UniProtKB - Q27395 (LI15B_CAEEL)
Protein
Protein lin-15B
Gene
lin-15B
Organism
Caenorhabditis elegans
Status
Functioni
Synthetic multivulva (synMuv) class B protein (PubMed:7982579, PubMed:8054684). SynMuv proteins are required to repress the induction of vulval development (PubMed:7982579, PubMed:8054684, PubMed:11463372). Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development (PubMed:8054684). Regulates let-23 basal activity (PubMed:8054684).3 Publications
Miscellaneous
The proteins lin-15A and lin-15B are produced from a single precursor mRNA with non-overlapping transcripts where lin-15B is the upstream transcript and lin-15A is the downstream one. The precursor mRNA is cleaved at the polyadenylation site and a 22-nucleotide SL2 leader sequence is trans-spliced to the 5'-end of lin-15A to allow its translation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1135 – 1209 | THAP-typePROSITE-ProRule annotationAdd BLAST | 75 | |
DNA bindingi | 1317 – 1329 | A.T hook 1Sequence analysisAdd BLAST | 13 | |
DNA bindingi | 1418 – 1430 | A.T hook 2Sequence analysisAdd BLAST | 13 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- negative regulation of Ras protein signal transduction Source: UniProtKB
- negative regulation of vulval development Source: UniProtKB
- regulation of cell fate specification Source: WormBase
- sex differentiation Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Sexual differentiation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Protein lin-15BAlternative name(s): Abnormal cell lineage protein 15B |
Gene namesi | Name:lin-15BImported ORF Names:ZK662.4Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | ZK662.4 ; CE15381 ; WBGene00023497 ; lin-15B |
Pathology & Biotechi
Disruption phenotypei
No obvious vulval development defects (PubMed:8054684, PubMed:11463372). Double knockout with the synthetic multivulva class A protein lin-15A results in a multiple vulva (Muv) phenotype (PubMed:8054684). Double knockout with the programmed cell death regulator mcd-1 results in 100% lethality during the L1 stage of larval development (PubMed:17237514).3 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000260044 | 1 – 1440 | Protein lin-15BAdd BLAST | 1440 |
Proteomic databases
EPDi | Q27395 |
PaxDbi | Q27395 |
PeptideAtlasi | Q27395 |
PRIDEi | Q27395 |
PTM databases
iPTMneti | Q27395 |
Expressioni
Gene expression databases
Bgeei | WBGene00023497, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 46554, 15 interactors |
STRINGi | 6239.ZK662.4.1 |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1135 – 1209 | THAP-typePROSITE-ProRule annotationAdd BLAST | 75 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1121, Eukaryota |
GeneTreei | ENSGT00390000009480 |
HOGENOMi | CLU_004462_0_0_1 |
InParanoidi | Q27395 |
OMAi | VCCYCSK |
OrthoDBi | 223749at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR040129, Lin-15B-like IPR012337, RNaseH-like_sf IPR006612, THAP_Znf |
PANTHERi | PTHR22716, PTHR22716, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q27395-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQTLKTARLT SNPASIPTSS SSSAISAAAI QKTLDAVNRP PAVRASGILR
60 70 80 90 100
HRTLPAPTQE TAHHLDADPK TTELMARFFI SQGIPFECAH EPAFLELMKH
110 120 130 140 150
VDPNCVIPPT NVTKKLVDKI STSSKPQVNY TKTVGPLSVT IDICGDEDEK
160 170 180 190 200
YLAFSIHYFE DLYERKNAIY LRKLLLTELD SNSLLTNIRR SVNSYSFSNV
210 220 230 240 250
KFTNIVCPNE EICKLVEESA VVKRYNVCFY NYVTRFVADL MEIEEFSSGL
260 270 280 290 300
TQLRTFVRYM KQNSDMYSKF RRMQLQKNAE LDIPSIDSGD WHSTAIFLTR
310 320 330 340 350
CLVWHDTFTE FCGKLDILHY IDNETFNHLI YLQRLLQQCM KHCRELSIPN
360 370 380 390 400
