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Entry version 140 (17 Jun 2020)
Sequence version 2 (30 Aug 2005)
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Protein

DNA repair protein complementing XP-C cells homolog

Gene

Xpc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes (By similarity).By similarity
Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5696394 DNA Damage Recognition in GG-NER
R-DME-5696395 Formation of Incision Complex in GG-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein complementing XP-C cells homolog
Alternative name(s):
Mutagen-sensitive 209 protein
XPCDM
Xeroderma pigmentosum group C-complementing protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XpcImported
Synonyms:mus210Imported, Xpcc
ORF Names:CG8153Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004698 Xpc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002182951 – 1293DNA repair protein complementing XP-C cells homologAdd BLAST1293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31Phosphoserine1 Publication1
Modified residuei32Phosphoserine1 Publication1
Modified residuei37Phosphoserine1 Publication1
Modified residuei533Phosphoserine1 Publication1
Modified residuei537Phosphoserine1 Publication1
Modified residuei908Phosphoserine1 Publication1
Modified residuei911Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24595

PRoteomics IDEntifications database

More...
PRIDEi
Q24595

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q24595

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004698 Expressed in eye disc (Drosophila) and 30 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q24595 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24595 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
62434, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q24595, 13 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086505

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q24595

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi922 – 938Nuclear localization signalSequence analysisAdd BLAST17
Motifi1195 – 1211Nuclear localization signalSequence analysisAdd BLAST17
Motifi1275 – 1291Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 40Poly-Asp8
Compositional biasi632 – 637Poly-Ser6
Compositional biasi686 – 693Poly-Ser8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPC family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2179 Eukaryota
COG5535 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005194

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009925_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24595

KEGG Orthology (KO)

More...
KOi
K10838

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMNCRLI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q24595

