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Protein

Tyrosine-protein kinase hopscotch

Gene

hop

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair-rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation.2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei926ATPPROSITE-ProRule annotation1
Active sitei1014Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi898 – 906ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cytokine receptor binding Source: FlyBase
  • non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  • protein tyrosine kinase activity Source: FlyBase
  • signaling receptor binding Source: GO_Central

GO - Biological processi

  • apical constriction Source: FlyBase
  • blastoderm segmentation Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell proliferation Source: FlyBase
  • compound eye development Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • compound eye photoreceptor cell differentiation Source: FlyBase
  • defense response to virus Source: FlyBase
  • equator specification Source: FlyBase
  • establishment of ommatidial planar polarity Source: FlyBase
  • eye-antennal disc morphogenesis Source: FlyBase
  • germ-line stem cell division Source: FlyBase
  • hemocyte differentiation Source: FlyBase
  • hemocyte proliferation Source: FlyBase
  • hemopoiesis Source: FlyBase
  • hindgut morphogenesis Source: FlyBase
  • humoral immune response Source: FlyBase
  • immune response Source: FlyBase
  • innate immune response Source: GO_Central
  • JAK-STAT cascade Source: FlyBase
  • lamellocyte differentiation Source: FlyBase
  • larval lymph gland hemopoiesis Source: FlyBase
  • locomotor rhythm Source: FlyBase
  • long-term memory Source: FlyBase
  • mediolateral intercalation Source: FlyBase
  • nervous system development Source: FlyBase
  • ommatidial rotation Source: FlyBase
  • oogenesis Source: FlyBase
  • open tracheal system development Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • ovarian follicle cell stalk formation Source: FlyBase
  • peptidyl-tyrosine autophosphorylation Source: FlyBase
  • periodic partitioning Source: FlyBase
  • positive regulation of heterochromatin assembly Source: FlyBase
  • primary sex determination Source: FlyBase
  • regulation of embryonic cell shape Source: FlyBase
  • regulation of hemocyte differentiation Source: FlyBase
  • regulation of hemocyte proliferation Source: FlyBase
  • regulation of JAK-STAT cascade Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • somatic stem cell division Source: FlyBase
  • stem cell population maintenance Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
  • tyrosine phosphorylation of STAT protein Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Kinase, Transferase, Tyrosine-protein kinase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 1994
ReactomeiR-DME-1433557 Signaling by SCF-KIT
R-DME-209209 Formation of the activated receptor complex
R-DME-209228 Formation of the activated STAT92E dimer and transport to the nucleus
R-DME-210688 Dephosphorylation by PTP61F phosphatases
R-DME-5673000 RAF activation
R-DME-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiQ24592

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase hopscotch (EC:2.7.10.2)
Gene namesi
Name:hop
Synonyms:HD-160
ORF Names:CG1594
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004864 hop

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881181 – 1177Tyrosine-protein kinase hopscotchAdd BLAST1177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40Phosphoserine1 Publication1
Modified residuei321Phosphoserine1 Publication1
Modified residuei1047Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1048Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24592
PRIDEiQ24592

PTM databases

iPTMnetiQ24592

Expressioni

Developmental stagei

Expressed both maternally and zygotically throughout development.1 Publication

Gene expression databases

BgeeiFBgn0004864
ExpressionAtlasiQ24592 baseline and differential
GenevisibleiQ24592 DM

Interactioni

Subunit structurei

Forms a complex with Hsp83 and piwi; probably Hop mediates the interaction between piwi and Hsp83.

GO - Molecular functioni

  • cytokine receptor binding Source: FlyBase
  • signaling receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi58492, 40 interactors
DIPiDIP-61595N
IntActiQ24592, 4 interactors
STRINGi7227.FBpp0073313

Structurei

3D structure databases

ProteinModelPortaliQ24592
SMRiQ24592
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 414FERMPROSITE-ProRule annotationAdd BLAST369
Domaini433 – 539SH2; atypicalAdd BLAST107
Domaini582 – 843Protein kinase 1PROSITE-ProRule annotationAdd BLAST262
Domaini892 – 1164Protein kinase 2PROSITE-ProRule annotationAdd BLAST273

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi542 – 547Poly-Leu6

Domaini

Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1 (By similarity).By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909
InParanoidiQ24592
KOiK04447
OMAiNCMESFL
OrthoDBiEOG091G01IS
PhylomeDBiQ24592

