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Protein

Integrin alpha-PS1

Gene

mew

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-PS1/beta-PS is a receptor for laminin.1 Publication

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • extracellular matrix binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase

GO - Biological processi

  • actin filament organization Source: FlyBase
  • apposition of dorsal and ventral imaginal disc-derived wing surfaces Source: FlyBase
  • axonal defasciculation Source: FlyBase
  • axon guidance Source: FlyBase
  • cell adhesion Source: FlyBase
  • cell adhesion mediated by integrin Source: FlyBase
  • cell-cell adhesion Source: FlyBase
  • cell differentiation Source: FlyBase
  • cell migration Source: FlyBase
  • ectodermal digestive tract morphogenesis Source: FlyBase
  • epithelial cell migration, open tracheal system Source: FlyBase
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • maintenance of epithelial integrity, open tracheal system Source: FlyBase
  • midgut development Source: FlyBase
  • muscle attachment Source: FlyBase
  • open tracheal system development Source: FlyBase
  • salivary gland boundary specification Source: FlyBase
  • salivary gland development Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • sensory perception of smell Source: FlyBase
  • substrate adhesion-dependent cell spreading Source: FlyBase
  • tracheal outgrowth, open tracheal system Source: FlyBase

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-DME-210991 Basigin interactions
R-DME-216083 Integrin cell surface interactions
R-DME-3000157 Laminin interactions
R-DME-3000170 Syndecan interactions
R-DME-3000178 ECM proteoglycans
R-DME-446107 Type I hemidesmosome assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-PS1
Alternative name(s):
Position-specific antigen subunit alpha-1
Protein multiple edematous wings
Cleaved into the following 2 chains:
Gene namesi
Name:mew
ORF Names:CG1771
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004456 mew

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 1085ExtracellularSequence analysisAdd BLAST1055
Transmembranei1086 – 1106HelicalSequence analysisAdd BLAST21
Topological domaini1107 – 1146CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001632031 – 1146Integrin alpha-PS1Add BLAST1116
ChainiPRO_000001632131 – ?960Integrin alpha-PS1 heavy chainSequence analysisAdd BLAST930
ChainiPRO_0000016322?961 – 1146Integrin alpha-PS1 light chainSequence analysisAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi511N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi657N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi680N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi711N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi718N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi761N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi928N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1027N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ24247
PRIDEiQ24247

PTM databases

iPTMnetiQ24247

Expressioni

Tissue specificityi

Expressed in follicle cells (at protein level). At syncytial blastoderm stage, expressed in the ectoderm but not in the mesodermal precursors. At embryonic stage 7, expressed in dorsal and ventrolateral ectoderm and in some yolk nuclei. At late stage 10, expression is homogeneous in the ectoderm and is particularly abundant in the anterior and posterior midgut primordia. At stage 11, strongly expressed in a metameric pattern in the ectoderm, in the proctodeum and in the posterior midgut primordium. At stage 12, accumulates at the segment boundaries that start to become morphologically visible, similar expression pattern is observed in the central nervous system. In third larval instar wing imaginal disk, strongly expressed in the dorsal compartment, in the adepithelial cells and in patches on the peripodial membrane covering the imaginal disk to the outside.2 Publications

Developmental stagei

Expressed during mid- and late-oogenesis (at protein level). Expressed throughout embryonic and larval development with peaks of expression during mid-embryogenesis and at third larval instar.2 Publications

Gene expression databases

BgeeiFBgn0004456
ExpressionAtlasiQ24247 baseline and differential
GenevisibleiQ24247 DM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS1 associates with beta-PS.

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi58660, 11 interactors
IntActiQ24247, 16 interactors
STRINGi7227.FBpp0302767

Structurei

3D structure databases

ProteinModelPortaliQ24247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati38 – 105FG-GAP 1PROSITE-ProRule annotationAdd BLAST68
Repeati121 – 186FG-GAP 2PROSITE-ProRule annotationAdd BLAST66
Repeati193 – 245FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati254 – 303FG-GAP 4PROSITE-ProRule annotationAdd BLAST50
Repeati304 – 366FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati367 – 422FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati432 – 494FG-GAP 7PROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBB Eukaryota
ENOG410XVGZ LUCA
GeneTreeiENSGT00760000118782
InParanoidiQ24247
OMAiTSWWPVS
OrthoDBiEOG091G02JI
PhylomeDBiQ24247

