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Protein

Putative histone H3.3-like type 3

Gene

his-69

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

  • nucleosomal DNA binding Source: GO_Central
  • protein heterodimerization activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histone H3.3-like type 3
Gene namesi
Name:his-69
ORF Names:E03A3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiE03A3.3 ; CE00942 ; WBGene00001943 ; his-69

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Disruption phenotypei

Worms exhibit slow postembryonic growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686351 – 127Putative histone H3.3-like type 3Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6N6-acetyllysineBy similarity1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei19N6-methylated lysineBy similarity1
Modified residuei28N6-methylated lysineBy similarity1
Modified residuei71N6-methylated lysineBy similarity1

Post-translational modificationi

Acetylation is generally linked to gene activation.By similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiQ27489
PeptideAtlasiQ27489
PRIDEiQ27489

Expressioni

Gene expression databases

BgeeiWBGene00001943 Expressed in 4 organ(s), highest expression level in adult organism

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi48808, 2 interactors
STRINGi6239.E03A3.3

Structurei

3D structure databases

ProteinModelPortaliQ27489
SMRiQ27489
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

eggNOGiKOG1745 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00760000118967
HOGENOMiHOG000155290
InParanoidiQ27489
KOiK11253
OMAiRPYRGGV
OrthoDBiEOG091G11DZ
PhylomeDBiQ27489

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000164 Histone_H3/CENP-A
PANTHERiPTHR11426 PTHR11426, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00622 HISTONEH3
SMARTiView protein in SMART
SM00428 H3, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00322 HISTONE_H3_1, 1 hit
PS00959 HISTONE_H3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q27489-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCPGGKAPRK QLATKAARKN AIVVGAVKKP HRFRPGTVAL REIRRYQKST
60 70 80 90 100
DLLLRKLPFQ RLVREIAQDV KQDLRFQSAA IQALQEASEY FLVGLFEDTN
110 120
LCAIHAKRVT IMPKDMQLAR RIRGERN
Length:127
Mass (Da):14,523
Last modified:November 1, 1996 - v1
Checksum:iC432C3D4C35CDCA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38112 Genomic DNA Translation: CAA86228.1
PIRiT20426
RefSeqiNP_497811.1, NM_065410.1
UniGeneiCel.10649

Genome annotation databases

EnsemblMetazoaiE03A3.3; E03A3.3; WBGene00001943
GeneIDi184005
KEGGicel:CELE_E03A3.3
UCSCiE03A3.3 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38112 Genomic DNA Translation: CAA86228.1
PIRiT20426
RefSeqiNP_497811.1, NM_065410.1
UniGeneiCel.10649

3D structure databases

ProteinModelPortaliQ27489
SMRiQ27489
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi48808, 2 interactors
STRINGi6239.E03A3.3

Proteomic databases

PaxDbiQ27489
PeptideAtlasiQ27489
PRIDEiQ27489

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiE03A3.3; E03A3.3; WBGene00001943
GeneIDi184005
KEGGicel:CELE_E03A3.3
UCSCiE03A3.3 c. elegans

Organism-specific databases

CTDi184005
WormBaseiE03A3.3 ; CE00942 ; WBGene00001943 ; his-69

Phylogenomic databases

eggNOGiKOG1745 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00760000118967
HOGENOMiHOG000155290
InParanoidiQ27489
KOiK11253
OMAiRPYRGGV
OrthoDBiEOG091G11DZ
PhylomeDBiQ27489

Gene expression databases

BgeeiWBGene00001943 Expressed in 4 organ(s), highest expression level in adult organism

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000164 Histone_H3/CENP-A
PANTHERiPTHR11426 PTHR11426, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00622 HISTONEH3
SMARTiView protein in SMART
SM00428 H3, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00322 HISTONE_H3_1, 1 hit
PS00959 HISTONE_H3_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH33L3_CAEEL
AccessioniPrimary (citable) accession number: Q27489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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