Family and domain databases

InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

Q24592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALANGGEDR MDDSSSGRTS LADSASLTNS SLRSGTSSQS IHTNDGTIRV
60 70 80 90 100
FNFTTGEFER FHPNMLCEEI CNTMCRQLGI APIAQLLYGI REHSTSRRPS
110 120 130 140 150
PLVRLDLTWC LPGERLNCQL VYCFRMRFRV PELDSQLELI DGRSHKFLYR
160 170 180 190 200
QMRYDMRTEQ IPEIRYPEHK DKSTGLAVMD MLIDDQEQSE DQQAMRSIEK
210 220 230 240 250
LYKLYLPPSL WRAHSFFVGS KIREVFRSLK ANSLSVERLK WHYVHQVSHL
260 270 280 290 300
APTYMTEQFT CTVQYLPNEE VARGSGPIGT SLAHSTSTLA SSGSTNTLST
310 320 330 340 350
LTTNTNSVAL GGSGKKAKRR STSGGIDVYV RVFPHDSLEP GLKVARVTSE
360 370 380 390 400
ATLKWILVGA VEGIFMISKI NDTSVRLEIV GLPKGYEMQF QTEKEMKSFI
410 420 430 440 450
SYLGIYIRLS SKWMQDLCHS YRTPSLEELS SLHCHGPIGG AYSLMKLHEN
460 470 480 490 500
GDKCGSYIVR ECDREYNIYY IDINTKIMAK KTDQERCKTE TFRIVRKDSQ
510 520 530 540 550
WKLSYNNGEH VLNSLHEVAH IIQADSPDRY RIPASKYDKP PLLLLLLPKN
560 570 580 590 600
LKAKKTDLQL SEAELQRRNP QIFNPRTDLQ WYPDSISLSD DGMMFTMRGD
610 620 630 640 650
WIQQSPVKDV SVTMKMLKSD GNFMEFFRLA QTWSLIQSPQ FLKLYGLTLA
660 670 680 690 700
DPYTMVMEYS RYGPLNKFLH SMPNVTLHCL LDLMHGLVRG MHYLEDNKII
710 720 730 740 750
HNYIRCSNLY VTKYDPNSYV LDAKISDPGY PRPYRESDSP WIPVKYYRNL
760 770 780 790 800
QAAKTDQFAQ LWAFATTIYE IFSRCKEDLS TLRQEQLLRQ KNLDGNILKM
810 820 830 840 850
LDQDICPAPI FETIMDGWSD DETKRFSHHD IFSRLNTIKA EILPNYMPPP
860 870 880 890 900
EIATNGTGDE TVIDRSDIPF LPFPRSNMLM VIPLTSECRV IYNMENMIGR
910 920 930 940 950
GHYGTVYKGH LEFNDKDQPR EQVAIKMLNT MQVSTDFHRE IGIMRTLSHP
960 970 980 990 1000
NIVKFKYWAE KSHCIIMEYL QSGSFDIYLR FTAPNLNNPR LVSFALDIAN
1010 1020 1030 1040 1050
GMKYLSDMGL IHRDLAARNI LVDHNGDGDC VKISDFGLAQ FANSDGYYYA
1060 1070 1080 1090 1100
KSKRDIPIRW YSPEAISTCR FSSYSDVWSY GVTLFEMFSR GEEPNLVPIQ
1110 1120 1130 1140 1150
TSQEDFLNRL QSGERLNRPA SCPDFIYDLM QLCWHATPRS RPSFATIVDI
1160 1170
ITREVATKVT HPTDGHQSPP NQPTDAE
Length:1,177
Mass (Da):135,062
Last modified:March 1, 2005 - v2
Checksum:iBF8587C420BF3A8F
GO

Sequence cautioni

The sequence AAL48491 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti365F → V in AAA62441 (PubMed:8314084).Curated1
Sequence conflicti592G → A in AAA62441 (PubMed:8314084).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26975 mRNA Translation: AAA62441.1
AE014298 Genomic DNA Translation: AAF48035.1
BT006331 mRNA Translation: AAP20030.1
AY070869 mRNA Translation: AAL48491.1 Different initiation.
AJ002915 Genomic DNA Translation: CAA05750.1
PIRiA36984
RefSeqiNP_511119.2, NM_078564.3
UniGeneiDm.2926

Genome annotation databases

EnsemblMetazoaiFBtr0073457; FBpp0073313; FBgn0004864
GeneIDi32080
KEGGidme:Dmel_CG1594

Similar proteinsi

Entry informationi

Entry nameiJAK_DROME
AccessioniPrimary (citable) accession number: Q24592
Secondary accession number(s): Q712V3, Q8SZI9, Q9VYZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 1, 2005
Last modified: July 18, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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