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Protein

Cathepsin L

Gene
N/A
Organism
Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for the overall degradation of proteins in lysosomes. Required for differentiation of imaginal disks.1 Publication

Catalytic activityi

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei146By similarity1
Active sitei285By similarity1
Active sitei306By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease, Thiol protease
Biological processDifferentiation

Protein family/group databases

MEROPSiC01.092

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin L (EC:3.4.22.15)
Cleaved into the following 2 chains:
OrganismiSarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)
Taxonomic identifieri7386 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaOestroideaSarcophagidaeSarcophagaBoettcherisca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
PropeptideiPRO_000002626918 – 121Activation peptide1 PublicationAdd BLAST104
ChainiPRO_0000026270122 – 294Cathepsin L heavy chainAdd BLAST173
PropeptideiPRO_0000026271295 – 298By similarity4
ChainiPRO_0000026272299 – 339Cathepsin L light chainAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 186By similarity
Disulfide bondi177 ↔ 219By similarity
Disulfide bondi278 ↔ 328Interchain (between heavy and light chains)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ26636

Expressioni

Developmental stagei

Highly expressed during embryonic development with higher levels in first instar than in third instar.1 Publication

Interactioni

Subunit structurei

Dimer of a heavy and a light chain linked by disulfide bonds.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ26636
SMRiQ26636
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q26636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTVLVALLA LVALTQAISP LDLIKEEWHT YKLQHRKNYA NEVEERFRMK
60 70 80 90 100
IFNENRHKIA KHNQLFAQGK VSYKLGLNKY ADMLHHEFKE TMNGYNHTLR
110 120 130 140 150
QLMRERTGLV GATYIPPAHV TVPKSVDWRE HGAVTGVKDQ GHCGSCWAFS
160 170 180 190 200
STGALEGQHF RKAGVLVSLS EQNLVDCSTK YGNNGCNGGL MDNAFRYIKD
210 220 230 240 250
NGGIDTEKSY PYEGIDDSCH FNKATIGATD TGFVDIPEGD EEKMKKAVAT
260 270 280 290 300
MGPVSVAIDA SHESFQLYSE GVYNEPECDE QNLDHGVLVV GYGTDESGMD
310 320 330
YWLVKNSWGT TWGEQGYIKM ARNQNNQCGI ATASSYPTV
Length:339
Mass (Da):37,847
Last modified:November 1, 1996 - v1
Checksum:i7401F3281A2FDA33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16533 mRNA Translation: BAA03970.1
PIRiA53810

Similar proteinsi

Entry informationi

Entry nameiCATL_SARPE
AccessioniPrimary (citable) accession number: Q26636
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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