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Entry version 146 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Histone-lysine N-methyltransferase trithorax

Gene

trx

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that trimethylates 'Lys-9' of histone H3 (H3K9me3). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3700S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei3702S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei3744S-adenosyl-L-methioninePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3770ZincBy similarity1
Metal bindingi3816ZincBy similarity1
Metal bindingi3818ZincBy similarity1
Metal bindingi3823ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi725 – 839Nuclear receptorPROSITE-ProRule annotationAdd BLAST115
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1251 – 1334PHD-type 1PROSITE-ProRule annotationAdd BLAST84
Zinc fingeri1335 – 1380PHD-type 2PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri1408 – 1469PHD-type 3PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri1708 – 1748C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri1769 – 1816PHD-type 4PROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, DNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase trithorax (EC:2.1.1.355By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trx
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila virilis (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7244 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014844, Dvir\trx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001248751 – 3828Histone-lysine N-methyltransferase trithoraxAdd BLAST3828

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q24742

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ash1 via its SET domain.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7244.FBpp0237016

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q24742

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1856 – 1913FYR N-terminalPROSITE-ProRule annotationAdd BLAST58
Domaini3493 – 3577FYR C-terminalPROSITE-ProRule annotationAdd BLAST85
Domaini3690 – 3806SETPROSITE-ProRule annotationAdd BLAST117
Domaini3812 – 3828Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 179DisorderedSequence analysisAdd BLAST155
Regioni356 – 390DisorderedSequence analysisAdd BLAST35
Regioni512 – 589DisorderedSequence analysisAdd BLAST78
Regioni933 – 1036DisorderedSequence analysisAdd BLAST104
Regioni1075 – 1094DisorderedSequence analysisAdd BLAST20
Regioni1131 – 1170DisorderedSequence analysisAdd BLAST40
Regioni2252 – 2272DisorderedSequence analysisAdd BLAST21
Regioni2464 – 2510DisorderedSequence analysisAdd BLAST47
Regioni2826 – 2848DisorderedSequence analysisAdd BLAST23
Regioni2897 – 2973DisorderedSequence analysisAdd BLAST77
Regioni2988 – 3031DisorderedSequence analysisAdd BLAST44
Regioni3117 – 3178DisorderedSequence analysisAdd BLAST62
Regioni3314 – 3338DisorderedSequence analysisAdd BLAST25
Regioni3457 – 3487DisorderedSequence analysisAdd BLAST31
Regioni3767 – 3768S-adenosyl-L-methionine bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 61Polar residuesSequence analysisAdd BLAST22
Compositional biasi69 – 87Polar residuesSequence analysisAdd BLAST19
Compositional biasi97 – 122Polar residuesSequence analysisAdd BLAST26
Compositional biasi358 – 390Polar residuesSequence analysisAdd BLAST33
Compositional biasi528 – 553Acidic residuesSequence analysisAdd BLAST26
Compositional biasi561 – 585Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi957 – 978Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi980 – 1033Polar residuesSequence analysisAdd BLAST54
Compositional biasi1137 – 1170Polar residuesSequence analysisAdd BLAST34
Compositional biasi2480 – 2510Polar residuesSequence analysisAdd BLAST31
Compositional biasi2897 – 2930Polar residuesSequence analysisAdd BLAST34
Compositional biasi2956 – 2973Polar residuesSequence analysisAdd BLAST18
Compositional biasi3117 – 3164Polar residuesSequence analysisAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1251 – 1334PHD-type 1PROSITE-ProRule annotationAdd BLAST84
Zinc fingeri1335 – 1380PHD-type 2PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri1408 – 1469PHD-type 3PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri1708 – 1748C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri1769 – 1816PHD-type 4PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1084, Eukaryota

