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UniProtKB - Q24498 (RYR_DROME)

Entry version 177 (02 Dec 2020)
Sequence version 3 (01 Jun 2003)
Previous versions | rss
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Protein

Ryanodine receptor

Gene

RyR

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intracellular calcium channel that is required for proper muscle function during embryonic development and may be essential for excitation-contraction coupling in larval body wall muscles.2 Publications

Miscellaneous

Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity and maintains the channel in an open conformation. The calcium release channel is modulated by calcium ions, magnesium ions, ATP and calmodulin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei4162Important for activation by Ca(2+)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Developmental protein, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.3.1.5, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ryanodine receptor
Alternative name(s):
Ryanodine receptor 44F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RyRImported
Synonyms:dry, Rya-r44FImported
ORF Names:CG10844Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0011286, RyR

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4451CytoplasmicSequence analysisAdd BLAST4451
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4452 – 4472HelicalSequence analysisAdd BLAST21
Transmembranei4651 – 4671HelicalSequence analysisAdd BLAST21
Transmembranei4683 – 4703HelicalSequence analysisAdd BLAST21
Transmembranei4742 – 4762HelicalSequence analysisAdd BLAST21
Transmembranei4885 – 4905HelicalSequence analysisAdd BLAST21
Transmembranei4924 – 4944HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei4974 – 4983Pore-formingBy similarity10
Transmembranei4984 – 5024HelicalSequence analysisAdd BLAST41
Topological domaini5025 – 5127CytoplasmicSequence analysisAdd BLAST103

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL6045

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193641 – 5127Ryanodine receptorAdd BLAST5127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1459Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q24498

PRoteomics IDEntifications database

More...PRIDEi		Q24498

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q24498

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During embryonic stages 9-10, expression is seen in mesoderm of all segments in progenitors of the cephalic and somatic muscles. Adults exhibit high expression in tubular 'jump' muscles of thorax and leg, and lower expression in the brain, ventral ganglion, head muscles and proboscis muscles.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Abundant in 6-12 hours embryos, reduced expression in second and third instar larval stages and adults.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0011286, Expressed in oviduct (Drosophila) and 32 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q24498, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q24498, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		71972, 9 interactors

Protein interaction database and analysis system

More...IntActi		Q24498, 13 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0293114

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q24498

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 148MIR 1PROSITE-ProRule annotationAdd BLAST55
Domaini155 – 200MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini210 – 264MIR 3PROSITE-ProRule annotationAdd BLAST55
Domaini270 – 328MIR 4PROSITE-ProRule annotationAdd BLAST59
Domaini336 – 394MIR 5PROSITE-ProRule annotationAdd BLAST59
Domaini577 – 803B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST227
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati845 – 9561By similarityAdd BLAST112
Repeati957 – 10752By similarityAdd BLAST119
Domaini1032 – 1217B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST186
Domaini1452 – 1673B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST222
Repeati2822 – 29453By similarityAdd BLAST124
Repeati2946 – 30634By similarityAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni845 – 30634 X approximate repeatsAdd BLAST2219

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4686 – 4711Gly-richAdd BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ryanodine receptor (TC 1.A.3.1) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2243, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000168850

