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UniProtKB - Q27589 (CP4D2_DROME)
Protein
Cytochrome P450 4d2
Gene
Cyp4d2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
By similarityCofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 311 | Heme; covalent, via 1 linkBy similarity | 1 | |
Metal bindingi | 449 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-DME-193144, Estrogen biosynthesis R-DME-211976, Endogenous sterols R-DME-2453902, The canonical retinoid cycle in rods (twilight vision) |
SignaLinki | Q27589 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp4d2 ORF Names:CG3466 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0011576, Cyp4d2 |
VEuPathDBi | VectorBase:FBgn0011576 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Peripheral membrane protein Curated
- Microsome membrane Curated; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051834 | 1 – 501 | Cytochrome P450 4d2Add BLAST | 501 |
Proteomic databases
PaxDbi | Q27589 |
Expressioni
Gene expression databases
Bgeei | FBgn0011576, Expressed in Malpighian tubule and 20 other tissues |
ExpressionAtlasi | Q27589, differential |
Genevisiblei | Q27589, DM |
Interactioni
Protein-protein interaction databases
IntActi | Q27589, 1 interactor |
STRINGi | 7227.FBpp0070371 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
HOGENOMi | CLU_001570_5_1_1 |
InParanoidi | Q27589 |
PhylomeDBi | Q27589 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q27589-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGVVGVLLL VAFATLLLWD FLWRRRGNGI LPGPRPLPFL GNLLMYRGLD
60 70 80 90 100
PEQIMDFVKK NQRKYGRLYR VWILHQLAVF STDPRDIEFV LSSQQHITKN
110 120 130 140 150
NLYKLLNCWL GDGLLMSTGR KWHGRRKIIT PTFHFKILEQ FVEIFDQQSA
160 170 180 190 200
VMVEQLQSRA DGKTPINIFP VICLTALDII AETAMGTKIN AQKNPNLPYV
210 220 230 240 250
QAVNDVTNIL IKRFIHAWQR VDWIFRLTQP TEAKRQDKAI KVMHDFTENI
260 270 280 290 300
IRERRETLVN NSKETTPEEE VNFLGQKRRM ALLDVLLQST IDGAPLSDED
310 320 330 340 350
IREEVDTFMF EGHDTTTSAI SFCLYEISRH PEVQQRLQQE IRDVLGEDRK
360 370 380 390 400
SPVTLRDLGE LKFMENVIKE SLRLHPPVPM IGRWFAEDVE IRGKHIPAGT
410 420 430 440 450
NFTMGIFVLL RDPEYFESPD EFRPERFDAD VPQIHPYAYI PFSAGPRNCI
460 470 480 490 500
GQKFAMLEMK STVSKLLRHF ELLPLGPEPR HSMNIVLRSA NGVHLGLKPR
A
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX2JI29 | X2JI29_DROME | Cytochrome P450-4d2, isoform B | Cyp4d2 4d2, CYP4D2, Cyp4D2, Cyt-P450-4D2, Dmel\CG3466 | 501 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 – 25 | Missing in CAA15698 (PubMed:10731132).CuratedAdd BLAST | 24 | |
Sequence conflicti | 30 | I → A in CAA80549 (PubMed:8024706).Curated | 1 | |
Sequence conflicti | 160 | A → R in CAA53568 (PubMed:8024706).Curated | 1 | |
Sequence conflicti | 160 | A → R in CAA80549 (PubMed:8024706).Curated | 1 | |
Sequence conflicti | 487 – 500 | LRSAN…GLKPR → CGRPTAFIL in CAA53568 (PubMed:8024706).CuratedAdd BLAST | 14 | |
