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Entry version 151 (02 Jun 2021)
Sequence version 2 (29 Mar 2005)
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Protein

Synapsin

Gene

Syn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a significant role in nervous system function, which is subtle at the cellular level but manifests itself in complex behavior.

1 Publication

Miscellaneous

Readthrough of the terminator UGA may occur between the codons for 581-Met and 583-Glu.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBehavior

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-181429, Serotonin Neurotransmitter Release Cycle
R-DME-212676, Dopamine Neurotransmitter Release Cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synapsin
Cleaved into the following 2 chains:
Synapsin-1
Short name:
Syn1
Alternative name(s):
Syn1-S
Synapsin-2
Short name:
Syn2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Syn
Synonyms:Syn-1, Syn-2
ORF Names:CG3985
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004575, Syn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants show no obvious defects in brain morphology and no striking qualitative changes in behavior are observed. Quantitative differenes are seen: mutants show faster habituation of an olfactory jump response, enhanced ethanol tolerance, and significant defects in learning and memory as measured using three different paradigms.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000334951 – 1025SynapsinAdd BLAST1025
ChainiPRO_00000334961 – 581Synapsin-1Add BLAST581
ChainiPRO_0000033497583 – 1025Synapsin-2Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei539Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24546

PeptideAtlas

More...
PeptideAtlasi
Q24546

PRoteomics IDEntifications database

More...
PRIDEi
Q24546

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q24546

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in the embryonic and adult nervous system synaptic terminals.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at all developmental stages after mid-embryogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004575, Expressed in central nervous system and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q24546, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24546, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a complex with Syt1 and nwk.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
66396, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q24546, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0099902

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 94DisorderedSequence analysisAdd BLAST94
Regioni439 – 784DisorderedSequence analysisAdd BLAST346
Regioni866 – 905DisorderedSequence analysisAdd BLAST40
Regioni994 – 1025DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 55Pro residuesSequence analysisAdd BLAST27
Compositional biasi439 – 466Polar residuesSequence analysisAdd BLAST28
Compositional biasi470 – 495Pro residuesSequence analysisAdd BLAST26
Compositional biasi500 – 563Polar residuesSequence analysisAdd BLAST64
Compositional biasi591 – 623Polar residuesSequence analysisAdd BLAST33
Compositional biasi630 – 677Polar residuesSequence analysisAdd BLAST48
Compositional biasi705 – 735Polar residuesSequence analysisAdd BLAST31
Compositional biasi736 – 751Pro residuesSequence analysisAdd BLAST16
Compositional biasi752 – 784Polar residuesSequence analysisAdd BLAST33
Compositional biasi867 – 904Polar residuesSequence analysisAdd BLAST38
Compositional biasi994 – 1010Polar residuesSequence analysisAdd BLAST17
Compositional biasi1011 – 1025Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3895, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010582_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24546

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR016185, PreATP-grasp_dom_sf
IPR001359, Synapsin
IPR020898, Synapsin_ATP-bd_dom
IPR020897, Synapsin_pre-ATP-grasp_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02078, Synapsin, 1 hit
PF02750, Synapsin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01368, SYNAPSIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52440, SSF52440, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform F (identifier: Q24546-1) [UniParc]FASTAAdd to basket
Also known as: Syn1-RT

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRGFSSGDL SSEVDDVDPN SLPPAARPIQ DQPTKPPVAG GPPNMPPPPA
60 70 80 90 100
PGQPAGAAPE LSLSFGAGKT PATAAPAPPR GVSAPTSPAK SRESLLQRVQ
110 120 130 140 150
SLTGAARDQG ASILGAAVQS ATQRAPAFSK DKYFTLLVLD DQNTDWSKYF
160 170 180 190 200
RGRRLHGDFD IRVEQAEFRD ITVVSSADTG PVVTMAAYRS GTRVARSFRP
210 220 230 240 250
DFVLIRQPPR DGSSDYRSTI LGLKYGGVPS INSLHSIYQF QDKPWVFSHL
260 270 280 290 300
LQLQRRLGRD GFPLIEQTFF PNPRDLFQFT KFPSVLKAGH CHGGVATARL
310 320 330 340 350
ENQSALQDAA GLVSGAGNDS HCYCTIEPYI DAKFSVHIQK IGNNYKAFMR
360 370 380 390 400
KSITGNWKTN QGSAMLEQIT LTEKYKSWVD EISELFGGME VCGLSVVVAK
410 420 430 440 450
DGREYIISAC DSTFALIGDT QEEDRRQIAD LVSGRMQNVC RPSMAQTGPG
460 470 480 490 500
KLPSRSSVSS RAESPTDEGV APTPPLPAGP RPAPMGGPPP IPERTSPAVG
510 520 530 540 550
SIGRLSSRSS ISEVPEEPSS SGPSTVGGVR RDSQTSQSST ISSSVSRAGQ
560 570 580 590 600
RPPQTQNSVV EDAEDTMKNL RKTFAGIFGD MXEIANKKRG RTASETSSGS
610 620 630 640 650
GPGSVPSSAG PGSGFSSSFL GKQFSFAGKG EGVISTQPTQ RPSEEPPAIP
660 670 680 690 700
TTASSAVRPE SSVSVSDSRN TDTLTERAGA GYQPVTNYEQ QERVNPFDKE
710 720 730 740 750
PSKSGSAASI HTSSSSSISS SSISSRINRN GNAIQSPPPP AGPPPPPPTN
760 770 780 790 800
VTAVGSNANS SSGYRNSFSS SLSKDKTSYG NYGSTTSVET ITRMDTNTTN
810 820 830 840 850
IGATATEAGE ASGVTAITNI SNSDGIVAPT TGTITTSVTT NDWRSAIGMR
860 870 880 890 900
SASVYSAPAA VTTVLPGDTS GYDSNSIASQ GEGLNNPSDL PSYTRPSYSR
910 920 930 940 950
SESNASKHSD LDVIFGDSKT TPASYGNGKY TRAAGSISDA DMIFGGPPSN
960 970 980 990 1000
YKTDRFGASK SMSMTSGGVG SGNGSGSGLG GYKIYDSIQN AAFSDFSDSG
1010 1020
SMSSIGSHTK RWSASKEEDD ELDLK
Length:1,025
Mass (Da):107,539
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD18B5AE0F8EE360C
GO
Isoform C (identifier: Q24546-3) [UniParc]FASTAAdd to basket
Also known as: Syn2

