UniProtKB - Q24318 (TFDP_DROME)
Protein
Transcription factor Dp
Gene
Dp
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes. Can stimulate E2F-dependent transcription.1 Publication
GO - Molecular functioni
- DNA binding Source: FlyBase
- DNA-binding transcription factor activity Source: InterPro
- transcription factor binding Source: FlyBase
GO - Biological processi
- dorsal/ventral axis specification, ovarian follicular epithelium Source: FlyBase
- eggshell chorion gene amplification Source: FlyBase
- endomitotic cell cycle Source: FlyBase
- intrinsic apoptotic signaling pathway in response to DNA damage Source: FlyBase
- nurse cell apoptotic process Source: FlyBase
- oogenesis Source: FlyBase
- positive regulation of gene expression Source: FlyBase
- positive regulation of nurse cell apoptotic process Source: FlyBase
- regulation of cell cycle Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-DME-69231, Cyclin D associated events in G1 R-DME-8953750, Transcriptional Regulation by E2F6 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor Dp |
Gene namesi | Name:Dp ORF Names:CG4654 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0011763, Dp |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: FlyBase
Other locations
- Myb complex Source: FlyBase
- Rb-E2F complex Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219479 | 1 – 445 | Transcription factor DpAdd BLAST | 445 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 398 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q24318 |
PRIDEi | Q24318 |
PTM databases
iPTMneti | Q24318 |
Expressioni
Gene expression databases
Bgeei | FBgn0011763, Expressed in embryo and 60 other tissues |
ExpressionAtlasi | Q24318, baseline and differential |
Genevisiblei | Q24318, DM |
Interactioni
Subunit structurei
Heterodimer of E2f and Dp. Cooperate to give sequence-specific DNA binding and optimal trans-activation.
Component of the DREAM complex at least composed of Myb, Caf1-55, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, Rpd3 and l3mbt.
2 PublicationsBinary interactionsi
Q24318
With | #Exp. | IntAct |
---|---|---|
Rbf [Q24472] | 3 | EBI-530830,EBI-145741 |
GO - Molecular functioni
- transcription factor binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 62224, 30 interactors |
IntActi | Q24318, 11 interactors |
STRINGi | 7227.FBpp0086853 |
Family & Domainsi
Sequence similaritiesi
Belongs to the E2F/DP family.Curated
Phylogenomic databases
eggNOGi | KOG2829, Eukaryota |
GeneTreei | ENSGT00940000169233 |
InParanoidi | Q24318 |
OMAi | SNQGQFI |
PhylomeDBi | Q24318 |
Family and domain databases
CDDi | cd14458, DP_DD, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.20.140.80, 1 hit |
InterProi | View protein in InterPro IPR037241, E2F-DP_heterodim IPR003316, E2F_WHTH_DNA-bd_dom IPR038168, TF_DP_C_sf IPR014889, Transc_factor_DP_C IPR015648, Transcrpt_fac_DP IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12548, PTHR12548, 1 hit |
Pfami | View protein in Pfam PF08781, DP, 1 hit PF02319, E2F_TDP, 1 hit |
PIRSFi | PIRSF009404, Transcription_factor_DP, 1 hit |
SMARTi | View protein in SMART SM01138, DP, 1 hit SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform A (identifier: Q24318-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAHSTGGTVK TDEVNFFFRN EHGQISKMLK PAQNKSEMEG GKPVAVVYAT
60 70 80 90 100
GSSARNSGSA SGIGNVGRMG AFSQMGSQGQ FIRLQDNGLS IPKTEAGTTY
110 120 130 140 150
TTVSAQKTSG AGSGHYDLPL KGDRYVKFTP NPIKMKSKLH AIQSNSLHSM
160 170 180 190 200
SASSSSVQRK RKPDKAGKGL RHFSMKVCEK VEEKGKTTYN EVADDLVSEE
210 220 230 240 250
MKNNAYDNNC DQKNIRRRVY DALNVLMAIN VISKDKKEIR WIGLPANSTE
260 270 280 290 300
