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UniProtKB - Q26671 (CDK2H_THEAN)
Protein
Cyclin-dependent kinase 2 homolog
Gene
CRK2
Organism
Theileria annulata
Status
Functioni
Serine/threonine-protein kinase (By similarity).
Involved in the control of the cell cycle. Required for entry into S-phase and mitosis (By similarity).
Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).
By similarityCatalytic activityi
Cofactori
Mg2+By similarity
Activity regulationi
Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 32 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 125 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CRK21 Publication ORF Names:TA06730 |
Organismi | Theileria annulata |
Taxonomic identifieri | 5874 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Piroplasmida › Theileriidae › Theileria |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PiroplasmaDB:TA06730 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000232673 | 1 – 298 | Cyclin-dependent kinase 2 homologAdd BLAST | 298 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 15 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 158 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PRIDEi | Q26671 |
Interactioni
Subunit structurei
May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.
By similarityProtein-protein interaction databases
STRINGi | 5874.XP_954049.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 284 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 281 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0594, Eukaryota |
InParanoidi | Q26671 |
OMAi | NNDVWPE |
OrthoDBi | 1010560at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q26671-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRYHKMEKI GEGTYGVVYK AQNNHGEICA LKKIRVEEED EGIPSTAIRE
60 70 80 90 100
ISLLKELHHP NIVWLRDVIH SEKCLTLVFE YLDQDLKKLL DACDGGLEPT
110 120 130 140 150
TAKSFLYQIL RGISYCHDHR ILHRDLKPQN LLINREGVLK LADFGLARAF
160 170 180 190 200
AIPVRSYTHE VVTLWYRAPD VLMGSKKYST AVDIWSVGCI FAEMINGVPL
210 220 230 240 250
FPGISEQDQL KRIFKILGTP NVDSWPQVVN LPAYNPDFCY YEKQAWSSIV
260 270 280 290
PKLNESGIDL ISRMLQLDPV QRISAKEALK HDYFKDLHRP SEFLNGVH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98768 mRNA Translation: CAA67306.1 CR940347 Genomic DNA Translation: CAI73372.1 |
RefSeqi | XP_954049.1, XM_948956.1 |
Genome annotation databases
GeneIDi | 3863999 |
KEGGi | tan:TA06730 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98768 mRNA Translation: CAA67306.1 CR940347 Genomic DNA Translation: CAI73372.1 |
RefSeqi | XP_954049.1, XM_948956.1 |
3D structure databases
AlphaFoldDBi | Q26671 |
SMRi | Q26671 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5874.XP_954049.1 |
Proteomic databases
PRIDEi | Q26671 |
Genome annotation databases
GeneIDi | 3863999 |
KEGGi | tan:TA06730 |
Organism-specific databases
VEuPathDBi | PiroplasmaDB:TA06730 |
Phylogenomic databases
eggNOGi | KOG0594, Eukaryota |
InParanoidi | Q26671 |
OMAi | NNDVWPE |
OrthoDBi | 1010560at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDK2H_THEAN | |
Accessioni | Q26671Primary (citable) accession number: Q26671 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families