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR011011, Znf_FYVE_PHD
IPR001628, Znf_hrmn_rcpt
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 1 hit
PF00856, SET, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354, Methyltransferase_trithorax, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS01359, ZF_PHD_1, 3 hits
PS50016, ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q24742-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRSKFPGNP SKSINRKRIS VLQLEDEAAS AAAAAAAATA ATTEQHQQSE
60 70 80 90 100
QSAGSSASRE KGNNCDNDDD DNAPSGAATS GNRGASSGAS DAAPEGGNSY
110 120 130 140 150
GNGSSTGSKT TNGGNVNGGS HHKSATAPAE LKECKNQGNQ IEPNNCIAAE
160 170 180 190 200
PDGTEDTNND DDDDSSNDKK PTAAAAAAAA AAFVPGPSAL QRARKGGNKK
210 220 230 240 250
FKNLNLARPE VMLPSTSKLK QQQQQQLQLN CPSASASSLS SSAAAAAAAA
260 270 280 290 300
APTTTTTTAS ASATLTATAT STSTSSLPGT PLSVIAGGGG GAAAAALLLA
310 320 330 340 350
NPFASVETKV VEVNAAATAA ATAAATAAAG AGEDVGMLKA SIEMANEAGL
360 370 380 390 400
EAPAVAVKSS GSSPNPNHNP NAVAGSTSAA APGAPTATKQ KKTVTFKNIL
410 420 430 440 450
ETSDDKSVVK RFYNPDNRVP LVSIMKKDSL NRPLNYCRGS EFIVRPSILS
460 470 480 490 500
KILNKNSNID KLNSLKFRSV HASSNSIQES SSSTTNLFGS GLSRAFGAPI
510 520 530 540 550
DDEDAVSGGV TFRKQEPQHK TPEDNDDDGS ASSDAIEDDE DIDDDDAEEN
560 570 580 590 600
EEAASEKSAE TTASVDEKEA DDRQLVMDKH FVLPKRSTRS SRIIKPNKRL
610 620 630 640 650
LEVGGICSKR SPSDANGKPK PKNYFGLATL PAKCTPRRRR SAATALSQKL
660 670 680 690 700
GKETFASFAT AKVNSSFVLR QPRLQFQTDK SRSFVSAKPT LPTTTVLPAS
710 720 730 740 750
SSAITSANVL SFGALNNANS AVAAASTCAV CSAPVNNKDA PLARKYGVIA
760 770 780 790 800
CEVCRKFNSR MTKISKLSTP MHSNPSTSTA QSGQQLKCTD GGNCSILSLK
810 820 830 840 850
SQLKNFKKLY KERCKACWLK KCLATLQLPA GHRSRLSAIL PASMREEVAP
860 870 880 890 900
KDDKCPELLS PTASLRFTAP TSSASSGTTI KWKSSAETAV NSIKSNPLAE
910 920 930 940 950
NNVTFGGTPL LRPAILEKPL FLKIGSDNKK AKESKEALGL SPVPSTSEAA
960 970 980 990 1000
VAPGKTTRKA KQDKEKAREL EAEKPLSPNA KKTTEANTPE TQKDEQPAST
1010 1020 1030 1040 1050
TTTVSAASSS TSHTSSAATN SSQLETTEAA NASAVPDNLK RQRIDLKGPR
1060 1070 1080 1090 1100
VKHVCRSASI VLGQPLATFG DEEEELAAAE AGPAPTTTTT TTSPEVIIKK
1110 1120 1130 1140 1150
PKSPQPMQMI IDENDNCASC ILTPTEATAE AQPAVKSVLE SRSSKSNTQT
1160 1170 1180 1190 1200
EAKKTPATSG SSKGKVTTRN ATATVTSVAS SLVATKKQRN IEVSSSISSS
1210 1220 1230 1240 1250
QAAATQSRRA LAKEVNRLKA LISIDFWENY DPAEVCQTGF GLIVTETVAQ
1260 1270 1280 1290 1300
RALCFLCGST GLDPLIFCAC CCEPYHQYCV LDEYNLKHSS FEDTLMTSLL
1310 1320 1330 1340 1350
ETSNNACAIS AATNTALNQL TQRLNWLCPR CTVCYTCNMS SGSKVKCQKC
1360 1370 1380 1390 1400
QKNYHSTCLG TSKRLLGADR PLICVNCLKC KSCATTKVSK FVGNLPMCTA
1410 1420 1430 1440 1450
