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Protein

Alanine racemase

Gene

DSY4942

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (DSY4022), Alanine racemase (DSY4942)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Active sitei262Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei335Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:DSY4942Imported
OrganismiDesulfitobacterium hafniense (strain Y51)Imported
Taxonomic identifieri138119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
Proteomesi
  • UP000001946 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi138119.DSY4942

Structurei

3D structure databases

ProteinModelPortaliQ24ML1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 371Ala_racemase_CInterPro annotationAdd BLAST131

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108NN5 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiCALHVDT
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q24ML1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAWIDINL DAIANNYREV TQQLSPAARV MAVVKADAYG LGAVPVAQTL
60 70 80 90 100
QKLGCPAFAV TTVEEGLMLR QHGVEGIILV LGPVSAEQMA EALASDLQLT
110 120 130 140 150
LSDFHMLREW ETVAAGLGME AKVHLKLETG MGRTGFFEKE WGELAAQLKQ
160 170 180 190 200
SPHITPVGVY THLARAAQRD RAYTRQQVES FQRGVNLLEE QGFAGLWKHV
210 220 230 240 250
CNSAAFLDYP DWHYDFIRTG TLLIGHFPAP AFAGKLTLQD PWVAKARIVS
260 270 280 290 300
LRRVPKGTFV GYQSIYRTKA ETQLAVIPVG YADGFGVQPH FVPQGVWDFI
310 320 330 340 350
KIVIKNFLAL CRIYIGQETV ILQGHRVPVA GKIGMQLTVL DVGNLSCETG
360 370 380 390
DEVILPLRRT QANPRLLRQY WSEKRLIAKR HIKEGFLQSY PEYP
Length:394
Mass (Da):43,864
Last modified:April 18, 2006 - v1
Checksum:i47CC99459CC8AC88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008230 Genomic DNA Translation: BAE86731.1
RefSeqiWP_011462255.1, NC_007907.1

Genome annotation databases

EnsemblBacteriaiBAE86731; BAE86731; DSY4942
KEGGidsy:DSY4942

Similar proteinsi

Entry informationi

Entry nameiQ24ML1_DESHY
AccessioniPrimary (citable) accession number: Q24ML1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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