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Entry version 196 (18 Sep 2019)
Sequence version 4 (22 Aug 2003)
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Protein

Peripheral plasma membrane protein CASK

Gene

CASK

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei41ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei141By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.17 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-212676 Dopamine Neurotransmitter Release Cycle
R-DME-6794361 Neurexins and neuroligins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q24210

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.106.3.2 the pock size-determining protein (psdp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peripheral plasma membrane protein CASK (EC:2.7.11.17)
Short name:
dCASK
Alternative name(s):
Calcium/calmodulin-dependent protein kinase
Short name:
CAKI
Short name:
Camguk
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASK
Synonyms:Caki, cmg
ORF Names:CG6703
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0013759 CASK

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increases synapse-specific, activity-dependent autophosphorylation of CaMKII Thr-287.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945711 – 898Peripheral plasma membrane protein CASKAdd BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei292Phosphothreonine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q24210

PRoteomics IDEntifications database

More...
PRIDEi
Q24210

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During embryogenesis, larval and pupal life, found almost exclusively in the central nervous system. In the adult head found in the lamina, the neuropil of the medulla, lobula, lobula plate and in the central brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0013759 Expressed in 28 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q24210 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24210 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with eag.

Interacts with CaMKII.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
67530, 14 interactors

Database of interacting proteins

More...
DIPi
DIP-19769N

Protein interaction database and analysis system

More...
IntActi
Q24210, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0290542

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q24210

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 278Protein kinasePROSITE-ProRule annotationAdd BLAST267
Domaini343 – 397L27 1PROSITE-ProRule annotationAdd BLAST55
Domaini402 – 461L27 2PROSITE-ProRule annotationAdd BLAST60
Domaini495 – 576PDZPROSITE-ProRule annotationAdd BLAST82
Domaini582 – 651SH3PROSITE-ProRule annotationAdd BLAST70
Domaini711 – 883Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST173

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni306 – 316Calmodulin-bindingAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated
Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0033 Eukaryota
KOG0609 Eukaryota
COG0194 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169045

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24210

KEGG Orthology (KO)

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KOi
K06103

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q24210

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12081 SH3_CASK, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035473 CASK_SH3
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR011009 Kinase-like_dom_sf
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 2 hits
PF00595 PDZ, 1 hit
PF00069 Pkinase, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101288 SSF101288, 2 hits
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: Q24210-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEDEILFDD VYELCEVIGK GPFSIVRRCI HRESNQQFAV KIVDVAKFTA
60 70 80 90 100
SPGLSTADLK REATICHMLK HPHIVELLET YSSEGMLYMV FEFMEGSDLC
110 120 130 140 150
FEVVRRAVAG FVYSEAVACH YMRQILEALR YCHENDILHR DVRPACALLA
160 170 180 190 200
TVDNSAPVKL GGFGSAIQLP GTRETIETHG RVGCPHYMAP EVVTRRLYGK
210 220 230 240 250
GCDVWGAGVM LHVLLSGRLP FLGSGVRLQQ SVARGRLSFE APEWKSISAN
260 270 280 290 300
AKDLVMKMLA ANPHHRLSIT EVLDHPWIRD RDKLQRTHLA DTVEELKRYN
310 320 330 340 350
ARRKLKGAVQ AIAGGTNMDP LYATDADMPI TGATDEWADE EAGIEAVQRI
360 370 380 390 400
LDCLDDIYSL QDAHVDADVL RDMLRDNRLH QFLQLFDRIA ATVVTSNGRA
410 420 430 440 450
PAAEAVGRCR DVLEQLSSTS GGNSLGGKYA KEELMRLLAA PHMQALLHSH
460 470 480 490 500
DVVARDVYGE EALRVTPPPM VPYLNGDELD NVEGGELQHV TRVRLVQFQK
510 520 530 540 550
NTDEPMGITL KMTEDGRCIV ARIMHGGMIH RQATLHVGDE IREINGQPVQ
560 570 580 590 600
HQSVGQLQRM LREARGSVTF KIVPSYRSAP PPCEIFVRAQ FDYNPLDDEL
610 620 630 640 650
IPCAQAGISF QVGDILQIIS KDDHHWWQAR LDTVGGSAGL IPSPELQEWR
660 670 680 690 700
IACQTVDKTK QEQVNCSIFG RKKKQCRDKY LAKHNAIFDT LDVVTYEEVV
710 720 730 740 750
KVPVGDPNFQ RKTLVLLGAH GVGRRHIKNT LISKYPDKYA YPIPHTTRPA
760 770 780 790 800
KPEEENGRSY YFVSHDEMMA DIGANEYLEY GTHEDAMYGT KLDTIRRIHT
810 820 830 840 850
EGKMAILDVE PQALKILRTA EFTPYVVFIA APSLQNIADY DGSLERLAKE
860 870 880 890
SEMLRQLYGH FFDLTIVNND ISETIATLET AIDRVHTTPQ WVPVSWLY
Length:898
Mass (Da):100,911
Last modified:August 22, 2003 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B16014EC66E0E9B
GO
Isoform A (identifier: Q24210-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-317: Missing.
     318-443: MDPLYATDAD...LMRLLAAPHM → MCQHHGLTSQ...VPNGSICSGH
     584-584: E → ELFRIRPAPVL