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q24498

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q24498

Family and domain databases

Conserved Domains Database

More...CDDi		cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform A1 Publication (identifier: Q24498-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAEGGSEQ DDVSFLRTED MVTLSCTATG ERVCLAAEGF GNRHCFLENI 
        60         70         80         90        100
ADKNVPPDLS QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG 
       110        120        130        140        150
NAILLRHHNS DMYLACLSTS SSNDKLSFDV GLQEHSQGEA CWWTVHPASK 
       160        170        180        190        200
QRSEGEKVRV GDDLILVSVA TERYLHTTKE NEQSIVNASF HVTHWSVQPY 
       210        220        230        240        250
GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWGREAG QNIVIYEGGV 
       260        270        280        290        300
VMAQARSLWR LELARTKWTG GFINWYHPMR IRHITTGRYL GVNDSNELIL 
       310        320        330        340        350
VKKEEASIAT TTFCLRQEKD DEKKVLEDKD LEVIGSPIIK YGDTTVIVQH 
       360        370        380        390        400
CETSLWLSYK SYETKKKGVG KVEEKQAILH EEGKMDDCLD FSRSQEEESK 
       410        420        430        440        450
TARVIRKCSS LFTQFITALE TLQSNRRHSI FFQKVNLNEM VMCLEDLINY 
       460        470        480        490        500
FSQPEDDMEH EEKQNRFRAL RNRQDLFQEE GVLNLILEAI DKINIITSQG 
       510        520        530        540        550
FLASFLAGDE TGQSWDLIST YLYQLLAAII KGNHTNCAQF ANSNRLNWLF 
       560        570        580        590        600
SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD 
       610        620        630        640        650
PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTL LVDHVASIRP 
       660        670        680        690        700
NIFVGRVDGS SMYQKWYFEV TMDHIEQTTH MMPHLRIGWA NTSGYVPYPG 
       710        720        730        740        750
GGKKWGGNGV GDDLYSFGFD GAFLWTGGRK TLVVDALPEE PFIRKGDVIG 
       760        770        780        790        800
VAIDLSVPII TFTFNGVKVR GSFRDFNLDG MFFPVMSCSS KLSCRFLFGG 
       810        820        830        840        850
DHGRLKFAPP MGFSALVQCL MPQQILSLDP CFYFGNLAKN VLAGPWLIED 
       860        870        880        890        900
DTAFVPKPVD TTGVTLPSSV DQIKEKLAEN IHEMWALNKI EAGWSWGEHR 
       910        920        930        940        950
DDYHRIHPCL THFEKLPAAE KRYDNQLAVQ TLKTIISLGY YITMDKPPAR 
       960        970        980        990       1000
IRPVRLPNEI FMQGNGYKPA PLDLSAVTLT PKLEELVDQL AENTHNLWAR 
      1010       1020       1030       1040       1050
ERIQQGWTYG LNEDSENHRS PHLVPYAKVD EAIKKANRDT ASETVRTLLV 
      1060       1070       1080       1090       1100
YGYVLDPPTG EGTEALLAEA QRLKFAGFRT YRVERNYAVT SGKWYFEFEV 
      1110       1120       1130       1140       1150
LTSGPMRVGW ARADCYPGAM LGSEDTSWAF DGHNVTKMHA GSIEHFGVRY 
      1160       1170       1180       1190       1200
EAGDVIGCFI DVKEQTISFS LNGELLMDAL GGETTFADVT AEGVGFVPAC 
