UniProtKB - Q24418 (NMDA1_DROME)
Glutamate [NMDA] receptor subunit 1
Nmdar1
Functioni
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation.
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 537 | GlycineBy similarity | 1 | |
Binding sitei | 703 | GlycineBy similarity | 1 | |
Binding sitei | 747 | GlycineBy similarity | 1 |
GO - Molecular functioni
- ligand-gated ion channel activity Source: GO_Central
- NMDA glutamate receptor activity Source: FlyBase
- signaling receptor activity Source: GO_Central
GO - Biological processi
- associative learning Source: FlyBase
- behavioral response to ethanol Source: FlyBase
- calcium ion homeostasis Source: UniProtKB
- chemical synaptic transmission Source: UniProtKB
- ionotropic glutamate receptor signaling pathway Source: FlyBase
- long-term memory Source: FlyBase
- medium-term memory Source: FlyBase
- olfactory learning Source: FlyBase
- phototaxis Source: FlyBase
- regulation of membrane potential Source: UniProtKB
- sensory perception of touch Source: FlyBase
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Ligand | Calcium, Magnesium |
Enzyme and pathway databases
Reactomei | R-DME-3928662, EPHB-mediated forward signaling R-DME-438066, Unblocking of NMDA receptors, glutamate binding and activation R-DME-8849932, Synaptic adhesion-like molecules R-DME-9609736, Assembly and cell surface presentation of NMDA receptors |
Protein family/group databases
TCDBi | 1.A.10.1.25, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate [NMDA] receptor subunit 11 PublicationShort name: DNMDAR-I1 Publication Short name: dNR11 Publication |
Gene namesi | ORF Names:CG2902 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0010399, Nmdar1 |
VEuPathDBi | VectorBase:FBgn0010399 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
- postsynaptic cell membrane 1 Publication
Other locations
- postsynaptic density 1 Publication
Plasma Membrane
- ionotropic glutamate receptor complex Source: FlyBase
- NMDA selective glutamate receptor complex Source: UniProtKB
- plasma membrane Source: GO_Central
- postsynaptic membrane Source: UniProtKB
Other locations
- integral component of membrane Source: FlyBase
- neuron projection Source: GO_Central
- postsynaptic density Source: UniProtKB-SubCell
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 573 | ExtracellularSequence analysisAdd BLAST | 547 | |
Transmembranei | 574 – 594 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 595 – 651 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 652 – 672 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 673 – 831 | ExtracellularSequence analysisAdd BLAST | 159 | |
Transmembranei | 832 – 852 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 853 – 997 | CytoplasmicSequence analysisAdd BLAST | 145 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000363996 | 27 – 997 | Glutamate [NMDA] receptor subunit 1Sequence analysisAdd BLAST | 971 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 93 | InterchainBy similarity | ||
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 314 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 345 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 397 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 454 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 481 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 501 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 693 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q24418 |
PRIDEi | Q24418 |
PTM databases
GlyGeni | Q24418, 8 sites |
iPTMneti | Q24418 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | FBgn0010399, Expressed in central nervous system and 21 other tissues |
Genevisiblei | Q24418, DM |
Interactioni
Subunit structurei
Forms a heteromeric NMDA channel with Nmdar2.
Protein-protein interaction databases
BioGRIDi | 65872, 5 interactors |
IntActi | Q24418, 6 interactors |
STRINGi | 7227.FBpp0078410 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 530 – 532 | Glycine bindingBy similarity | 3 | |
Regioni | 970 – 997 | DisorderedSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4440, Eukaryota |
GeneTreei | ENSGT00940000158016 |
HOGENOMi | CLU_007257_2_0_1 |
InParanoidi | Q24418 |
