UniProtKB - Q25378 (KPC1_LYTPI)
Protein
Protein kinase C
Gene
PKC1
Organism
Lytechinus pictus (Painted sea urchin)
Status
Functioni
This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.By similarity
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity).By similarity
Catalytic activityi
Cofactori
Ca2+PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 178 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 178 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 184 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 237 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 237 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 239 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 239 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 245 | Calcium 2PROSITE-ProRule annotation | 1 | |
Binding sitei | 354 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 449 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 27 – 77 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 92 – 142 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 51 | |
Nucleotide bindingi | 331 – 339 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium-dependent protein kinase C activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- intracellular signal transduction Source: InterPro
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PKC1 |
Organismi | Lytechinus pictus (Painted sea urchin) |
Taxonomic identifieri | 7653 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Echinodermata › Eleutherozoa › Echinozoa › Echinoidea › Euechinoidea › Echinacea › Temnopleuroida › Toxopneustidae › Lytechinus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055729 | 1 – 658 | Protein kinase CAdd BLAST | 658 |
Keywords - PTMi
PhosphoproteinProteomic databases
PRIDEi | Q25378 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 266 | C2PROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 325 – 583 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 259 | |
Domaini | 584 – 654 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 71 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 27 – 77 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 92 – 142 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Repeat, Zinc-fingerFamily and domain databases
CDDi | cd00029, C1, 2 hits |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR000008, C2_dom IPR035892, C2_domain_sf IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR014375, Protein_kinase_C_a/b/g IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00168, C2, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000550, PKC_alpha, 1 hit |
PRINTSi | PR00360, C2DOMAIN PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00239, C2, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q25378-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNSTLEMKG FARRGALRQK NVHEIKNHKF IPRFFKQPTF CSHCKDFIWG
60 70 80 90 100
FGKQGFQCKV CSFVVHKRCH EFVTFQCPGL DPGVDSDDPR NKHKFKVHSY
110 120 130 140 150
NSPTFCDHCG SLLYGLYHQG MKCGACDMNV HKRCQKSVPN LCGADHTERR
160 170 180 190 200
GRIKVKAEVI GNKLQVTVAE AKNLIPMDPN GLSDPFVKLK LIPDQKRETK
210 220 230 240 250
KKTRTIKGSL NPTWGESFDF NLEDTDRNRR LLVEVWDWDR ATRNDFMGAL
260 270 280 290 300
SFGISELMKA GVDAWYKLLG QEEGEYYNVP AIAETESIDE LTSNIKKLPM
310 320 330 340 350
PTQEHVKPQN SNSMSGMGVV RASDFNFLSV LGKGSFGKVM LAEKKGTDEL
360 370 380 390 400
YAIKILKKDV IIQDDDVECT MTEKRVLGLP SKPAFLTALH SCFQTMDRLF
410 420 430 440 450
FVMEFVNGGD LMFQIQKVGK FREPHAVFYA AEIAVGLFYL HSQGVIYRDL
460 470 480 490 500
KLDNVLVDAE GHIKIADFGM CKEHMNEGDT TRTFCGTPDY IAPEIVAYQP
510 520 530 540 550
YGKAVDWWAF GVLLYEMLAG QPPFDGEDED ELFQSIMEHV PSYPKSMSRE
560 570 580 590 600
SVTMCKGFLT KHPGKRLGSG PTGEQDIREH QFFRRIDWEK LANREIQPPF
610 620 630 640 650
VPSVRNPRAA ENFDPYFTKI PCALTPTDKL IIMNIQDEFQ GFTFVNEVFD
GYVRSLPS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02967 mRNA Translation: AAA03447.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02967 mRNA Translation: AAA03447.1 |
3D structure databases
SMRi | Q25378 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q25378 |
Family and domain databases
CDDi | cd00029, C1, 2 hits |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR000008, C2_dom IPR035892, C2_domain_sf IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR014375, Protein_kinase_C_a/b/g IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00168, C2, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000550, PKC_alpha, 1 hit |
PRINTSi | PR00360, C2DOMAIN PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00239, C2, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KPC1_LYTPI | |
Accessioni | Q25378Primary (citable) accession number: Q25378 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1996 | |
Last modified: | October 7, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |