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Entry version 188 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

AP complex subunit beta

Gene

AP-1-2beta

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • clathrin adaptor activity Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transportUniRule annotationARBA annotation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-177504, Retrograde neurotrophin signalling
R-DME-432720, Lysosome Vesicle Biogenesis
R-DME-432722, Golgi Associated Vesicle Biogenesis
R-DME-437239, Recycling pathway of L1
R-DME-5099900, WNT5A-dependent internalization of FZD4
R-DME-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-DME-8856825, Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828, Clathrin-mediated endocytosis
R-DME-8866427, VLDLR internalisation and degradation
R-DME-8964038, LDL clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP complex subunit betaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AP-1-2betaImported
Synonyms:2Imported, 2betaImported, AP-1Imported, AP-1-2-betaImported, AP-1betaImported, AP-1beta1Imported, AP-2betaImported, AP-beta1Imported, AP1beta1Imported, AP2beta2Imported, apl1Imported, apl2Imported, BAD1Imported, BAPImported, BapImported, bapImported, Beta-adaptinImported, beta1Imported, beta2-adaImported, cg12532Imported, Dmel\CG12532Imported
ORF Names:CG12532Imported, Dmel_CG12532Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010380, AP-1-2beta

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q24253

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010380, Expressed in second segment of antenna (Drosophila) and 38 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-20749N

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0074558

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q24253

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini691 – 800Alpha_adaptinC2InterPro annotationAdd BLAST110
Domaini809 – 919B2-adapt-app_CInterPro annotationAdd BLAST111

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adaptor complexes large subunit family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1061, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006320_1_1_1

KEGG Orthology (KO)

More...
KOi
K12392

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFCATLT

Database of Orthologous Groups

More...
OrthoDBi
323029at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit
2.60.40.1150, 1 hit
3.30.310.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026739, AP_beta
IPR016342, AP_complex_bsu_1_2_4
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015151, B-adaptin_app_sub_C
IPR002553, Clathrin/coatomer_adapt-like_N
IPR008152, Clathrin_a/b/g-adaptin_app_Ig
IPR013041, Clathrin_app_Ig-like_sf
IPR013037, Clathrin_b-adaptin_app_Ig-like
IPR009028, Coatomer/calthrin_app_sub_C
IPR012295, TBP_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11134, PTHR11134, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01602, Adaptin_N, 1 hit
PF02883, Alpha_adaptinC2, 1 hit
PF09066, B2-adapt-app_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002291, AP_complex_beta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00809, Alpha_adaptinC2, 1 hit
SM01020, B2-adapt-app_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF49348, SSF49348, 1 hit
SSF55711, SSF55711, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q24253-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDSKYFTTT KKGEIFELKS ELNNDKKEKK KEAVKKVIAS MTVGKDVSAL
60 70 80 90 100
FPDVVNCMQT DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDSNP
110 120 130 140 150
LIRALAVRTM GCIRVDKITE YLCEPLRKCL KDEDPYVRKT AAVCVAKLYD
160 170 180 190 200
ISATMVEDQG FLDQLKDLLS DSNPMVVANA VAALSEINEA SQSGQPLVEM
210 220 230 240 250
NSVTINKLLT ALNECTEWGQ VFILDSLANY SPKDEREAQS ICERITPRLA
260 270 280 290 300
HANAAVVLSA VKVLMKLLEM LSSDSDFCAT LTKKLAPPLV TLLSSEPEVQ
310 320 330 340 350
YVALRNINLI VQKRPDILKH EMKVFFVKYN DPIYVKLEKL DIMIRLANQS
360 370 380 390 400
NIAQVLSELK EYATEVDVDF VRKAVRAIGR CAIKVEPSAE RCVSTLLDLI
410 420 430 440 450
QTKVNYVVQE AIVVIKDIFR KYPNKYESII STLCENLDTL DEPEARASMV
460 470 480 490 500
WIIGEYAERI DNADELLDSF LEGFQDENAQ VQLQLLTAVV KLFLKRPSDT
510 520 530 540 550
QELVQHVLSL ATQDSDNPDL RDRGFIYWRL LSTDPAAAKE VVLADKPLIS
560 570 580 590 600
EETDLLEPTL LDELICHISS LASVYHKPPT AFVEGRGAGV RKSLPNRAAG
610 620 630 640 650
SAAGAEQAEN AAGSEAMVIP NQESLIGDLL SMDINAPAMP SAPAATSNVD
660 670 680 690 700
LLGGGLDILL GGPPAEAAPG GATSLLGDIF GLGGATLSVG VQIPKVTWLP
710 720 730 740 750
AEKGKGLEIQ GTFSRRNGEV FMDMTLTNKA MQPMTNFAIQ LNKNSFGLVP
760 770 780 790 800
ASPMQAAPLP PNQSIEVSMA LGTNGPIQRM EPLNNLQVAV KNNIDIFYFA
810 820 830 840 850
CLVHGNVLFA EDGQLDKRVF LNTWKEIPAA NELQYTLSGV IGTTDGIASK
860 870 880 890 900
MTTNNIFTIA KRNVEGQDML YQSLKLTNNI WVLLELKLQP GNPEATLSLK
910 920
SRSVEVANII FAAYEAIIRS P
Length:921
Mass (Da):101,180
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1CCFE6F8939855E5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF49013.1
BT016054 mRNA Translation: AAV36939.1
X75910 mRNA Translation: CAA53509.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S39295

