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Entry version 149 (02 Jun 2021)
Sequence version 2 (11 Oct 2004)
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Protein

Netrin receptor unc-5

Gene

unc-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for netrin (unc-6) required for axon guidance (PubMed:8332188, PubMed:11454756).

Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:1384987, PubMed:8332188, PubMed:11454756).

Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:11454756).

Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced-10/Rac, ced-12/ELMO and mig-2/RhoG (PubMed:10631179, PubMed:26292279).

5 Publications

Caution

In contrast to other members of the family, it lacks a canonical signal sequence; the existence of the signal sequence is therefore unsure.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • netrin receptor activity Source: UniProtKB
  • protein tyrosine kinase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-373752, Netrin-1 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Netrin receptor unc-5
Alternative name(s):
Uncoordinated protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-5
ORF Names:B0273.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
B0273.4a ; CE16790 ; WBGene00006745 ; unc-5
B0273.4b ; CE37693 ; WBGene00006745 ; unc-5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini? – 340ExtracellularSequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 919CytoplasmicSequence analysisAdd BLAST558

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Failed distal tip cell migration along the dorsal-ventral axis of the body. RNAi-mediated knockdown in mom-5, ced-10, ced-12 or mig-2 mutant backgrounds suppresses the migratory defect of distal tip cells in the respective single mutants.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi181C → Y in ev585; temperature-sensitive allele leading to distal tip cells migration defects. 1 Publication1
Mutagenesisi283 – 919Missing in e53; Disregulates axon guidance and migration. On an unc-129 mutant background, does not contribute to an increase in axonal guidance defects. 1 PublicationAdd BLAST637
Mutagenesisi387 – 388YY → FF: Induces a strong decrease in tyrosine phosphorylation but only weakly affects function in vivo; when associated with F-417; F-439; F-538 and F-691. 1 Publication2
Mutagenesisi417Y → F: Induces a strong decrease in tyrosine phosphorylation but only weakly affects function in vivo; when associated with F-387; F-388; F-439; F-538 and F-691. 1 Publication1
Mutagenesisi439Y → F: Induces a strong decrease in tyrosine phosphorylation but only weakly affects function in vivo; when associated with F-387; F-388; F-417; F-538 and F-691. 1 Publication1
Mutagenesisi482Y → F: Loss of function and induces a strong decrease in tyrosine phosphorylation. 1 Publication1
Mutagenesisi538Y → F: Induces a strong decrease in tyrosine phosphorylation but only weakly affects function in vivo; when associated with F-387; F-388; F-417; F-439 and F-691. 1 Publication1
Mutagenesisi691Y → F: Induces a strong decrease in tyrosine phosphorylation but only weakly affects function in vivo; when associated with F-387; F-388; F-417; F-439 and F-538. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – ?Sequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000036081? – 919Netrin receptor unc-5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 84By similarity
Disulfide bondi132 ↔ 181By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi178N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi215 ↔ 267By similarity
Disulfide bondi219 ↔ 271By similarity
Disulfide bondi245 ↔ 257By similarity
Glycosylationi277C-linked (Man) tryptophan1 Publication1
Glycosylationi280C-linked (Man) tryptophan1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei482Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on different cytoplasmic tyrosine residues (PubMed:11533026, PubMed:12435363, PubMed:16024786). May be phosphorylated on tyrosine residues by src-1 (PubMed:16024786). Tyrosine phosphorylation is unc-6-dependent (PubMed:11533026).3 Publications
Glycosylated via C-mannosylation by dpy-19 at Trp-277 and Trp-280.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q26261

PeptideAtlas

More...
PeptideAtlasi
Q26261

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q26261

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cell bodies and axons of the VNC motor neurons that extend axons to the dorsal midline and within the ventral nerve cord (PubMed:12435363). Expressed in gonadal distal tip cells (DTC) (PubMed:16251208).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006745, Expressed in multi-cellular organism and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q26261, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via cytoplasmic domain) with src-1 (via SH2 domain and SH3 domain) (PubMed:16024786).

Interacts with madd-4 (PubMed:25122090).