      1210       1220       1230       1240       1250
TLGVGQKARL IYGQDVDSLK FFTTCGLQEG YEPFCVNMRR PVTHWYTKDQ 
      1260       1270       1280       1290       1300
PIFENTEEMP DCRIDVTRIP GGADTPPHLK ISHNTFETME KANWEFLRLS 
      1310       1320       1330       1340       1350
LPVTCMGEFI SEQEKARRWD EIKNRQYRLM REAEIAAQMQ VQTQAAHMDH 
      1360       1370       1380       1390       1400
MLKGGFNMND IKGLTRNFDE HADAEADHMM RGPNRPPRKG SLTRNITFET 
      1410       1420       1430       1440       1450
DMSAALDEMQ RSTSVLDMNG LGEEMDDKKK RGRSPFKFFS KKSRDQSREK 
      1460       1470       1480       1490       1500
MGARTLDTSL ERRNTVAHGR NVVNQQMTTR APTLRLNNAE IPPSPVPQGP 
      1510       1520       1530       1540       1550
KQLSGSNLGQ QPVETSGDEM FDAECLKLIN EYFYGVRIFP GQDPTHVYVG 
      1560       1570       1580       1590       1600
WVTTQYHLHS REFNKNKVRR GSVYIEDDYE MAIERIDRQS CYVVRADELF 
      1610       1620       1630       1640       1650
NEVTQDASGK GASQGMFVGC FVDTATGIIR FTCEGKDTSH RWMMEPDTKL 
      1660       1670       1680       1690       1700
FPAIFVEATS KEILQIELGR TPTTLPLSAA VLPTSDKHIN PQSPPRLKVQ 
      1710       1720       1730       1740       1750
CLRPHQWARV PNTALQVHAL KLSDVRGWSM LCEDPVSMLA LHIPEEDRCI 
      1760       1770       1780       1790       1800
DILELIEMDK LLSFHAHSLT LYAALCYQSN YRAAHALCQH VDQKQLLYAI 
      1810       1820       1830       1840       1850
RSEYMSGPLR QGFYDLLIAL HLESHATTME VCKNEYITPL GAELKELYSD 
      1860       1870       1880       1890       1900
EEMQHSLRSL VTESVRPQLR MTEITPPVIA TSSMPSVSSE PIPDIDQLYS 
      1910       1920       1930       1940       1950
PKFPLEVVRQ FVMEALKDAV EINQVHNRDP IGWTNENLFL PLIKLTDRLL 
      1960       1970       1980       1990       2000
LVGVLTDEDV QRLLVMIDPE TWDQAFEREG KDEHRKGLLT MKMAEGAKLQ 
      2010       2020       2030       2040       2050
MCYLLHHLYD TQLRHRVESI IAFSHDFVGD LQTDQLRRYI EIKQSDLPSA 
      2060       2070       2080       2090       2100
VAAKKTKEFR CPPREQMNQI LCFKNLEPDD QDNCTCGLEL RGRLGDFHDS 
      2110       2120       2130       2140       2150
LMQKVSLNAL QEPDGVEGTA IEEVKTGPIT KIYNFINTVK ELEEGPKEVE 
      2160       2170       2180       2190       2200
EPEKKTPEEV FRKVLIKTIV SWAEESQIEN PKLVREMFSL LLRQYDTVGE 
      2210       2220       2230       2240       2250
LVRALEKTYV INTRARDDVA EMWVGLSQIR ALLPVQMSQE EEELMRKRLW 
      2260       2270       2280       2290       2300
KLVNNATFFQ HPDLIRILRV HENVMAVMMN TLGRRAQAQS DAPTQSEVAE 
      2310       2320       2330       2340       2350
GAPSKEKDTS HEMVVACCRF LCYFCRTGRQ NQKAMFDHFD FLLDNANILL 
      2360       2370       2380       2390       2400
ARPSLRGSTP LDVAYSSLME NTELALALRE HYLEKIAVYL SRCGLQSNSE 
      2410       2420       2430       2440       2450
LVEKGYPDLG WDPVEGERYL DFLRYCVWVN GESVEENANL VIRLLIRRPE 
      2460       2470       2480       2490       2500
CLGPALRGEG EGLFRAIVEA NRMSERISDR CKMQDEAEGT IAGLNFTHPL 
      2510       2520       2530       2540       2550
PEGEEDEDYI DTGAAILNFY CTLVDLLGRC APDASVIEQG KNESLRARAI 
