTCQCEE CQCEEPYLGK FCEIDPEKDN KLCLFYEPCV TCLIEQKQGM
660 670 680 690 700
GVCENLTEIC SSLDRQETYP YNFVHELDPE QDQCLVRLVN KHGIQCDSFF
710 720 730 740 750
VYQVIDHSNF LTIQAVDCEP PDYVALVGYI SAFTLLIGLL IIFIILWYIR
760 770 780 790
AKDAREYAKF EEDQKNSVRQ ENPIYRDPVG RYEVPKALSV KYDENPFAS
Length:799
Mass (Da):90,842
Last modified:April 27, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i351869D523F07DEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0S0WGT1A0A0S0WGT1_DROME
Integrin beta
Itgbn beta integrin, beta-nu, Beta[[nu]], beta[[v]], beta[nu]-integrin
799Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti680E → G in AAC37169 (PubMed:8076521).Curated1
Sequence conflicti701V → A in AAC37169 (PubMed:8076521).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L13305 mRNA Translation: AAC37169.1
AE014134 Genomic DNA Translation: AAF53952.1
BT031252 mRNA Translation: ABY20493.1

NCBI Reference Sequences

More...
RefSeqi
NP_001303333.1, NM_001316404.1
NP_523608.2, NM_078884.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081461; FBpp0080990; FBgn0010395
FBtr0346711; FBpp0312322; FBgn0010395

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35368

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1762

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13305 mRNA Translation: AAC37169.1
AE014134 Genomic DNA Translation: AAF53952.1
BT031252 mRNA Translation: ABY20493.1
RefSeqiNP_001303333.1, NM_001316404.1
NP_523608.2, NM_078884.3

3D structure databases

SMRiQ27591
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi61326, 5 interactors
IntActiQ27591, 2 interactors
STRINGi7227.FBpp0080990

Proteomic databases

PaxDbiQ27591

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
35368

Genome annotation databases

EnsemblMetazoaiFBtr0081461; FBpp0080990; FBgn0010395
FBtr0346711; FBpp0312322; FBgn0010395
GeneIDi35368
KEGGidme:Dmel_CG1762

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35368
FlyBaseiFBgn0010395, Itgbn

Phylogenomic databases

eggNOGiKOG1226, Eukaryota
GeneTreeiENSGT01030000234611
HOGENOMiCLU_011772_1_0_1
InParanoidiQ27591
OMAiVTDGFMH
OrthoDBi473040at2759
PhylomeDBiQ27591

Enzyme and pathway databases

ReactomeiR-DME-114608, Platelet degranulation
R-DME-1236973, Cross-presentation of particulate exogenous antigens (phagosomes)
R-DME-2129379, Molecules associated with elastic fibres
R-DME-216083, Integrin cell surface interactions
R-DME-3000157, Laminin interactions
R-DME-3000170, Syndecan interactions
R-DME-3000178, ECM proteoglycans
R-DME-354192, Integrin signaling
R-DME-446107, Type I hemidesmosome assembly
R-DME-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35368, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35368

Protein Ontology

More...
PROi
PR:Q27591

Gene expression databases

BgeeiFBgn0010395, Expressed in digestive system element and 18 other tissues
ExpressionAtlasiQ27591, baseline and differential
GenevisibleiQ27591, DM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013111, EGF_extracell
IPR033760, Integrin_beta_N
IPR015812, Integrin_bsu
IPR014836, Integrin_bsu_cyt_dom
IPR002369, Integrin_bsu_VWA
IPR032695, Integrin_dom_sf
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PANTHERiPTHR10082, PTHR10082, 1 hit
PfamiView protein in Pfam
PF07974, EGF_2, 1 hit
PF08725, Integrin_b_cyt, 1 hit
PF00362, Integrin_beta, 1 hit
PF17205, PSI_integrin, 1 hit
PIRSFiPIRSF002512, Integrin_B, 1 hit
PRINTSiPR01186, INTEGRINB
SMARTiView protein in SMART
SM00187, INB, 1 hit
SM01241, Integrin_b_cyt, 1 hit
SM00327, VWA, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
SSF69179, SSF69179, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 4 hits
PS00243, INTEGRIN_BETA, 1 hit
PS50234, VWFA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITBN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q27591
Secondary accession number(s): A9UN88, Q9VIG7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: June 2, 2021
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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