Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear egress protein 1

Gene

UL31

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri106 – 225CCCH-typeUniRule annotationAdd BLAST120

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear egress protein 1UniRule annotation
Gene namesi
Name:UL31Imported
Synonyms:NEC1UniRule annotation
ORF Names:HHV1gp048Imported, hmpv208_0032Imported, hmpv214_0032Imported
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000126435 Componenti: Genome
  • UP000121444 Componenti: Genome
  • UP000180758 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host membraneUniRule annotation, Host nucleusUniRule annotation, Membrane

PTM / Processingi

Post-translational modificationi

Phosphorylated at serine residues in the N-terminus. This phosphorylation regulates the localization within the inner nuclear membrane.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Forms a heterohexameric complex with NEC2. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae NEC1 protein family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri106 – 225CCCH-typeUniRule annotationAdd BLAST120

Keywords - Domaini

Zinc-fingerUniRule annotation

Family and domain databases

HAMAPiMF_04023 HSV_NEC1, 1 hit
InterProiView protein in InterPro
IPR021152 Herpes_UL31
PfamiView protein in Pfam
PF02718 Herpes_UL31, 1 hit

Sequencei

Sequence statusi: Complete.

Q25BX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYDTDPHRRG SRPGPYHGKE RRRSRSSAAG GTLGVVRRAS RKSLPPHARK
60 70 80 90 100
QELCLHERQR YRGLFAALAQ TPSEEIAIVR SLSVPLVKTT PVSLPFCLDQ
110 120 130 140 150
TVADNCLTLS GMGYYLGIGG CCPACNAGDG RFAATSREAL ILAFVQQINT
160 170 180 190 200
IFEHRAFLAS LVVLADRHNA PLQDLLAGIL GQPELFFVHT ILRGGGACDP
210 220 230 240 250
RLLFYPDPTY GGHMLYVIFP GTSAHLHYRL IDRMLTACPG YRFVAHVWQS
260 270 280 290 300
TFVLVVRRNA EKPTDAEIPT VSAADIYCKM RDISFDGGLM LEYQRLYATF

