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Protein

Phosphoinositide phospholipase C

Gene

sl

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

  • border follicle cell migration Source: FlyBase
  • intracellular signal transduction Source: InterPro
  • negative regulation of cell differentiation Source: FlyBase
  • negative regulation of epidermal growth factor receptor signaling pathway Source: FlyBase
  • phospholipid catabolic process Source: InterPro
  • positive regulation of cell growth Source: FlyBase
  • response to insulin Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation, TransducerSAAS annotation
Biological processLipid degradationUniRule annotationSAAS annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-DME-114604 GPVI-mediated activation cascade
R-DME-1855204 Synthesis of IP3 and IP4 in the cytosol
R-DME-202433 Generation of second messenger molecules
R-DME-212718 EGFR interacts with phospholipase C-gamma
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5654219 Phospholipase C-mediated cascade: FGFR1
R-DME-5654221 Phospholipase C-mediated cascade, FGFR2
R-DME-5654227 Phospholipase C-mediated cascade, FGFR3
R-DME-5654228 Phospholipase C-mediated cascade, FGFR4
SignaLinkiQ24284

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:slImported
ORF Names:CG4200Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0003416 sl

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiQ24284

Expressioni

Gene expression databases

BgeeiFBgn0003416
ExpressionAtlasiQ24284 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ24284
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 132PHInterPro annotationAdd BLAST119
Domaini319 – 462PI-PLC X-boxInterPro annotationAdd BLAST144
Domaini583 – 684SH2InterPro annotationAdd BLAST102
Domaini695 – 783SH2InterPro annotationAdd BLAST89
Domaini818 – 878SH3InterPro annotationAdd BLAST61
Domaini974 – 1086PI-PLC Y-boxInterPro annotationAdd BLAST113
Domaini1098 – 1190C2InterPro annotationAdd BLAST93

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1264 Eukaryota
ENOG410XPXE LUCA
OrthoDBiEOG091G07R3

Family and domain databases

CDDicd09932 SH2_C-SH2_PLC_gamma_like, 1 hit
cd10341 SH2_N-SH2_PLC_gamma_like, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR016279 PLC-gamma
IPR035023 PLC-gamma_C-SH2
IPR035024 PLC-gamma_N-SH2
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PF00017 SH2, 2 hits
PF00018 SH3_1, 1 hit
PIRSFiPIRSF000952 PLC-gamma, 1 hit
PRINTSiPR00390 PHPHLIPASEC
PR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SM00252 SH2, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF50044 SSF50044, 1 hit
SSF51695 SSF51695, 2 hits
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit
PS50001 SH2, 2 hits
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q24284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPLLGEME QTIGMLERGT IVTKLYGKQR RPDRRHLMLI RETRQLLWAT
60 70 80 90 100
VATQTPRTDY EGAIQLREIR EIRVGKHSKE FRLFADDCQR FESSKCFVIL
110 120 130 140 150
HGNHFKLKSF SVVALSEIEA DNWVRGLRYM VKDTLGAPYP LQIDRWLRRE
160 170 180 190 200
YYQIENVNTH SAKATEQSPA QVTIKDFKLF LAGVSCKMTT GKFMEHFTED
210 220 230 240 250
VRRKHDLKFD DFSRLYQKLL LPNGFASVLS GSGVANFPYS EDQQVVRPAE
260 270 280 290 300
LKQFLETEQR DVSASEISSA AIASFIRDFV QDVERDVQEP YLTFPEFVDF
310 320 330 340 350
LFSKQNDLWN SKYDQVFMDM NLPLSSYWIA SSHNTYLTGD QFSSESSCEA
360 370 380 390 400
YARALRMGCR CIELDCWNGP DNLPYIFHGH TITSKIKFMD VIKTIKDHAF
410 420 430 440 450
TSSEYPVILS IEQNCSLEQQ RNMAQALIEV FGDMLLTQPC DRNEQHLPSP
460 470 480 490 500
YQLRRKIILK HKKLPQFDDI ANGISSTGSL GHRSSLGGAG GGAHGENDGE
510 520 530 540 550
NVRKVFKEGL LYFKDPVDKS WNLYQFVLTH QELIYSSEIN ESRNGNSEDD
560 570 580 590 600
DFGLSSSCSL NSNMQQKQKD TSANDELHFG ENWFHGKLEG GRKEADDLLK
610 620 630 640 650
KYKHFGDGTF LVRESATFVG DYSLSFWRRN RPNHCRIKLK HENGSIKYYL
660 670 680 690 700
VENFVFDSLY SLIVYYRKNM LRSSEFSIIL KEPVPQPKKH EDQEWFHPNT
710 720 730 740 750
TKEQAEQGLY RLEIGSFLVR PSVQSINAFV ISFTINRKIK HCRIMQEGCL
760 770 780 790 800
YGIDTMNFES LVSLINYYTR NPLYRNVKLS HPVSQELLRQ ALAEAAQGDH
810 820 830 840 850
SGGHDDNGAS NYMGSNLEEN VTCKALYSYK ANKPDELSFP KHAIITNVQR
860 870 880 890 900
DNSMWWIGDY GGMIKKHLPA NYVKVIDSTT EDYNSLNEEG TDGRTDSIEI
910 920 930 940 950
FGAVASLFES NDPGIIFKLQ IQTPTMQNPF VIGFDNQETA YEWIKAIQEA
960 970 980 990 1000
ALIASQLASE RRKKERTARV AKEMSDLIIY FRSVPFREHS WIFQEMSSFP
1010 1020 1030 1040 1050
ETKAEKQFFQ QNTQLFLSYH RNQISRVYPK GQRLDSSNFN PMPFWNVGSQ
1060 1070 1080 1090 1100
MIALNYQTGD KAMQLNQAKF RNNGQCGYIL KPSFMKSDSF NPNNPLCDGL
1110 1120 1130 1140 1150
SEVKVSIRLI AARHLFRGGK SNNPQIVVEL IGASFDTGVK YRTKVIENGF
1160 1170 1180 1190 1200
NPVWNESCEF NVRNPQFAIL RFEVQDEDMF AETHFIAQAC YPLTCIRQGY
1210 1220 1230
RSVILRNKFS EELELSSLLI NIKIANVTAP
Length:1,230
Mass (Da):141,372
Last modified:November 1, 1996 - v1
Checksum:iA12C4805A95F221E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29806 mRNA Translation: BAA06189.1
PIRiA53970

Similar proteinsi

Entry informationi

Entry nameiQ24284_DROME
AccessioniPrimary (citable) accession number: Q24284
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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