Note: No experimental confirmation available.
Show »
Length:591
Mass (Da):65,197
Checksum:i645638C40343145C
GO
Isoform G (identifier: Q24210-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-317: Missing.
     318-443: MDPLYATDAD...LMRLLAAPHM → MCQHHGLTSQ...VPNGSICSGH
     584-584: E → ELFRIRPAPVL
     663-663: Q → QGEPGAGCSAHADGCDGSA

Note: No experimental confirmation available.
Show »
Length:609
Mass (Da):66,741
Checksum:i7F0A65E1DD31AD9D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JIS7E1JIS7_DROME
CASK, isoform F
CASK CAKI, Caki, caki, CAMGUK, CamGUK
916Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KH39A0A0B4KH39_DROME
CASK, isoform H
CASK CAKI, Caki, caki, CAMGUK, CamGUK
929Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JR71A8JR71_DROME
CASK, isoform D
CASK CAKI, Caki, caki, Caki-RD, CAMGUK
591Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JR72A8JR72_DROME
CASK, isoform E
CASK CAKI, Caki, caki, CAMGUK, CamGUK
469Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM11269 differs from that shown. Probable cloning artifact.Curated
The sequence AAO39536 differs from that shown. Reason: Frameshift at position 114.Curated
The sequence CAA63940 differs from that shown. Reason: Frameshift at positions 537 and 667.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7L → V in AAC80169 (PubMed:9178262).Curated1
Sequence conflicti136D → E in AAC80169 (PubMed:9178262).Curated1
Sequence conflicti463L → A in AAC80169 (PubMed:9178262).Curated1
Sequence conflicti465 – 477VTPPP…YLNGD → HPAPDGALPQWR in AAC80169 (PubMed:9178262).CuratedAdd BLAST13
Sequence conflicti497Q → H in AAC80169 (PubMed:9178262).Curated1
Sequence conflicti523I → L in AAC80169 (PubMed:9178262).Curated1
Sequence conflicti632D → G in AAC80169 (PubMed:9178262).Curated1
Sequence conflicti740A → V in AAC80169 (PubMed:9178262).Curated1
Sequence conflicti759S → N in AAO39554 (PubMed:12537569).Curated1
Sequence conflicti886 – 892HTTPQWV → DIPPRSGC in CAA63940 (PubMed:8617233).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0080881 – 317Missing in isoform A and isoform G. 1 PublicationAdd BLAST317
Alternative sequenceiVSP_008089318 – 443MDPLY…AAPHM → MCQHHGLTSQSLMSGGSHIS LLGSSGSSGMSGSGVGSSGQ SVPQCPAAVAAADAAMMGSN AGGHCRSLSGLSSISIPPPP PALFNPCSSALSLQQAAVTR WGPRTSCPVHSPFRVRVPNG SICSGH in isoform A and isoform G. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_008090584E → ELFRIRPAPVL in isoform A and isoform G. 1 Publication1
Alternative sequenceiVSP_041854663Q → QGEPGAGCSAHADGCDGSA in isoform G. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U53190 mRNA Translation: AAC80169.1
X94264 mRNA Translation: CAA63940.1 Frameshift.
AE014297 Genomic DNA Translation: AAF55920.3
AE014297 Genomic DNA Translation: AAF55921.2
AE014297 Genomic DNA Translation: AAF55922.2
AY094916 mRNA Translation: AAM11269.1 Sequence problems.
BT003532 mRNA Translation: AAO39536.1 Frameshift.
BT003550 mRNA Translation: AAO39554.1
BT046172 mRNA Translation: ACI49771.1