DEFPPP
Length:306
Mass (Da):33,953
Last modified:April 18, 2006 - v1
Checksum:iD4FE0FD98D934C46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ889502 Genomic DNA Translation: ABI63493.1
GU734771 Genomic DNA Translation: ADD60001.1
GU734772 Genomic DNA Translation: ADD60078.1
HM585496 Genomic DNA Translation: ADM22354.1
HM585497 Genomic DNA Translation: ADM22431.1
HM585498 Genomic DNA Translation: ADM22507.1
HM585499 Genomic DNA Translation: ADM22584.1
HM585500 Genomic DNA Translation: ADM22661.1
HM585501 Genomic DNA Translation: ADM22738.1
HM585502 Genomic DNA Translation: ADM22814.1
HM585503 Genomic DNA Translation: ADM22891.1
HM585505 Genomic DNA Translation: ADM23044.1
HM585506 Genomic DNA Translation: ADM23120.1
HM585507 Genomic DNA Translation: ADM23197.1
HM585510 Genomic DNA Translation: ADM23422.1
HM585511 Genomic DNA Translation: ADM23496.1
HM585512 Genomic DNA Translation: ADM23570.1
HM585513 Genomic DNA Translation: ADM23645.1
HM585514 Genomic DNA Translation: ADM23720.1
HM585515 Genomic DNA Translation: ADM23796.1
JN555585 Genomic DNA Translation: AEQ77062.1
JN420337 Genomic DNA Translation: AER37685.1
JQ730035 Genomic DNA Translation: AFK50377.1
JX142173 Genomic DNA Translation: AFP86395.1
KM222724 Genomic DNA Translation: AJE60189.1
KM222725 Genomic DNA Translation: AJE60262.1
KM222726 Genomic DNA Translation: AJE60332.1
KM222727 Genomic DNA Translation: AJE60405.1
KT425107 Genomic DNA Translation: ALM22600.1
KU310657 Genomic DNA Translation: AMB65629.1
KU310658 Genomic DNA Translation: AMB65702.1
KU310659 Genomic DNA Translation: AMB65776.1
KU310660 Genomic DNA Translation: AMB65849.1
KX791914 Genomic DNA Translation: AOY34236.1
KX791987 Genomic DNA Translation: AOY34299.1
KX946970 Genomic DNA Translation: AOY36650.1
MH160359 Genomic DNA Translation: AWO69144.1
MH160360 Genomic DNA Translation: AWO69234.1
MH160361 Genomic DNA Translation: AWO69334.1
MH160362 Genomic DNA Translation: AWO69434.1
MH160364 Genomic DNA Translation: AWO69628.1
MH160365 Genomic DNA Translation: AWO69725.1
MH160366 Genomic DNA Translation: AWO69823.1
MH160367 Genomic DNA Translation: AWO69917.1
MH160368 Genomic DNA Translation: AWO70012.1
MH160371 Genomic DNA Translation: AWO70285.1
MH160372 Genomic DNA Translation: AWO70376.1
MH160377 Genomic DNA Translation: AWO70840.1
MH160378 Genomic DNA Translation: AWO70935.1
MH160382 Genomic DNA Translation: AWO71300.1
MH160383 Genomic DNA Translation: AWO71395.1
MH160384 Genomic DNA Translation: AWO71491.1
MH160385 Genomic DNA Translation: AWO71589.1
MH160386 Genomic DNA Translation: AWO71676.1
MH160387 Genomic DNA Translation: AWO71761.1
MH160389 Genomic DNA Translation: AWO71946.1
MH160390 Genomic DNA Translation: AWO72042.1
MH160391 Genomic DNA Translation: AWO72138.1
MG999838 Genomic DNA Translation: AWW07798.1
MG999839 Genomic DNA Translation: AWW07880.1
MG999841 Genomic DNA Translation: AWW08126.1
MG999845 Genomic DNA Translation: AWW08488.1
MG999847 Genomic DNA Translation: AWW08690.1
MG999849 Genomic DNA Translation: AWW08868.1
MG999851 Genomic DNA Translation: AWW09043.1
MG999856 Genomic DNA Translation: AWW09487.1
MG999857 Genomic DNA Translation: AWW09581.1
MG999858 Genomic DNA Translation: AWW09676.1
MG999859 Genomic DNA Translation: AWW09764.1
MG999860 Genomic DNA Translation: AWW09846.1
MG999863 Genomic DNA Translation: AWW10126.1
MG999865 Genomic DNA Translation: AWW10304.1
MG999869 Genomic DNA Translation: AWW10663.1
MG999870 Genomic DNA Translation: AWW10748.1
MG999871 Genomic DNA Translation: AWW10826.1
MG999872 Genomic DNA Translation: AWW10952.1
MG999873 Genomic DNA Translation: AWW11054.1
MG999875 Genomic DNA Translation: AWW11237.1
MG999876 Genomic DNA Translation: AWW11322.1
MG999878 Genomic DNA Translation: AWW11504.1
MG999879 Genomic DNA Translation: AWW11594.1
MG999881 Genomic DNA Translation: AWW11782.1
MG999884 Genomic DNA Translation: AWW12058.1
MG999885 Genomic DNA Translation: AWW12133.1
MG999886 Genomic DNA Translation: AWW12224.1
MG999887 Genomic DNA Translation: AWW12307.1
MG999889 Genomic DNA Translation: AWW12476.1
MG999890 Genomic DNA Translation: AWW12559.1
MG999894 Genomic DNA Translation: AWW12941.1
MG999896 Genomic DNA Translation: AWW13124.1
MG999897 Genomic DNA Translation: AWW13216.1
MG999898 Genomic DNA Translation: AWW13297.1
MG999899 Genomic DNA Translation: AWW13384.1
AB252864 Genomic DNA Translation: BAE87040.1
LT594105 Genomic DNA Translation: SBS69261.1
LT594107 Genomic DNA Translation: SBS69333.1
LT594112 Genomic DNA Translation: SBS69373.1
LT594109 Genomic DNA Translation: SBS69492.1
LT594111 Genomic DNA Translation: SBS69513.1
LT594192 Genomic DNA Translation: SBS69777.1
RefSeqiYP_009137106.1, NC_001806.2

