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Protein

Protein dif-1

Gene

dif-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to play a role in the maintenance of tissue differentiation in the developing embryo, but not for its initiation.

GO - Molecular functioni

  • carnitine:acyl carnitine antiporter activity Source: GO_Central
  • carnitine transmembrane transporter activity Source: GO_Central
  • transporter activity Source: UniProtKB

GO - Biological processi

  • carnitine transport Source: GO_Central
  • mitochondrial transport Source: UniProtKB
  • multicellular organism development Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-CEL-200425 Import of palmitoyl-CoA into the mitochondrial matrix

Protein family/group databases

TCDBi2.A.29.8.2 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dif-1
Gene namesi
Name:dif-1
ORF Names:F49E8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF49E8.5 ; CE28408 ; WBGene00000996 ; dif-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei172 – 192Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei261 – 282Helical; Name=6Sequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906931 – 312Protein dif-1Add BLAST312

Proteomic databases

EPDiQ27257
PaxDbiQ27257
PeptideAtlasiQ27257
PRIDEiQ27257

Expressioni

Developmental stagei

Although dif-1 activity is required only during embryogenesis, it is expressed at all stages of development.

Gene expression databases

BgeeiWBGene00000996

Interactioni

Protein-protein interaction databases

IntActiQ27257, 1 interactor
STRINGi6239.F49E8.5.1

Structurei

3D structure databases

ProteinModelPortaliQ27257
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 93Solcar 1Add BLAST92
Repeati102 – 193Solcar 2Add BLAST92
Repeati203 – 289Solcar 3Add BLAST87

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758 Eukaryota
ENOG410XS86 LUCA
GeneTreeiENSGT00700000104295
HOGENOMiHOG000168307
InParanoidiQ27257
KOiK15109
OMAiNIVAPNF
OrthoDBiEOG091G0HVE
PhylomeDBiQ27257

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q27257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVLLNFIA GGVGGSCTVI VGHPFDTVKV RIQTMPMPKP GEKPQFTGAL
60 70 80 90 100
DCVKRTVSKE GFFALYKGMA APLVGVSPLF AVFFGGCAVG KWLQQTDPSQ
110 120 130 140 150
EMTFIQNANA GALAGVFTTI VMVPGERIKC LLQVQQAGSA GSGVHYDGPL
160 170 180 190 200
DVVKKLYKQG GISSIYRGTG ATLLRDIPAS AAYLSVYEYL KKKFSGEGAQ
210 220 230 240 250
RTLSPGATLM AGGLAGIANW GVCIPADVLK SRLQTAPEGK YPDGIRGVLR
260 270 280 290 300
EVLREEGPRA LFKGFWPVML RAFPANAACF FGLELTLAAF RYFGIGGHPT
310
PSTEVVPLPH DE
Length:312
Mass (Da):33,135
Last modified:November 1, 1996 - v1
Checksum:iCCF1300CAE4DF64F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76115 mRNA Translation: CAA53721.1
Z48240 Genomic DNA Translation: CAA88283.1
FO081280 Genomic DNA Translation: CCD70447.1
PIRiT29640
RefSeqiNP_501223.1, NM_068822.5
UniGeneiCel.8694

Genome annotation databases

EnsemblMetazoaiF49E8.5.1; F49E8.5.1; WBGene00000996
F49E8.5.2; F49E8.5.2; WBGene00000996
F49E8.5.3; F49E8.5.3; WBGene00000996
GeneIDi177530
KEGGicel:CELE_F49E8.5
UCSCiF49E8.5.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiDIF1_CAEEL
AccessioniPrimary (citable) accession number: Q27257
Secondary accession number(s): Q20630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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