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Protein

Serine/threonine-protein phosphatase PP1-alpha

Gene

gsp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion (PubMed:11940606, PubMed:14622138). Dephosphorylates histone H3 at 'Ser-10' (PubMed:10975519). Dephosphorylates translation initiation factor eIF2alpha (PubMed:22719267). Involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation (PubMed:12163466).5 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Manganese 1By similarity1
Metal bindingi66Manganese 1By similarity1
Metal bindingi92Manganese 1By similarity1
Metal bindingi92Manganese 2By similarity1
Metal bindingi124Manganese 2By similarity1
Active sitei125Proton donorBy similarity1
Metal bindingi173Manganese 2By similarity1
Metal bindingi248Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromatin organization Source: UniProtKB-KW
  • meiotic cell cycle Source: UniProtKB-KW
  • negative regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Meiosis, Mitosis
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-alpha (EC:3.1.3.16)
Alternative name(s):
CeGLC-7-alpha
Glc seven-like phosphatase 1
Gene namesi
Name:gsp-1
ORF Names:F29F11.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF29F11.6 ; CE20735 ; WBGene00001747 ; gsp-1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686371 – 329Serine/threonine-protein phosphatase PP1-alphaAdd BLAST329

Proteomic databases

EPDiQ27497
PaxDbiQ27497
PRIDEiQ27497

PTM databases

iPTMnetiQ27497

Expressioni

Gene expression databases

BgeeiWBGene00001747
ExpressionAtlasiQ27497 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
lab-1Q176043EBI-2416859,EBI-16011794

Protein-protein interaction databases

BioGridi44515, 2 interactors
DIPiDIP-55373N
IntActiQ27497, 4 interactors
STRINGi6239.F29F11.6b

Structurei

3D structure databases

ProteinModelPortaliQ27497
SMRiQ27497
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IN85 Eukaryota
ENOG410XPVF LUCA
GeneTreeiENSGT00530000062911
HOGENOMiHOG000172697
InParanoidiQ27497
KOiK06269
OMAiDHQEADI
OrthoDBiEOG091G0EKF
PhylomeDBiQ27497

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR037981 PPP1CC
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PANTHERiPTHR11668:SF204 PTHR11668:SF204, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q27497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNDGDLNID NLITRLLEVR GCRPGKPVTM SEAEIRALCH KSREIFLSQP
60 70 80 90 100
ILLELEAPLK ICGDIHGQYN DLLRLFEYGG FPPEANYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KVKYPENFFL LRGNHECASI NRIYGFYDEC KRRFSIKLWK
160 170 180 190 200
TFTDCFNCLP IAALIDEKIF CCHGGLSPDL QNMEQIRRVM RPTDVPDTGL
210 220 230 240 250
LCDLLWSDPD KDVTGWGEND RGVSFTFGPD VVAKFLNRHD LDLICRAHQV
260 270 280 290 300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG GMMSVDETLM CSFQILKPSE
310 320
KKAKYQYQGM NSGRPAVGGG RPGTTAGKK
Length:329
Mass (Da):37,205
Last modified:January 1, 1999 - v2
Checksum:i500145324CA16D1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73974 Genomic DNA Translation: CAA98273.1
PIRiT21553
RefSeqiNP_001256249.1, NM_001269320.1
NP_001256250.1, NM_001269321.1
UniGeneiCel.17676

Genome annotation databases

EnsemblMetazoaiF29F11.6a; F29F11.6a; WBGene00001747
F29F11.6b; F29F11.6b; WBGene00001747
GeneIDi179486
KEGGicel:CELE_F29F11.6
UCSCiF29F11.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGLC7A_CAEEL
AccessioniPrimary (citable) accession number: Q27497
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 1, 1999
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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