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Entry version 98 (02 Jun 2021)
Sequence version 1 (01 Nov 1997)
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Protein

Aldehyde-alcohol dehydrogenase 2

Gene

ADH2

Organism
Entamoeba histolytica
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme has two NAD+-dependent activities: ADH and ACDH. May be a critical enzyme in the fermentative pathway.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity, Fe2+By similarityNote: Zinc or iron.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=80 mM for ethanol1 Publication
  2. KM=0.15 mM for acetaldehyde1 Publication
  3. KM=0.015 mM for acetyl-CoA1 Publication
  4. KM=0.15 mM for NAD+ (for ADH activity)1 Publication
  5. KM=0.05 mM for NADH (for ADH activity)1 Publication
  6. KM=0.18 mM for NADH (for ACDH activity)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei252By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi431 – 436NADSequence analysis6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMultifunctional enzyme, Oxidoreductase
LigandIron, NAD

Protein family/group databases

MoonProt database of moonlighting proteins

More...
MoonProti
Q24803

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldehyde-alcohol dehydrogenase 2Curated
Including the following 2 domains:
Alcohol dehydrogenase2 Publications (EC:1.1.1.12 Publications)
Short name:
ADH2 Publications
Acetaldehyde dehydrogenase2 Publications (EC:1.2.1.102 Publications)
Short name:
ACDH1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEntamoeba histolytica
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5759 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaArchamoebaeMastigamoebidaEntamoebidaeEntamoeba

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
AmoebaDB:EHI5A_157720
AmoebaDB:EHI7A_198850
AmoebaDB:EHI8A_086570
AmoebaDB:EHI_160940
AmoebaDB:KM1_283380

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000878351 – 870Aldehyde-alcohol dehydrogenase 2Add BLAST870

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q24803

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Seems to form a rod shaped homomer composed of at least 20 identical subunits.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5759.rna_EHI_150490-1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q24803

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the aldehyde dehydrogenase family.Curated
In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3857, Eukaryota

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08178, AAD_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.309.10, 1 hit
3.40.605.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034789, AAD_C
IPR001670, ADH_Fe/GldA
IPR018211, ADH_Fe_CS
IPR039697, Alcohol_dehydrogenase_Fe
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR012079, Bifunc_Ald-ADH

The PANTHER Classification System

More...
PANTHERi
PTHR11496, PTHR11496, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00171, Aldedh, 1 hit
PF00465, Fe-ADH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000111, ALDH_ADH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53720, SSF53720, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00913, ADH_IRON_1, 1 hit
PS00060, ADH_IRON_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q24803-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTQQTMTVD EHINQLVRKA QVALKEYLKP EYTQEKIDYI VKKASVAALD
60 70 80 90 100
QHCALAAAAV EETGRGIFED KATKNIFACE HVTHEMRHAK TVGIINVDPL
110 120 130 140 150
YGITEIAEPV GVVCGVTPVT NPTSTAIFKS LISIKTRNPI VFSFHPSALK
160 170 180 190 200
CSIMAAKIVR DAAIAAGAPE NCIQWIEFGG IEASNKLMNH PGVATILATG
210 220 230 240 250
GNAMVKAAYS SGKPALGVGA GNVPTYIEKT CNIKQAANDV VMSKSFDNGM
260 270 280 290 300
ICASEQAAII DKEIYDQVVE EMKTLGAYFI NEEEKAKLEK FMFGVNAYSA
310 320 330 340 350
DVNNARLNPK CPGMSPQWFA EQVGIKVPED CNIICAVCKE VGPNEPLTRE
360 370 380 390 400
KLSPVLAILK AENTQDGIDK AEAMVEFNGR GHSAAIHSND KAVVEKYALT
410 420 430 440 450
MKACRILHNT PSSQGGIGSI YNYIWPSFTL GCGSYGGNSV SANVTYHNLL
460 470 480 490 500
NIKRLADRRN NLQWFRVPPK IFFEPHSIRY LAELKELSKI FIVSDRMMYK
510 520 530 540 550
LGYVDRVMDV LKRRSNEVEI EIFIDVEPDP SIQTVQKGLA VMNTFGPDNI
560 570 580 590 600
IAIGGGSAMD AAKIMWLLYE HPEADFFAMK QKFIDLRKRA FKFPTMGKKA
610 620 630 640 650
RLICIPTTSG TGSEVTPFAV ISDHETGKKY PLADYSLTPS VAIVDPMFTM
660 670 680 690 700
SLPKRAIADT GLDVLVHATE AYVSVMANEY TDGLAREAVK LVFENLLKSY
710 720 730 740 750
NGDLEAREKM HNAATIAGMA FASAFLGMDH SMAHKVGAAF HLPHGRCVAV
760 770 780 790 800
LLPHVIRYNG QKPRKLAMWP KYNFYKADQR YMELAQMVGL KCNTPAEGVE
810 820 830 840 850
AFAKACEELM KATETITGFK KANIDEAAWM SKVPEMALLA FEDQCSPANP
860 870
RVPMVKDMEK ILKAAYYPIA
Length:870
Mass (Da):95,659
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66733AD08CE3D0A5
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA54388 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18R → A in CAA54388 (PubMed:7980441).Curated1
Sequence conflicti380R → E AA sequence (PubMed:7935603).Curated1
Sequence conflicti382H → Q AA sequence (PubMed:7935603).Curated1
Sequence conflicti387 – 388HS → NP AA sequence (PubMed:7935603).Curated2
Sequence conflicti482A → R in CAA54388 (PubMed:7980441).Curated1
Sequence conflicti534T → I in CAA54388 (PubMed:7980441).Curated1
Sequence conflicti566W → R in CAA54388 (PubMed:7980441).Curated1
Sequence conflicti739A → G in CAA54388 (PubMed:7980441).Curated1
Sequence conflicti821K → Q in CAA54388 (PubMed:7980441).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U04863 mRNA Translation: AAA81906.1
X77132 mRNA Translation: CAA54388.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
S53319

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04863 mRNA Translation: AAA81906.1
X77132 mRNA Translation: CAA54388.1 Different initiation.
PIRiS53319

3D structure databases

SMRiQ24803
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5759.rna_EHI_150490-1

Protein family/group databases

MoonProtiQ24803

Proteomic databases

PRIDEiQ24803

Organism-specific databases

VEuPathDBiAmoebaDB:EHI5A_157720
AmoebaDB:EHI7A_198850
AmoebaDB:EHI8A_086570
AmoebaDB:EHI_160940
AmoebaDB:KM1_283380

Phylogenomic databases

eggNOGiKOG3857, Eukaryota

Family and domain databases

CDDicd08178, AAD_C, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR034789, AAD_C
IPR001670, ADH_Fe/GldA
IPR018211, ADH_Fe_CS
IPR039697, Alcohol_dehydrogenase_Fe
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR012079, Bifunc_Ald-ADH
PANTHERiPTHR11496, PTHR11496, 1 hit
PfamiView protein in Pfam
PF00171, Aldedh, 1 hit
PF00465, Fe-ADH, 1 hit
PIRSFiPIRSF000111, ALDH_ADH, 1 hit
SUPFAMiSSF53720, SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00913, ADH_IRON_1, 1 hit
PS00060, ADH_IRON_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADH2_ENTHI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24803
Secondary accession number(s): Q27649
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 2, 2021
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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