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.2460, 1 hit
3.90.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018327 BHD_2
IPR004583 DNA_repair_Rad4
IPR018026 DNA_repair_Rad4_subgr
IPR038765 Papain-like_cys_pep_sf
IPR018325 Rad4/PNGase_transGLS-fold
IPR018326 Rad4_beta-hairpin_dom1
IPR018328 Rad4_beta-hairpin_dom3
IPR042488 Rad4_BHD3_sf
IPR036985 Transglutaminase-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12135 PTHR12135, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10403 BHD_1, 1 hit
PF10404 BHD_2, 1 hit
PF10405 BHD_3, 1 hit
PF03835 Rad4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01030 BHD_1, 1 hit
SM01031 BHD_2, 1 hit
SM01032 BHD_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00605 rad4, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q24595-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDEEEDSVS EGFSASEDEW KPSKDVKGGE SSDDDDSDFD ELQAEGGAAG
60 70 80 90 100
SSGRSSAVAG KRGDHKAPSG IKGSSVKKRK PTGQSLRSKL YNKYRPPPKT
110 120 130 140 150
FPTSPSQQKE NTPRASGSKN AKTPNESGAR NQHGPADSSS ESSVEDYLVN
160 170 180 190 200
PADLDLHSTF FAGGQKEKSP APQFDCNAGI TNLSDSGSED NNESSFEDKA
210 220 230 240 250
GNAFDFRGLL ENANSLERTR DALSKRNVTA TPPRSQAATM DVNALLALGE
260 270 280 290 300
NQNYQSVEVE EREGNQRKKA GRGAPAAPPT LDEPSRLSKT KSTRIKRHTK
310 320 330 340 350
TRPVSTVVAN AGDTDDSDFE EVADADLSSD QDDGETPNIS GDLEIRVGLE
360 370 380 390 400
GLRPTKEQKT QHELEMALKR RLNRDIKDRQ ILLHKVSLMC QIARSLKYNR
410 420 430 440 450
LLSESDSLMQ ATLKLLPSRN AYPTERGTEL KYLQSFVTWF KTSIKLLSPN
460 470 480 490 500
LYSAQSPATK EAILEALLEQ VKRKEARCKQ DMIFIFIALA RGMGMHCRLI
510 520 530 540 550
VNLQPMPLRP AASDLIPIKL RPDDKNKSQT VESERESEDE KPKKDKKAGK
560 570 580 590 600
PAEKESSKST ISKEAEKKNN AKKAEAKPLS KSTTKGSETT KSGTVPKVKK
610 620 630 640 650
ELSLSSKLVE KSKHQKAYTS SKSDTSFDEK PSTSSSSKCL KEEYSELGLS
660 670 680 690 700
KKLLKPTLSS KLVLKSKNQS SFSSNKSDTS FEENPSTSSS SKSLKEETAK
710 720 730 740 750
LSSSKLEDKK VASPAETKTK VQSSLLKRVT TQNISESGDS KKPKVAPVDT
760 770 780 790 800
FSPVAGRTRR ATVKPKTEEK PQVVGSPVIP KLMLSKVKQL NAKHSDTENA
810 820 830 840 850
SPANKHLQEQ RNTRETRSRS KSPKVLISPS FLKKKSDGAD STSDPQKHQM
860 870 880 890 900
APETKARISP NFLSEALPAR QLRSRGQKAS SLAIPQLDGG DDVPLPKKRP
910 920 930 940 950
KLEKLKNSQD SDEVFEPAKP VKKAPVLPKS VQNLRKDRRV MSTDDEGGSR
960 970 980 990 1000
LNRKTDASDM WVEVWSDVEE QWICIDLFKG KLHCVDTIRK NATPGLAYVF
1010 1020 1030 1040 1050
AFQDDQSLKD VTARYCASWS TTVRKARVEK AWLDETIAPY LGRRTKRDIT
1060 1070 1080 1090 1100
EDDQLRRIHS DKPLPKSISE FKDHPLYVLE RHLLKFQGLY PPDAPTLGFI
1110 1120 1130 1140 1150
RGEAVYSRDC VHLLHSREIW LKSARVVKLG EQPYKVVKAR PKWDRLTRTV
1160 1170 1180 1190 1200
IKDQPLEIFG YWQTQEYEPP TAENGIVPRN AYGNVELFKD CMLPKKTVHL
1210 1220 1230 1240 1250
RLPGLMRICK KLNIDCANAV VGFDFHQGAC HPMYDGFIVC EEFREVVTAA
1260 1270 1280 1290
WEEDQQVQVL KEQEKYETRV YGNWKKLIKG LLIRERLKKK YNF
Length:1,293
Mass (Da):144,224
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3F2BFE7A8DE6A57
GO
Isoform 2 (identifier: Q24595-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-782: Missing.

Show »
Length:511
Mass (Da):58,860
Checksum:iE833365397D958D0
GO
Isoform 3 (identifier: Q24595-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     63-63: G → GS

Show »
Length:1,294
Mass (Da):144,311
Checksum:i00F79F933D6E1DDF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K739A0A0B4K739_DROME
Xeroderma pigmentosum, complementat...
Xpc DhR4, DhXPC, Dmel\CG8153, DmXPC, Mus 210
330Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109K → Q in CAA82262 (PubMed:8127661).Curated1
Sequence conflicti109K → Q in AAF24766 (PubMed:10812334).Curated1
Sequence conflicti134G → D in CAA82262 (PubMed:8127661).Curated1
Sequence conflicti618Y → H in CAA82262 (PubMed:8127661).Curated1
Sequence conflicti743P → S in CAA82262 (PubMed:8127661).Curated1
Sequence conflicti844D → A in CAA82262 (PubMed:8127661).Curated1
Sequence conflicti945D → E in AAF24766 (PubMed:10812334).Curated1
Sequence conflicti945D → E in AAF24767 (PubMed:10812334).Curated1
Sequence conflicti1245E → D in CAA82262 (PubMed:8127661).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0151971 – 782Missing in isoform 2. CuratedAdd BLAST782
Alternative sequenceiVSP_01519863G → GS in isoform 3. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z28622 mRNA Translation: CAA82262.1
AF209743 Genomic DNA Translation: AAF24766.1
AF209743 Genomic DNA Translation: AAF24767.1
AE013599 Genomic DNA Translation: AAF58150.1
AE013599 Genomic DNA Translation: AAM68530.1
AY070566 mRNA Translation: AAL48037.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S42402