      2560       2570       2580       2590       2600
LRSLVPLEDL QGVLSLKFTL SQTAPGEEKP KSDMPSGLLP NNKQSIVLFL 
      2610       2620       2630       2640       2650
ERVYGIEAQD LFYRLLEDAF LPDLRTATIL DKSDGSESDM ALAMNRYIGN 
      2660       2670       2680       2690       2700
SILPLLIKHS KFYNEAENYA SLLDATLHTV YRLSKNRMLT KGQREAVSDF 
      2710       2720       2730       2740       2750
LVALTSQMQP AMLLKLLRKL TVDVSKLSEY TTVALRLLTL HFDRCAKYYG 
      2760       2770       2780       2790       2800
STQGQGSYGA SSDEEKRLTM LLFSNIFDSL SNMDYDPELF GKALPCLIAI 
      2810       2820       2830       2840       2850
GCALPPDYSL SKNTDEDYYG RQMGAPDQPQ YMPNPIDTNN VHLDNDLNSL 
      2860       2870       2880       2890       2900
VQKFSEHYHD AWASRRLEGG WTYGDIRSDN DRKHPRLKPY NMLSEYERER 
      2910       2920       2930       2940       2950
YRDPVRECLK GLLAIGWTVE HSEVEVALNH RGSTRRQSKP QINEFQNEGS 
      2960       2970       2980       2990       3000
PFNYNPHPVD MSNLTLSREM QNMAERLAEN SHDIWAKKKN EELNGCGGVI 
      3010       3020       3030       3040       3050
HPQLVPYDLL TDKEKKKDRE RSQEFLKYMQ YQGYKLHKPS KGGAVEEGGA 
      3060       3070       3080       3090       3100
TQAAVELRFS YSLLEKLIQY LDRATINMKL LKPSTTFSRR SSFKTATRDI 
      3110       3120       3130       3140       3150
KFFSKVVLPL MEKYFSTHRN YFIAIATATN NIGAASLKEK EMVASIFCKL 
      3160       3170       3180       3190       3200
AALLRNRLSA FGPDVRITVR CLQVLVKGID ARTLTKNCPE FIRTSMLTFF 
      3210       3220       3230       3240       3250
NQTSDDLGNT ILNLQDGKYS HLRGTHLKTS TSLGYVNQVV LPVLTAMFDH 
      3260       3270       3280       3290       3300
LAACDYGSDL LLDEIQVASY KILAALYHLG TDGTLTHDRK YLKTEIERHR 
      3310       3320       3330       3340       3350
PALGSCLGAY SSCFPVAFLE PHLNKHNQYS LLNRIADHSL EAQDIMVKME 
      3360       3370       3380       3390       3400
SCMPNLETIL AEVDQFVESD KTYNDAPHII DVILPLLCAY LPFWWSQGPD 
      3410       3420       3430       3440       3450
NVSPTSGNHV TMVTADHMNP LLRNVLKMIK KNIGNDNAPW MTRIAAYTQQ 
      3460       3470       3480       3490       3500
IIINTSEELL KDPFLPLAER VKKRTENMLH KEDSMRGFIK SATDDTSQVE 
      3510       3520       3530       3540       3550
TQLQEDWNLL VRDIYSFYPL LIKYVDLQRN HWLKDNIPEA EELYNHVAEI 
      3560       3570       3580       3590       3600
FNIWSKSQYF LKEEQNFISA NEIDNMALIM PTATRRSAIS EGAPAVGGKV 
      3610       3620       3630       3640       3650
KKKKKNRDKK RDKDKEVQAS LMVACLKRLL PVGLNLFAGR EQELVQHCKD 
      3660       3670       3680       3690       3700
RYLKKMPEYD VIEFARNQLT LPDKLDPSDE MSWQHYLYSK LGKTEEPVDE 
      3710       3720       3730       3740       3750
QALEKANVNS NEKGKDKTQE TVDRIVAMAK VLFGLHMIDH PQQQSKNVYR 
      3760       3770       3780       3790       3800
SVVSIQRKRA VIACFRQTSL HSLPRHRACN IFARSYYEQW LQEENVGQEV 
      3810       3820       3830       3840       3850
MVEDLTQTFE DSEKSKKEGE ETDSKPDPLT QLVTTFCRGA MTERSGALQE 
      3860       3870       3880       3890       3900
DLLYMSYAQI AAKSTGKEEE EGGDEEGGEG GEEGEGTSIH EQEMEKQKLL 
