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UniProtKB - Q27395 (LI15B_CAEEL)

Entry version 122 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Protein lin-15B

Gene

lin-15B

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Synthetic multivulva (synMuv) class B protein (PubMed:7982579, PubMed:8054684). SynMuv proteins are required to repress the induction of vulval development (PubMed:7982579, PubMed:8054684, PubMed:11463372). Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development (PubMed:8054684). Regulates let-23 basal activity (PubMed:8054684).3 Publications

Miscellaneous

The proteins lin-15A and lin-15B are produced from a single precursor mRNA with non-overlapping transcripts where lin-15B is the upstream transcript and lin-15A is the downstream one. The precursor mRNA is cleaved at the polyadenylation site and a 22-nucleotide SL2 leader sequence is trans-spliced to the 5'-end of lin-15A to allow its translation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1135 – 1209THAP-typePROSITE-ProRule annotationAdd BLAST75
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1317 – 1329A.T hook 1Sequence analysisAdd BLAST13
DNA bindingi1418 – 1430A.T hook 2Sequence analysisAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Sexual differentiation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein lin-15B
Alternative name(s):
Abnormal cell lineage protein 15B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lin-15BImported
ORF Names:ZK662.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...WormBasei		ZK662.4 ; CE15381 ; WBGene00023497 ; lin-15B

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No obvious vulval development defects (PubMed:8054684, PubMed:11463372). Double knockout with the synthetic multivulva class A protein lin-15A results in a multiple vulva (Muv) phenotype (PubMed:8054684). Double knockout with the programmed cell death regulator mcd-1 results in 100% lethality during the L1 stage of larval development (PubMed:17237514).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002600441 – 1440Protein lin-15BAdd BLAST1440

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q27395

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q27395

PeptideAtlas

More...PeptideAtlasi		Q27395

PRoteomics IDEntifications database

More...PRIDEi		Q27395

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q27395

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00023497, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		46554, 1 interactor

STRING: functional protein association networks

More...STRINGi		6239.ZK662.4.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1135 – 1209THAP-typePROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1121, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009480

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004462_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q27395

Identification of Orthologs from Complete Genome Data

More...OMAi		VCCYCSK

Database of Orthologous Groups

More...OrthoDBi		223749at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040129, Lin-15B-like
IPR012337, RNaseH-like_sf
IPR006612, THAP_Znf