The sequence of this isoform differs from the canonical sequence as follows:
     438-532: NVCRPSMAQT...PSTVGGVRRD → VERLPSQHGA...GTQHSGWGAS
     533-1025: Missing.

Show »
Length:532
Mass (Da):57,487
Checksum:iF79067F651FDB35E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2QCY9E2QCY9_DROME
Synapsin, isoform D
Syn Dmel\CG3985, Dsyn-1, SYN, syn, SYN1
1,041Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E2QCZ0E2QCZ0_DROME
Synapsin, isoform E
Syn Dmel\CG3985, Dsyn-1, SYN, syn, SYN1
597Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN13462 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAN13464 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAO41538 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA64722 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA64723 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94S → G in CAA64722 (PubMed:8627354).Curated1
Sequence conflicti94S → G in CAA64723 (PubMed:8627354).Curated1
Sequence conflicti163V → G in CAA64722 (PubMed:8627354).Curated1
Sequence conflicti163V → G in CAA64723 (PubMed:8627354).Curated1
Sequence conflicti163V → G in CAA64724 (PubMed:8627354).Curated1
Sequence conflicti411D → N in CAA64722 (PubMed:8627354).Curated1
Sequence conflicti411D → N in CAA64723 (PubMed:8627354).Curated1
Sequence conflicti411D → N in CAA64724 (PubMed:8627354).Curated1
Sequence conflicti735Q → K in CAA64723 (PubMed:8627354).Curated1
Sequence conflicti987S → G in CAA64723 (PubMed:8627354).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013200438 – 532NVCRP…GVRRD → VERLPSQHGADGSGQVALPL LGLFPSRESHGRGRGSNTTT PSWTKTRAHGWTTTDTGAYL TRRGFHWAAEQSQQHFGGAG GTLLVGTQHSGWGAS in isoform C. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_013201533 – 1025Missing in isoform C. 1 PublicationAdd BLAST493

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X95453 mRNA Translation: CAA64722.1 Different initiation.
X95453 mRNA Translation: CAA64723.1 Different initiation.
X95454 mRNA Translation: CAA64724.1
AE014297 Genomic DNA Translation: AAN13462.1 Sequence problems.
AE014297 Genomic DNA Translation: AAN13464.2 Sequence problems.
AE014297 Genomic DNA Translation: AAO41538.2 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_731457.2, NM_169332.3
NP_788628.2, NM_176451.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41247

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3985

UCSC genome browser

More...
UCSCi
CG3985-RA, d. melanogaster [Q24546-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95453 mRNA Translation: CAA64722.1 Different initiation.
X95453 mRNA Translation: CAA64723.1 Different initiation.
X95454 mRNA Translation: CAA64724.1
AE014297 Genomic DNA Translation: AAN13462.1 Sequence problems.
AE014297 Genomic DNA Translation: AAN13464.2 Sequence problems.
AE014297 Genomic DNA Translation: AAO41538.2 Sequence problems.
RefSeqiNP_731457.2, NM_169332.3
NP_788628.2, NM_176451.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

BioGRIDi66396, 8 interactors
IntActiQ24546, 2 interactors
STRINGi7227.FBpp0099902

PTM databases

iPTMnetiQ24546

Proteomic databases

PaxDbiQ24546
PeptideAtlasiQ24546
PRIDEiQ24546

Genome annotation databases

GeneIDi41247
KEGGidme:Dmel_CG3985
UCSCiCG3985-RA, d. melanogaster [Q24546-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41247
FlyBaseiFBgn0004575, Syn

Phylogenomic databases

eggNOGiKOG3895, Eukaryota
HOGENOMiCLU_010582_1_0_1
InParanoidiQ24546

Enzyme and pathway databases

ReactomeiR-DME-181429, Serotonin Neurotransmitter Release Cycle
R-DME-212676, Dopamine Neurotransmitter Release Cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
41247, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sdc, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
41247

Protein Ontology

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PROi
PR:Q24546

Gene expression databases

BgeeiFBgn0004575, Expressed in central nervous system and 26 other tissues
ExpressionAtlasiQ24546, baseline and differential
GenevisibleiQ24546, DM

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR016185, PreATP-grasp_dom_sf
IPR001359, Synapsin
IPR020898, Synapsin_ATP-bd_dom
IPR020897, Synapsin_pre-ATP-grasp_dom
PfamiView protein in Pfam
PF02078, Synapsin, 1 hit
PF02750, Synapsin_C, 1 hit
PRINTSiPR01368, SYNAPSIN
SUPFAMiSSF52440, SSF52440, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24546
Secondary accession number(s): Q24544
, Q24545, Q86BA0, Q8INM4, Q8INM6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: June 2, 2021
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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