Death-associated inhibitor of apoptosis 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.3 Publications

  Manual assertion based on experiment inⁱ

  • Ref.11

    "Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases."
    Broemer M., Tenev T., Rigbolt K.T., Hempel S., Blagoev B., Silke J., Ditzel M., Meier P.
    Mol. Cell 40:810-822(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE OF THE NEDD8 CONJUGATION PATHWAY, CATALYTIC ACTIVITY.
  • Ref.13

    "XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling."
    Hanson A.J., Wallace H.A., Freeman T.J., Beauchamp R.D., Lee L.A., Lee E.
    Mol. Cell 45:619-628(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, CATALYTIC ACTIVITY.
  • Ref.18

    "Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination."
    Chai J., Yan N., Huh J.R., Wu J.-W., Li W., Hay B.A., Shi Y.
    Nat. Struct. Biol. 10:892-898(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 201-324 IN COMPLEX WITH DRONC, FUNCTION, CATALYTIC ACTIVITY.

  EC:2.3.2.27

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• caspase binding Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery."
    Leulier F., Ribeiro P.S., Palmer E., Tenev T., Takahashi K., Robertson D., Zachariou A., Pichaud F., Ueda R., Meier P.
    Cell Death Differ 13:1663-1674(2006) [PubMed] [Europe PMC] [Abstract]
• cysteine-type endopeptidase inhibitor activity Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID."
    Wang S.L., Hawkins C.J., Yoo S.J., Muller H.A., Hay B.A.
    Cell 98:453-463(1999) [PubMed] [Europe PMC] [Abstract]
• cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: FlyBaseInferred from direct assayⁱ
  • "Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim."
    Yan N., Wu J.W., Chai J., Li W., Shi Y.
    Nat Struct Mol Biol 11:420-428(2004) [PubMed] [Europe PMC] [Abstract]
• NEDD8 ligase activity Source: FlyBaseInferred from direct assayⁱ
  • Ref.11

    "Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases."
    Broemer M., Tenev T., Rigbolt K.T., Hempel S., Blagoev B., Silke J., Ditzel M., Meier P.
    Mol. Cell 40:810-822(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE OF THE NEDD8 CONJUGATION PATHWAY, CATALYTIC ACTIVITY.
• ubiquitin conjugating enzyme binding Source: FlyBaseInferred from physical interactionⁱ
  • "Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1."
    Ryoo H.D., Bergmann A., Gonen H., Ciechanover A., Steller H.
    Nat Cell Biol 4:432-438(2002) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-like protein conjugating enzyme binding Source: FlyBaseInferred from physical interactionⁱ
  • Ref.11

    "Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases."
    Broemer M., Tenev T., Rigbolt K.T., Hempel S., Blagoev B., Silke J., Ditzel M., Meier P.
    Mol. Cell 40:810-822(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE OF THE NEDD8 CONJUGATION PATHWAY, CATALYTIC ACTIVITY.
• ubiquitin protein ligase activity Source: FlyBaseInferred from direct assayⁱ
  • "Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1."
    Ryoo H.D., Bergmann A., Gonen H., Ciechanover A., Steller H.
    Nat Cell Biol 4:432-438(2002) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways."
    Herman-Bachinsky Y., Ryoo H.D., Ciechanover A., Gonen H.
    Cell Death Differ 14:861-871(2007) [PubMed] [Europe PMC] [Abstract]
  • "Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting."
    Yeh T.C., Bratton S.B.
    Proc Natl Acad Sci U S A 110:14284-14289(2013) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: FlyBaseInferred from physical interactionⁱ
  • "Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways."
    Herman-Bachinsky Y., Ryoo H.D., Ciechanover A., Gonen H.
    Cell Death Differ 14:861-871(2007) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-protein transferase activity Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.13