Sequence conflicti | 487 – 500 | LRSAN…GLKPR → CGRPTAFIL in CAA80549 (PubMed:8024706).CuratedAdd BLAST | 14 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 163 | K → M in strain: CAM-44, CAM-48 and Berkeley. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75955 Genomic DNA Translation: CAA53568.1 Z23005 Genomic DNA Translation: CAA80549.1 AE014298 Genomic DNA Translation: AAF45741.1 AL009194 Genomic DNA Translation: CAA15698.1 AY118763 mRNA Translation: AAM50623.1 AF017006 Genomic DNA Translation: AAB71169.1 AF017007 Genomic DNA Translation: AAB71170.1 AF017008 Genomic DNA Translation: AAB71171.1 AF017009 Genomic DNA Translation: AAB71172.1 AF017010 Genomic DNA Translation: AAB71173.1 AF017011 Genomic DNA Translation: AAB71174.1 AF017012 Genomic DNA Translation: AAB71175.1 AF017013 Genomic DNA Translation: AAB71176.1 AF017014 Genomic DNA Translation: AAB71177.1 AF017015 Genomic DNA Translation: AAB71178.1 AF017016 Genomic DNA Translation: AAB71179.1 AF017017 Genomic DNA Translation: AAB71180.1 AF017018 Genomic DNA Translation: AAB71181.1 |
PIRi | S41192 |
RefSeqi | NP_001284806.1, NM_001297877.1 NP_525043.1, NM_080304.3 |
Genome annotation databases
GeneIDi | 31192 |
KEGGi | dme:Dmel_CG3466 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75955 Genomic DNA Translation: CAA53568.1 Z23005 Genomic DNA Translation: CAA80549.1 AE014298 Genomic DNA Translation: AAF45741.1 AL009194 Genomic DNA Translation: CAA15698.1 AY118763 mRNA Translation: AAM50623.1 AF017006 Genomic DNA Translation: AAB71169.1 AF017007 Genomic DNA Translation: AAB71170.1 AF017008 Genomic DNA Translation: AAB71171.1 AF017009 Genomic DNA Translation: AAB71172.1 AF017010 Genomic DNA Translation: AAB71173.1 AF017011 Genomic DNA Translation: AAB71174.1 AF017012 Genomic DNA Translation: AAB71175.1 AF017013 Genomic DNA Translation: AAB71176.1 AF017014 Genomic DNA Translation: AAB71177.1 AF017015 Genomic DNA Translation: AAB71178.1 AF017016 Genomic DNA Translation: AAB71179.1 AF017017 Genomic DNA Translation: AAB71180.1 AF017018 Genomic DNA Translation: AAB71181.1 |
PIRi | S41192 |
RefSeqi | NP_001284806.1, NM_001297877.1 NP_525043.1, NM_080304.3 |
3D structure databases
SMRi | Q27589 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q27589, 1 interactor |
STRINGi | 7227.FBpp0070371 |
Proteomic databases
PaxDbi | Q27589 |
Protocols and materials databases
DNASUi | 31192 |
Genome annotation databases
GeneIDi | 31192 |
KEGGi | dme:Dmel_CG3466 |
Organism-specific databases
CTDi | 31192 |
FlyBasei | FBgn0011576, Cyp4d2 |
VEuPathDBi | VectorBase:FBgn0011576 |
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
HOGENOMi | CLU_001570_5_1_1 |
InParanoidi | Q27589 |
PhylomeDBi | Q27589 |
Enzyme and pathway databases
Reactomei | R-DME-193144, Estrogen biosynthesis R-DME-211976, Endogenous sterols R-DME-2453902, The canonical retinoid cycle in rods (twilight vision) |
SignaLinki | Q27589 |
Miscellaneous databases
BioGRID-ORCSi | 31192, 0 hits in 3 CRISPR screens |
GenomeRNAii | 31192 |
PROi | PR:Q27589 |
Gene expression databases
Bgeei | FBgn0011576, Expressed in Malpighian tubule and 20 other tissues |
ExpressionAtlasi | Q27589, differential |
Genevisiblei | Q27589, DM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP4D2_DROME | |
Accessioni | Q27589Primary (citable) accession number: Q27589 Secondary accession number(s): O18651 Q9W514 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families