Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 134 (02 Jun 2021)
Sequence version 2 (21 Jun 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Larval serum protein 2

Gene

Lsp2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionStorage protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Larval serum protein 2
Short name:
LSP-2
Alternative name(s):
Hexamerin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lsp2
ORF Names:CG6806
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002565, Lsp2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001333622 – 701Larval serum protein 2Add BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24388

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002565, Expressed in arthropod fat body and 18 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q24388, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24388, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
69593, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q24388, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088363

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the hemocyanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR98, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012213_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24388

Identification of Orthologs from Complete Genome Data

More...
OMAi
NHIKRAS

Database of Orthologous Groups

More...
OrthoDBi
244455at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q24388

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1280.10, 1 hit
1.20.1370.10, 1 hit
2.60.40.1520, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013788, Hemocyanin/hexamerin
IPR000896, Hemocyanin/hexamerin_mid_dom
IPR005203, Hemocyanin_C
IPR037020, Hemocyanin_C_sf
IPR005204, Hemocyanin_N
IPR036697, Hemocyanin_N_sf
IPR014756, Ig_E-set
IPR008922, Unchr_di-copper_centre

The PANTHER Classification System

More...
PANTHERi
PTHR11511, PTHR11511, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03723, Hemocyanin_C, 1 hit
PF00372, Hemocyanin_M, 1 hit
PF03722, Hemocyanin_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00187, HAEMOCYANIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48050, SSF48050, 1 hit
SSF48056, SSF48056, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00210, HEMOCYANIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q24388-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSFTVIALA AVALLATLGQ AKHLDSKVAD KDFLMKQKFM YQILQHIYQD
60 70 80 90 100
DVFTTPFGGS YVEYKPWEHV ADYVHPEMLE HFFELWQHQP FTDDMVWSVM
110 120 130 140 150
YDKHEEYVVG LVRLFYFAKN WETFQHVVYW ARQHVNKQLF VYAVTIASLF
160 170 180 190 200
RDDMQGVVLP AHYEIHPWSY FDSQALEWAE HYKMHGFHHV KQMDNIYNVV
210 220 230 240 250
IRTNYSNVHG SLNYDHDLAY YLEDVGFNAF YYYFNLDYPF WTKGGEEHVL
260 270 280 290 300
NKDRRGELYL YVHWQLLARW YLERLSHDLG EVPAFNMYVP TESGYASNLR
310 320 330 340 350
TYYGVPQWHR ENHHSFYHEH NYEHIEHVEM YTQRVMDWIH KNEKFDVETI
360 370 380 390 400
NVLGNIIQGN ADSVDKKFYG SLDKLYRFIV NEGHHYGHGD ESFPGLFMHY
410 420 430 440 450
DTSMRDPIFY EVYKTIVSHY WHLMETYPEY HKKDYAFEGV HIDAVHMPES
460 470 480 490 500
LTTYFEHFDS DISNAVNVEP AVEGSADPLY TFGRNSHYKG SSYVIKARQQ
510 520 530 540 550
RLNHKPFEFT LDVTSDKAQD AVVKVFIGPK YDEHGHEIPL EHNYQNFFEL
560 570 580 590 600
EHFKVHLEAG VNHIKRASGD FSFWVNDRTT YLELYQKLMD ATNSDYKFKL
610 620 630 640 650
DQSEAHCGVP NRMMLPRGKK GGQVFQFFYM VYPYHQPEVA QFTGYDPVVS
660 670 680 690 700
CGVGHGSRYV DALPFGFPFN RPVKHDYYFD VHNFKFVDVK IFHRDEHTNV

V
Length:701
Mass (Da):83,349
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CC348AC7C05138D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JCV2X2JCV2_DROME
Larval serum protein 2, isoform B
Lsp2 C23, CG11538, Dmel\CG6806, DmeLSP2, LHP
701Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA66371 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti271Y → H in CAA66371 (PubMed:9128741).Curated1
Sequence conflicti335V → L in CAA66371 (PubMed:9128741).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X97770 Genomic DNA Translation: CAA66371.1 Frameshift.
AE014296 Genomic DNA Translation: AAF49958.1
AY119005 mRNA Translation: AAM50865.1

NCBI Reference Sequences

More...
RefSeqi
NP_001287042.1, NM_001300113.1
NP_524816.1, NM_080077.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089324; FBpp0088363; FBgn0002565
FBtr0345352; FBpp0311507; FBgn0002565

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
45326

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6806

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97770 Genomic DNA Translation: CAA66371.1 Frameshift.
AE014296 Genomic DNA Translation: AAF49958.1
AY119005 mRNA Translation: AAM50865.1
RefSeqiNP_001287042.1, NM_001300113.1
NP_524816.1, NM_080077.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi69593, 30 interactors
IntActiQ24388, 1 interactor
STRINGi7227.FBpp0088363

Proteomic databases

PaxDbiQ24388

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
45326

Genome annotation databases

EnsemblMetazoaiFBtr0089324; FBpp0088363; FBgn0002565
FBtr0345352; FBpp0311507; FBgn0002565
GeneIDi45326
KEGGidme:Dmel_CG6806

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
45326
FlyBaseiFBgn0002565, Lsp2

Phylogenomic databases

eggNOGiENOG502QR98, Eukaryota
HOGENOMiCLU_012213_1_0_1
InParanoidiQ24388
OMAiNHIKRAS
OrthoDBi244455at2759
PhylomeDBiQ24388

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
45326, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lsp2, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
45326

Protein Ontology

More...
PROi
PR:Q24388

Gene expression databases

BgeeiFBgn0002565, Expressed in arthropod fat body and 18 other tissues
ExpressionAtlasiQ24388, baseline and differential
GenevisibleiQ24388, DM

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
1.20.1370.10, 1 hit
2.60.40.1520, 1 hit
InterProiView protein in InterPro
IPR013788, Hemocyanin/hexamerin
IPR000896, Hemocyanin/hexamerin_mid_dom
IPR005203, Hemocyanin_C
IPR037020, Hemocyanin_C_sf
IPR005204, Hemocyanin_N
IPR036697, Hemocyanin_N_sf
IPR014756, Ig_E-set
IPR008922, Unchr_di-copper_centre
PANTHERiPTHR11511, PTHR11511, 1 hit
PfamiView protein in Pfam
PF03723, Hemocyanin_C, 1 hit
PF00372, Hemocyanin_M, 1 hit
PF03722, Hemocyanin_N, 1 hit
PRINTSiPR00187, HAEMOCYANIN
SUPFAMiSSF48050, SSF48050, 1 hit
SSF48056, SSF48056, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00210, HEMOCYANIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLSP2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24388
Secondary accession number(s): Q9VTT8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 21, 2005
Last modified: June 2, 2021
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again