Interacts with unc-129; the interaction is direct (PubMed:19169249).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
42456, 7 interactors

STRING: functional protein association networks

More...
STRINGi
6239.B0273.4a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q26261

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 113Ig-likeAdd BLAST99
Domaini111 – 198Ig-like C2-typeAdd BLAST88
Domaini202 – 272TSP type-1 1PROSITE-ProRule annotationAdd BLAST71
Domaini274 – 326TSP type-1 2PROSITE-ProRule annotationAdd BLAST53
Domaini502 – 630ZU5PROSITE-ProRule annotationAdd BLAST129
Domaini829 – 910DeathPROSITE-ProRule annotationAdd BLAST82

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-5 family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1480, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182815

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q26261

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTAECRG

Database of Orthologous Groups

More...
OrthoDBi
334938at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q26261

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 2 hits
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR037936, UNC5
IPR033772, UPA
IPR000906, ZU5_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12582, PTHR12582, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00531, Death, 1 hit
PF13895, Ig_2, 1 hit
PF00090, TSP_1, 1 hit
PF17217, UPA, 1 hit
PF00791, ZU5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00005, DEATH, 1 hit
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00209, TSP1, 2 hits
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48726, SSF48726, 1 hit
SSF82895, SSF82895, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS50835, IG_LIKE, 1 hit
PS50092, TSP1, 2 hits
PS51145, ZU5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform a (identifier: Q26261-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEITITTQP KSGYVIRNKP LRLQCRANHA TKIRYKCSSK WIDDSRIEKL
60 70 80 90 100
IGTDSTSGVG YIDASVDISR IDVDTSGHVD AFQCQCYASG DDDQDVVASD
110 120 130 140 150
VATVHLAYMR KHFLKSPVAQ RVQEGTTLQL PCQAPESDPK AELTWYKDGV
160 170 180 190 200
VVQPDANVIR ASDGSLIMSA ARLSDSGNYT CEATNVANSR KTDPVEVQIY
210 220 230 240 250
VDGGWSEWSP WIGTCHVDCP LLRQHAHRIR DPHDVLPHQR RTRTCNNPAP
260 270 280 290 300
LNDGEYCKGE EEMTRSCKVP CKLDGGWSSW SDWSACSSSC HRYRTRACTV
310 320 330 340 350
PPPMNGGQPC FGDDLMTQEC PAQLCTADSS RIVISDTAVY GSVASIFIVA
360 370 380 390 400
SFILAILAMF CCKRGNSKKS KPLKPQKMNS EKAGGIYYSE PPGVRRLLLE
410 420 430 440 450
HQHGTLLGEK ISSCSQYFEP PPLPHSTTLR SGKSAFSGYS STRNAGSRAA
460 470 480 490 500
LIQECSSSSS GSGGKRTMLR TSSSNCSDDD NYATLYDYME DKSVLGLDTS
510 520 530 540 550
QNIVAAQIDS NGARLSLSKS GARLIVPELA VEGEKMLYLA VSDTLTDQPH
560 570 580 590 600
LKPIESALSP VIVIGQCDVS MSAHDNILRR PVVVSFRHCA STFPRDNWQF
610 620 630 640 650
TLYADEGSGW QKAVTIGEEN LNTNMFVQFE QPGKKNDGFG WCHVMTYSLA
660 670 680 690 700
RLMLAGHPRR NSLSAAKRVH LAVFGPTEMS AYRRPFELRV YCVPETGAAM
710 720 730 740 750
ESVWKQEDGS RLLCESNDFI LNEKGNLCIC IEDVIPGFSC DGPEVVEISE
760 770 780 790 800
TQHRFVAQNG LHCSLKFRPK EINGSQFSTR VIVYQKASST EPMVMEVSNE
810 820 830 840 850
PELYDATSEE REKGSVCVEF RLPFGVKDEL ARLLDMPNES HSDWRGLAKK
860 870 880 890 900
LHYDRYLQFF ASFPDCSPTS LLLDLWEASS SGSARAVPDL LQTLRVMGRP
910
DAVMVLERFL SAFPQIVSP
Length:919
Mass (Da):101,626
Last modified:October 11, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i841BC6A514414F39
GO
Isoform b (identifier: Q26261-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     553-567: PIESALSPVIVIGQC → RECKKILKIYISKIS
     568-919: Missing.

