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Protein

Argininosuccinate synthase

Gene

argG

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei93CitrullineUniRule annotation1
Binding sitei98CitrullineUniRule annotation1
Binding sitei123ATP; via amide nitrogenUniRule annotation1
Binding sitei125AspartateUniRule annotation1
Binding sitei129AspartateUniRule annotation1
Binding sitei129CitrullineUniRule annotation1
Binding sitei130AspartateUniRule annotation1
Binding sitei133CitrullineUniRule annotation1
Binding sitei182CitrullineUniRule annotation1
Binding sitei191CitrullineUniRule annotation1
Binding sitei267CitrullineUniRule annotation1
Binding sitei279CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:DSY0785
OrganismiDesulfitobacterium hafniense (strain Y51)
Taxonomic identifieri138119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
Proteomesi
  • UP000001946 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002639211 – 409Argininosuccinate synthaseAdd BLAST409

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi138119.DSY0785

Structurei

3D structure databases

ProteinModelPortaliQ24ZG8
SMRiQ24ZG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q24ZG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKEVIPMK KVVLAYSGGL DTSIIIPWLK ENYGYEVIAM AADLGQGEEL
60 70 80 90 100
EPLHEKAIKS GASKLYIEDL QEEFVTDFIY PTLKAGAVYE GKYLLGTSFA
110 120 130 140 150
RPLIAQRLVE IAAKEGAVAI AHGATGKGND QVRFELAVKA LNPDLEIIAP
160 170 180 190 200
WRIWDIKSRE DAIDYAVERG IPVPVTKDRP YSMDRNVWHL SHEGGDLEDP
210 220 230 240 250
WNEPKKDLYL LGVSPEDAPD EAEYLELDFE QGIPVSLNGE KLGPVQLLET
260 270 280 290 300
LNEVGGKHGI GIVDMVENRL VGMKSRGVYE TPGGTILYTA HQALEHLTLD
310 320 330 340 350
RLTLHYKEQI ALKYAELVYD GVWHSPLREA LDAFVDVTQK NVTGTVRLKL
360 370 380 390 400
YKGNCSLAGV KSPYSLYSEE FATFGRDGVY NQKDAEGFIN LFGLPLKVRA

LMEKKSGLR
Length:409
Mass (Da):45,535
Last modified:April 18, 2006 - v1
Checksum:iDE018F6449827761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008230 Genomic DNA Translation: BAE82574.1

Genome annotation databases

EnsemblBacteriaiBAE82574; BAE82574; DSY0785
KEGGidsy:DSY0785

Similar proteinsi

Entry informationi

Entry nameiASSY_DESHY
AccessioniPrimary (citable) accession number: Q24ZG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 18, 2006
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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