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Protein
Submitted name:

Aspartic proteinase

Gene

ctsd

Organism
Schistosoma japonicum (Blood fluke)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84PROSITE-ProRule annotation1
Active sitei270PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.009

Names & Taxonomyi

Protein namesi
Submitted name:
Aspartic proteinaseImported
Submitted name:
Cathepsin D (Lysosomal aspartyl protease)Imported (EC:3.4.23.5Imported)
Gene namesi
Name:ctsdImported
OrganismiSchistosoma japonicum (Blood fluke)Imported
Taxonomic identifieri6182 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Structurei

3D structure databases

ProteinModelPortaliQ26515
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 380Peptidase A1InterPro annotationAdd BLAST315

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Family and domain databases

Gene3Di2.40.70.10, 3 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Q26515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHLLLLLHL VSSEVVRVPL YPLKSARRSL IEFETSLENV QKVWFSRFSN
60 70 80 90 100
VEPRPEYLKN YLDAQYYGDI TIGTPPQTFS VVFDTGSSNL WVPSKHCSYF
110 120 130 140 150
DIACLLHRKY DSSKSTTYVP NGTDFSIRYG TGSLSGFLST DSLQLGSLGV
160 170 180 190 200
KGQTFGEATK QPGLVFVMAK FDGILGMAYP SLAVGGVTPV FVNMIKQGVV
210 220 230 240 250
DSPVFSFYLS RNITNVLGGE LMIGGIDDKY YTGEINYVNL TEKSYWLFKM
260 270 280 290 300
DNLTISDLSI CTDGCQAIAD TGTSMIAGPT DEVKQINQKL GATHLPGGIY
310 320 330 340 350
TVSCDVINNL PSIDFVINGK HMTLEPTDYI MKVSKLGSEI CLTGFIGMDL
360 370 380 390 400
PRKKLWILGD VFIGKFYTIF DMGKNRVGFA KAVKPDSSYH HTKVYSPMLR
410 420
LFPAQSIPKV APKSPNGVFA FSKLLHDAN
Length:429
Mass (Da):47,382
Last modified:January 1, 1998 - v2
Checksum:iD0CFD8B65C1F4FC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41346 mRNA Translation: AAC37302.1
FN316577 mRNA Translation: CAX72308.1
FN316578 mRNA Translation: CAX72309.1
FN316579 mRNA Translation: CAX72310.1
FN316580 mRNA Translation: CAX72311.1
FN316581 mRNA Translation: CAX72312.1
FN316582 mRNA Translation: CAX72313.1
FN316584 mRNA Translation: CAX72315.1
FN316586 mRNA Translation: CAX72317.1
FN316587 mRNA Translation: CAX72318.1
FN316592 mRNA Translation: CAX72323.1
FN316593 mRNA Translation: CAX72324.1
FN316595 mRNA Translation: CAX72326.1
FN316596 mRNA Translation: CAX72327.1
FN316597 mRNA Translation: CAX72328.1
FN316598 mRNA Translation: CAX72329.1
FN316602 mRNA Translation: CAX72333.1
FN316603 mRNA Translation: CAX72334.1
FN316605 mRNA Translation: CAX72336.1
FN316606 mRNA Translation: CAX72337.1
FN316607 mRNA Translation: CAX72338.1
FN316608 mRNA Translation: CAX72339.1
FN316611 mRNA Translation: CAX72342.1
FN323678 mRNA Translation: CAX79402.1

Similar proteinsi

Entry informationi

Entry nameiQ26515_SCHJA
AccessioniPrimary (citable) accession number: Q26515
Secondary accession number(s): O02027
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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