UniProtKB - Q24246 (DYIN_DROME)
Cytoplasmic dynein 1 intermediate chain
sw
Functioni
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).
By similarity1 PublicationGO - Molecular functioni
- dynactin binding Source: FlyBase
- dynein heavy chain binding Source: FlyBase
- dynein light chain binding Source: CAFA
GO - Biological processi
- axo-dendritic transport Source: FlyBase
- cellularization Source: FlyBase
- centrosome localization Source: FlyBase
- eye photoreceptor cell differentiation Source: FlyBase
- microtubule-based movement Source: FlyBase
- microtubule cytoskeleton organization Source: FlyBase
- protein localization to kinetochore Source: FlyBase
- sperm individualization Source: FlyBase
- spindle organization Source: FlyBase
- transport along microtubule Source: GO_Central
Keywordsi
Molecular function | Motor protein |
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-DME-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-DME-6807878, COPI-mediated anterograde transport R-DME-6811436, COPI-independent Golgi-to-ER retrograde traffic R-DME-9646399, Aggrephagy |
SignaLinki | Q24246 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytoplasmic dynein 1 intermediate chainShort name: DH IC Alternative name(s): Dynein intermediate chain, cytosolic Protein short wing |
Gene namesi | Name:sw Synonyms:Cdic, Dic19B ORF Names:CG18000 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0003654, sw |
VEuPathDBi | VectorBase:FBgn0003654 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Lysosome
Note: Aggregates in cytoplasm around lysosomes.
Nucleus
Note: Aggregates in cytoplasm around the nucleus.
Nucleus
Note: Aggregates in cytoplasm around the nucleus.
Cytoskeleton
- cytoplasmic dynein complex Source: FlyBase
- microtubule Source: UniProtKB-KW
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- neuron projection Source: GOC
- protein-containing complex Source: CAFA
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Dynein, Lysosome, Membrane, Microtubule, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114661 | 1 – 663 | Cytoplasmic dynein 1 intermediate chainAdd BLAST | 663 |
Proteomic databases
PaxDbi | Q24246 |
PRIDEi | Q24246 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | FBgn0003654, Expressed in arthropod fat body and 21 other tissues |
ExpressionAtlasi | Q24246, baseline and differential |
Genevisiblei | Q24246, DM |
Interactioni
Subunit structurei
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).
By similarityGO - Molecular functioni
- dynactin binding Source: FlyBase
- dynein heavy chain binding Source: FlyBase
- dynein light chain binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 68871, 25 interactors |
DIPi | DIP-19664N |
ELMi | Q24246 |
IntActi | Q24246, 6 interactors |
STRINGi | 7227.FBpp0088428 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q24246 |
BMRBi | Q24246 |
SMRi | Q24246 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q24246 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 311 – 360 | WD 1Add BLAST | 50 | |
Repeati | 364 – 404 | WD 2Add BLAST | 41 | |
Repeati | 413 – 454 | WD 3Add BLAST | 42 | |
Repeati | 463 – 503 | WD 4Add BLAST | 41 | |
Repeati | 508 – 553 | WD 5Add BLAST | 46 | |
Repeati | 556 – 596 | WD 6Add BLAST | 41 | |
Repeati | 602 – 641 | WD 7Add BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 17 – 52 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 75 – 107 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 36 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1587, Eukaryota |
GeneTreei | ENSGT00940000166605 |
InParanoidi | Q24246 |
OMAi | EEGSIYP |
PhylomeDBi | Q24246 |
Family and domain databases
DisProti | DP00605 |
Gene3Di | 2.130.10.10, 2 hits |
IDEALi | IID50052 |
InterProi | View protein in InterPro IPR025956, DYNC1I1/DYNC1I2 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF11540, Dynein_IC2, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
s (11+)i Sequence
Sequence statusi: Complete.