The PANTHER Classification System

More...PANTHERi		PTHR22716, PTHR22716, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00692, DM3, 1 hit
SM00980, THAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53098, SSF53098, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50950, ZF_THAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q27395-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQTLKTARLT SNPASIPTSS SSSAISAAAI QKTLDAVNRP PAVRASGILR 
        60         70         80         90        100
HRTLPAPTQE TAHHLDADPK TTELMARFFI SQGIPFECAH EPAFLELMKH 
       110        120        130        140        150
VDPNCVIPPT NVTKKLVDKI STSSKPQVNY TKTVGPLSVT IDICGDEDEK 
       160        170        180        190        200
YLAFSIHYFE DLYERKNAIY LRKLLLTELD SNSLLTNIRR SVNSYSFSNV 
       210        220        230        240        250
KFTNIVCPNE EICKLVEESA VVKRYNVCFY NYVTRFVADL MEIEEFSSGL 
       260        270        280        290        300
TQLRTFVRYM KQNSDMYSKF RRMQLQKNAE LDIPSIDSGD WHSTAIFLTR 
       310        320        330        340        350
CLVWHDTFTE FCGKLDILHY IDNETFNHLI YLQRLLQQCM KHCRELSIPN 
       360        370        380        390        400
NSISQVVPAI MSIRNFIASN SMGYRFQKRI RDSFTTSFKE ITSGPSQDRY 
       410        420        430        440        450
DIATLLDPRF AYRDTVYTAQ TWRSLEKKVI DDFVNSDLQN DKNFYQDISI 
       460        470        480        490        500
LNQEQRYDII KKEFAYYRQT SFVERPEENE NSNHWWGMRQ TDMEFLAVIA 
       510        520        530        540        550
REYLASPAVS IDAGYYFGNG GKFQHICHTY SHQRLENCLA LAGNYQTFRG 
       560        570        580        590        600
KGASVDVISQ SMIETLNNTA SRLQKQVHLG LYAHGVDNIS SDRDVQSIVG 
       610        620        630        640        650
HHYPPMPTVA NYDIPHVPKE EEKPPVANLQ STSSPATSSP TIIRPRAAPP 
       660        670        680        690        700
PRTLAQGRPI PLNGKELKAV PIRQIPLQVR PLPPRPANVP IVPRPTVPQQ 
       710        720        730        740        750
FIKAPAPKPI TLQAVVCSIP EKEIKKETED VALLEKIKDE PLDEDDFNHP 
       760        770        780        790        800
STDPVPNRTT ASSQGPSSYP RKIVVLASKL PTSQSSSPST ATSAQARSHV 
       810        820        830        840        850
TTAQLIRCGP SEGTVPQKIH SHNFVQKFAQ KQNFVHKYAL NSQDHTGRLN 
       860        870        880        890        900
QTVPMRAALR LPNSEQKSGA PSSINGKVQR DDFKLEPLDD FNGEPDYDNL 
       910        920        930        940        950
IGAQRLMYSD NLNDASAEDA FARHRVTMEF QKRRACNRRC AVCGHLEIHE 
       960        970        980        990       1000
RLKNVTIENE KLLIMLGCIY RGEFTLGQAQ LFMARESKTY ICRLHFLETL 
      1010       1020       1030       1040       1050
DEIYQMLRLK SADDILICPL DLIQNALITV SALRPHIIAS QLRKILHDFA 
      1060       1070       1080       1090       1100
ERNNHLRETP AELKKLGQQY FDYREPEPEP ERNDVDEQEI IPKLFRQPRK 
      1110       1120       1130       1140       1150
QVLEADQHDG TVKVIEQEDF KLPTVKPSEN EECDNPGVCC FCSKRGDRGG 
      1160       1170       1180       1190       1200
MLRVPRSEER LARWVDKLGP EFEARLHTNT ENLICRSHFP DAAFSSRGRL 
      1210       1220       1230       1240       1250
LKGMIPDAAP EKVETTYIIQ GNNFLKLKER KSGTDKNSAI DLANMLNPDG 
      1260       1270       1280       1290       1300
VEYTQEEEEE EEYEEMSRSP TEETSDDEPS QAAVYNNAPV IKRTYRKREL 
      1310       1320       1330       1340       1350
SNEDGPLNLV TPPAHTPNPR GRPRKYPKNS VTPEAEKSLT DYDYNPGTSQ 
      1360       1370       1380       1390       1400
RRALKKGYVQ LEDGEIVGED CEYVPEKTPS GRLIRQAVAR RSFAFADEEE 
      1410       1420       1430       1440
EEEEYEESPI VKKPKIAGRP VGRPRKDANK LPTPTPPSNE
Length:1,440
Mass (Da):163,594
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5B649C642CA07E0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U10412 mRNA Translation: AAA20088.1
U10413 Genomic DNA Translation: AAA20089.1
Z29967 Genomic DNA Translation: CAA82854.1
Z79604, Z79605 Genomic DNA Translation: CAB01901.1

Protein sequence database of the Protein Information Resource

More...PIRi		T27942

NCBI Reference Sequences

More...RefSeqi		NP_510587.1, NM_078186.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		ZK662.4.1; ZK662.4.1; WBGene00023497
ZK662.4.2; ZK662.4.2; WBGene00023497

Database of genes from NCBI RefSeq genomes

More...GeneIDi		181662

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_ZK662.4

UCSC genome browser

More...UCSCi		ZK662.4.2, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10412 mRNA Translation: AAA20088.1
U10413 Genomic DNA Translation: AAA20089.1
Z29967 Genomic DNA Translation: CAA82854.1
Z79604, Z79605 Genomic DNA Translation: CAB01901.1
PIRiT27942
RefSeqiNP_510587.1, NM_078186.6

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi46554, 1 interactor
STRINGi6239.ZK662.4.1

PTM databases

iPTMnetiQ27395

Proteomic databases

EPDiQ27395
PaxDbiQ27395
PeptideAtlasiQ27395
PRIDEiQ27395

Genome annotation databases

EnsemblMetazoaiZK662.4.1; ZK662.4.1; WBGene00023497
ZK662.4.2; ZK662.4.2; WBGene00023497
GeneIDi181662
KEGGicel:CELE_ZK662.4
UCSCiZK662.4.2, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		181662
WormBaseiZK662.4 ; CE15381 ; WBGene00023497 ; lin-15B

Phylogenomic databases

eggNOGiKOG1121, Eukaryota
GeneTreeiENSGT00390000009480
HOGENOMiCLU_004462_0_0_1
InParanoidiQ27395
OMAiVCCYCSK
OrthoDBi223749at2759

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q27395

Gene expression databases

BgeeiWBGene00023497, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR040129, Lin-15B-like
IPR012337, RNaseH-like_sf
IPR006612, THAP_Znf
PANTHERiPTHR22716, PTHR22716, 1 hit
SMARTiView protein in SMART
SM00692, DM3, 1 hit
SM00980, THAP, 1 hit
SUPFAMiSSF53098, SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50950, ZF_THAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLI15B_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q27395
Secondary accession number(s): Q94409, Q94414
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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