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Protein

Alcohol dehydrogenase

Gene

Adh1

more
Organism
Drosophila lacicola (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh1
Synonyms:Adh-1
AND
Name:Adh2
Synonyms:Adh-2
OrganismiDrosophila lacicola (Fruit fly)
Taxonomic identifieri40369 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Organism-specific databases

FlyBaseiFBgn0013821 Dlac\Adh1
FBgn0013822 Dlac\Adh2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000544701 – 254Alcohol dehydrogenaseAdd BLAST254

Proteomic databases

PRIDEiQ27404

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ27404
SMRiQ27404
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q27404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIANKNIIF VAGLGGIGLD TSREIVKSGP KNLVILDRID NPTAIAELKA
60 70 80 90 100
INPKVTVTFY PYDVTVPVAE TTKLLKTIFA QLKTVDLLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG TVNTTTAIME FWDKRKGGPG GVVANICSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAALS FTNSLARLAP ITGVTAYSIN PGITRTPLVH KFNSWLDVEP
210 220 230 240 250
RVGELLLEHP TQTTLECAQN FVKAIEANKN GAIWQLDLGQ LIAVEWTKHW

DSHI
Length:254
Mass (Da):27,536
Last modified:November 1, 1996 - v1
Checksum:i2CC1A502F26F5A49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26840 Genomic DNA Translation: AAB02626.1
U26841 Genomic DNA Translation: AAB02627.1

Similar proteinsi

Entry informationi

Entry nameiADH_DROLA
AccessioniPrimary (citable) accession number: Q27404
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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