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Entry version 187 (12 Aug 2020)
Sequence version 2 (21 Feb 2001)
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Protein

Integrin alpha-PS1

Gene

mew

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-PS1/beta-PS is a receptor for laminin.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-210991, Basigin interactions
R-DME-216083, Integrin cell surface interactions
R-DME-3000170, Syndecan interactions
R-DME-446107, Type I hemidesmosome assembly

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-PS1
Alternative name(s):
Position-specific antigen subunit alpha-1
Protein multiple edematous wings
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mew
ORF Names:CG1771
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004456, mew

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 1085ExtracellularSequence analysisAdd BLAST1055
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1086 – 1106HelicalSequence analysisAdd BLAST21
Topological domaini1107 – 1146CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001632031 – 1146Integrin alpha-PS1Add BLAST1116
ChainiPRO_000001632131 – ?960Integrin alpha-PS1 heavy chainSequence analysisAdd BLAST930
ChainiPRO_0000016322?961 – 1146Integrin alpha-PS1 light chainSequence analysisAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi511N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi657N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi680N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi711N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi718N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi761N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi928N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1027N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24247

PRoteomics IDEntifications database

More...
PRIDEi
Q24247

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q24247

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in follicle cells (at protein level). At syncytial blastoderm stage, expressed in the ectoderm but not in the mesodermal precursors. At embryonic stage 7, expressed in dorsal and ventrolateral ectoderm and in some yolk nuclei. At late stage 10, expression is homogeneous in the ectoderm and is particularly abundant in the anterior and posterior midgut primordia. At stage 11, strongly expressed in a metameric pattern in the ectoderm, in the proctodeum and in the posterior midgut primordium. At stage 12, accumulates at the segment boundaries that start to become morphologically visible, similar expression pattern is observed in the central nervous system. In third larval instar wing imaginal disk, strongly expressed in the dorsal compartment, in the adepithelial cells and in patches on the peripodial membrane covering the imaginal disk to the outside.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during mid- and late-oogenesis (at protein level). Expressed throughout embryonic and larval development with peaks of expression during mid-embryogenesis and at third larval instar.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004456, Expressed in spermathecum and 73 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q24247, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24247, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS1 associates with beta-PS.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58660, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q24247, 15 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0302767

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati38 – 105FG-GAP 1PROSITE-ProRule annotationAdd BLAST68
Repeati121 – 186FG-GAP 2PROSITE-ProRule annotationAdd BLAST66
Repeati193 – 245FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati254 – 303FG-GAP 4PROSITE-ProRule annotationAdd BLAST50
Repeati304 – 366FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati367 – 422FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati432 – 494FG-GAP 7PROSITE-ProRule annotationAdd BLAST63

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3637, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167229

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004111_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24247

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIDFEGT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q24247