Genome annotation databases

GeneIDi2703350
KEGGivg:2703350

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ889502 Genomic DNA Translation: ABI63493.1
GU734771 Genomic DNA Translation: ADD60001.1
GU734772 Genomic DNA Translation: ADD60078.1
HM585496 Genomic DNA Translation: ADM22354.1
HM585497 Genomic DNA Translation: ADM22431.1
HM585498 Genomic DNA Translation: ADM22507.1
HM585499 Genomic DNA Translation: ADM22584.1
HM585500 Genomic DNA Translation: ADM22661.1
HM585501 Genomic DNA Translation: ADM22738.1
HM585502 Genomic DNA Translation: ADM22814.1
HM585503 Genomic DNA Translation: ADM22891.1
HM585505 Genomic DNA Translation: ADM23044.1
HM585506 Genomic DNA Translation: ADM23120.1
HM585507 Genomic DNA Translation: ADM23197.1
HM585510 Genomic DNA Translation: ADM23422.1
HM585511 Genomic DNA Translation: ADM23496.1
HM585512 Genomic DNA Translation: ADM23570.1
HM585513 Genomic DNA Translation: ADM23645.1
HM585514 Genomic DNA Translation: ADM23720.1
HM585515 Genomic DNA Translation: ADM23796.1
JN555585 Genomic DNA Translation: AEQ77062.1
JN420337 Genomic DNA Translation: AER37685.1
JQ730035 Genomic DNA Translation: AFK50377.1
JX142173 Genomic DNA Translation: AFP86395.1
KM222724 Genomic DNA Translation: AJE60189.1
KM222725 Genomic DNA Translation: AJE60262.1
KM222726 Genomic DNA Translation: AJE60332.1
KM222727 Genomic DNA Translation: AJE60405.1
KT425107 Genomic DNA Translation: ALM22600.1
KU310657 Genomic DNA Translation: AMB65629.1
KU310658 Genomic DNA Translation: AMB65702.1
KU310659 Genomic DNA Translation: AMB65776.1
KU310660 Genomic DNA Translation: AMB65849.1
KX791914 Genomic DNA Translation: AOY34236.1
KX791987 Genomic DNA Translation: AOY34299.1
KX946970 Genomic DNA Translation: AOY36650.1
MH160359 Genomic DNA Translation: AWO69144.1
MH160360 Genomic DNA Translation: AWO69234.1
MH160361 Genomic DNA Translation: AWO69334.1
MH160362 Genomic DNA Translation: AWO69434.1
MH160364 Genomic DNA Translation: AWO69628.1
MH160365 Genomic DNA Translation: AWO69725.1
MH160366 Genomic DNA Translation: AWO69823.1
MH160367 Genomic DNA Translation: AWO69917.1
MH160368 Genomic DNA Translation: AWO70012.1
MH160371 Genomic DNA Translation: AWO70285.1
MH160372 Genomic DNA Translation: AWO70376.1
MH160377 Genomic DNA Translation: AWO70840.1
MH160378 Genomic DNA Translation: AWO70935.1
MH160382 Genomic DNA Translation: AWO71300.1
MH160383 Genomic DNA Translation: AWO71395.1
MH160384 Genomic DNA Translation: AWO71491.1
MH160385 Genomic DNA Translation: AWO71589.1
MH160386 Genomic DNA Translation: AWO71676.1
MH160387 Genomic DNA Translation: AWO71761.1
MH160389 Genomic DNA Translation: AWO71946.1
MH160390 Genomic DNA Translation: AWO72042.1
MH160391 Genomic DNA Translation: AWO72138.1
MG999838 Genomic DNA Translation: AWW07798.1
MG999839 Genomic DNA Translation: AWW07880.1
MG999841 Genomic DNA Translation: AWW08126.1
MG999845 Genomic DNA Translation: AWW08488.1
MG999847 Genomic DNA Translation: AWW08690.1
MG999849 Genomic DNA Translation: AWW08868.1
MG999851 Genomic DNA Translation: AWW09043.1
MG999856 Genomic DNA Translation: AWW09487.1
MG999857 Genomic DNA Translation: AWW09581.1
MG999858 Genomic DNA Translation: AWW09676.1
MG999859 Genomic DNA Translation: AWW09764.1
MG999860 Genomic DNA Translation: AWW09846.1
MG999863 Genomic DNA Translation: AWW10126.1
MG999865 Genomic DNA Translation: AWW10304.1
MG999869 Genomic DNA Translation: AWW10663.1
MG999870 Genomic DNA Translation: AWW10748.1
MG999871 Genomic DNA Translation: AWW10826.1
MG999872 Genomic DNA Translation: AWW10952.1
MG999873 Genomic DNA Translation: AWW11054.1
MG999875 Genomic DNA Translation: AWW11237.1
MG999876 Genomic DNA Translation: AWW11322.1
MG999878 Genomic DNA Translation: AWW11504.1
MG999879 Genomic DNA Translation: AWW11594.1
MG999881 Genomic DNA Translation: AWW11782.1
MG999884 Genomic DNA Translation: AWW12058.1
MG999885 Genomic DNA Translation: AWW12133.1
MG999886 Genomic DNA Translation: AWW12224.1
MG999887 Genomic DNA Translation: AWW12307.1
MG999889 Genomic DNA Translation: AWW12476.1
MG999890 Genomic DNA Translation: AWW12559.1
MG999894 Genomic DNA Translation: AWW12941.1
MG999896 Genomic DNA Translation: AWW13124.1
MG999897 Genomic DNA Translation: AWW13216.1
MG999898 Genomic DNA Translation: AWW13297.1
MG999899 Genomic DNA Translation: AWW13384.1
AB252864 Genomic DNA Translation: BAE87040.1
LT594105 Genomic DNA Translation: SBS69261.1
LT594107 Genomic DNA Translation: SBS69333.1
LT594112 Genomic DNA Translation: SBS69373.1
LT594109 Genomic DNA Translation: SBS69492.1
LT594111 Genomic DNA Translation: SBS69513.1
LT594192 Genomic DNA Translation: SBS69777.1
RefSeqiYP_009137106.1, NC_001806.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703350
KEGGivg:2703350

Family and domain databases

HAMAPiMF_04023 HSV_NEC1, 1 hit
InterProiView protein in InterPro
IPR021152 Herpes_UL31
PfamiView protein in Pfam
PF02718 Herpes_UL31, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ25BX0_HHV1
AccessioniPrimary (citable) accession number: Q25BX0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 7, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again