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Entry version 163 (02 Jun 2021)
Sequence version 2 (02 Nov 2001)
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Protein

Cullin homolog 1

Gene

Cul1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890).

The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555).

Also part of an SCF complex required for caspase activation during sperm differentiation (PubMed:20392747).

Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in the regulation of zip and ck function in scolopidial apical attachment (PubMed:27331610).

May function by acting in a Ubr3-mediated pathway that negatively regulates the ubiquitination of zip, consequently affecting its interaction with ck (PubMed:27331610).

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1169091, Activation of NF-kappaB in B cells
R-DME-187577, SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253, Degradation of beta-catenin by the destruction complex
R-DME-202424, Downstream TCR signaling
R-DME-209360, Ubiquitination and proteolysis of phosphorylated CI
R-DME-209461, Ubiquitination and degradation of phosphorylated ARM
R-DME-2565942, Regulation of PLK1 Activity at G2/M Transition
R-DME-2871837, FCERI mediated NF-kB activation
R-DME-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764, CLEC7A (Dectin-1) signaling
R-DME-5610780, Degradation of GLI1 by the proteasome
R-DME-5610785, GLI3 is processed to GLI3R by the proteasome
R-DME-5676590, NIK-->noncanonical NF-kB signaling
R-DME-68949, Orc1 removal from chromatin
R-DME-69231, Cyclin D associated events in G1
R-DME-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902, Regulation of RUNX2 expression and activity
R-DME-8951664, Neddylation
R-DME-9020702, Interleukin-1 signaling
R-DME-917937, Iron uptake and transport
R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q24311

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin homolog 1
Alternative name(s):
Lin-19 homolog protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cul1
Synonyms:cul-1, lin19
ORF Names:CG1877
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0015509, Cul1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Severe dendrite pruning defects in ddaC neurons at 16 hours after puparium formation (APF) and axon pruning defects in mushroom body gamma neurons at 24 hours APF. RNAi-mediated knockdown results in a significant increase in Akt1 protein levels and activity in ddaC somas (PubMed:24068890). In the larval brain there is a large increase in the number of neuroblasts, 40% of which show a spindle misorientation at metaphase (PubMed:24413555). RNAi-mediated knockdown results in apical detachment of scolopidial cells in Johnston's organ (PubMed:27331610).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001197861 – 774Cullin homolog 1Add BLAST774

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki718Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Neddylated (PubMed:12183637, PubMed:18493598). Deneddylated via its interaction with the COP9 signalosome (CSN) complex (PubMed:12183637).2 Publications

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24311

PRoteomics IDEntifications database

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PRIDEi
Q24311

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0015509, Expressed in egg chamber and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q24311, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24311, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of SCF E3 ubiquitin-protein ligase complexes consisting of Skpa, Cul1, Roc1a and an F-box protein. In larval neuroblast self renewal and asymmetric division, as well as ddaC dendrite and mushroom body axon pruning, the complex contains the F-box protein slmb (SCF-slmb) (PubMed:24068890, PubMed:24413555). In caspase activation during sperm differentiation, the complex contains the F-box protein ntc (PubMed:20392747).

Interacts directly with Roc1a (PubMed:11500045).

Interacts with Fsn (PubMed:20123973).

Interacts with Dlish (PubMed:27692068).

Interacts with Cad99C (via the cytoplasmic domain) (PubMed:27331610).

Interacts with Sans (PubMed:27331610).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
61606, 40 interactors

Database of interacting proteins

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DIPi
DIP-19461N

Protein interaction database and analysis system

More...
IntActi
Q24311, 8 interactors

Molecular INTeraction database

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MINTi
Q24311

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0087921

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q24311

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2166, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154774

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004747_6_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q24311

Identification of Orthologs from Complete Genome Data

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OMAi
WLWHLCK

Database of Orthologous Groups

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OrthoDBi
1040292at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q24311

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016157, Cullin_CS
IPR016158, Cullin_homology
IPR036317, Cullin_homology_sf
IPR001373, Cullin_N
IPR019559, Cullin_neddylation_domain
IPR016159, Cullin_repeat-like_dom_sf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00888, Cullin, 1 hit
PF10557, Cullin_Nedd8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00182, CULLIN, 1 hit
SM00884, Cullin_Nedd8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF74788, SSF74788, 1 hit
SSF75632, SSF75632, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01256, CULLIN_1, 1 hit
PS50069, CULLIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q24311-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRSGNSQTT QKLVNLDDIW SELVEGIMQV FEHEKSLTRS QYMRFYTHVY
60 70 80 90 100
DYCTSVSAAP SGRSSGKTGG AQLVGKKLYD RLEQFLKSYL SELLTKFKAI
110 120 130 140 150
SGEEVLLSRY TKQWKSYQFS STVLDGICNY LNRNWVKREC EEGQKGIYKI
160 170 180 190 200
YRLALVAWKG HLFQVLNEPV TKAVLKSIEE ERQGKLINRS LVRDVIECYV
210 220 230 240 250
ELSFNEEDTD AEQQKLSVYK QNFENKFIAD TSAFYEKESD AFLSTNTVTE
260 270 280 290 300
YLKHVENRLE EETQRVRGFN SKNGLSYLHE TTADVLKSTC EEVLIEKHLK
310 320 330 340 350
IFHTEFQNLL NADRNDDLKR MYSLVALSSK NLTDLKSILE NHILHQGTEA
360 370 380 390 400
IAKCCTTDAA NDPKTYVQTI LDVHKKYNAL VLTAFNNDNG FVAALDKACG
410 420 430 440 450
KFINSNVVTI ANSASKSPEL LAKYCDLLLK KSSKNPEDKE LEDNLNQVMV
460 470 480 490 500
VFKYIEDKDV FQKYYSKMLA KRLVNHTSAS DDAEAMMISK LKQTCGYEYT
510 520 530 540 550
VKLQRMFQDI GVSKDLNSYF KQYLAEKNLT MEIDFGIEVL SSGSWPFQLS
560 570 580 590 600
NNFLLPSELE RSVRQFNEFY AARHSGRKLN WLYQMCKGEL IMNVNRNNSS
610 620 630 640 650
TYTLQASTFQ MSVLLQFNDQ LSFTVQQLQD NTQTQQENLI QVLQILLKAK
660 670 680 690 700
VLTSSDNENS LTPESTVELF LDYKNKKRRI NINQPLKTEL KVEQETVHKH
710 720 730 740 750
IEEDRKLLIQ AAIVRIMKMR KRLNHTNLIS EVLNQLSTRF KPKVPVIKKC
760 770
IDILIEKEYL ERMEGHKDTY SYLA
Length:774
Mass (Da):89,511
Last modified:November 2, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AF0D035DE85363C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti266Missing in AAA85085 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L41642 mRNA Translation: AAA85085.1
AF136343 mRNA Translation: AAD33676.1
AE013599 Genomic DNA Translation: AAF59174.1
AE013599 Genomic DNA Translation: AAM68871.1
AE013599 Genomic DNA Translation: AAM68872.1
BT010290 mRNA Translation: AAQ23608.1