This entry describes 11 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 11 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDRKAELERK KAKLAALREE KDRRRREKEI KDMEEAAGRI GGGAGIDKDQ
60 70 80 90 100
RKDLDEMLSS LGVAPVSEVL SSLSSVNSMT SDNSNTQTPD ASLQATVNGQ
110 120 130 140 150
SGGKKQPLNL SVYNVQATNI PPKETLVYTK QTQTTSTGGG NGDVLSCHSS
160 170 180 190 200
PLSGYMEDWW RPRKAHATDY YDEYNLNPGL EWEDEFTDDE ESSLQNLGNG
210 220 230 240 250
FTSKLPPGYL THGLPTVKDV APAITPLEIK KETEVKKEVN ELSEEQKQMI
260 270 280 290 300
ILSENFQRFV VRAGRVIERA LSENVDIYTD YIGGGDSEEA NDERSHARLS
310 320 330 340 350
LNRVFYDERW SKNRCITSMD WSTHFPELVV GSYHNNEESP NEPDGVVMVW
360 370 380 390 400
NTKFKKSTPE DVFHCQSAVM STCFAKFNPN LILGGTYSGQ IVLWDNRVQK
410 420 430 440 450
RTPIQRTPLS AAAHTHPVYC LQMVGTQNAH NVISISSDGK LCSWSLDMLS
460 470 480 490 500
QPQDTLELQQ RQSKAIAITS MAFPANEINS LVMGSEDGYV YSASRHGLRS
510 520 530 540 550
GVNEVYERHL GPITGISTHY NQLSPDFGHL FLTSSIDWTI KLWSLKDTKP
560 570 580 590 600
LYSFEDNSDY VMDVAWSPVH PALFAAVDGS GRLDLWNLNQ DTEVPTASIV
610 620 630 640 650
VAGAPALNRV SWTPSGLHVC IGDEAGKLYV YDVAENLAQP SRDEWSRFNT
660
HLSEIKMNQS DEV
The sequence of this isoform differs from the canonical sequence as follows:
144-187: VLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFT → AHATDYYVLAFDAQG
The sequence of this isoform differs from the canonical sequence as follows:
144-187: VLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFT → AHATDYYG
The sequence of this isoform differs from the canonical sequence as follows:
144-187: VLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFT → AHATDYY
The sequence of this isoform differs from the canonical sequence as follows:
144-164: Missing.
187-187: T → TG
The sequence of this isoform differs from the canonical sequence as follows:
144-164: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
144-164: Missing.
187-187: T → TVLAFDAQG
The sequence of this isoform differs from the canonical sequence as follows:
144-171: Missing.
187-187: T → TG
The sequence of this isoform differs from the canonical sequence as follows:
144-171: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
144-153: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA4V4T4 | A4V4T4_DROME | SD27396p | sw 17-234, Cdic, cDIC, Cdic2b, DIC | 643 | Annotation score: | ||
E8NH77 | E8NH77_DROME | SD15168p | sw 17-234, Cdic, cDIC, Cdic2b, DIC | 634 | Annotation score: | ||
X2JLF7 | X2JLF7_DROME | Short wing, isoform O | sw 17-234, Cdic, cDIC, Cdic2b, DIC | 643 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | D → G in AAC78306 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70933 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70934 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70935 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70936 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70937 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70938 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70939 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70940 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70941 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70942 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 47 | D → G in AAC70943 (PubMed:9774695).Curated | 1 | |
Sequence conflicti | 139 – 145 | GGNGDVL → AETAMV in AAB51185 (Ref. 6) Curated | 7 | |
Sequence conflicti | 235 | V → L in AAB51185 (Ref. 6) Curated | 1 | |
Sequence conflicti | 296 – 297 | HA → SM in AAB51185 (Ref. 6) Curated | 2 | |
Sequence conflicti | 521 – 522 | NQ → KP in AAB51185 (Ref. 6) Curated | 2 | |
Sequence conflicti | 537 – 548 | DWTIK…SLKDT → KIWSLKLPISSCQFSVVSGI NSN in AAB51185 (Ref. 6) CuratedAdd BLAST | 12 | |
Sequence conflicti | 579 | G → A in AAB51185 (Ref. 6) Curated | 1 | |
Sequence conflicti | 593 | E → K in AAB51185 (Ref. 6) Curated | 1 | |
Sequence conflicti | 628 | L → Q in AAB51185 (Ref. 6) Curated | 1 | |
Sequence conflicti | 645 – 663 | WSRFN…QSDEV → IKMNQSVRSRTI in AAB51185 (Ref. 6) CuratedAdd BLAST | 19 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001345 | 144 – 187 | VLSCH…EDEFT → AHATDYYVLAFDAQG in isoform 1a. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_001346 | 144 – 187 | VLSCH…EDEFT → AHATDYYG in isoform 1b. 2 PublicationsAdd BLAST | 44 | |