CFKLRKKGNF CPICQKCYDD NDFDLKMMEC GDCNQWVHSK CEGLSDEQYN
1460 1470 1480 1490 1500
LLSTLPESIE FICKKCARRC DVSRNKADEW RQAVMEEFKS SLYSVLKLLS
1510 1520 1530 1540 1550
KSRQACALLK LSPRKNWRCC SAGAQPAKAH SQGKLQPKAL QFTYNGLGSD
1560 1570 1580 1590 1600
GESQNSDDIY EFKEQHSTNR KPSTPVPCSC LQPLSQSPSF SLVDIKQKIA
1610 1620 1630 1640 1650
SNAYVSLAEF NYDMSQVIQQ SNCDELDIAY KELLSEQFPW FQNETKACTD
1660 1670 1680 1690 1700
ALEEDMFESC GYEELKESPT TYAEHHTASQ APRTGLLDIP LDDVDDLGGC
1710 1720 1730 1740 1750
AVKTRLDTRV CLFCRKSGEG LSGEEARLLY CGHDCWVHIN CAMWSAEVFE
1760 1770 1780 1790 1800
EIDGSLQNVH SAVARGRMIK CTVCGNRGAT VGCNVKSCGE HYHYPCARTI
1810 1820 1830 1840 1850
DCAFLTDKSM YCPAHARNAL KANGSPSVTY ESNFEVSRPV YVELERKRKK
1860 1870 1880 1890 1900
LIVPAKVQFH IGSVAVRQLG SIVPRFSDSF EAIVPINFLC SRLYWSSKEP
1910 1920 1930 1940 1950
WKIVEYTVRT TIQNSYSSTL TLDAGRNFTV DHTNPNCSLV QLGLAQIARW
1960 1970 1980 1990 2000
HSSLARSDLL DTDWAEFPNS YVPADENTEE EPQQNADLLP PEIKDAIFED
2010 2020 2030 2040 2050
LPHELLDGIS MLDIFMYEDL GDKTELFAMS EQSKDGTTAT SQAGGASVII
2060 2070 2080 2090 2100
CDEDTRNSNS LNKHLVLSNC CTASNPVDDA MLCAARSSSQ EKECGDVLKK
2110 2120 2130 2140 2150
TDTAPTRSWP KLDGGSVAAF KRRKLSKNIA EGVLLSLNQR SKKEMATVAG
2160 2170 2180 2190 2200
ITRRQSVCGS SELPAEGSAT MRTKSFTWSA AKCLFEKNES REEPAKLTIM
2210 2220 2230 2240 2250
QMDGVDDSIT EYRIIGSDGN LSTAQFTGQV KCERCQCTYR NYDSFQRHLG
2260 2270 2280 2290 2300
SCEPMSTSES ESETATGTAQ LSAESLNELQ KQALAAATLS NTGGLNYLQT
2310 2320 2330 2340 2350
SFPQVQNLAT LGQFGVQGLQ GLQTLQLQPQ SLGNGFFLSQ PNAAQATSNG
2360 2370 2380 2390 2400
NDVLQLYANS LQNLAANLGG GFTLTQPTMS TQAQPQLIAL STNPDGTQQF
2410 2420 2430 2440 2450
IQLPQSNGAT TQLLQTAAPL RCNATYQTLQ ATNSDKKIVL LFLEAGDPLQ
2460 2470 2480 2490 2500
EVVTQAAQQA TAAAHQKQLK SGHGVKPIQA KLQGQQQQQR HQQHQQHQQH
2510 2520 2530 2540 2550
QQQQQQQQQQ QQQQQTPITV AQHGGTTQLL GQNLLQPQLL FQSNAQPQTQ
2560 2570 2580 2590 2600
QLLLPQTQAQ NIISFVTGDG SQNQPLQYIS IPTTNDFKPQ QTTSTPTFLT
2610 2620 2630 2640 2650
APGGGATFLQ TDASGNLMLT TAPANSGLQM LTGQLQTQPQ VIGTLIQPQT
2660 2670 2680 2690 2700
LQLTTGADGT QTATAQQPLI LGGATGGGTT GLEFATAPQV ILATQPMYYG
2710 2720 2730 2740 2750
LETIVQNTVM SSQQFVSTAM PGVLSQNSSF SATTTQVFQA SKIEPIVDLP
2760 2770 2780 2790 2800
AGYVVLNNAV DASGNTSWLQ QSQTQATDDA TAQLLQNAGF QFQTTPTTST
2810 2820 2830 2840 2850
QQTMSTDYAP PLVVTAKVPP VAQMKRNTNA NKSPISVLSK VQPQPQQSQV
2860 2870 2880 2890 2900
VNKVLPTNVI QQQQQQQQQQ QQQQQQMQPK QQLAGNANLK LTSQFQRQQQ
2910 2920 2930 2940 2950
ANELKNKQAA GQQTGSTCGA PPSIASKPLQ KKTNLIRPIH KVEVKPKIMK
2960 2970 2980 2990 3000
QAPKLATSAA SMQHHQQQQS PAAINQVAKV ALLQQRLAPA PQPQQQEPQE
3010 3020 3030 3040 3050
EQQHLHQQQQ QQQQQQQHMQ QHQQQQQQLS MPQLLRAQQP IISIVNTAEP
