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Protein
Submitted name:

Tumor suppressor

Gene

wts

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ24590

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor suppressorImported
Gene namesi
Name:wtsImported
ORF Names:CG12072Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0011739 wts

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiQ24590

Expressioni

Gene expression databases

BgeeiFBgn0011739 Expressed in 26 organ(s), highest expression level in embryo
ExpressionAtlasiQ24590 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ24590, 2 interactors
MINTiQ24590

Structurei

3D structure databases

ProteinModelPortaliQ24590
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini713 – 1014Protein kinaseInterPro annotationAdd BLAST302
Domaini1015 – 1085AGC-kinase C-terminalInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili475 – 530Sequence analysisAdd BLAST56

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0605 Eukaryota
ENOG410XQC0 LUCA
OrthoDBiEOG091G028J

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR028741 LATS1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24356:SF138 PTHR24356:SF138, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q24590-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPAGEKRGG RPNDKYTAEA LESIKQDLTR FEVQNNHRNN QNYTPLRYTA
60 70 80 90 100
TNGRNDALTP DYHHAKQPME PPPSASPAPD VVIPPPPAIV GQPGAGSISV
110 120 130 140 150
SGVGVGVVGV ANGRVPKMMT ALMPNKLIRK PSIERDTASS HYLRCSPALD
160 170 180 190 200
SGAGSSRSDS PHSHHTHQPS SRTVGNPGGN GGFSPSPSGF SEVAPPAPPP
210 220 230 240 250
RNPTASSAAT PPPPVPPTSQ AYVKRRSPAL NNRPPAIAPP TQRGNSPVIT
260 270 280 290 300
QNGLKNPQQQ LTQQLKSLNL YPGGGSGAVV EPPPPYLIQG GAGGAAPPPP
310 320 330 340 350
PPSYTASMQS RQSPTQSQQS DYRKSPSSGI YSATSAGSPS PITVSLPPAP
360 370 380 390 400
LAKPQPRVYQ ARSQQPIIMQ SVKSTQVQKP VLQTAVAPQS PSSASASNSP
410 420 430 440 450
VHVLAAPPSY PQKSAAVVQQ QQQAAAAAHQ QQHQHQQSKP ATPTTPPLVG
460 470 480 490 500
LNSKPNCLEP PSYAKSMQAK AATVVQQQQQ QQQQQQVQQQ QVQQQQQQQQ
510 520 530 540 550
QQLQALRVLQ AQAQRERDQR ERERDQQKLA NGNPGRQMLP PPPYQSNNNN
560 570 580 590 600
NSEIKPPSCN NNNIQISNSN LATTPPIPPA KYNNNSSNTG ANSSGGSNGS
610 620 630 640 650
TGTTASSSTS CKKIKHASPI PERKKISKEK EEERKEFRIR QYSPQAFKFF
660 670 680 690 700
MEQHIENVIK SYRQRTYRKN QLEKEMHKVG LPDQTQIEMR KMLNQKESNY
710 720 730 740 750
IRLKRAKMDK SMFVKLKPIG VGAFGEVTLV SKIDTSNHLY AMKTLRKADV
760 770 780 790 800
LKRNQVAHVK AERDILAEAD NNWVVKLYYS FQDKDNLYFV MDYIPGGDLM
810 820 830 840 850
SLLIKLGIFE EELARFYIAE VTCAVDSVHK MGFIHRDIKP DNILIDRDGH
860 870 880 890 900
IKLTDFGLCT GFRWTHNSKY YQENGNHSRQ DSMEPWEEYS ENGPKPTVLE
910 920 930 940 950
RRRMRDHQRV LAHSLVGTPN YIAPEVLERS GYTQLCDYWS VGVILYEMLV
960 970 980 990 1000
GQPPFLANSP LETQQKVINW EKTLHIPPQA ELSREATDLI RRLCASADKR
1010 1020 1030 1040 1050
LGKSVDEVKS HDFFKGIDFA DMRKQKAPYI PEIKHPTDTS NFDPVDPEKL
1060 1070 1080 1090
RSNDSTMSSG DDVDQNDRTF HGFFEFTFRR FFDDKQPPDM TDDQAPVYV
Length:1,099
Mass (Da):121,634
Last modified:November 1, 1996 - v1
Checksum:iEB35192A10470805
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39837 mRNA Translation: AAA73959.1
PIRiA56155

Genome annotation databases

EnsemblMetazoaiFBtr0085720; FBpp0085082; FBgn0011739

Similar proteinsi

Entry informationi

Entry nameiQ24590_DROME
AccessioniPrimary (citable) accession number: Q24590
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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