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Entry version 134 (12 Aug 2020)
Sequence version 2 (09 Jan 2007)
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Protein

Protein let-653

Gene

let-653

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for epithelial tube development and shaping (PubMed:27482894). Involved in the morphogenesis and function of the three unicellular tubes of the excretory system, the canal cell, the duct cell and the pore cell (PubMed:7476875, PubMed:27482894). Also plays a role in cuticle development, alae formation and shaping of the vulval lumen (PubMed:27482894). Required for larval development (PubMed:7476875, PubMed:27482894).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein let-653Curated
Alternative name(s):
Lethal protein 653Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:let-653Imported
ORF Names:C29E6.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C29E6.1a ; CE40548 ; WBGene00002827 ; let-653
C29E6.1b ; CE37323 ; WBGene00002827 ; let-653
C29E6.1c ; CE05332 ; WBGene00002827 ; let-653

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Lethal at the larval stage of development. Defects in the development of the excretory system during embryogenesis and the early stages of larval development. Dilated lumens of both the excretory canal cell and excretory duct which become apparent between the early and mid 3-fold stages of embryogenesis and increases in severity as development progresses. Lumen dialation may be as a result of fluid accumulation due to blockage of the lumen. At around the time of hatching, the autocellular junction, which usually seals the excretory pore tube, is absent. Detached excretory duct and pore cells, which usually connects the excretory canal cell to the outside environment for excretion. Irregular morphology of the epidermis and vulva in larvae at the L1 stage of larval development.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500420349222 – 812Protein let-653CuratedAdd BLAST791

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi26 ↔ 116PROSITE-ProRule annotation
Disulfide bondi53 ↔ 88PROSITE-ProRule annotation
Disulfide bondi57 ↔ 72PROSITE-ProRule annotation
Disulfide bondi123 ↔ 209PROSITE-ProRule annotation
Disulfide bondi154 ↔ 178PROSITE-ProRule annotation
Disulfide bondi158 ↔ 166PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi172N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi211N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi272N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi771N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved at the C-terminal domain.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q27394

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q27394

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in external cuticle-producing epithelial cells including the epidermis, vulva, rectum, excretory duct and excretory pore.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Secreted in the region between the embryo and inner layer of the eggshell. Expressed in excretory canal cells of embryos and at the 1.5-fold stage of embryonic development accumulates in the lumen of the excretory duct and pore. Expression ceases in the lumen of the excretory duct and pore prior to cuticle secretion. Thereafter expressed transiently in the lumen of the excretory duct and pore in the latter phase of each subsequent larval developmental stage. During the molt phase of larval development, accumulates in the space in between the new and old cuticles. During the L4 stage of larval development, accumulates in the vulval lumen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002827, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C29E6.1a.2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 116Apple 1PROSITE-ProRule annotationAdd BLAST91
Domaini123 – 209Apple 2PROSITE-ProRule annotationAdd BLAST87
Domaini221 – 725ZPPROSITE-ProRule annotationAdd BLAST505

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi367 – 576Thr-richPROSITE-ProRule annotationAdd BLAST210

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ZP domain is required for localization at the apical cell membrane, secretion and excretory tube and vulval lumen expansion.1 Publication

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SMP8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000196473

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q27394

Identification of Orthologs from Complete Genome Data

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OMAi
CHMSKDS

Database of Orthologous Groups

More...
OrthoDBi
357404at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003609, Pan_app
IPR001507, ZP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00024, PAN_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00473, PAN_AP, 2 hits
SM00241, ZP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50948, PAN, 2 hits
PS51034, ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q27394-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRHPLISLLL LIAFYSTSSE AFVPKCNSFY VRWPRVRLNF KAVAEARLSL
60 70 80 90 100
KGCQSACSLG EDPVSPGKQL ECAAVNHQAS PDGFSHLCAV FQPHQLQNVD
110 120 130 140 150
GYVEADDRFT FYWKYCLPST RKCSGEYAFT YLSDRYMDQK SVIKWTTKAN
160 170 180 190 200
LEECLSDCLD EKSFECRSIS FNRTDGGCHM SKDSQISRPE AIRLNNNPNY
210 220 230 240 250
RIDYYENNCY NLSESFTFKH ECRDNGISVS VKSRLPYTGA IYGLYDFFTC
260 270 280 290 300
RTEPKEATEF DHFFPYQTVS KNCSDSIKYK GNEMVLEVVL STDGIEPLYF
310 320 330 340 350
ITPEDLTYQA KCPISGVKAK DPANTKSSAH LDNRNKAMEA SAHALFELLS
360 370 380 390 400
KTGDDEALQN TFPLPLTTTT EVIRQVTTTT KKPSTTTSTK KLTTTTTTTP
410 420 430 440 450
KPSQKPTTTT TKSPVVITTT TKTSPKPTTS PSTTTSTTTS TTIPPSTTTR
460 470 480 490 500
KPANPRRSTI MSATSKVAII VGKDSSFARA RLFTTKHPST QKIDVPTTTV
510 520 530 540 550
QTSTTVPTTP SKTTATTTTT PKPTTTETAT TSSSTTTVTT QKPTTVTSTT
560 570 580 590 600
TLPSTTASTT TKTTTSTPTS PQTTTTHVGA PASSVASVAH DGSTLAGKPK
610 620 630 640 650
VPVIFDIFHN GQPVEAVVVG TKISLSFRPH YPIPPEYVDV RGCQVEPIDP
660 670 680 690 700
KYEWEHEPLF IIRDGCPADG VGLVCPPTHS EFGAKVSVEA FRYQTTGQVQ
710 720 730 740 750
YSCLVRICPF APCPKNTCDD VEGCDSSYMH RYRRELSLED IKKALEANPE
760 770 780 790 800
LASQFGISPS AFARNPSKSK NFTSVVEEQQ RIALGGDYLV RRRLIVVNSE
810
DQLRYYVRTG NI
Length:812
Mass (Da):89,480
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E491EC768A43C60
GO
Isoform bImported (identifier: Q27394-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-493: RNKAMEASAH...TTKHPSTQKI → S