NSISQVVPAI MSIRNFIASN SMGYRFQKRI RDSFTTSFKE ITSGPSQDRY
410 420 430 440 450
DIATLLDPRF AYRDTVYTAQ TWRSLEKKVI DDFVNSDLQN DKNFYQDISI
460 470 480 490 500
LNQEQRYDII KKEFAYYRQT SFVERPEENE NSNHWWGMRQ TDMEFLAVIA
510 520 530 540 550
REYLASPAVS IDAGYYFGNG GKFQHICHTY SHQRLENCLA LAGNYQTFRG
560 570 580 590 600
KGASVDVISQ SMIETLNNTA SRLQKQVHLG LYAHGVDNIS SDRDVQSIVG
610 620 630 640 650
HHYPPMPTVA NYDIPHVPKE EEKPPVANLQ STSSPATSSP TIIRPRAAPP
660 670 680 690 700
PRTLAQGRPI PLNGKELKAV PIRQIPLQVR PLPPRPANVP IVPRPTVPQQ
710 720 730 740 750
FIKAPAPKPI TLQAVVCSIP EKEIKKETED VALLEKIKDE PLDEDDFNHP
760 770 780 790 800
STDPVPNRTT ASSQGPSSYP RKIVVLASKL PTSQSSSPST ATSAQARSHV
810 820 830 840 850
TTAQLIRCGP SEGTVPQKIH SHNFVQKFAQ KQNFVHKYAL NSQDHTGRLN
860 870 880 890 900
QTVPMRAALR LPNSEQKSGA PSSINGKVQR DDFKLEPLDD FNGEPDYDNL
910 920 930 940 950
IGAQRLMYSD NLNDASAEDA FARHRVTMEF QKRRACNRRC AVCGHLEIHE
960 970 980 990 1000
RLKNVTIENE KLLIMLGCIY RGEFTLGQAQ LFMARESKTY ICRLHFLETL
1010 1020 1030 1040 1050
DEIYQMLRLK SADDILICPL DLIQNALITV SALRPHIIAS QLRKILHDFA
1060 1070 1080 1090 1100
ERNNHLRETP AELKKLGQQY FDYREPEPEP ERNDVDEQEI IPKLFRQPRK
1110 1120 1130 1140 1150
QVLEADQHDG TVKVIEQEDF KLPTVKPSEN EECDNPGVCC FCSKRGDRGG
1160 1170 1180 1190 1200
MLRVPRSEER LARWVDKLGP EFEARLHTNT ENLICRSHFP DAAFSSRGRL
1210 1220 1230 1240 1250
LKGMIPDAAP EKVETTYIIQ GNNFLKLKER KSGTDKNSAI DLANMLNPDG
1260 1270 1280 1290 1300
VEYTQEEEEE EEYEEMSRSP TEETSDDEPS QAAVYNNAPV IKRTYRKREL
1310 1320 1330 1340 1350
SNEDGPLNLV TPPAHTPNPR GRPRKYPKNS VTPEAEKSLT DYDYNPGTSQ
1360 1370 1380 1390 1400
RRALKKGYVQ LEDGEIVGED CEYVPEKTPS GRLIRQAVAR RSFAFADEEE
1410 1420 1430 1440
EEEEYEESPI VKKPKIAGRP VGRPRKDANK LPTPTPPSNE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10412 mRNA Translation: AAA20088.1 U10413 Genomic DNA Translation: AAA20089.1 Z29967 Genomic DNA Translation: CAA82854.1 Z79604, Z79605 Genomic DNA Translation: CAB01901.1 |
PIRi | T27942 |
RefSeqi | NP_510587.1, NM_078186.6 |
Genome annotation databases
EnsemblMetazoai | ZK662.4.1; ZK662.4.1; WBGene00023497 ZK662.4.2; ZK662.4.2; WBGene00023497 |
GeneIDi | 181662 |
KEGGi | cel:CELE_ZK662.4 |
UCSCi | ZK662.4.2, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10412 mRNA Translation: AAA20088.1 U10413 Genomic DNA Translation: AAA20089.1 Z29967 Genomic DNA Translation: CAA82854.1 Z79604, Z79605 Genomic DNA Translation: CAB01901.1 |
PIRi | T27942 |
RefSeqi | NP_510587.1, NM_078186.6 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 46554, 15 interactors |
STRINGi | 6239.ZK662.4.1 |
PTM databases
iPTMneti | Q27395 |
Proteomic databases
EPDi | Q27395 |
PaxDbi | Q27395 |
PeptideAtlasi | Q27395 |
PRIDEi | Q27395 |
Genome annotation databases
EnsemblMetazoai | ZK662.4.1; ZK662.4.1; WBGene00023497 ZK662.4.2; ZK662.4.2; WBGene00023497 |
GeneIDi | 181662 |
KEGGi | cel:CELE_ZK662.4 |
UCSCi | ZK662.4.2, c. elegans |
Organism-specific databases
CTDi | 181662 |
WormBasei | ZK662.4 ; CE15381 ; WBGene00023497 ; lin-15B |
Phylogenomic databases
eggNOGi | KOG1121, Eukaryota |
GeneTreei | ENSGT00390000009480 |
HOGENOMi | CLU_004462_0_0_1 |
InParanoidi | Q27395 |
OMAi | VCCYCSK |
OrthoDBi | 223749at2759 |
Miscellaneous databases
PROi | PR:Q27395 |
Gene expression databases
Bgeei | WBGene00023497, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR040129, Lin-15B-like IPR012337, RNaseH-like_sf IPR006612, THAP_Znf |
PANTHERi | PTHR22716, PTHR22716, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LI15B_CAEEL | |
Accessioni | Q27395Primary (citable) accession number: Q27395 Secondary accession number(s): Q94409, Q94414 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 14, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase