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Entry version 174 (03 Jul 2019)
Sequence version 3 (02 Sep 2008)
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Protein

Death-associated inhibitor of apoptosis 2

Gene

Diap2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria (PubMed:16894030, PubMed:17068333). Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides (PubMed:17068333, PubMed:24374974). Binds, polyubiquitinates and activates Dredd which is required for Rel-mediated induction of antimicrobial peptides (PubMed:22549468). Anti-apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice (PubMed:18166655). Suppresses rpr and hid-dependent cell death in the eye (PubMed:8548811). However, has also been shown to have little, if any, role in the regulation of the canonical caspase-dependent apoptosis pathway (PubMed:17068333). Plays a role in regulating the expression of ion channels (PubMed:24374974).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi249ZincPROSITE-ProRule annotation1
Metal bindingi252ZincPROSITE-ProRule annotation1
Metal bindingi269ZincPROSITE-ProRule annotation1
Metal bindingi276ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri451 – 486RING-typePROSITE-ProRule annotationAdd BLAST36

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Immunity, Innate immunity
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-111465 Apoptotic cleavage of cellular proteins
R-DME-111469 SMAC, XIAP-regulated apoptotic response
R-DME-209447 Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY
R-DME-3769402 Deactivation of the beta-catenin transactivating complex
R-DME-5675482 Regulation of necroptotic cell death
R-DME-8948747 Regulation of PTEN localization
R-DME-8948751 Regulation of PTEN stability and activity

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q24307

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I32.011

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Death-associated inhibitor of apoptosis 2
Alternative name(s):
Apoptosis 2 inhibitor
IAP homolog A
IAP-like protein
Short name:
ILP
Short name:
dILP
Inhibitor of apoptosis 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Diap2
Synonyms:DIHA, Iap2, Ilp
ORF Names:CG8293
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0015247 Diap2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Normal development and viability (PubMed:16894030, PubMed:17068333). Acute sensitivity to infection by Gram-negative bacteria with failure to induce expression of antibacterial peptide genes and inability to mount a proper innate immune response (PubMed:16894030, PubMed:17068333, PubMed:24374974). Loss of cleavage and nuclear translocation of Rel (PubMed:17068333, PubMed:24374974). Increased activity of the effector caspase Drice and increased apoptosis following x-ray irradiation (PubMed:18166655). Reduced ion channel expression in Malpighian tubules (PubMed:24374974).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi92D → E: No effect on caspase-mediated cleavage. 1 Publication1
Mutagenesisi100D → E: Loss of caspase-mediated cleavage, failure to protect against Drice-mediated cell death and loss of binding to Drice. 1 Publication1
Mutagenesisi149C → G: No effect on binding to Drice or Dredd. 2 Publications1
Mutagenesisi163D → A: No effect on binding to Drice. Loss of immunity to Gram-negative bacteria; when associated with A-263. 2 Publications1
Mutagenesisi249C → G: Abolishes binding to Drice and fails to inhibit cell death. No effect on binding to Dredd. 2 Publications1
Mutagenesisi263D → A: Abolishes binding to Drice. Loss of immunity to Gram-negative bacteria; when associated with A-163. 2 Publications1
Mutagenesisi466C → Y: Fails to bind to Dredd and promote its polyubiquitylation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001223681 – 498Death-associated inhibitor of apoptosis 2Add BLAST498

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Caspase-dependent cleavage is required for suppression of Drice-mediated cell death.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei100 – 101Cleavage; by caspases1 Publication2

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24307

PRoteomics IDEntifications database

More...
PRIDEi
Q24307

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in both principal and stellar cells of the Malphigian tubules.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in Malpighian tubules from the 3rd instar larval stage and expression continues in pupae and adults with highest levels in adults (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Constitutively expressed (PubMed:17068333). Up-regulated by bacterial lipopolysaccharides (LPS) in Malpighian tubules but not in salivary glands (PubMed:24374974).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0015247 Expressed in 31 organ(s), highest expression level in brain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24307 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the caspase Strica (PubMed:11550090).

Interacts (via BIR2 domain) with rpr and grim (PubMed:18166655).

Interacts (via the BIR2 and BIR3 domains) with hid (PubMed:18166655).

Interacts (via BIR3 domain) with Drice (PubMed:18166655).

Interacts with Dredd; likely to bind Dredd simultaneously with Fadd to form a trimeric complex (PubMed:22549468).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
62475, 179 interactors

Protein interaction database and analysis system

More...
IntActi
Q24307, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086432

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q24307

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati12 – 77BIR 1PROSITE-ProRule annotationAdd BLAST66
Repeati116 – 180BIR 2PROSITE-ProRule annotationAdd BLAST65
Repeati215 – 280BIR 3PROSITE-ProRule annotationAdd BLAST66

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IAP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri451 – 486RING-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1101 Eukaryota
ENOG410YPNM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169803

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24307

KEGG Orthology (KO)

More...
KOi
K16060

Identification of Orthologs from Complete Genome Data

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OMAi
CSMVLAP

Database of Orthologous Groups

More...
OrthoDBi
1340284at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q24307