NCBI Reference Sequences

More...
RefSeqi
NP_523655.1, NM_078931.4
NP_724621.1, NM_165569.2
NP_724622.1, NM_165570.3
NP_724623.1, NM_165571.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0088845; FBpp0087921; FBgn0015509
FBtr0088846; FBpp0087922; FBgn0015509
FBtr0088847; FBpp0087923; FBgn0015509
FBtr0088848; FBpp0087924; FBgn0015509

Database of genes from NCBI RefSeq genomes

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GeneIDi
35742

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1877

UCSC genome browser

More...
UCSCi
CG1877-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41642 mRNA Translation: AAA85085.1
AF136343 mRNA Translation: AAD33676.1
AE013599 Genomic DNA Translation: AAF59174.1
AE013599 Genomic DNA Translation: AAM68871.1
AE013599 Genomic DNA Translation: AAM68872.1
BT010290 mRNA Translation: AAQ23608.1
RefSeqiNP_523655.1, NM_078931.4
NP_724621.1, NM_165569.2
NP_724622.1, NM_165570.3
NP_724623.1, NM_165571.2

3D structure databases

SMRiQ24311
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi61606, 40 interactors
DIPiDIP-19461N
IntActiQ24311, 8 interactors
MINTiQ24311
STRINGi7227.FBpp0087921

Proteomic databases

PaxDbiQ24311
PRIDEiQ24311

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
35742

Genome annotation databases

EnsemblMetazoaiFBtr0088845; FBpp0087921; FBgn0015509
FBtr0088846; FBpp0087922; FBgn0015509
FBtr0088847; FBpp0087923; FBgn0015509
FBtr0088848; FBpp0087924; FBgn0015509
GeneIDi35742
KEGGidme:Dmel_CG1877
UCSCiCG1877-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8454
FlyBaseiFBgn0015509, Cul1

Phylogenomic databases

eggNOGiKOG2166, Eukaryota
GeneTreeiENSGT00940000154774
HOGENOMiCLU_004747_6_1_1
InParanoidiQ24311
OMAiWLWHLCK
OrthoDBi1040292at2759
PhylomeDBiQ24311

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-DME-1169091, Activation of NF-kappaB in B cells
R-DME-187577, SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253, Degradation of beta-catenin by the destruction complex
R-DME-202424, Downstream TCR signaling
R-DME-209360, Ubiquitination and proteolysis of phosphorylated CI
R-DME-209461, Ubiquitination and degradation of phosphorylated ARM
R-DME-2565942, Regulation of PLK1 Activity at G2/M Transition
R-DME-2871837, FCERI mediated NF-kB activation
R-DME-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764, CLEC7A (Dectin-1) signaling
R-DME-5610780, Degradation of GLI1 by the proteasome
R-DME-5610785, GLI3 is processed to GLI3R by the proteasome
R-DME-5676590, NIK-->noncanonical NF-kB signaling
R-DME-68949, Orc1 removal from chromatin
R-DME-69231, Cyclin D associated events in G1
R-DME-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902, Regulation of RUNX2 expression and activity
R-DME-8951664, Neddylation
R-DME-9020702, Interleukin-1 signaling
R-DME-917937, Iron uptake and transport
R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ24311

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
35742, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
35742

Protein Ontology

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PROi
PR:Q24311

Gene expression databases

BgeeiFBgn0015509, Expressed in egg chamber and 34 other tissues
ExpressionAtlasiQ24311, baseline and differential
GenevisibleiQ24311, DM

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR016157, Cullin_CS
IPR016158, Cullin_homology
IPR036317, Cullin_homology_sf
IPR001373, Cullin_N
IPR019559, Cullin_neddylation_domain
IPR016159, Cullin_repeat-like_dom_sf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00888, Cullin, 1 hit
PF10557, Cullin_Nedd8, 1 hit
SMARTiView protein in SMART
SM00182, CULLIN, 1 hit
SM00884, Cullin_Nedd8, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF74788, SSF74788, 1 hit
SSF75632, SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS01256, CULLIN_1, 1 hit
PS50069, CULLIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUL1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24311
Secondary accession number(s): A4UZ78, Q0E9G0, Q9V312
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2001
Last modified: June 2, 2021
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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