Alternative sequenceiVSP_001347 | 144 – 187 | VLSCH…EDEFT → AHATDYY in isoform 1c. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_001342 | 144 – 171 | Missing in isoform 3a and isoform 3b. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_007686 | 144 – 164 | Missing in isoform 2a, isoform 2b and isoform 2c. 2 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_007685 | 144 – 153 | Missing in isoform 5b. 1 Publication | 10 | |
Alternative sequenceiVSP_001343 | 146 – 187 | SCHSS…EDEFT → AFDAQG in isoform 4. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_001348 | 187 | T → TG in isoform 2a and isoform 3a. 1 Publication | 1 | |
Alternative sequenceiVSP_007687 | 187 | T → TVLAFDAQG in isoform 2c. 1 Publication | 1 |
Sequence databases
Genome annotation databases
EnsemblMetazoai | FBtr0089397; FBpp0088419; FBgn0003654 [Q24246-2] FBtr0089398; FBpp0088420; FBgn0003654 [Q24246-3] FBtr0089399; FBpp0088421; FBgn0003654 [Q24246-4] FBtr0089400; FBpp0088422; FBgn0003654 [Q24246-5] FBtr0089401; FBpp0088423; FBgn0003654 [Q24246-6] FBtr0089402; FBpp0088424; FBgn0003654 [Q24246-7] FBtr0089403; FBpp0088425; FBgn0003654 [Q24246-8] FBtr0089404; FBpp0088426; FBgn0003654 [Q24246-9] FBtr0089405; FBpp0088427; FBgn0003654 [Q24246-10] FBtr0089406; FBpp0088428; FBgn0003654 [Q24246-11] FBtr0089407; FBpp0088429; FBgn0003654 [Q24246-12] FBtr0089408; FBpp0089020; FBgn0003654 [Q24246-5] FBtr0089409; FBpp0089021; FBgn0003654 [Q24246-5] FBtr0340360; FBpp0309318; FBgn0003654 [Q24246-2] |
GeneIDi | 44160 |
KEGGi | dme:Dmel_CG18000 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2P2T | X-ray | 3.00 | C | 123-138 | [»] | |
3FM7 | X-ray | 3.50 | C/D | 109-135 | [»] | |
3L9K | X-ray | 3.00 | W/X/Y/Z | 242-279 | [»] | |
AlphaFoldDBi | Q24246 | |||||
BMRBi | Q24246 | |||||
SMRi | Q24246 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 68871, 25 interactors |
DIPi | DIP-19664N |
ELMi | Q24246 |
IntActi | Q24246, 6 interactors |
STRINGi | 7227.FBpp0088428 |
Proteomic databases
PaxDbi | Q24246 |
PRIDEi | Q24246 |
Protocols and materials databases
DNASUi | 44160 |
Genome annotation databases
EnsemblMetazoai | FBtr0089397; FBpp0088419; FBgn0003654 [Q24246-2] FBtr0089398; FBpp0088420; FBgn0003654 [Q24246-3] FBtr0089399; FBpp0088421; FBgn0003654 [Q24246-4] FBtr0089400; FBpp0088422; FBgn0003654 [Q24246-5] FBtr0089401; FBpp0088423; FBgn0003654 [Q24246-6] FBtr0089402; FBpp0088424; FBgn0003654 [Q24246-7] FBtr0089403; FBpp0088425; FBgn0003654 [Q24246-8] FBtr0089404; FBpp0088426; FBgn0003654 [Q24246-9] FBtr0089405; FBpp0088427; FBgn0003654 [Q24246-10] FBtr0089406; FBpp0088428; FBgn0003654 [Q24246-11] FBtr0089407; FBpp0088429; FBgn0003654 [Q24246-12] FBtr0089408; FBpp0089020; FBgn0003654 [Q24246-5] FBtr0089409; FBpp0089021; FBgn0003654 [Q24246-5] FBtr0340360; FBpp0309318; FBgn0003654 [Q24246-2] |
GeneIDi | 44160 |
KEGGi | dme:Dmel_CG18000 |
Organism-specific databases
CTDi | 44160 |
FlyBasei | FBgn0003654, sw |
VEuPathDBi | VectorBase:FBgn0003654 |
Phylogenomic databases
eggNOGi | KOG1587, Eukaryota |
GeneTreei | ENSGT00940000166605 |
InParanoidi | Q24246 |
OMAi | EEGSIYP |
PhylomeDBi | Q24246 |
Enzyme and pathway databases
Reactomei | R-DME-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-DME-6807878, COPI-mediated anterograde transport R-DME-6811436, COPI-independent Golgi-to-ER retrograde traffic R-DME-9646399, Aggrephagy |
SignaLinki | Q24246 |
Miscellaneous databases
BioGRID-ORCSi | 44160, 0 hits in 3 CRISPR screens |
EvolutionaryTracei | Q24246 |
GenomeRNAii | 44160 |
PROi | PR:Q24246 |
Gene expression databases
Bgeei | FBgn0003654, Expressed in arthropod fat body and 21 other tissues |
ExpressionAtlasi | Q24246, baseline and differential |
Genevisiblei | Q24246, DM |
Family and domain databases
DisProti | DP00605 |
Gene3Di | 2.130.10.10, 2 hits |
IDEALi | IID50052 |
InterProi | View protein in InterPro IPR025956, DYNC1I1/DYNC1I2 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF11540, Dynein_IC2, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DYIN_DROME | |
Accessioni | Q24246Primary (citable) accession number: Q24246 Secondary accession number(s): O96508 Q9VR78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 3, 2003 | |
Last modified: | May 25, 2022 | |
This is version 206 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families