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Entry version 159 (23 Feb 2022)
Sequence version 2 (01 Dec 2000)
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Protein

Cytochrome P450 4d2

Gene

Cyp4d2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei311Heme; covalent, via 1 linkBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi449Iron (heme axial ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-193144, Estrogen biosynthesis
R-DME-211976, Endogenous sterols
R-DME-2453902, The canonical retinoid cycle in rods (twilight vision)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q27589

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 4d2 (EC:1.14.-.-)
Alternative name(s):
CYPIVD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cyp4d2
ORF Names:CG3466
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0011576, Cyp4d2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0011576

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000518341 – 501Cytochrome P450 4d2Add BLAST501

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q27589

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0011576, Expressed in Malpighian tubule and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q27589, differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q27589, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q27589, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070371

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q27589

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0157, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001570_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q27589

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q27589

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR036396, Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067, p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00463, EP450I
PR00385, P450

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48264, SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q27589-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGVVGVLLL VAFATLLLWD FLWRRRGNGI LPGPRPLPFL GNLLMYRGLD
60 70 80 90 100
PEQIMDFVKK NQRKYGRLYR VWILHQLAVF STDPRDIEFV LSSQQHITKN
110 120 130 140 150
NLYKLLNCWL GDGLLMSTGR KWHGRRKIIT PTFHFKILEQ FVEIFDQQSA
160 170 180 190 200
VMVEQLQSRA DGKTPINIFP VICLTALDII AETAMGTKIN AQKNPNLPYV
210 220 230 240 250
QAVNDVTNIL IKRFIHAWQR VDWIFRLTQP TEAKRQDKAI KVMHDFTENI
260 270 280 290 300
IRERRETLVN NSKETTPEEE VNFLGQKRRM ALLDVLLQST IDGAPLSDED
310 320 330 340 350
IREEVDTFMF EGHDTTTSAI SFCLYEISRH PEVQQRLQQE IRDVLGEDRK
360 370 380 390 400
SPVTLRDLGE LKFMENVIKE SLRLHPPVPM IGRWFAEDVE IRGKHIPAGT
410 420 430 440 450
NFTMGIFVLL RDPEYFESPD EFRPERFDAD VPQIHPYAYI PFSAGPRNCI
460 470 480 490 500
GQKFAMLEMK STVSKLLRHF ELLPLGPEPR HSMNIVLRSA NGVHLGLKPR

A
Length:501
Mass (Da):57,914
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F8D98DBF39FD1A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JI29X2JI29_DROME
Cytochrome P450-4d2, isoform B
Cyp4d2 4d2, CYP4D2, Cyp4D2, Cyt-P450-4D2, Dmel\CG3466
501Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2 – 25Missing in CAA15698 (PubMed:10731132).CuratedAdd BLAST24
Sequence conflicti30I → A in CAA80549 (PubMed:8024706).Curated1
Sequence conflicti160A → R in CAA53568 (PubMed:8024706).Curated1
Sequence conflicti160A → R in CAA80549 (PubMed:8024706).Curated1
Sequence conflicti487 – 500LRSAN…GLKPR → CGRPTAFIL in CAA53568 (PubMed:8024706).CuratedAdd BLAST14
Sequence conflicti487 – 500LRSAN…GLKPR → CGRPTAFIL in CAA80549 (PubMed:8024706).CuratedAdd BLAST14

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti163K → M in strain: CAM-44, CAM-48 and Berkeley. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X75955 Genomic DNA Translation: CAA53568.1
Z23005 Genomic DNA Translation: CAA80549.1
AE014298 Genomic DNA Translation: AAF45741.1
AL009194 Genomic DNA Translation: CAA15698.1
AY118763 mRNA Translation: AAM50623.1
AF017006 Genomic DNA Translation: AAB71169.1
AF017007 Genomic DNA Translation: AAB71170.1
AF017008 Genomic DNA Translation: AAB71171.1
AF017009 Genomic DNA Translation: AAB71172.1
AF017010 Genomic DNA Translation: AAB71173.1
AF017011 Genomic DNA Translation: AAB71174.1
AF017012 Genomic DNA Translation: AAB71175.1
AF017013 Genomic DNA Translation: AAB71176.1
AF017014 Genomic DNA Translation: AAB71177.1
AF017015 Genomic DNA Translation: AAB71178.1
AF017016 Genomic DNA Translation: AAB71179.1
AF017017 Genomic DNA Translation: AAB71180.1
AF017018 Genomic DNA Translation: AAB71181.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S41192

NCBI Reference Sequences

More...
RefSeqi
NP_001284806.1, NM_001297877.1
NP_525043.1, NM_080304.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31192

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3466

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75955 Genomic DNA Translation: CAA53568.1
Z23005 Genomic DNA Translation: CAA80549.1
AE014298 Genomic DNA Translation: AAF45741.1
AL009194 Genomic DNA Translation: CAA15698.1
AY118763 mRNA Translation: AAM50623.1
AF017006 Genomic DNA Translation: AAB71169.1
AF017007 Genomic DNA Translation: AAB71170.1
AF017008 Genomic DNA Translation: AAB71171.1
AF017009 Genomic DNA Translation: AAB71172.1
AF017010 Genomic DNA Translation: AAB71173.1
AF017011 Genomic DNA Translation: AAB71174.1
AF017012 Genomic DNA Translation: AAB71175.1
AF017013 Genomic DNA Translation: AAB71176.1
AF017014 Genomic DNA Translation: AAB71177.1
AF017015 Genomic DNA Translation: AAB71178.1
AF017016 Genomic DNA Translation: AAB71179.1
AF017017 Genomic DNA Translation: AAB71180.1
AF017018 Genomic DNA Translation: AAB71181.1
PIRiS41192
RefSeqiNP_001284806.1, NM_001297877.1
NP_525043.1, NM_080304.3

3D structure databases

SMRiQ27589
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ27589, 1 interactor
STRINGi7227.FBpp0070371

Proteomic databases

PaxDbiQ27589

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
31192

Genome annotation databases

GeneIDi31192
KEGGidme:Dmel_CG3466

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31192
FlyBaseiFBgn0011576, Cyp4d2
VEuPathDBiVectorBase:FBgn0011576

Phylogenomic databases

eggNOGiKOG0157, Eukaryota
HOGENOMiCLU_001570_5_1_1
InParanoidiQ27589
PhylomeDBiQ27589

Enzyme and pathway databases

ReactomeiR-DME-193144, Estrogen biosynthesis
R-DME-211976, Endogenous sterols
R-DME-2453902, The canonical retinoid cycle in rods (twilight vision)
SignaLinkiQ27589

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31192, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31192

Protein Ontology

More...
PROi
PR:Q27589

Gene expression databases

BgeeiFBgn0011576, Expressed in Malpighian tubule and 20 other tissues
ExpressionAtlasiQ27589, differential
GenevisibleiQ27589, DM

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR036396, Cyt_P450_sf
PfamiView protein in Pfam
PF00067, p450, 1 hit
PRINTSiPR00463, EP450I
PR00385, P450
SUPFAMiSSF48264, SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP4D2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q27589
Secondary accession number(s): O18651
, O18674, O46053, Q27588, Q9W514
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 1, 2000
Last modified: February 23, 2022
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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