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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-23a1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-156581 Methylation
R-CEL-193048 Androgen biosynthesis
R-CEL-193993 Mineralocorticoid biosynthesis
R-CEL-194002 Glucocorticoid biosynthesis
R-CEL-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
R-CEL-211976 Endogenous sterols
R-CEL-211981 Xenobiotics
R-CEL-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-CEL-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-CEL-5423646 Aflatoxin activation and detoxification
R-CEL-9018681 Biosynthesis of protectins
R-CEL-9027307 Biosynthesis of maresin-like SPMs

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-23a1Imported
Synonyms:cyp-23A1Imported
ORF Names:B0304.3Imported, CELE_B0304.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiB0304.3 ; CE27050 ; WBGene00015135 ; cyp-23A1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 25HelicalSequence analysisAdd BLAST19
Transmembranei31 – 47HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ27465
PaxDbiQ27465

Expressioni

Gene expression databases

BgeeiWBGene00015135 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

STRINGi6239.B0304.3

Structurei

3D structure databases

ProteinModelPortaliQ27465
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140831
HOGENOMiHOG000036993
InParanoidiQ27465
KOiK17946
OMAiAVCVGNI
OrthoDBiEOG091G0BT8
PhylomeDBiQ27465

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q27465-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSLRNAILL TIATTFLYFR IMRTLNFDNY MATYIYFLTC ITLYAIYELN
60 70 80 90 100
YKRRRLPNGP VPWLVAGNMP SFINVNNVDV LFQSWKQQYG GIFTVWIGPI
110 120 130 140 150
PLVMVSDLPT IKKYFIQHAD SFSNRWRNFV TDSIMEGSNG IVQIDGNKWR
160 170 180 190 200
EQRRFALHTL RDFGVGKPLM EQMITLEVTS LMNHMEKSCG LDGKELHLCP
210 220 230 240 250
SIAVCVGNII NNMLFGLRFN QDNSYMHRLH QLLDDQSHTV MQPIMGAYIA
260 270 280 290 300
FPVTSKIPII NGEWNRLMGI KNELLEFLET QIEGHRMNWK DEMIEQEPED
310 320 330 340 350
LTYAYMIEVE KRKRNGEDVG FFDDQQLKML LLDLFFAGME TTVTTLKWAF
360 370 380 390 400
LLMAKNQKVQ KNVQAELDSI GQPMIEIQHR TRLPYVQATI NEIQRIANIL
410 420 430 440 450
PINLLRTVAE DIEIDGYNFK KGDLIIPQIS ILMNDPEIFE NPEEFNPSRF
460 470 480 490 500
LDEDNNVKKI DEFLPFSIGR RQCLGESLAR AELYLVFANL IQNFNFEVAD
510 520 530
DVTTERVLGL TVSPVEYSCK ITRRGLDHNQ NSVK
Length:534
Mass (Da):61,947
Last modified:June 1, 2001 - v2
Checksum:i8A3C99165F8EBE7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD61735.1
RefSeqiNP_494797.1, NM_062396.4
UniGeneiCel.16058

Genome annotation databases

EnsemblMetazoaiB0304.3; B0304.3; WBGene00015135
GeneIDi173787
KEGGicel:CELE_B0304.3
UCSCiB0304.3 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD61735.1
RefSeqiNP_494797.1, NM_062396.4
UniGeneiCel.16058

3D structure databases

ProteinModelPortaliQ27465
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.B0304.3

Proteomic databases

EPDiQ27465
PaxDbiQ27465

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0304.3; B0304.3; WBGene00015135
GeneIDi173787
KEGGicel:CELE_B0304.3
UCSCiB0304.3 c. elegans

Organism-specific databases

CTDi173787
WormBaseiB0304.3 ; CE27050 ; WBGene00015135 ; cyp-23A1

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140831
HOGENOMiHOG000036993
InParanoidiQ27465
KOiK17946
OMAiAVCVGNI
OrthoDBiEOG091G0BT8
PhylomeDBiQ27465

Enzyme and pathway databases

ReactomeiR-CEL-156581 Methylation
R-CEL-193048 Androgen biosynthesis
R-CEL-193993 Mineralocorticoid biosynthesis
R-CEL-194002 Glucocorticoid biosynthesis
R-CEL-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
R-CEL-211976 Endogenous sterols
R-CEL-211981 Xenobiotics
R-CEL-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-CEL-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-CEL-5423646 Aflatoxin activation and detoxification
R-CEL-9018681 Biosynthesis of protectins
R-CEL-9027307 Biosynthesis of maresin-like SPMs

Gene expression databases

BgeeiWBGene00015135 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ27465_CAEEL
AccessioniPrimary (citable) accession number: Q27465
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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