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Entry version 141 (13 Nov 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Cno

Gene

cno

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q24279

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CnoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cnoImported
ORF Names:CG42312Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0259212 cno

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q24279

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0259212 Expressed in 31 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q24279, 2 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 133Ras-associatingInterPro annotationAdd BLAST95
Domaini256 – 348Ras-associatingInterPro annotationAdd BLAST93
Domaini520 – 748DiluteInterPro annotationAdd BLAST229
Domaini843 – 928PDZInterPro annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni142 – 203DisorderedSequence analysisAdd BLAST62
Regioni224 – 257DisorderedSequence analysisAdd BLAST34
Regioni345 – 371DisorderedSequence analysisAdd BLAST27
Regioni948 – 979DisorderedSequence analysisAdd BLAST32
Regioni1016 – 1082DisorderedSequence analysisAdd BLAST67
Regioni1116 – 1186DisorderedSequence analysisAdd BLAST71
Regioni1241 – 1282DisorderedSequence analysisAdd BLAST42
Regioni1302 – 1380DisorderedSequence analysisAdd BLAST79
Regioni1404 – 1431DisorderedSequence analysisAdd BLAST28
Regioni1533 – 1593DisorderedSequence analysisAdd BLAST61
Regioni1834 – 1893DisorderedSequence analysisAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1472 – 1502Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi144 – 166PolyampholyteSequence analysisAdd BLAST23
Compositional biasi167 – 201PolarSequence analysisAdd BLAST35
Compositional biasi229 – 249PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1020 – 1049PolarSequence analysisAdd BLAST30
Compositional biasi1063 – 1082PolarSequence analysisAdd BLAST20
Compositional biasi1117 – 1186PolarSequence analysisAdd BLAST70
Compositional biasi1302 – 1327PolarSequence analysisAdd BLAST26
Compositional biasi1404 – 1421PolarSequence analysisAdd BLAST18
Compositional biasi1551 – 1565PolarSequence analysisAdd BLAST15
Compositional biasi1577 – 1591PolarSequence analysisAdd BLAST15
Compositional biasi1854 – 1893PolyampholyteSequence analysisAdd BLAST40

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1892 Eukaryota
ENOG410XR0S LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000264068

