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UniProtKB - Q27556 (GPDA_DROAE)
Protein
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Gene
Gpdh1
Organism
Drosophila americana (Fruit fly)
Status
Functioni
Catalytic activityi
- EC:1.1.1.8
: alpha-glycerophosphate cycle Pathwayi
This protein is involved in the pathway alpha-glycerophosphate cycle, which is part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the pathway alpha-glycerophosphate cycle and in Phospholipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 98 | NADBy similarity | 1 | |
Binding sitei | 121 | NAD; via amide nitrogenBy similarity | 1 | |
Binding sitei | 121 | SubstrateBy similarity | 1 | |
Binding sitei | 155 | NAD; via amide nitrogenBy similarity | 1 | |
Active sitei | 206 | Proton acceptorBy similarity | 1 | |
Binding sitei | 270 | NADBy similarity | 1 | |
Binding sitei | 299 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 11 – 16 | NADBy similarity | 6 |
GO - Molecular functioni
- glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
- NAD binding Source: InterPro
- protein homodimerization activity Source: InterPro
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- glycerol-3-phosphate catabolic process Source: InterPro
- glycerophospholipid metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
UniPathwayi | UPA00086 |
Names & Taxonomyi
Protein namesi | Recommended name: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (EC:1.1.1.8)Short name: GPD-C Short name: GPDH-C |
Gene namesi | Name:Gpdh1By similarity Synonyms:GpdhBy similarity |
Organismi | Drosophila americana (Fruit fly) |
Taxonomic identifieri | 40366 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › |
Organism-specific databases
FlyBasei | FBgn0015636, Dame\Gpdh |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- glycerol-3-phosphate dehydrogenase complex Source: InterPro
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000138072 | 2 – 350 | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicAdd BLAST | 349 |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- protein homodimerization activity Source: InterPro
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 270 – 271 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.Curated
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006168, G3P_DH_NAD-dep IPR006109, G3P_DH_NAD-dep_C IPR017751, G3P_DH_NAD-dep_euk IPR011128, G3P_DH_NAD-dep_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF07479, NAD_Gly3P_dh_C, 1 hit PF01210, NAD_Gly3P_dh_N, 1 hit |
PIRSFi | PIRSF000114, Glycerol-3-P_dh, 1 hit |
PRINTSi | PR00077, GPDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR03376, glycerol3P_DH, 1 hit |
PROSITEi | View protein in PROSITE PS00957, NAD_G3PDH, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q27556-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEKVNVCIV GSGNWGSAIA KIVGANAAAL PEFEERVTMF VYEEMIDGKK
60 70 80 90 100
LTEIINETHE NVKYLKGHKL PTNVVAVPDL VEAAKNADIL IFVVPHQFIP
110 120 130 140 150
NFCKQLLGKI KPNAIAISLI KGFDKAEGGG IDLISHIITR HLKIPCAVLM
160 170 180 190 200
GANLANEVAE GNFCETTIGC TDKKYGKVLR DLFQANHFRV VVVEDAEAVE
210 220 230 240 250
VCGALKNIVA CGAGFVDGLK LGDNTKAAVI RLGLMEMIRF VDVFYPGSKL
260 270 280 290 300
STFFESCGVA DLITTCYGGR NRRVSEAFVT SGKTIEDLEK EMLNGQKLQG
310 320 330 340 350
PPTAEEVNYM LKNKGLEDKF PLFTAIHKIC TNQLKPKDLI DCIRNHPEHM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50089 Genomic DNA Translation: BAA20286.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50089 Genomic DNA Translation: BAA20286.1 |
3D structure databases
AlphaFoldDBi | Q27556 |
SMRi | Q27556 |
ModBasei | Search... |
Organism-specific databases
FlyBasei | FBgn0015636, Dame\Gpdh |
Enzyme and pathway databases
UniPathwayi | UPA00086 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006168, G3P_DH_NAD-dep IPR006109, G3P_DH_NAD-dep_C IPR017751, G3P_DH_NAD-dep_euk IPR011128, G3P_DH_NAD-dep_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF07479, NAD_Gly3P_dh_C, 1 hit PF01210, NAD_Gly3P_dh_N, 1 hit |
PIRSFi | PIRSF000114, Glycerol-3-P_dh, 1 hit |
PRINTSi | PR00077, GPDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR03376, glycerol3P_DH, 1 hit |
PROSITEi | View protein in PROSITE PS00957, NAD_G3PDH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GPDA_DROAE | |
Accessioni | Q27556Primary (citable) accession number: Q27556 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 109 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Documents
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families