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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140SubstrateBy similarity1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 35NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
ORF Names:GD23968
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000304 Componentsi: Chromosome 2L, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012824 Dsim\Adh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000544942 – 256Alcohol dehydrogenaseAdd BLAST255

Expressioni

Gene expression databases

BgeeiFBgn0012824 Expressed in 4 organ(s), highest expression level in multi-tissue structure

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ24641
SMRiQ24641
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00001
OMAiWSKHWDS
OrthoDBiEOG091G0OC9
PhylomeDBiQ24641

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24641-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFTLTNKNV IFVAGLGGIG LDTSKELLKR DLKNLVILDR IENPAAIAEL
60 70 80 90 100
KAINPKVTVT FYPYDVTVPI AETTKLLKTI FAKLKTVDVL INGAGILDDH
110 120 130 140 150
QIERTIAVNY TGLVNTTTAI LDFWDKRKGG PGGIICNIGS VTGFNAIYQV
160 170 180 190 200
PVYSGTKAAV VNFTSSLAKL APITGVTAYT VNPGITRTTL VHKFNSWLDV
210 220 230 240 250
EPQVAEKLLA HPTQPSLACA ENFVKAIELN QNGAIWKLDL GTLEAIQWTK

HWDSGI
Length:256
Mass (Da):27,745
Last modified:January 23, 2007 - v5
Checksum:i2BEC8BDBFFD7E00B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52A → V in AAA28360 (PubMed:6427630).Curated1
Sequence conflicti156T → N in AAA28360 (PubMed:6427630).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00607 Genomic DNA Translation: CAA25249.1
M19276 Genomic DNA Translation: AAA28360.1
M19263 Genomic DNA Translation: AAA28337.1
M36581 Genomic DNA Translation: AAA28333.1
X57361 Genomic DNA Translation: CAA40635.1
X57362 Genomic DNA Translation: CAA40636.1
X57363 Genomic DNA Translation: CAA40637.1
X57364 Genomic DNA Translation: CAA40638.1
CM000361 Genomic DNA Translation: EDX05053.1
AY459545 Genomic DNA Translation: AAR23003.1
PIRiS18273
RefSeqiXP_016024999.1, XM_016180148.1

Genome annotation databases

EnsemblMetazoaiFBtr0223878; FBpp0222370; FBgn0012824
GeneIDi6732347
KEGGidsi:Dsimw501_GD23968

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00607 Genomic DNA Translation: CAA25249.1
M19276 Genomic DNA Translation: AAA28360.1
M19263 Genomic DNA Translation: AAA28337.1
M36581 Genomic DNA Translation: AAA28333.1
X57361 Genomic DNA Translation: CAA40635.1
X57362 Genomic DNA Translation: CAA40636.1
X57363 Genomic DNA Translation: CAA40637.1
X57364 Genomic DNA Translation: CAA40638.1
CM000361 Genomic DNA Translation: EDX05053.1
AY459545 Genomic DNA Translation: AAR23003.1
PIRiS18273
RefSeqiXP_016024999.1, XM_016180148.1

3D structure databases

ProteinModelPortaliQ24641
SMRiQ24641
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0223878; FBpp0222370; FBgn0012824
GeneIDi6732347
KEGGidsi:Dsimw501_GD23968

Organism-specific databases

FlyBaseiFBgn0012824 Dsim\Adh

Phylogenomic databases

KOiK00001
OMAiWSKHWDS
OrthoDBiEOG091G0OC9
PhylomeDBiQ24641

Gene expression databases

BgeeiFBgn0012824 Expressed in 4 organ(s), highest expression level in multi-tissue structure

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROSI
AccessioniPrimary (citable) accession number: Q24641
Secondary accession number(s): B4Q5K9, P07163, Q6SE55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 105 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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