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060 FHA, 1 hit
cd15471 Myo5p-like_CBD_afadin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037977 CBD_Afadin
IPR002710 Dilute_dom
IPR000253 FHA_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843 DIL, 1 hit
PF00498 FHA, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132 DIL, 1 hit
SM00240 FHA, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q24279-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHDKKMLDR EAVRSVIQQW NANRLDLFAL SEPDENLLFH GVMRFYFQDA
60 70 80 90 100
GQKVATKCIR VASDATVTDV IDTLIEKFRP DMRMLSVPNY ALYEVHANGE
110 120 130 140 150
ERRLNADEKP LLVQLNWHID DREGRFLLKN IDQKTTPIEQ TDLNFKRKLS
160 170 180 190 200
KREKKEQKKK DKMAKLSSDP PTSNGSHLGL GNGVGASSGS AHMNGNAGGT
210 220 230 240 250
GGDSSDAVAG KLYTELPETS FTRSISNPEA VMRRRRQQKL EKKLQQFRSR
260 270 280 290 300
DGGPDTGGTL KIYGESLCQD VPYKTLLLSI RDCAQAVVRE MLTKYGLEKA
310 320 330 340 350
DPLHYCLVQV NSDGTEYILD DDECPLSILM NHPTSRGSIM FHVRRRPADS
360 370 380 390 400
QPRRRKKKPL GAANGANHIS GDREGPVLVE VTHSGDGGRR IKLGSDPVEV
410 420 430 440 450
GSANTNCLQL FGPSIQPRHC LISLLEGVCT VTPLHTDALT FVNGHHISQP
460 470 480 490 500
TILHNGSVVM FGRVASYRFL DSPTDGRYNL ALSQSQLDSA CLYERYRAST
510 520 530 540 550
HYRPELQPTE RAHKLTMFLH HVANLVYSVV QEQYTDPRIL AFWMANSSEF
560 570 580 590 600
LHFLKSDRHI SAFSVQAQEV LAEAVQTAFR NLVNCFRLEL SQTLNQFLSE
610 620 630 640 650
NIDHDSAAGL VLTVLGSAMA LLRRCRVNAA LTIQLFSQLF HYINVICFNT
660 670 680 690 700
IVANSQMCTG DWGKVMTERL QLLELWAERQ GLELAADCHL AKINQCAQFL
710 720 730 740 750
QAPKSSVEEI QQLACSCFRL NSLQMAALLQ QEKLPRNLVD TAIRMAESVA
760 770 780 790 800
DELTRADGRE VRLEESPELH LALLLPDDGF SCDVVRGIPT GLVDFLNPLQ
810 820 830 840 850
QQGMCRLAAQ PTSIGLWTVY MHQFNARSSS AMSNKLPQPE LQLIKLHKNS
860 870 880 890 900
NGMGLSIVAS KGAGQEKLGI YIKSVVPGGA ADADGRLQAG DQLLRVDGQS
910 920 930 940 950
LIGITQERAA DYLVRTGPVV SLEVAKQGAI YHGLATLLQQ PSPVIQRGNR
960 970 980 990 1000
RMSERDLTRM GGAESTKSLG PLIANNHPNH SLSLSQHLNN SHNNTLGNSN
1010 1020 1030 1040 1050
NSSIINPLAA HLPNSKSVPA LHHHTGSGTI SLANSKSRST HSLHNNTSGM
1060 1070 1080 1090 1100
GGIGGAAAGG MLGQPNGSQN NANGNGNGNE QGFYQNLSVY RAQNQSQPIL
1110 1120 1130 1140 1150
NERPPIAAHA AMNAYNGSSP LAPQQQPQQQ QQSPYQQQQQ QQHMQANANL
1160 1170 1180 1190 1200
PPTRPVSAYY HSQQSAQQQL QQQQQQQQQH SLQQQQFALS SGNLNGQQQQ
1210 1220 1230 1240 1250
QQQHQHQLTL NNRTKSQQNF QHTLRMQQMM APSMPNISNM YHHQQQHQQQ
1260 1270 1280 1290 1300
LPLQQQQQQQ QQPLMSSSQS MQNVNDFAGG YQNGSLEYRR SQLHDPSTLY
1310 1320 1330 1340 1350
EIQQQQLQQQ QQQQQQQQQQ QQASPNFIAL PPKPLGSLQS PNKPNVPPST
1360 1370 1380 1390 1400
APKPQQQQQR YLGQSLPAED KPPLPPTATH PLFKATQQIA PGMNYVASTL
1410 1420 1430 1440 1450
DPPKGSYVAS NQGNNRPLHS GSNPWEREER EKDLEMRREH IRQWREQQIS
1460 1470 1480 1490 1500
ELSQIVSRSP MQEEQLKTLI LERDFERRAQ ELQEQEEQDQ EQQYDKENVQ
1510 1520 1530 1540 1550
ELFRLAGGGQ VSAIQTPITS YRQTEIKLAE MPDSNSLVDS VPPQPPAPTA
1560 1570 1580 1590 1600
QPLSSNTQQP KSILKHNRYS EGGVGPSGAP SSPSKSQKSA SFANERHLHT
1610 1620 1630 1640 1650
EHPISNLAKE LNQLTMLDKD NNNETLDAVV PPPPPPERNS SYLIMSQQKL
1660 1670 1680 1690 1700
RGSTGNATSS MGLLKTATSN QAAAAVEIKK ASLLNTQTNN NNNLSGSLNN
1710 1720 1730 1740 1750
NTMHGSPLSA MELNAAYVSA TGTGIIGGLG TPPPPPPLMQ RDNKRVSFHD
1760 1770 1780 1790 1800
EENNFVSGNS QQQQLQQQYI MDNYGMEHQD LDTIREDTSY LQHNLDASML
1810 1820 1830 1840 1850
PSMPATPDAA LWNTSVQSTP GVIGAQEVYR DPRTRRLAEK QQQQQQQRAG
1860 1870 1880 1890
DAVPEKLSFK EKMKMFALES GEDKTPKDKL KISRAQRDID AVH
Length:1,893
Mass (Da):210,188
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE958E3470783CDDA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D49534 mRNA Translation: BAA08478.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A56158

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49534 mRNA Translation: BAA08478.1
PIRiA56158

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ24279, 2 interactors

Proteomic databases

PRIDEiQ24279

Organism-specific databases

FlyBaseiFBgn0259212 cno

Phylogenomic databases

eggNOGiKOG1892 Eukaryota
ENOG410XR0S LUCA
HOGENOMiHOG000264068

Enzyme and pathway databases

SignaLinkiQ24279

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
cno fly

Gene expression databases

BgeeiFBgn0259212 Expressed in 31 organ(s), highest expression level in embryo

Family and domain databases

CDDicd00060 FHA, 1 hit
cd15471 Myo5p-like_CBD_afadin, 1 hit
InterProiView protein in InterPro
IPR037977 CBD_Afadin
IPR002710 Dilute_dom
IPR000253 FHA_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00498 FHA, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 2 hits
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00240 FHA, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 2 hits
SUPFAMiSSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ24279_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24279
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 13, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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