    "XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling."
    Hanson A.J., Wallace H.A., Freeman T.J., Beauchamp R.D., Lee L.A., Lee E.
    Mol. Cell 45:619-628(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, CATALYTIC ACTIVITY.
• ubiquitin-specific protease binding Source: FlyBaseInferred from physical interactionⁱ
  • "The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis."
    Yang C.S., Sinenko S.A., Thomenius M.J., Robeson A.C., Freel C.D., Horn S.R., Kornbluth S.
    Cell Death Differ 21:604-611(2014) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: FlyBaseInferred from sequence modelⁱ
  • "Comprehensively surveying structure and function of RING domains from Drosophila melanogaster."
    Ying M., Huang X., Zhao H., Wu Y., Wan F., Huang C., Jie K.
    PLoS One 6:e23863-e23863(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• antennal morphogenesis Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Role of programmed cell death in patterning the Drosophila antennal arista."
    Cullen K., McCall K.
    Dev Biol 275:82-92(2004) [PubMed] [Europe PMC] [Abstract]
• apoptotic process Source: FlyBaseInferred from physical interactionⁱ
  • "Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function."
    Goyal L., McCall K., Agapite J., Hartwieg E., Steller H.
    EMBO J 19:589-597(2000) [PubMed] [Europe PMC] [Abstract]
• border follicle cell migration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration."
    Geisbrecht E.R., Montell D.J.
    Cell 118:111-125(2004) [PubMed] [Europe PMC] [Abstract]
• chaeta development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development."
    Kanuka H., Kuranaga E., Takemoto K., Hiratou T., Okano H., Miura M.
    EMBO J 24:3793-3806(2005) [PubMed] [Europe PMC] [Abstract]
• inhibition of cysteine-type endopeptidase activity Source: FlyBaseInferred from direct assayⁱ
  • "The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID."
    Wang S.L., Hawkins C.J., Yoo S.J., Muller H.A., Hay B.A.
    Cell 98:453-463(1999) [PubMed] [Europe PMC] [Abstract]
• inhibition of cysteine-type endopeptidase activity involved in apoptotic process Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID."
    Wang S.L., Hawkins C.J., Yoo S.J., Muller H.A., Hay B.A.
    Cell 98:453-463(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: FlyBaseInferred from direct assayⁱ
  • "Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells."
    Hawkins C.J., Ekert P.G., Uren A.G., Holmgreen S.P., Vaux D.L.
    Cell Death Differ 5:569-576(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of compound eye retinal cell programmed cell death Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery."
    Leulier F., Ribeiro P.S., Palmer E., Tenev T., Takahashi K., Robertson D., Zachariou A., Pichaud F., Ueda R., Meier P.
    Cell Death Differ 13:1663-1674(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: FlyBaseInferred from direct assayⁱ
  • "Characterization of the Drosophila caspase, DAMM."
    Harvey N.L., Daish T., Mills K., Dorstyn L., Quinn L.M., Read S.H., Richardson H., Kumar S.
    J Biol Chem 276:25342-25350(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: FlyBaseInferred from direct assayⁱ
  • "Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim."
    Yan N., Wu J.W., Chai J., Li W., Shi Y.
    Nat Struct Mol Biol 11:420-428(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of JNK cascade Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila."
    Kuranaga E., Kanuka H., Igaki T., Sawamoto K., Ichijo H., Okano H., Miura M.
    Nat Cell Biol 4:705-710(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of border follicle cell migration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila."
    Mathieu J., Sung H.H., Pugieux C., Soetaert J., Rorth P.
    Genetics 176:1579-1590(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of canonical Wnt signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.13

    "XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling."
    Hanson A.J., Wallace H.A., Freeman T.J., Beauchamp R.D., Lee L.A., Lee E.
    Mol. Cell 45:619-628(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, CATALYTIC ACTIVITY.
• positive regulation of protein ubiquitination Source: FlyBaseInferred from direct assayⁱ
  • "Inactivation of effector caspases through nondegradative polyubiquitylation."
    Ditzel M., Broemer M., Tenev T., Bolduc C., Lee T.V., Rigbolt K.T., Elliott R., Zvelebil M., Blagoev B., Bergmann A., Meier P.
    Mol Cell 32:540-553(2008) [PubMed] [Europe PMC] [Abstract]
• protein autoubiquitination Source: FlyBaseInferred from direct assayⁱ
  • "Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1."
    Ryoo H.D., Bergmann A., Gonen H., Ciechanover A., Steller H.
    Nat Cell Biol 4:432-438(2002) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways."
    Herman-Bachinsky Y., Ryoo H.D., Ciechanover A., Gonen H.
    Cell Death Differ 14:861-871(2007) [PubMed] [Europe PMC] [Abstract]
• protein K48-linked ubiquitination Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting."
    Yeh T.C., Bratton S.B.
    Proc Natl Acad Sci U S A 110:14284-14289(2013) [PubMed] [Europe PMC] [Abstract]
• protein neddylation Source: FlyBaseInferred from direct assayⁱ
  • Ref.11