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 4 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: Q24247-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLELPFTTIR PNCRLRQNLG ILIILQCVLT CYNFNLEQRL PIVKYGHPHS
60 70 80 90 100
HFGYSVATHT IGEANGPNKT NCVLVGAPLD QNRQPNTTHS GALWRCPMTQ
110 120 130 140 150
RFDDCEQVIT DGRRNFDSEI LSPPGNDEIK EDQWMGVTVR SNPLQANGSG
160 170 180 190 200
GKVIVCAHRY MYIVRENRYG QGLCYLLTND LQFEEVHEPC KGRPVQRQHE
210 220 230 240 250
DYGLCQAGTS AALLDDDTMV LGSPGPYTWR GSIWVTQVGG EYLQRDKTTY
260 270 280 290 300
YSDHSDLNSP VDKYSYLGMS VTGGRFFGHM SYAAGAPRSE GHGQVVIFDK
310 320 330 340 350
STDNPIPVHS ILDGEQFGSS FGYELATADI NGDHRPDLIV AAPLYFTKTE
360 370 380 390 400
GGAVYVYQNI QDTLPMKYTL KLTGPLESRF GLALANIGDL NKDNCEDLAV
410 420 430 440 450
GAPYEGNGVV YIYLGSSQGL NSKPAQKIQA SELGGTIPNG QPIRTFGISI
460 470 480 490 500
SGNTDLDDNS YPDVVIGAFN SSAAVILLAR PIISIQTSVQ RKELHNMDPN
510 520 530 540 550
TPGCLDDPAS NLTCFTFRAC CSIEPYDEKN KELRLAYSVE AETFDHLKKF
560 570 580 590 600
SRVFFFDREN KRTNVLSRVV RVHTNGRTEC QAVTGYIKAN TRDIQTPVRF
610 620 630 640 650
RLKYSLVEPP LADSALVRLN PILDQTQAHV DFEGTFQKDC GDDDLCESNL
660 670 680 690 700
IIRVEPNITE SSGNEYTLIL DETELEVRIN VSNLADSAYE AQLFIAHQAG
710 720 730 740 750
VSYVATKKPT NATCNSYNTT LVACSLGNPM LRDTTTFVTI RFQPKGLEPS
760 770 780 790 800
EKIMLFHIFA NTTSKLVGPE RPERDLRVNV VRRAKLNFRG WAIPEQSFYS
810 820 830 840 850
GSSVANSVAN TAATDIEGHG PMGMDDVGSQ VHHMFTIFNE GPSTAPKVQM
860 870 880 890 900
VIHWPYSLYS DPQSGRPVQY LLYLEQVPTV EVSQGECHVA KEYVNPLNLA
910 920 930 940 950
SGSRENPAYL SAPAQMRMFP SQSRHSFNKS LIHSQRSYYS SSHRDDHSDD
960 970 980 990 1000
TQSNRNRVRR SFLERVTRLE RLMYDPESSN AANGKKQDIV ELDCNKGATN
1010 1020 1030 1040 1050
CVRIECDILN MPALSEAQVV VKARLWNSTL VSEYPRVERV RIFSTATAQI
1060 1070 1080 1090 1100
PESYGVEVMD HNNIEVETRA YPELRNQQRD TSIPWLIIIL GIVGGLLLLA
1110 1120 1130 1140
LVTYVLWKVG FFKRIRPTDP TLSGNLEKMN EEKPFLAPSK NTHHVF
Length:1,146
Mass (Da):127,973
Last modified:February 21, 2001 - v2
Checksum:iE8AB75BC8DE6854E
GO
Isoform A (identifier: Q24247-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: No experimental confirmation available.
Show »
Length:1,049
Mass (Da):117,097
Checksum:i49304E861063716F
GO
Isoform C (identifier: Q24247-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-115: RN → RTNGAYEINKH

Note: No experimental confirmation available.
Show »
Length:1,155
Mass (Da):128,987
Checksum:i0E1C9A43562D9DF1
GO
Isoform D (identifier: Q24247-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     114-115: RN → RTNGAYEINKH

Note: No experimental confirmation available.
Show »
Length:1,058
Mass (Da):118,111
Checksum:i9316E6312504B21E
GO
Isoform E (identifier: Q24247-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     1146-1146: F → FXQEGTVGWD...ASAAWWGHHM

Note: No experimental confirmation available.
Show »
Length:1,146
Mass (Da):128,348
Checksum:i38098E971537C1C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti730 – 731ML → IV in CAA52155 (PubMed:8240969).Curated2
Sequence conflicti815D → E in CAA52155 (PubMed:8240969).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0092701 – 97Missing in isoform A, isoform D and isoform E. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_053396114 – 115RN → RTNGAYEINKH in isoform C and isoform D. Curated2
Alternative sequenceiVSP_0533971146F → FXQEGTVGWDLVRRRRRRRR LKLRLPVTAQPRHGWRKTTD KSINNNNNNNHNNNSSNSRN DSDVDVLSLTPPPPPLSIFS WGNDGYYQASAAWWGHHM in isoform E. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73975 mRNA Translation: CAA52155.1
AE014298 Genomic DNA Translation: AAF48242.2
AE014298 Genomic DNA Translation: AAN09652.1
AE014298 Genomic DNA Translation: AGB95345.1
AE014298 Genomic DNA Translation: AGB95346.1
AE014298 Genomic DNA Translation: AGB95347.1
AY075338 mRNA Translation: AAL68203.1
PIRiS40311
RefSeqiNP_001259503.1, NM_001272574.1 [Q24247-5]
NP_001259504.1, NM_001272575.2 [Q24247-3]
NP_001259505.1, NM_001272576.2 [Q24247-4]
NP_511145.2, NM_078590.3 [Q24247-1]
NP_727679.1, NM_167354.2 [Q24247-2]
UniGeneiDm.152

Genome annotation databases

EnsemblMetazoaiFBtr0073731; FBpp0073562; FBgn0004456 [Q24247-2]
FBtr0073732; FBpp0073563; FBgn0004456 [Q24247-1]
FBtr0310647; FBpp0302767; FBgn0004456 [Q24247-3]
FBtr0310648; FBpp0302768; FBgn0004456 [Q24247-4]
FBtr0330398; FBpp0303424; FBgn0004456 [Q24247-5]
GeneIDi32275
KEGGidme:Dmel_CG1771

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiITA1_DROME
AccessioniPrimary (citable) accession number: Q24247
Secondary accession number(s): M9PEG3
, M9PHG7, M9PJL8, Q8SY51, Q9VYF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 21, 2001
Last modified: July 18, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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