3060 3070 3080 3090 3100
QAATQFVIRP ALQAQAQPIQ LQEQQSQQQQ QQPAEQLING KAARLQRYAS
3110 3120 3130 3140 3150
NSLPTNVVNP LQQQRCASAN NSSNSNVTQQ NSTITINSRP TNRVLPMQQR
3160 3170 3180 3190 3200
QEPTPLSNDV VVQSPTPPKP IEEPVPAGAS TQKPIVKCYA QLEQKSPGYE
3210 3220 3230 3240 3250
TELKTNITLD NLEQTNSITT MQLQQPQQGP IYGEQIFEKQ SEAQVQLEKP
3260 3270 3280 3290 3300
KHNDLMLLEA TSCQQQQQQQ QHMEMVVDNG FQLTSNESCL LEKHGFNVEA
3310 3320 3330 3340 3350
VPMDTEDHYA SMKNGSGGGA AEGIGQVDDA EEDEDDDDDF SLKMATSACN
3360 3370 3380 3390 3400
DHEMSDSEEP AVKEKISKIL DNLTNDDCSD SIATATTVEA SAGYQQMVED
3410 3420 3430 3440 3450
VLATTAAGSV STDDETFTAT AEAVEAAASY INEMAEAHEL QLKQLQAGVE
3460 3470 3480 3490 3500
LDLKKPKLDV PQQQPDTVPP NVVPTAAAPQ QPPPMRDPKK ISGPHLLYEI
3510 3520 3530 3540 3550
QSEDGFTYKS SSIAEIWEKV FEAVQVARRA HGLTPLPEGP LADMSGVQMI
3560 3570 3580 3590 3600
GLKTNALKYL IEQLPGVEKC VKYTPKYHKR NGNVSTAAGG GHARTAGSNP
3610 3620 3630 3640 3650
AALAAGAESL IDYGSDQEEL QENAYECARC EPYVSRSEYD MFSWLASRHR
3660 3670 3680 3690 3700
KQPIQVFVQP SDNELVPRRG TGSNLPMAMK YRTLKETYKD YVGVFRSHIH
3710 3720 3730 3740 3750
GRGLYCTKDI EAGEMVIEYA GELIRSTLTD KRERYYDSRG IGCYMFKIDD
3760 3770 3780 3790 3800
NLVVDATMRG NAARFINHSC EPNCYSKVVD ILGHKHIIIF ALRRIVQGEE
3810 3820
LTYDYKFPFE DEKIPCSCGS KRCRKYLN
Length:3,828
Mass (Da):413,724
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32059CF303A3C504
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z50038 Genomic DNA Translation: CAA90349.1

Protein sequence database of the Protein Information Resource

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PIRi
T13857

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50038 Genomic DNA Translation: CAA90349.1
PIRiT13857

3D structure databases

SMRiQ24742
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7244.FBpp0237016

Proteomic databases

PRIDEiQ24742

Organism-specific databases

FlyBaseiFBgn0014844, Dvir\trx

Phylogenomic databases

eggNOGiKOG1084, Eukaryota

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
trx, fly

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR011011, Znf_FYVE_PHD
IPR001628, Znf_hrmn_rcpt
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 1 hit
PF00856, SET, 1 hit
PIRSFiPIRSF010354, Methyltransferase_trithorax, 1 hit
SMARTiView protein in SMART
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS01359, ZF_PHD_1, 3 hits
PS50016, ZF_PHD_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRX_DROVI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24742
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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