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Entry version 44 (25 May 2022)
Sequence version 1 (01 Nov 1996)
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Protein

LWamide neuropeptides

Gene
N/A
Organism
Hydractinia echinata (Snail fur) (Hermit crab hydroid)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

LWamide peptides may be involved in induction of metamorphosis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeuropeptide

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LWamide neuropeptides
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHydractinia echinata (Snail fur) (Hermit crab hydroid)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri35630 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidolinaAnthoathecataFiliferaHydractiniidaeHydractinia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001004528 – 104Sequence analysisAdd BLAST77
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_0000010046105 – 110LWamide ISequence analysis6
PropeptideiPRO_0000010047113 – 140Sequence analysisAdd BLAST28
PeptideiPRO_0000010048141 – 146LWamide IISequence analysis6
PropeptideiPRO_0000010049149 – 150Sequence analysis2
PeptideiPRO_0000010050151 – 156LWamide IISequence analysis6
PropeptideiPRO_0000010051159 – 160Sequence analysis2
PeptideiPRO_0000010052161 – 166LWamide IISequence analysis6
PropeptideiPRO_0000010053169 – 170Sequence analysis2
PeptideiPRO_0000010054171 – 176LWamide IISequence analysis6
PropeptideiPRO_0000010055179 – 180Sequence analysis2
PeptideiPRO_0000010056181 – 186LWamide IISequence analysis6
PropeptideiPRO_0000010057189 – 190Sequence analysis2
PeptideiPRO_0000010058191 – 196LWamide IISequence analysis6
PropeptideiPRO_0000010059199 – 200Sequence analysis2
PeptideiPRO_0000010060201 – 206LWamide IISequence analysis6
PropeptideiPRO_0000010061209 – 210Sequence analysis2
PeptideiPRO_0000010062211 – 216LWamide IISequence analysis6
PropeptideiPRO_0000010063218 – 220Seems to have a sequencing error or a mutation in position 218; Gly instead of Arg3
PeptideiPRO_0000010064221 – 226LWamide IISequence analysis6
PropeptideiPRO_0000010065229 – 230Sequence analysis2
PeptideiPRO_0000010066231 – 236LWamide IISequence analysis6
PropeptideiPRO_0000010067239 – 240Sequence analysis2
PeptideiPRO_0000010068241 – 246LWamide IISequence analysis6
PropeptideiPRO_0000010069249 – 250Sequence analysis2
PeptideiPRO_0000010070251 – 256LWamide IISequence analysis6
PropeptideiPRO_0000010071259 – 260Sequence analysis2
PeptideiPRO_0000010072261 – 266LWamide IISequence analysis6
PropeptideiPRO_0000010073269 – 270Sequence analysis2
PeptideiPRO_0000010074271 – 276LWamide IISequence analysis6
PropeptideiPRO_0000010075279 – 280Sequence analysis2
PeptideiPRO_0000010076281 – 286LWamide IISequence analysis6
PropeptideiPRO_0000010077289 – 290Sequence analysis2
PeptideiPRO_0000010078291 – 296LWamide IISequence analysis6
PropeptideiPRO_0000010079299 – 300Sequence analysis2
PeptideiPRO_0000010080301 – 307LWSSequence analysis7
PropeptideiPRO_0000010081309 – 320Sequence analysisAdd BLAST12
PeptideiPRO_0000010082321 – 326LWamide IISequence analysis6
PropeptideiPRO_0000010083329 – 419Sequence analysisAdd BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei110Tryptophan amideSequence analysis1
Modified residuei146Tryptophan amideSequence analysis1
Modified residuei156Tryptophan amideSequence analysis1
Modified residuei166Tryptophan amideSequence analysis1
Modified residuei176Tryptophan amideSequence analysis1
Modified residuei186Tryptophan amideSequence analysis1
Modified residuei196Tryptophan amideSequence analysis1
Modified residuei206Tryptophan amideSequence analysis1
Modified residuei216Tryptophan amideSequence analysis1
Modified residuei226Tryptophan amideSequence analysis1
Modified residuei236Tryptophan amideSequence analysis1
Modified residuei246Tryptophan amideSequence analysis1
Modified residuei256Tryptophan amideSequence analysis1
Modified residuei266Tryptophan amideSequence analysis1
Modified residuei276Tryptophan amideSequence analysis1
Modified residuei286Tryptophan amideSequence analysis1
Modified residuei296Tryptophan amideSequence analysis1
Modified residuei326Tryptophan amideSequence analysis1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In planula larvae, expressed in a narrow ring of ectodermal neurosensory cells around the widest circumference at the anterior of the larvae. In primary polyps, expression is confined to endodermal cells of the hypostome. In mature polyps, expression is strong in the epidermis from the tentacle level to the base of the polyp and weak in the gastrodermal cells in the apical hypostome.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at a low level in mature polyps and planula larvae, and at a high level in primary polyps.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q25060

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 48DisorderedSequence analysisAdd BLAST22
Regioni120 – 332DisorderedSequence analysisAdd BLAST213

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LWamide neuropeptide family.Curated

Keywords - Domaini

Repeat, Signal

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q25060-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKEMRNLML LVLLTVILDN GIGKCNAKSE EDQDGNARNN RIDKNDDNSD
60 70 80 90 100
SIEKYLREVT DELSKILAKR IYRDIQLREN NKKAENRQSW IGDLENLDID
110 120 130 140 150
STVQRPPGLW GREADFDNTR AHDSAQISDE KQSGLWVGDA KPPGLWGRDA
160 170 180 190 200
KPPGLWGRDA KPPGLWGRDA KPPGLWGRDA KPPGLWGRDA KPPGLWGRDA
210 220 230 240 250
KPPGLWGRDA KPPGLWGGDA KPPGLWGRDA KPPGLWGRDA KPPGLWGRDA
260 270 280 290 300
KPPGLWGRDA KPPGLWGRDA KPPGLWGRDT KPPGLWGRDA KPPGLWGRDA
310 320 330 340 350
KPPSLWSKDN NVIKSRSDDA KPPGLWGRQV EDGPTKIWGD GFLDAERHIR
360 370 380 390 400
LLKNDERFNR LEKKADMEEE LRVAQGPSVT NAKDTFGELA DLLRKRIVKR
410
LHKNDSLNNR RNNKKNNKF
Length:419
Mass (Da):47,058
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD383FFBE7D3775DC
GO
Isoform 2 (identifier: Q25060-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-214: Missing.

Show »
Length:389
Mass (Da):43,823
Checksum:i9C640A72738D315C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti66I → T in clone M6. 1
Natural varianti414K → N in clone M6. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050202185 – 214Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X89734 mRNA Translation: CAA61886.1

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89734 mRNA Translation: CAA61886.1

3D structure databases

AlphaFoldDBiQ25060
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLWA_HYDEC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q25060
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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