Show »
Length:653
Mass (Da):72,485
Checksum:iFDD95C20649DF5B8
GO
Isoform cImported (identifier: Q27394-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     374-493: RQVTTTTKKP...TTKHPSTQKI → S

Show »
Length:693
Mass (Da):76,842
Checksum:i335BF94F4DA503AD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058741334 – 493RNKAM…STQKI → S in isoform b. CuratedAdd BLAST160
Alternative sequenceiVSP_058742374 – 493RQVTT…STQKI → S in isoform c. CuratedAdd BLAST120

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X91045 Genomic DNA Translation: CAA62505.1
BX284604 Genomic DNA Translation: CAA96602.2
BX284604 Genomic DNA Translation: CAH60755.1
BX284604 Genomic DNA Translation: CCD31038.1

Protein sequence database of the Protein Information Resource

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PIRi
T19551

NCBI Reference Sequences

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RefSeqi
NP_001021336.2, NM_001026165.4 [Q27394-1]
NP_001021337.1, NM_001026166.3 [Q27394-2]
NP_001255594.1, NM_001268665.1 [Q27394-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C29E6.1a.1; C29E6.1a.1; WBGene00002827 [Q27394-1]
C29E6.1a.2; C29E6.1a.2; WBGene00002827 [Q27394-1]
C29E6.1b.1; C29E6.1b.1; WBGene00002827 [Q27394-2]
C29E6.1b.2; C29E6.1b.2; WBGene00002827 [Q27394-2]
C29E6.1c.1; C29E6.1c.1; WBGene00002827 [Q27394-3]
C29E6.1c.2; C29E6.1c.2; WBGene00002827 [Q27394-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
178120

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_C29E6.1

UCSC genome browser

More...
UCSCi
C29E6.1b.1, c. elegans [Q27394-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91045 Genomic DNA Translation: CAA62505.1
BX284604 Genomic DNA Translation: CAA96602.2
BX284604 Genomic DNA Translation: CAH60755.1
BX284604 Genomic DNA Translation: CCD31038.1
PIRiT19551
RefSeqiNP_001021336.2, NM_001026165.4 [Q27394-1]
NP_001021337.1, NM_001026166.3 [Q27394-2]
NP_001255594.1, NM_001268665.1 [Q27394-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.C29E6.1a.2

Proteomic databases

EPDiQ27394
PaxDbiQ27394

Genome annotation databases

EnsemblMetazoaiC29E6.1a.1; C29E6.1a.1; WBGene00002827 [Q27394-1]
C29E6.1a.2; C29E6.1a.2; WBGene00002827 [Q27394-1]
C29E6.1b.1; C29E6.1b.1; WBGene00002827 [Q27394-2]
C29E6.1b.2; C29E6.1b.2; WBGene00002827 [Q27394-2]
C29E6.1c.1; C29E6.1c.1; WBGene00002827 [Q27394-3]
C29E6.1c.2; C29E6.1c.2; WBGene00002827 [Q27394-3]
GeneIDi178120
KEGGicel:CELE_C29E6.1
UCSCiC29E6.1b.1, c. elegans [Q27394-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178120
WormBaseiC29E6.1a ; CE40548 ; WBGene00002827 ; let-653
C29E6.1b ; CE37323 ; WBGene00002827 ; let-653
C29E6.1c ; CE05332 ; WBGene00002827 ; let-653

Phylogenomic databases

eggNOGiENOG502SMP8, Eukaryota
GeneTreeiENSGT00970000196473
InParanoidiQ27394
OMAiCHMSKDS
OrthoDBi357404at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q27394

Gene expression databases

BgeeiWBGene00002827, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003609, Pan_app
IPR001507, ZP_dom
PfamiView protein in Pfam
PF00024, PAN_1, 1 hit
SMARTiView protein in SMART
SM00473, PAN_AP, 2 hits
SM00241, ZP, 1 hit
PROSITEiView protein in PROSITE
PS50948, PAN, 2 hits
PS51034, ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLE653_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q27394
Secondary accession number(s): G5ECH8, Q5WRN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 18, 2017
Last sequence update: January 9, 2007
Last modified: August 12, 2020
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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