NCBI Reference Sequences

More...
RefSeqi
NP_476861.1, NM_057513.4 [Q24595-1]
NP_725451.1, NM_166087.2 [Q24595-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087373; FBpp0086505; FBgn0004698 [Q24595-3]
FBtr0087374; FBpp0086506; FBgn0004698 [Q24595-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36697

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8153

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28622 mRNA Translation: CAA82262.1
AF209743 Genomic DNA Translation: AAF24766.1
AF209743 Genomic DNA Translation: AAF24767.1
AE013599 Genomic DNA Translation: AAF58150.1
AE013599 Genomic DNA Translation: AAM68530.1
AY070566 mRNA Translation: AAL48037.1
PIRiS42402
RefSeqiNP_476861.1, NM_057513.4 [Q24595-1]
NP_725451.1, NM_166087.2 [Q24595-3]

3D structure databases

SMRiQ24595
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi62434, 6 interactors
IntActiQ24595, 13 interactors
STRINGi7227.FBpp0086505

PTM databases

iPTMnetiQ24595

Proteomic databases

PaxDbiQ24595
PRIDEiQ24595

Genome annotation databases

EnsemblMetazoaiFBtr0087373; FBpp0086505; FBgn0004698 [Q24595-3]
FBtr0087374; FBpp0086506; FBgn0004698 [Q24595-1]
GeneIDi36697
KEGGidme:Dmel_CG8153

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7508
FlyBaseiFBgn0004698 Xpc

Phylogenomic databases

eggNOGiKOG2179 Eukaryota
COG5535 LUCA
GeneTreeiENSGT00390000005194
HOGENOMiCLU_009925_0_0_1
InParanoidiQ24595
KOiK10838
OMAiGMNCRLI
PhylomeDBiQ24595

Enzyme and pathway databases

ReactomeiR-DME-5696394 DNA Damage Recognition in GG-NER
R-DME-5696395 Formation of Incision Complex in GG-NER

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36697 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36697

Protein Ontology

More...
PROi
PR:Q24595

Gene expression databases

BgeeiFBgn0004698 Expressed in eye disc (Drosophila) and 30 other tissues
ExpressionAtlasiQ24595 baseline and differential
GenevisibleiQ24595 DM

Family and domain databases

Gene3Di3.30.70.2460, 1 hit
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR018327 BHD_2
IPR004583 DNA_repair_Rad4
IPR018026 DNA_repair_Rad4_subgr
IPR038765 Papain-like_cys_pep_sf
IPR018325 Rad4/PNGase_transGLS-fold
IPR018326 Rad4_beta-hairpin_dom1
IPR018328 Rad4_beta-hairpin_dom3
IPR042488 Rad4_BHD3_sf
IPR036985 Transglutaminase-like_sf
PANTHERiPTHR12135 PTHR12135, 2 hits
PfamiView protein in Pfam
PF10403 BHD_1, 1 hit
PF10404 BHD_2, 1 hit
PF10405 BHD_3, 1 hit
PF03835 Rad4, 1 hit
SMARTiView protein in SMART
SM01030 BHD_1, 1 hit
SM01031 BHD_2, 1 hit
SM01032 BHD_3, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
TIGRFAMsiTIGR00605 rad4, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPC_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24595
Secondary accession number(s): Q7KJI5
, Q8MLA1, Q8MLA2, Q9U3Z0, Q9U3Z1, Q9V7A8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 30, 2005
Last modified: June 17, 2020
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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