OMAi | KPEGFMI |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q24418 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR018882, CaM-bd_C0_NMDA_rcpt_NR1 IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 2 hits PF10562, CaM_bdg_C0, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAMAEFVFCR PLFGLAIVLL VAPIDAAQRH TASDNPSTYN IGGVLSNSDS
60 70 80 90 100
EEHFSTTIKH LNFDQQYVPR KVTYYDKTIR MDKNPIKTVF NVCDKLIENR
110 120 130 140 150
VYAVVVSHEQ TSGDLSPAAV SYTSGFYSIP VIGISSRDAA FSDKNIHVSF
160 170 180 190 200
LRTVPPYYHQ ADVWLEMLSH FAYTKVIIIH SSDTDGRAIL GRFQTTSQTY
210 220 230 240 250
YDDVDVRATV ELIVEFEPKL ESFTEHLIDM KTAQSRVYLM YASTEDAQVI
260 270 280 290 300
FRDAGEYNMT GEGHVWIVTE QALFSNNTPD GVLGLQLEHA HSDKGHIRDS
310 320 330 340 350
VYVLASAIKE MISNETIAEA PKDCGDSAVN WESGKRLFQY LKSRNITGET
360 370 380 390 400
GQVAFDDNGD RIYAGYDVIN IREQQKKHVV GKFSYDSMRA KMRMRINDSE
410 420 430 440 450
IIWPGKQRRK PEGIMIPTHL RLLTIEEKPF VYVRRMGDDE FRCEPDERPC
460 470 480 490 500
PLFNNSDATA NEFCCRGYCI DLLIELSKRI NFTYDLALSP DGQFGHYILR
510 520 530 540 550
NNTGAMTLRK EWTGLIGELV NERADMIVAP LTINPERAEY IEFSKPFKYQ
560 570 580 590 600
GITILEKKPS RSSTLVSFLQ PFSNTLWILV MVSVHVVALV LYLLDRFSPF
610 620 630 640 650
GRFKLSHSDS NEEKALNLSS AVWFAWGVLL NSGIGEGTPR SFSARVLGMV
660 670 680 690 700
WAGFAMIIVA SYTANLAAFL VLERPKTKLS GINDARLRNT MENLTCATVK
710 720 730 740 750
GSSVDMYFRR QVELSNMYRT MEANNYATAE QAIQDVKKGK LMAFIWDSSR
760 770 780 790 800
LEYEASKDCE LVTAGELFGR SGYGIGLQKG SPWTDAVTLA ILEFHESGFM
810 820 830 840 850
EKLDKQWIFH GHVQQNCELF EKTPNTLGLK NMAGVFILVG VGIAGGVGLI
860 870 880 890 900
IIEVIYKKHQ VKKQKRLDIA RHAADKWRGT IEKRKTIRAS LAMQRQYNVG
910 920 930 940 950
LNSTHAPGTI SLAVDKRRYP RLGQRLGPER AWPGDAADVL RIRRPYELGN
960 970 980 990
PGQSPKVMAA NQPGMPMPML GKTRPQQSVL PPRYSPGYTS DVSHLVV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71790 mRNA Translation: CAA50675.1 AE014297 Genomic DNA Translation: AAF52016.1 AY070577 mRNA Translation: AAL48048.1 |
PIRi | S33754 |
RefSeqi | NP_730940.1, NM_169059.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0078763; FBpp0078410; FBgn0010399 |
GeneIDi | 40665 |
KEGGi | dme:Dmel_CG2902 |
UCSCi | CG2902-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71790 mRNA Translation: CAA50675.1 AE014297 Genomic DNA Translation: AAF52016.1 AY070577 mRNA Translation: AAL48048.1 |
PIRi | S33754 |
RefSeqi | NP_730940.1, NM_169059.2 |
3D structure databases
AlphaFoldDBi | Q24418 |
SMRi | Q24418 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 65872, 5 interactors |
IntActi | Q24418, 6 interactors |
STRINGi | 7227.FBpp0078410 |
Protein family/group databases
TCDBi | 1.A.10.1.25, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
PTM databases
GlyGeni | Q24418, 8 sites |
iPTMneti | Q24418 |
Proteomic databases
PaxDbi | Q24418 |
PRIDEi | Q24418 |
Genome annotation databases
EnsemblMetazoai | FBtr0078763; FBpp0078410; FBgn0010399 |
GeneIDi | 40665 |
KEGGi | dme:Dmel_CG2902 |
UCSCi | CG2902-RA, d. melanogaster |
Organism-specific databases
CTDi | 40665 |
FlyBasei | FBgn0010399, Nmdar1 |
VEuPathDBi | VectorBase:FBgn0010399 |
Phylogenomic databases
eggNOGi | KOG4440, Eukaryota |
GeneTreei | ENSGT00940000158016 |
HOGENOMi | CLU_007257_2_0_1 |
InParanoidi | Q24418 |
OMAi | KPEGFMI |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q24418 |
Enzyme and pathway databases
Reactomei | R-DME-3928662, EPHB-mediated forward signaling R-DME-438066, Unblocking of NMDA receptors, glutamate binding and activation R-DME-8849932, Synaptic adhesion-like molecules R-DME-9609736, Assembly and cell surface presentation of NMDA receptors |
Miscellaneous databases
BioGRID-ORCSi | 40665, 0 hits in 3 CRISPR screens |
GenomeRNAii | 40665 |
PROi | PR:Q24418 |
Gene expression databases
Bgeei | FBgn0010399, Expressed in central nervous system and 21 other tissues |
Genevisiblei | Q24418, DM |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR018882, CaM-bd_C0_NMDA_rcpt_NR1 IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 2 hits PF10562, CaM_bdg_C0, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NMDA1_DROME | |
Accessioni | Q24418Primary (citable) accession number: Q24418 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 10, 2009 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families