Show »
Length:567
Mass (Da):62,176
Checksum:iF59F4AA1D0855C4F
GO
Isoform c (identifier: Q26261-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEDDTPDVSSDSNGDAAYSDYFLDYKSIM

Show »
Length:947
Mass (Da):104,729
Checksum:iA60286D544A2F187
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V6CK86V6CK86_CAEEL
Netrin receptor UNC5
unc-5 B0273.4, CELE_B0273.4
947Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CLL7V6CLL7_CAEEL
Netrin receptor UNC5
unc-5 B0273.4, CELE_B0273.4
811Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CLK6V6CLK6_CAEEL
Netrin receptor UNC5
unc-5 B0273.4, CELE_B0273.4
752Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CLG6V6CLG6_CAEEL
Netrin receptor UNC5
unc-5 B0273.4, CELE_B0273.4
657Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti614V → L in AAB23866 (PubMed:1384987).Curated1
Sequence conflicti614V → L in AAB23867 (PubMed:1384987).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0117041M → MEDDTPDVSSDSNGDAAYSD YFLDYKSIM in isoform c. Curated1
Alternative sequenceiVSP_013846553 – 567PIESA…VIGQC → RECKKILKIYISKIS in isoform b. CuratedAdd BLAST15
Alternative sequenceiVSP_013847568 – 919Missing in isoform b. CuratedAdd BLAST352

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
S47168 S47167 Genomic DNA Translation: AAB23866.2
S47168 S47167 Genomic DNA Translation: AAB23867.2
FO080145 Genomic DNA Translation: CCD61588.1
FO080145 Genomic DNA Translation: CCD61589.1

Protein sequence database of the Protein Information Resource

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PIRi
B44294
T32541

NCBI Reference Sequences

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RefSeqi
NP_500822.2, NM_068421.4 [Q26261-1]
NP_500823.1, NM_068422.5 [Q26261-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
B0273.4a.1; B0273.4a.1; WBGene00006745 [Q26261-2]
B0273.4b.1; B0273.4b.1; WBGene00006745 [Q26261-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
177334

UCSC genome browser

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UCSCi
B0273.4a, c. elegans [Q26261-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S47168 S47167 Genomic DNA Translation: AAB23866.2
S47168 S47167 Genomic DNA Translation: AAB23867.2
FO080145 Genomic DNA Translation: CCD61588.1
FO080145 Genomic DNA Translation: CCD61589.1
PIRiB44294
T32541
RefSeqiNP_500822.2, NM_068421.4 [Q26261-1]
NP_500823.1, NM_068422.5 [Q26261-2]

3D structure databases

SMRiQ26261
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi42456, 7 interactors
STRINGi6239.B0273.4a

PTM databases

iPTMnetiQ26261

Proteomic databases

PaxDbiQ26261
PeptideAtlasiQ26261

Genome annotation databases

EnsemblMetazoaiB0273.4a.1; B0273.4a.1; WBGene00006745 [Q26261-2]
B0273.4b.1; B0273.4b.1; WBGene00006745 [Q26261-1]
GeneIDi177334
UCSCiB0273.4a, c. elegans [Q26261-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36703
WormBaseiB0273.4a ; CE16790 ; WBGene00006745 ; unc-5
B0273.4b ; CE37693 ; WBGene00006745 ; unc-5

Phylogenomic databases

eggNOGiKOG1480, Eukaryota
GeneTreeiENSGT00950000182815
InParanoidiQ26261
OMAiQTAECRG
OrthoDBi334938at2759
PhylomeDBiQ26261

Enzyme and pathway databases

ReactomeiR-CEL-373752, Netrin-1 signaling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q26261

Gene expression databases

BgeeiWBGene00006745, Expressed in multi-cellular organism and 4 other tissues
ExpressionAtlasiQ26261, baseline and differential

Family and domain databases

Gene3Di2.20.100.10, 2 hits
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR037936, UNC5
IPR033772, UPA
IPR000906, ZU5_dom
PANTHERiPTHR12582, PTHR12582, 1 hit
PfamiView protein in Pfam
PF00531, Death, 1 hit
PF13895, Ig_2, 1 hit
PF00090, TSP_1, 1 hit
PF17217, UPA, 1 hit
PF00791, ZU5, 1 hit
SMARTiView protein in SMART
SM00005, DEATH, 1 hit
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00209, TSP1, 2 hits
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48726, SSF48726, 1 hit
SSF82895, SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS50835, IG_LIKE, 1 hit
PS50092, TSP1, 2 hits
PS51145, ZU5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNC5_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q26261
Secondary accession number(s): O44171
, Q26262, Q7JPT6, Q7KPX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 2, 2021
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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