    "Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases."
    Broemer M., Tenev T., Rigbolt K.T., Hempel S., Blagoev B., Silke J., Ditzel M., Meier P.
    Mol. Cell 40:810-822(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE OF THE NEDD8 CONJUGATION PATHWAY, CATALYTIC ACTIVITY.
• protein polyubiquitination Source: FlyBaseInferred from direct assayⁱ
  • "Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila."
    Kuranaga E., Kanuka H., Igaki T., Sawamoto K., Ichijo H., Okano H., Miura M.
    Nat Cell Biol 4:705-710(2002) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways."
    Herman-Bachinsky Y., Ryoo H.D., Ciechanover A., Gonen H.
    Cell Death Differ 14:861-871(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cell cycle Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sensory organ precursor cell division Source: FlyBaseInferred from genetic interactionⁱ
  • "Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development."
    Koto A., Kuranaga E., Miura M.
    J Cell Biol 187:219-231(2009) [PubMed] [Europe PMC] [Abstract]
• spermatid nucleus differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization."
    Huh J.R., Vernooy S.Y., Yu H., Yan N., Shi Y., Guo M., Hay B.A.
    PLoS Biol 2:E15-E15(2004) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Anent the genomics of spermatogenesis in Drosophila melanogaster."
    Lindsley D.L., Roote J., Kennison J.A.
    PLoS One 8:e55915-e55915(2013) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• caspase binding Source: FlyBaseInferred from physical interactionⁱ
  • "Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery."
    Leulier F., Ribeiro P.S., Palmer E., Tenev T., Takahashi K., Robertson D., Zachariou A., Pichaud F., Ueda R., Meier P.
    Cell Death Differ 13:1663-1674(2006) [PubMed] [Europe PMC] [Abstract]
• ubiquitin conjugating enzyme binding Source: FlyBaseInferred from physical interactionⁱ
  • "Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1."
    Ryoo H.D., Bergmann A., Gonen H., Ciechanover A., Steller H.
    Nat Cell Biol 4:432-438(2002) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-like protein conjugating enzyme binding Source: FlyBaseInferred from physical interactionⁱ
  • Ref.11

    "Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases."
    Broemer M., Tenev T., Rigbolt K.T., Hempel S., Blagoev B., Silke J., Ditzel M., Meier P.
    Mol. Cell 40:810-822(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE OF THE NEDD8 CONJUGATION PATHWAY, CATALYTIC ACTIVITY.
• ubiquitin protein ligase binding Source: FlyBaseInferred from physical interactionⁱ
  • "Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways."
    Herman-Bachinsky Y., Ryoo H.D., Ciechanover A., Gonen H.
    Cell Death Differ 14:861-871(2007) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-specific protease binding Source: FlyBaseInferred from physical interactionⁱ
  • "The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis."
    Yang C.S., Sinenko S.A., Thomenius M.J., Robeson A.C., Freel C.D., Horn S.R., Kornbluth S.
    Cell Death Differ 21:604-611(2014) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MASVVADLPS YGPIAFDQVD NNTNATQLFK NNINKTRMND LNREETRLKT 
        60         70         80         90        100
FTDWPLDWLD KRQLAQTGMY FTHAGDKVKC FFCGVEIGCW EQEDQPVPEH 
       110        120        130        140        150
QRWSPNCPLL RRRTTNNVPI NAEALDRILP PISYDICGAN DSTLEMREHA 
       160        170        180        190        200
YAEGVIPMSQ LIQSIGMNAV NAAGSVTGTA APQPRVTVAT HASTATQATG 
       210        220        230        240        250
DVQPETCRPS AASGNYFPQY PEYAIETARL RTFEAWPRNL KQKPHQLAEA 
       260        270        280        290        300
GFFYTGVGDR VRCFSCGGGL MDWNDNDEPW EQHALWLSQC RFVKLMKGQL 
       310        320        330        340        350
YIDTVAAKPV LAEEKEESSS IGGVAVASTQ ASEEEQQTSL SSEEAVSGDV 
       360        370        380        390        400
APSVAPTAAT RIFNKIVEAT AVATPSTNSS GSTSIPEEKL CKICYGAEYN 
       410        420        430 
TAFLPCGHVV ACAKCASSVT KCPLCRKPFT DVMRVYFS              

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families