      3910       3920       3930       3940       3950
FHQARLSNRG VAEMVLLHIS ASKGIPSEMV MTTLNLGIAI LRGGNIDIQM 
      3960       3970       3980       3990       4000
GMLNHLKEKK DVGFFTSIAG LMNSCSVLDL DAFERNTKAE GLGVGSEGAA 
      4010       4020       4030       4040       4050
GEKNMHDAEF TCALFRFIQL TCEGHNLEWQ NYLRTQAGNT TTVNVVICTV 
      4060       4070       4080       4090       4100
DYLLRLQESI MDFYWHYSSK EIIDPAGKAN FFKAIEVASQ VFNTLTEVIQ 
      4110       4120       4130       4140       4150
GPCTLNQQAL AHSRLWDAVG GFLFLFSHMQ DKLSKHSSQV DLLKELLNLQ 
      4160       4170       4180       4190       4200
KDMITMMLSM LEGNVVNGTI GKQMVDTLVE SASNVELILK YFDMFLKLAD 
      4210       4220       4230       4240       4250
LIESPSFHEV DMKNEGWVTP KDFREKMEQS KNYTPEEMDF LLACCERNHE 
      4260       4270       4280       4290       4300
GKIDYRAFVE HFHEPSKEIG FNLAVLLTNL SEHMPNEPRL ARFLETAGSV 
      4310       4320       4330       4340       4350
LNYFEPFLGR IEILGSSKRI ERVYFEIKDS NIEQWEKPQI RESKRAFFYS 
      4360       4370       4380       4390       4400
IVTEGGDKEK LEAFVNFCED AIFEMTHASG LMATDDGGGN VKRDTAYSSY 
      4410       4420       4430       4440       4450
MSEEEEERAA RDPIRRTITA VKEGLKFGVH MLSPANIKHQ IGVMQTKSIP 
      4460       4470       4480       4490       4500
ELIVGFFKII FYIFYYTGYA HFCVVRYIFG ILLNLMRGPA PEQEEEPVVE 
      4510       4520       4530       4540       4550
EETFGRALPP LPLEEPPGTV QAFGLDINKE ENGMYKVVVH ESPANSSMEE 
      4560       4570       4580       4590       4600
GGESSPEDGA AASGELVEGE PHQEPISIVD LLGGEAAKKA AQERQEAQKA 
      4610       4620       4630       4640       4650
QEAAMASIEA EAKKSSSAPQ ETPAVHQIDF SQYTHRAVSF LARNFYNLKY 
      4660       4670       4680       4690       4700
VALVLAFSIN FMLLFYKVTS FTEEADSSAE EELILGSGSG GGADITGSGF 
      4710       4720       4730       4740       4750
GGSGDGGSGD GEMEDEIPEL VHVDEDFFYM EHVLRIAACL HSLVSLAMLI 
      4760       4770       4780       4790       4800
AYYHLKVPLA IFKREKEIAR RLEFEGLFIA EQPEDDDFKS HWDKLVISAK 
      4810       4820       4830       4840       4850
SFPVNYWDKF VKKKVRQKYS ETYDFDSISN LLGMEKSTFA AQESEETGIF 
      4860       4870       4880       4890       4900
KYIMNIDWRY QVWKAGVTFT DNAFLYSLWY FSFSVMGNFN NFFFAAHLLD 
      4910       4920       4930       4940       4950
VAVGFKTLRT ILQSVTHNGK QLVLTVMLLT IIVYIYTVIA FNFFRKFYIQ 
      4960       4970       4980       4990       5000
EEDEEVDKKC HDMLTCFVFH LYKGVRAGGG IGDEIGDPDG DDYEVYRIIF 
      5010       5020       5030       5040       5050
DITFFFFVII ILLAIIQGLI IDAFGELRDQ LESVKDNMES NCFICGMGKD 
      5060       5070       5080       5090       5100
FFDIVPHGFD THVQKEHNLA NYMFFLMHLI NKPDTEYTGQ ETYVWNMYQQ 
      5110       5120 
RSWDFFPVGD CFRKQYEDEL SGGGGGG
Length:5,127
Mass (Da):581,012
Last modified:June 1, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01B637D778DECE6A
GO
Isoform B1 Publication (identifier: Q24498-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1876-1889: Missing.

