Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein singed

Gene

sn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably acts as an actin bundling protein. May have a role in the asymmetric organization and/or movement of cytoplasmic components. It has a role in somatic cells during the formation of adult bristles and hairs, and in the female germline during oogenesis.

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: FlyBase
  • actin filament bundle assembly Source: FlyBase
  • actin filament organization Source: FlyBase
  • antennal morphogenesis Source: FlyBase
  • chaeta morphogenesis Source: FlyBase
  • cuticle pattern formation Source: FlyBase
  • dendrite development Source: FlyBase
  • epidermal cell differentiation Source: FlyBase
  • establishment or maintenance of cell polarity Source: FlyBase
  • filopodium assembly Source: FlyBase
  • hemocyte migration Source: FlyBase
  • imaginal disc-derived wing hair organization Source: FlyBase
  • microvillar actin bundle assembly Source: FlyBase
  • neuron projection morphogenesis Source: FlyBase
  • oogenesis Source: UniProtKB-KW
  • wound healing Source: FlyBase

Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processDifferentiation, Oogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein singed
Gene namesi
Name:sn
ORF Names:CG1536
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003447 sn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193871 – 512Protein singedAdd BLAST512

Proteomic databases

PaxDbiQ24524
PRIDEiQ24524

PTM databases

iPTMnetiQ24524

Expressioni

Gene expression databases

BgeeiFBgn0003447
ExpressionAtlasiQ24524 baseline and differential
GenevisibleiQ24524 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi58189, 4 interactors
STRINGi7227.FBpp0290893

Structurei

3D structure databases

ProteinModelPortaliQ24524
SMRiQ24524
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fascin family.Curated

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
InParanoidiQ24524
KOiK17455
OMAiCTAKAPG
OrthoDBiEOG091G0C6S
PhylomeDBiQ24524

Family and domain databases

CDDicd00257 Fascin, 4 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
PANTHERiPTHR10551 PTHR10551, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 4 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits

Sequencei

Sequence statusi: Complete.

Q24524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGQGCELGH SNGDIISQNQ QKGWWTIGLI NGQHKYMTAE TFGFKLNANG
60 70 80 90 100
ASLKKKQLWT LEPSNTGESI IYLRSHLNKY LSVDQFGNVL CESDERDAGS
110 120 130 140 150
RFQISISEDG SGRWALKNES RGYFLGGTPD KLVCTAKTPG ASEFWTVHLA
160 170 180 190 200
ARPQVNLRSI GRKRFAHLSE SQDEIHVDAN IPWGEDTLFT LEFRAEEGGR
210 220 230 240 250
YALHTCNNKY LNANGKLQVV CNEDCLFSAE YHGGHLALRD RQGQYLSPIG
260 270 280 290 300
SKAVLKSRSS SVTRDELFSL EDSLPQASFI AGLNLRYVSV KQGVDVTANQ
310 320 330 340 350
DEVGENETFQ LEYDWSAHRW ALRTTQDRYW CLSAGGGIQA TGNRRCADAL
360 370 380 390 400
FELIWHGDGS LSFRANNGKF LATKRSGHLF ATSESIEEIA KFYFYLINRP
410 420 430 440 450
ILVLKCEQGF VGYRTPGNLK LECNKATYET ILVERAQKGL VHLKAHSGKY
460 470 480 490 500
WRIEGESISV DADAPSDGFF LELREPTRIC IRSQQGKYLG ATKNGAFKLL
510
DDGTDSATQW EF
Length:512
Mass (Da):57,279
Last modified:November 1, 1996 - v1
Checksum:iA021886A9C7B6C48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17549, X17550 Genomic DNA Translation: CAA35585.1
AE014298 Genomic DNA Translation: AAF46307.1
RefSeqiNP_001162697.1, NM_001169226.2
NP_511076.3, NM_078521.3
NP_727226.1, NM_167142.3
NP_727227.1, NM_167143.3
UniGeneiDm.7274

Genome annotation databases

EnsemblMetazoaiFBtr0071101; FBpp0071057; FBgn0003447
FBtr0071102; FBpp0071058; FBgn0003447
FBtr0301677; FBpp0290891; FBgn0003447
FBtr0301679; FBpp0290893; FBgn0003447
GeneIDi31717
KEGGidme:Dmel_CG32858
UCSCiCG32858-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiSING_DROME
AccessioniPrimary (citable) accession number: Q24524
Secondary accession number(s): Q9W3L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health