TFLALEEENC QRRERIKQKN EMLREMIMQH VAFKGLVERN KRNESQGVVP
310 320 330 340 350
SPNASIQLPF IIVNTHKSTK INCSVTNDKS EYIFKFDKTF EMHDDIEVLK
360 370 380 390 400
RMGFLLGLDK GECTPENIER VKSWVPPNLA KYVEAYGTGK TGENMYESDD
410 420 430 440
EDNEFNGYLE SANESQGFAQ HSAQHTTDGE FKLEMDDDEL DDDID
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KEQ0 | A0A0B4KEQ0_DROME | Transcription factor | Dp 49Fk, dDP, dDp, DDP1, dDP1 | 417 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 117 | D → G in AAO24938 (Ref. 4) Curated | 1 | |
Sequence conflicti | 343 | H → L in AAB87765 (PubMed:9271122).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014146 | 1 – 22 | MAHST…FRNEH → MCISETKEPPHLPISNSA in isoform B. 1 PublicationAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58403.1 AE013599 Genomic DNA Translation: AAM68602.1 AY069526 mRNA Translation: AAL39671.1 BT003183 mRNA Translation: AAO24938.1 BT056266 mRNA Translation: ACL68713.1 X79708 mRNA Translation: CAA56147.2 AF011362 Genomic DNA Translation: AAB87765.1 |
PIRi | B55745 |
RefSeqi | NP_477039.1, NM_057691.4 [Q24318-1] NP_725267.1, NM_165974.3 [Q24318-2] |
Genome annotation databases
EnsemblMetazoai | FBtr0087740; FBpp0086853; FBgn0011763 [Q24318-1] FBtr0087741; FBpp0086854; FBgn0011763 [Q24318-2] |
GeneIDi | 36461 |
KEGGi | dme:Dmel_CG4654 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58403.1 AE013599 Genomic DNA Translation: AAM68602.1 AY069526 mRNA Translation: AAL39671.1 BT003183 mRNA Translation: AAO24938.1 BT056266 mRNA Translation: ACL68713.1 X79708 mRNA Translation: CAA56147.2 AF011362 Genomic DNA Translation: AAB87765.1 |
PIRi | B55745 |
RefSeqi | NP_477039.1, NM_057691.4 [Q24318-1] NP_725267.1, NM_165974.3 [Q24318-2] |
3D structure databases
SMRi | Q24318 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 62224, 30 interactors |
IntActi | Q24318, 11 interactors |
STRINGi | 7227.FBpp0086853 |
PTM databases
iPTMneti | Q24318 |
Proteomic databases
PaxDbi | Q24318 |
PRIDEi | Q24318 |
Genome annotation databases
EnsemblMetazoai | FBtr0087740; FBpp0086853; FBgn0011763 [Q24318-1] FBtr0087741; FBpp0086854; FBgn0011763 [Q24318-2] |
GeneIDi | 36461 |
KEGGi | dme:Dmel_CG4654 |
Organism-specific databases
CTDi | 13450 |
FlyBasei | FBgn0011763, Dp |
Phylogenomic databases
eggNOGi | KOG2829, Eukaryota |
GeneTreei | ENSGT00940000169233 |
InParanoidi | Q24318 |
OMAi | SNQGQFI |
PhylomeDBi | Q24318 |
Enzyme and pathway databases
Reactomei | R-DME-69231, Cyclin D associated events in G1 R-DME-8953750, Transcriptional Regulation by E2F6 |
Miscellaneous databases
BioGRID-ORCSi | 36461, 1 hit in 3 CRISPR screens |
ChiTaRSi | Dp, fly |
GenomeRNAii | 36461 |
PROi | PR:Q24318 |
Gene expression databases
Bgeei | FBgn0011763, Expressed in embryo and 60 other tissues |
ExpressionAtlasi | Q24318, baseline and differential |
Genevisiblei | Q24318, DM |
Family and domain databases
CDDi | cd14458, DP_DD, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.20.140.80, 1 hit |
InterProi | View protein in InterPro IPR037241, E2F-DP_heterodim IPR003316, E2F_WHTH_DNA-bd_dom IPR038168, TF_DP_C_sf IPR014889, Transc_factor_DP_C IPR015648, Transcrpt_fac_DP IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12548, PTHR12548, 1 hit |
Pfami | View protein in Pfam PF08781, DP, 1 hit PF02319, E2F_TDP, 1 hit |
PIRSFi | PIRSF009404, Transcription_factor_DP, 1 hit |
SMARTi | View protein in SMART SM01138, DP, 1 hit SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TFDP_DROME | |
Accessioni | Q24318Primary (citable) accession number: Q24318 Secondary accession number(s): B8A3X4 Q9V6M0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | June 21, 2005 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families