NCBI Reference Sequences

More...
RefSeqi
NP_523415.1, NM_078691.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074789; FBpp0074558; FBgn0010380

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG12532

UCSC genome browser

More...
UCSCi
CG12532-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF49013.1
BT016054 mRNA Translation: AAV36939.1
X75910 mRNA Translation: CAA53509.1
PIRiS39295
RefSeqiNP_523415.1, NM_078691.3

3D structure databases

SMRiQ24253
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-20749N
STRINGi7227.FBpp0074558

Proteomic databases

PRIDEiQ24253

Genome annotation databases

EnsemblMetazoaiFBtr0074789; FBpp0074558; FBgn0010380
GeneIDi32987
KEGGidme:Dmel_CG12532
UCSCiCG12532-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32987
FlyBaseiFBgn0010380, AP-1-2beta

Phylogenomic databases

eggNOGiKOG1061, Eukaryota
HOGENOMiCLU_006320_1_1_1
KOiK12392
OMAiDFCATLT
OrthoDBi323029at2759

Enzyme and pathway databases

ReactomeiR-DME-177504, Retrograde neurotrophin signalling
R-DME-432720, Lysosome Vesicle Biogenesis
R-DME-432722, Golgi Associated Vesicle Biogenesis
R-DME-437239, Recycling pathway of L1
R-DME-5099900, WNT5A-dependent internalization of FZD4
R-DME-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-DME-8856825, Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828, Clathrin-mediated endocytosis
R-DME-8866427, VLDLR internalisation and degradation
R-DME-8964038, LDL clearance

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
32987, 1 hit in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
kay, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32987

Gene expression databases

BgeeiFBgn0010380, Expressed in second segment of antenna (Drosophila) and 38 other tissues

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.60.40.1150, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR026739, AP_beta
IPR016342, AP_complex_bsu_1_2_4
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015151, B-adaptin_app_sub_C
IPR002553, Clathrin/coatomer_adapt-like_N
IPR008152, Clathrin_a/b/g-adaptin_app_Ig
IPR013041, Clathrin_app_Ig-like_sf
IPR013037, Clathrin_b-adaptin_app_Ig-like
IPR009028, Coatomer/calthrin_app_sub_C
IPR012295, TBP_dom_sf
PANTHERiPTHR11134, PTHR11134, 1 hit
PfamiView protein in Pfam
PF01602, Adaptin_N, 1 hit
PF02883, Alpha_adaptinC2, 1 hit
PF09066, B2-adapt-app_C, 1 hit
PIRSFiPIRSF002291, AP_complex_beta, 1 hit
SMARTiView protein in SMART
SM00809, Alpha_adaptinC2, 1 hit
SM01020, B2-adapt-app_C, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF49348, SSF49348, 1 hit
SSF55711, SSF55711, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ24253_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24253
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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