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839, FG-GAP, 2 hits
PF08441, Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185, INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00191, Int_alpha, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69179, SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470, FG_GAP, 7 hits
PS00242, INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform B (identifier: Q24247-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLELPFTTIR PNCRLRQNLG ILIILQCVLT CYNFNLEQRL PIVKYGHPHS
60 70 80 90 100
HFGYSVATHT IGEANGPNKT NCVLVGAPLD QNRQPNTTHS GALWRCPMTQ
110 120 130 140 150
RFDDCEQVIT DGRRNFDSEI LSPPGNDEIK EDQWMGVTVR SNPLQANGSG
160 170 180 190 200
GKVIVCAHRY MYIVRENRYG QGLCYLLTND LQFEEVHEPC KGRPVQRQHE
210 220 230 240 250
DYGLCQAGTS AALLDDDTMV LGSPGPYTWR GSIWVTQVGG EYLQRDKTTY
260 270 280 290 300
YSDHSDLNSP VDKYSYLGMS VTGGRFFGHM SYAAGAPRSE GHGQVVIFDK
310 320 330 340 350
STDNPIPVHS ILDGEQFGSS FGYELATADI NGDHRPDLIV AAPLYFTKTE
360 370 380 390 400
GGAVYVYQNI QDTLPMKYTL KLTGPLESRF GLALANIGDL NKDNCEDLAV
410 420 430 440 450
GAPYEGNGVV YIYLGSSQGL NSKPAQKIQA SELGGTIPNG QPIRTFGISI
460 470 480 490 500
SGNTDLDDNS YPDVVIGAFN SSAAVILLAR PIISIQTSVQ RKELHNMDPN
510 520 530 540 550
TPGCLDDPAS NLTCFTFRAC CSIEPYDEKN KELRLAYSVE AETFDHLKKF
560 570 580 590 600
SRVFFFDREN KRTNVLSRVV RVHTNGRTEC QAVTGYIKAN TRDIQTPVRF
610 620 630 640 650
RLKYSLVEPP LADSALVRLN PILDQTQAHV DFEGTFQKDC GDDDLCESNL
660 670 680 690 700
IIRVEPNITE SSGNEYTLIL DETELEVRIN VSNLADSAYE AQLFIAHQAG
710 720 730 740 750
VSYVATKKPT NATCNSYNTT LVACSLGNPM LRDTTTFVTI RFQPKGLEPS
760 770 780 790 800
EKIMLFHIFA NTTSKLVGPE RPERDLRVNV VRRAKLNFRG WAIPEQSFYS
810 820 830 840 850
GSSVANSVAN TAATDIEGHG PMGMDDVGSQ VHHMFTIFNE GPSTAPKVQM
860 870 880 890 900
VIHWPYSLYS DPQSGRPVQY LLYLEQVPTV EVSQGECHVA KEYVNPLNLA
910 920 930 940 950
SGSRENPAYL SAPAQMRMFP SQSRHSFNKS LIHSQRSYYS SSHRDDHSDD
960 970 980 990 1000
TQSNRNRVRR SFLERVTRLE RLMYDPESSN AANGKKQDIV ELDCNKGATN
1010 1020 1030 1040 1050
CVRIECDILN MPALSEAQVV VKARLWNSTL VSEYPRVERV RIFSTATAQI
1060 1070 1080 1090 1100
PESYGVEVMD HNNIEVETRA YPELRNQQRD TSIPWLIIIL GIVGGLLLLA
1110 1120 1130 1140
LVTYVLWKVG FFKRIRPTDP TLSGNLEKMN EEKPFLAPSK NTHHVF
Length:1,146
Mass (Da):127,973
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8AB75BC8DE6854E
GO
Isoform A (identifier: Q24247-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Show »
Length:1,049
Mass (Da):117,097
Checksum:i49304E861063716F
GO
Isoform C (identifier: Q24247-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-115: RN → RTNGAYEINKH

Show »
Length:1,155
Mass (Da):128,987
Checksum:i0E1C9A43562D9DF1
GO
Isoform D (identifier: Q24247-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     114-115: RN → RTNGAYEINKH

Show »
Length:1,058
Mass (Da):118,111
Checksum:i9316E6312504B21E
GO
Isoform E (identifier: Q24247-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     1146-1146: F → FXQEGTVGWD...ASAAWWGHHM

Show »
Length:1,146
Mass (Da):128,348
Checksum:i38098E971537C1C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JDJ5X2JDJ5_DROME
Multiple edematous wings, isoform F
mew alpha-PS1, alpha1Int, alpha[[PS1]], alphaPS1, aPS1
1,243Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti730 – 731ML → IV in CAA52155 (PubMed:8240969).Curated2
Sequence conflicti815D → E in CAA52155 (PubMed:8240969).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0092701 – 97Missing in isoform A, isoform D and isoform E. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_053396114 – 115RN → RTNGAYEINKH in isoform C and isoform D. Curated2
Alternative sequenceiVSP_0533971146F → FXQEGTVGWDLVRRRRRRRR LKLRLPVTAQPRHGWRKTTD KSINNNNNNNHNNNSSNSRN DSDVDVLSLTPPPPPLSIFS WGNDGYYQASAAWWGHHM in isoform E. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X73975 mRNA Translation: CAA52155.1
AE014298 Genomic DNA Translation: AAF48242.2
AE014298 Genomic DNA Translation: AAN09652.1
AE014298 Genomic DNA Translation: AGB95345.1
AE014298 Genomic DNA Translation: AGB95346.1
AE014298 Genomic DNA Translation: AGB95347.1
AY075338 mRNA Translation: AAL68203.1