Show »
Length:5,113
Mass (Da):579,671
Checksum:iCFE36D40BE6729B5
GO
Isoform C1 Publication (identifier: Q24498-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1135-1165: VTKMHAGSIEHFGVRYEAGDVIGCFIDVKEQ → EEKVYGGVSESFGKQCGPGDIVGVFLDLADH

Show »
Length:5,127
Mass (Da):580,829
Checksum:iC4F4F3B75DCEC0AC
GO
Isoform D1 Publication (identifier: Q24498-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1135-1165: VTKMHAGSIEHFGVRYEAGDVIGCFIDVKEQ → EEKVYGGVSESFGKQCGPGDIVGVFLDLADH
     1876-1889: Missing.

Show »
Length:5,113
Mass (Da):579,487
Checksum:i6BE70740475694AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K715A0A0B4K715_DROME
Ryanodine receptor, isoform J
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,115Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K719A0A0B4K719_DROME
Ryanodine receptor, isoform I
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,134Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7U9A0A0B4K7U9_DROME
Ryanodine receptor, isoform G
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,123Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7K0A0A0B4K7K0_DROME
Ryanodine receptor, isoform F
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,119Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K837A0A0B4K837_DROME
Ryanodine receptor, isoform E
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,117Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6T5A0A0B4K6T5_DROME
Ryanodine receptor, isoform H
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,130Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti314 – 316CLR → SW in BAA41469 (PubMed:8276118).Curated3
Sequence conflicti314 – 316CLR → SW in BAA41470 (PubMed:8276118).Curated3
Sequence conflicti314 – 316CLR → SW in BAA41471 (PubMed:8276118).Curated3
Sequence conflicti314 – 316CLR → SW in BAA04212 (PubMed:8276118).Curated3
Sequence conflicti1045 – 1079VRTLL…FAGFR → SANAPGLRICLGSSDGRRNG GTSGRGTTPQVRRIP in BAA41469 (PubMed:8276118).CuratedAdd BLAST35
Sequence conflicti1045 – 1079VRTLL…FAGFR → SANAPGLRICLGSSDGRRNG GTSGRGTTPQVRRIP in BAA41470 (PubMed:8276118).CuratedAdd BLAST35
Sequence conflicti1045 – 1079VRTLL…FAGFR → SANAPGLRICLGSSDGRRNG GTSGRGTTPQVRRIP in BAA41471 (PubMed:8276118).CuratedAdd BLAST35
Sequence conflicti1045 – 1079VRTLL…FAGFR → SANAPGLRICLGSSDGRRNG GTSGRGTTPQVRRIP in BAA04212 (PubMed:8276118).CuratedAdd BLAST35
Sequence conflicti2282L → I in BAA41469 (PubMed:8276118).Curated1
Sequence conflicti2282L → I in BAA41470 (PubMed:8276118).Curated1
Sequence conflicti2282L → I in BAA41471 (PubMed:8276118).Curated1
Sequence conflicti2282L → I in BAA04212 (PubMed:8276118).Curated1
Sequence conflicti2550I → S in BAA41469 (PubMed:8276118).Curated1
Sequence conflicti2550I → S in BAA41470 (PubMed:8276118).Curated1
Sequence conflicti2550I → S in BAA41471 (PubMed:8276118).Curated1
Sequence conflicti2550I → S in BAA04212 (PubMed:8276118).Curated1
Sequence conflicti2927A → P in BAA41469 (PubMed:8276118).Curated1
Sequence conflicti2927A → P in BAA41470 (PubMed:8276118).Curated1
Sequence conflicti2927A → P in BAA41471 (PubMed:8276118).Curated1
Sequence conflicti2927A → P in BAA04212 (PubMed:8276118).Curated1
Sequence conflicti3214L → Q in BAA41469 (PubMed:8276118).Curated1
Sequence conflicti3214L → Q in BAA41470 (PubMed:8276118).Curated1
Sequence conflicti3214L → Q in BAA41471 (PubMed:8276118).Curated1
Sequence conflicti3214L → Q in BAA04212 (PubMed:8276118).Curated1
Sequence conflicti3361A → G in BAA41469 (PubMed:8276118).Curated1
Sequence conflicti3361A → G in BAA41470 (PubMed:8276118).Curated1
Sequence conflicti3361A → G in BAA41471 (PubMed:8276118).Curated1
Sequence conflicti3361A → G in BAA04212 (PubMed:8276118).Curated1
Sequence conflicti4096T → I in BAA41469 (PubMed:8276118).Curated1
Sequence conflicti4096T → I in BAA41470 (PubMed:8276118).Curated1
Sequence conflicti4096T → I in BAA41471 (PubMed:8276118).Curated1
Sequence conflicti4096T → I in BAA04212 (PubMed:8276118).Curated1
Sequence conflicti4633Y → D (PubMed:1338312).Curated1
Sequence conflicti4695I → T (PubMed:1338312).Curated1
Sequence conflicti5022 – 5024DAF → AL (PubMed:1338312).Curated3
Sequence conflicti5073M → I (PubMed:1338312).Curated1
Sequence conflicti5077M → L (PubMed:1338312).Curated1
Sequence conflicti5103 – 5127WDFFP…GGGGG → GTSSQWETASASNTRMSFPA EAAAA (PubMed:1338312).CuratedAdd BLAST25