Protein sequence database of the Protein Information Resource

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PIRi
S69210

NCBI Reference Sequences

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RefSeqi
NP_001097862.1, NM_001104392.3 [Q24210-2]
NP_524441.2, NM_079717.4 [Q24210-3]
NP_732661.1, NM_169970.2 [Q24210-2]
NP_732662.2, NM_169971.3 [Q24210-4]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0084161; FBpp0083559; FBgn0013759 [Q24210-3]
FBtr0084162; FBpp0083560; FBgn0013759 [Q24210-2]
FBtr0112872; FBpp0111785; FBgn0013759 [Q24210-2]
FBtr0301328; FBpp0290543; FBgn0013759 [Q24210-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
42567

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG6703

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53190 mRNA Translation: AAC80169.1
X94264 mRNA Translation: CAA63940.1 Frameshift.
AE014297 Genomic DNA Translation: AAF55920.3
AE014297 Genomic DNA Translation: AAF55921.2
AE014297 Genomic DNA Translation: AAF55922.2
AY094916 mRNA Translation: AAM11269.1 Sequence problems.
BT003532 mRNA Translation: AAO39536.1 Frameshift.
BT003550 mRNA Translation: AAO39554.1
BT046172 mRNA Translation: ACI49771.1
PIRiS69210
RefSeqiNP_001097862.1, NM_001104392.3 [Q24210-2]
NP_524441.2, NM_079717.4 [Q24210-3]
NP_732661.1, NM_169970.2 [Q24210-2]
NP_732662.2, NM_169971.3 [Q24210-4]

3D structure databases

SMRiQ24210
ModBaseiSearch...

Protein-protein interaction databases

BioGridi67530, 14 interactors
DIPiDIP-19769N
IntActiQ24210, 7 interactors
STRINGi7227.FBpp0290542

Protein family/group databases

TCDBi9.B.106.3.2 the pock size-determining protein (psdp) family

Proteomic databases

PaxDbiQ24210
PRIDEiQ24210

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084161; FBpp0083559; FBgn0013759 [Q24210-3]
FBtr0084162; FBpp0083560; FBgn0013759 [Q24210-2]
FBtr0112872; FBpp0111785; FBgn0013759 [Q24210-2]
FBtr0301328; FBpp0290543; FBgn0013759 [Q24210-4]
GeneIDi42567
KEGGidme:Dmel_CG6703

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8573
FlyBaseiFBgn0013759 CASK

Phylogenomic databases

eggNOGiKOG0033 Eukaryota
KOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00940000169045
InParanoidiQ24210
KOiK06103
PhylomeDBiQ24210

Enzyme and pathway databases

BRENDAi2.7.11.17 1994
ReactomeiR-DME-212676 Dopamine Neurotransmitter Release Cycle
R-DME-6794361 Neurexins and neuroligins
SignaLinkiQ24210

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CASK fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
42567

Protein Ontology

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PROi
PR:Q24210

Gene expression databases

BgeeiFBgn0013759 Expressed in 28 organ(s), highest expression level in head
ExpressionAtlasiQ24210 baseline and differential
GenevisibleiQ24210 DM

Family and domain databases

CDDicd12081 SH3_CASK, 1 hit
InterProiView protein in InterPro
IPR035473 CASK_SH3
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR011009 Kinase-like_dom_sf
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 2 hits
PF00595 PDZ, 1 hit
PF00069 Pkinase, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF101288 SSF101288, 2 hits
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSKP_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24210
Secondary accession number(s): B5X553
, Q24272, Q86P03, Q86P17, Q8SX09, Q9VD77, Q9VD78, Q9VD79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 22, 2003
Last modified: September 18, 2019
This is version 196 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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