Protein sequence database of the Protein Information Resource

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PIRi
S40311

NCBI Reference Sequences

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RefSeqi
NP_001259503.1, NM_001272574.1 [Q24247-5]
NP_001259504.1, NM_001272575.2 [Q24247-3]
NP_001259505.1, NM_001272576.2 [Q24247-4]
NP_511145.2, NM_078590.3 [Q24247-1]
NP_727679.1, NM_167354.2 [Q24247-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0073731; FBpp0073562; FBgn0004456 [Q24247-2]
FBtr0073732; FBpp0073563; FBgn0004456 [Q24247-1]
FBtr0310647; FBpp0302767; FBgn0004456 [Q24247-3]
FBtr0310648; FBpp0302768; FBgn0004456 [Q24247-4]
FBtr0330398; FBpp0303424; FBgn0004456 [Q24247-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
32275

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG1771

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73975 mRNA Translation: CAA52155.1
AE014298 Genomic DNA Translation: AAF48242.2
AE014298 Genomic DNA Translation: AAN09652.1
AE014298 Genomic DNA Translation: AGB95345.1
AE014298 Genomic DNA Translation: AGB95346.1
AE014298 Genomic DNA Translation: AGB95347.1
AY075338 mRNA Translation: AAL68203.1
PIRiS40311
RefSeqiNP_001259503.1, NM_001272574.1 [Q24247-5]
NP_001259504.1, NM_001272575.2 [Q24247-3]
NP_001259505.1, NM_001272576.2 [Q24247-4]
NP_511145.2, NM_078590.3 [Q24247-1]
NP_727679.1, NM_167354.2 [Q24247-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi58660, 11 interactors
IntActiQ24247, 15 interactors
STRINGi7227.FBpp0302767

PTM databases

iPTMnetiQ24247

Proteomic databases

PaxDbiQ24247
PRIDEiQ24247

Genome annotation databases

EnsemblMetazoaiFBtr0073731; FBpp0073562; FBgn0004456 [Q24247-2]
FBtr0073732; FBpp0073563; FBgn0004456 [Q24247-1]
FBtr0310647; FBpp0302767; FBgn0004456 [Q24247-3]
FBtr0310648; FBpp0302768; FBgn0004456 [Q24247-4]
FBtr0330398; FBpp0303424; FBgn0004456 [Q24247-5]
GeneIDi32275
KEGGidme:Dmel_CG1771

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
32275
FlyBaseiFBgn0004456, mew

Phylogenomic databases

eggNOGiKOG3637, Eukaryota
GeneTreeiENSGT00940000167229
HOGENOMiCLU_004111_1_0_1
InParanoidiQ24247
OMAiHIDFEGT
PhylomeDBiQ24247

Enzyme and pathway databases

ReactomeiR-DME-210991, Basigin interactions
R-DME-216083, Integrin cell surface interactions
R-DME-3000170, Syndecan interactions
R-DME-446107, Type I hemidesmosome assembly

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
32275, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32275

Protein Ontology

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PROi
PR:Q24247

Gene expression databases

BgeeiFBgn0004456, Expressed in spermathecum and 73 other tissues
ExpressionAtlasiQ24247, baseline and differential
GenevisibleiQ24247, DM

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf
PfamiView protein in Pfam
PF01839, FG-GAP, 2 hits
PF08441, Integrin_alpha2, 1 hit
PRINTSiPR01185, INTEGRINA
SMARTiView protein in SMART
SM00191, Int_alpha, 5 hits
SUPFAMiSSF69179, SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470, FG_GAP, 7 hits
PS00242, INTEGRIN_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITA1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24247
Secondary accession number(s): M9PEG3
, M9PHG7, M9PJL8, Q8SY51, Q9VYF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 21, 2001
Last modified: August 12, 2020
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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