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0501951135 – 1165VTKMH…DVKEQ → EEKVYGGVSESFGKQCGPGD IVGVFLDLADH in isoform C and isoform D. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0501961876 – 1889Missing in isoform B and isoform D. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D17389 Genomic DNA Translation: BAA04212.1
D17389 Genomic DNA Translation: BAA41469.1
D17389 Genomic DNA Translation: BAA41470.1
D17389 Genomic DNA Translation: BAA41471.1
AE013599 Genomic DNA Translation: AAF59036.2
AE013599 Genomic DNA Translation: AAM71082.1
AE013599 Genomic DNA Translation: AAM71083.1
AE013599 Genomic DNA Translation: AAM71084.1
Z18536 mRNA Translation: CAA79221.1

Protein sequence database of the Protein Information Resource

More...PIRi		B49131
S40450

NCBI Reference Sequences

More...RefSeqi		NP_476991.1, NM_057643.4 [Q24498-2]
NP_476992.1, NM_057644.4 [Q24498-3]
NP_476993.1, NM_057645.3 [Q24498-4]
NP_476994.1, NM_057646.4 [Q24498-5]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0088637; FBpp0087718; FBgn0011286 [Q24498-4]
FBtr0088638; FBpp0087719; FBgn0011286 [Q24498-3]
FBtr0088639; FBpp0087720; FBgn0011286 [Q24498-5]
FBtr0088640; FBpp0087721; FBgn0011286 [Q24498-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		49090

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG10844

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17389 Genomic DNA Translation: BAA04212.1
D17389 Genomic DNA Translation: BAA41469.1
D17389 Genomic DNA Translation: BAA41470.1
D17389 Genomic DNA Translation: BAA41471.1
AE013599 Genomic DNA Translation: AAF59036.2
AE013599 Genomic DNA Translation: AAM71082.1
AE013599 Genomic DNA Translation: AAM71083.1
AE013599 Genomic DNA Translation: AAM71084.1
Z18536 mRNA Translation: CAA79221.1
PIRiB49131
S40450
RefSeqiNP_476991.1, NM_057643.4 [Q24498-2]
NP_476992.1, NM_057644.4 [Q24498-3]
NP_476993.1, NM_057645.3 [Q24498-4]
NP_476994.1, NM_057646.4 [Q24498-5]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi71972, 9 interactors
IntActiQ24498, 13 interactors
STRINGi7227.FBpp0293114

Chemistry databases

BindingDBiQ24498
ChEMBLiCHEMBL6045

Protein family/group databases

TCDBi1.A.3.1.5, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

PTM databases

iPTMnetiQ24498

Proteomic databases

PaxDbiQ24498
PRIDEiQ24498

Genome annotation databases

EnsemblMetazoaiFBtr0088637; FBpp0087718; FBgn0011286 [Q24498-4]
FBtr0088638; FBpp0087719; FBgn0011286 [Q24498-3]
FBtr0088639; FBpp0087720; FBgn0011286 [Q24498-5]
FBtr0088640; FBpp0087721; FBgn0011286 [Q24498-2]
GeneIDi49090
KEGGidme:Dmel_CG10844

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		49090
FlyBaseiFBgn0011286, RyR

Phylogenomic databases

eggNOGiKOG2243, Eukaryota
GeneTreeiENSGT00940000168850
InParanoidiQ24498
PhylomeDBiQ24498

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		49090, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		49090

Protein Ontology

More...PROi		PR:Q24498

Gene expression databases

BgeeiFBgn0011286, Expressed in oviduct (Drosophila) and 32 other tissues
ExpressionAtlasiQ24498, baseline and differential
GenevisibleiQ24498, DM

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRYR_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24498
Secondary accession number(s): Q24321
, Q24499, Q24500, Q24501, Q8MKS3, Q8MKS4, Q8MKS5, Q9V4Y7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2003
Last modified: December 2, 2020
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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