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00022 BIR, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001370 BIR_rpt
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00653 BIR, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00238 BIR, 3 hits
SM00184 RING, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01282 BIR_REPEAT_1, 3 hits
PS50143 BIR_REPEAT_2, 3 hits
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q24307-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTELGMELES VRLATFGEWP LNAPVSAEDL VANGFFATGN WLEAECHFCH
60 70 80 90 100
VRIDRWEYGD QVAERHRRSS PICSMVLAPN HCGNVPRSQE SDNEGNSVVD
110 120 130 140 150
SPESCSCPDL LLEANRLVTF KDWPNPNITP QALAKAGFYY LNRLDHVKCV
160 170 180 190 200
WCNGVIAKWE KNDNAFEEHK RFFPQCPRVQ MGPLIEFATG KNLDELGIQP
210 220 230 240 250
TTLPLRPKYA CVDARLRTFT DWPISNIQPA SALAQAGLYY QKIGDQVRCF
260 270 280 290 300
HCNIGLRSWQ KEDEPWFEHA KWSPKCQFVL LAKGPAYVSE VLATTAANAS
310 320 330 340 350
SQPATAPAPT LQADVLMDEA PAKEALALGI DGGVVRNAIQ RKLLSSGCAF
360 370 380 390 400
STLDELLHDI FDDAGAGAAL EVREPPEPSA PFIEPCQATT SKAASVPIPV
410 420 430 440 450
ADSIPAKPQA AEAVANISKI TDEIQKMSVA TPNGNLSLEE ENRQLKDARL
460 470 480 490
CKVCLDEEVG VVFLPCGHLA TCNQCAPSVA NCPMCRADIK GFVRTFLS
Length:498
Mass (Da):54,538
Last modified:September 2, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D0303DB2B26FA22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5G → V in AAC46988 (PubMed:8552191).Curated1
Sequence conflicti40N → K in AAC46988 (PubMed:8552191).Curated1
Sequence conflicti64 – 65ER → AG in AAC47155 (PubMed:8654366).Curated2
Sequence conflicti94E → K in AAC41610 (PubMed:8548811).Curated1
Sequence conflicti282A → D in AAB08398 (PubMed:8643514).Curated1
Sequence conflicti286A → S in AAC47155 (PubMed:8654366).Curated1
Sequence conflicti302Q → P in AAC41610 (PubMed:8548811).Curated1
Sequence conflicti302Q → P in AAC47155 (PubMed:8654366).Curated1
Sequence conflicti302Q → P in AAB08398 (PubMed:8643514).Curated1
Sequence conflicti303P → T in AAB08398 (PubMed:8643514).Curated1
Sequence conflicti327A → T in AAC46988 (PubMed:8552191).Curated1
Sequence conflicti369 – 376ALEVREPP → DWRCASR in AAC47155 (PubMed:8654366).Curated8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L49441 mRNA Translation: AAC41610.1
U45881 mRNA Translation: AAC46988.1
U32373 mRNA Translation: AAC47155.1
M96581 Genomic DNA No translation available.
AE013599 Genomic DNA Translation: AAF58095.1
AE013599 Genomic DNA Translation: AAO41389.1
AY051844 mRNA Translation: AAK93268.1
U38809 mRNA Translation: AAB08398.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S68452
S69545

NCBI Reference Sequences

More...
RefSeqi
NP_477127.1, NM_057779.5
NP_788362.1, NM_176182.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087296; FBpp0086431; FBgn0015247
FBtr0087297; FBpp0086432; FBgn0015247

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36748

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8293

UCSC genome browser

More...
UCSCi
CG8293-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49441 mRNA Translation: AAC41610.1
U45881 mRNA Translation: AAC46988.1
U32373 mRNA Translation: AAC47155.1
M96581 Genomic DNA No translation available.
AE013599 Genomic DNA Translation: AAF58095.1
AE013599 Genomic DNA Translation: AAO41389.1
AY051844 mRNA Translation: AAK93268.1
U38809 mRNA Translation: AAB08398.1
PIRiS68452
S69545
RefSeqiNP_477127.1, NM_057779.5
NP_788362.1, NM_176182.2

3D structure databases

SMRiQ24307
ModBaseiSearch...

Protein-protein interaction databases

BioGridi62475, 179 interactors
IntActiQ24307, 1 interactor
STRINGi7227.FBpp0086432

Protein family/group databases

MEROPSiI32.011

Proteomic databases

PaxDbiQ24307
PRIDEiQ24307

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087296; FBpp0086431; FBgn0015247
FBtr0087297; FBpp0086432; FBgn0015247
GeneIDi36748
KEGGidme:Dmel_CG8293
UCSCiCG8293-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36748
FlyBaseiFBgn0015247 Diap2

Phylogenomic databases

eggNOGiKOG1101 Eukaryota
ENOG410YPNM LUCA
GeneTreeiENSGT00940000169803
InParanoidiQ24307
KOiK16060
OMAiCSMVLAP
OrthoDBi1340284at2759
PhylomeDBiQ24307

Enzyme and pathway databases

ReactomeiR-DME-111465 Apoptotic cleavage of cellular proteins
R-DME-111469 SMAC, XIAP-regulated apoptotic response
R-DME-209447 Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY
R-DME-3769402 Deactivation of the beta-catenin transactivating complex
R-DME-5675482 Regulation of necroptotic cell death
R-DME-8948747 Regulation of PTEN localization
R-DME-8948751 Regulation of PTEN stability and activity
SignaLinkiQ24307

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
36748

Protein Ontology

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PROi
PR:Q24307

Gene expression databases

BgeeiFBgn0015247 Expressed in 31 organ(s), highest expression level in brain
GenevisibleiQ24307 DM

Family and domain databases

CDDicd00022 BIR, 3 hits
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001370 BIR_rpt
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00653 BIR, 3 hits
SMARTiView protein in SMART
SM00238 BIR, 3 hits
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS01282 BIR_REPEAT_1, 3 hits
PS50143 BIR_REPEAT_2, 3 hits
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIAP2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24307
Secondary accession number(s): A4UZI4
, Q24115, Q24149, Q24177, Q960U3, Q9V7G1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 2, 2008
Last modified: July 3, 2019
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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