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Entry version 178 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Eukaryotic translation initiation factor 2 subunit 3

Gene

eIF2gamma

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi50 – 55GTPBy similarity6
Nucleotide bindingi189 – 192GTPBy similarity4
Nucleotide bindingi224 – 226GTPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Initiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-381042, PERK regulates gene expression
R-DME-382556, ABC-family proteins mediated transport
R-DME-72649, Translation initiation complex formation
R-DME-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702, Ribosomal scanning and start codon recognition
R-DME-72731, Recycling of eIF2:GDP

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2 subunit 3 (EC:3.6.5.3)
Alternative name(s):
Eukaryotic translation initiation factor 2 subunit gamma
Short name:
eIF-2-gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eIF2gammaImported
Synonyms:eIF-2gamma, eIF2g
ORF Names:CG6476Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0263740, eIF2gamma

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0263740

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001374441 – 475Eukaryotic translation initiation factor 2 subunit 3Add BLAST475

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24208

PRoteomics IDEntifications database

More...
PRIDEi
Q24208

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform B expressed maternally and zygotically. Isoform B expressed throughout development, in larvae, in pupae and in adult flies.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0263740, Expressed in egg chamber and 55 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q24208, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24208, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Eukaryotic translation initiation factor 2 (eIF-2) is a heterotrimeric G-protein composed of an alpha, a beta and a gamma subunit. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
66907, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0302537

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 247tr-type GPROSITE-ProRule annotationAdd BLAST210

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 54G1PROSITE-ProRule annotation8
Regioni75 – 79G2PROSITE-ProRule annotation5
Regioni133 – 136G3PROSITE-ProRule annotation4
Regioni189 – 192G4PROSITE-ProRule annotation4
Regioni224 – 226G5PROSITE-ProRule annotation3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0466, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000172475

Identification of Orthologs from Complete Genome Data

More...
OMAi
NIGMVGH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q24208

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01888, eIF2_gamma, 1 hit
cd03688, eIF2_gamma_II, 1 hit
cd15490, eIF2_gamma_III, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004161, EFTu-like_2
IPR015256, eIF2g_C
IPR044127, eIF2g_dom_2
IPR044128, eIF2g_GTP-bd
IPR027417, P-loop_NTPase
IPR000795, T_Tr_GTP-bd_dom
IPR009000, Transl_B-barrel_sf
IPR009001, Transl_elong_EF1A/Init_IF2_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09173, eIF2_C, 1 hit
PF00009, GTP_EFTU, 1 hit
PF03144, GTP_EFTU_D2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00315, ELONGATNFCT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50447, SSF50447, 1 hit
SSF50465, SSF50465, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51722, G_TR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform B (identifier: Q24208-1) [UniParc]FASTAAdd to basket
Also known as: eIF-2gamma

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAEAQIGV NRNLQKQDLS NLDVSKLTPL SPEVISRQAT INIGTIGHVA
60 70 80 90 100
HGKSTVVKAI SGVQTVRFKN ELERNITIKL GYANAKIYKC DNPKCPRPAS
110 120 130 140 150
FVSDASSKDD SLPCTRLNCS GNFRLVRHVS FVDCPGHDIL MATMLNGAAV
160 170 180 190 200
MDAALLLIAG NESCPQPQTS EHLAAIEIMK LKQILILQNK IDLIKESQAK
210 220 230 240 250
EQYEEITKFV QGTVAEGAPI IPISAQLKYN IDVLCEYIVN KIPVPPRDFN
260 270 280 290 300
APPRLIVIRS FDVNKPGCEV ADLKGGVAGG SILSGVLKVG QEIEVRPGVV
310 320 330 340 350
TKDSDGNITC RPIFSRIVSL FAEQNELQYA VPGGLIGVGT KIDPTLCRAD
360 370 380 390 400
RLVGQVLGAV GQLPDIYQEL EISYYLLRRL LGVRTDGDKK GARVEKLQKN
410 420 430 440 450
EILLVNIGSL STGGRISATK GDLAKIVLTT PVCTEKGEKI ALSRRVENHW
460 470
RLIGWGQIFG GKTITPVLDS QVAKK
Length:475
Mass (Da):51,485
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8370B07089DD5422
GO
Isoform C (identifier: Q24208-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MATAEAQIGVNRNLQKQDLSNL → MHLRGDVLLGGVAA

Show »
Length:467
Mass (Da):50,479
Checksum:i86EED8A178B745D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KGP8A0A0B4KGP8_DROME
Protein-synthesizing GTPase
eIF2gamma 51kDa protein, CG6476, Dmel\CG43665, eIF-2G, eIF-2gamma
475Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0014321 – 22MATAE…DLSNL → MHLRGDVLLGGVAA in isoform C. CuratedAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X80069 mRNA Translation: CAA56375.1
AJ290956 Genomic DNA Translation: CAB93767.1
AE014297 Genomic DNA Translation: AAF55153.1
AE014297 Genomic DNA Translation: AAN13641.1
AY061102 mRNA Translation: AAL28650.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S47005, S46941

NCBI Reference Sequences

More...
RefSeqi
NP_001262587.1, NM_001275658.1 [Q24208-1]
NP_731993.1, NM_169629.2 [Q24208-1]
NP_731994.1, NM_169630.2 [Q24208-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0310386; FBpp0302537; FBgn0263740 [Q24208-1]
FBtr0310387; FBpp0302538; FBgn0263740 [Q24208-2]
FBtr0337054; FBpp0307983; FBgn0263740 [Q24208-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41843

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG43665

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80069 mRNA Translation: CAA56375.1
AJ290956 Genomic DNA Translation: CAB93767.1
AE014297 Genomic DNA Translation: AAF55153.1
AE014297 Genomic DNA Translation: AAN13641.1
AY061102 mRNA Translation: AAL28650.1
PIRiS47005, S46941
RefSeqiNP_001262587.1, NM_001275658.1 [Q24208-1]
NP_731993.1, NM_169629.2 [Q24208-1]
NP_731994.1, NM_169630.2 [Q24208-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi66907, 9 interactors
STRINGi7227.FBpp0302537

Proteomic databases

PaxDbiQ24208
PRIDEiQ24208

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
41843

Genome annotation databases

EnsemblMetazoaiFBtr0310386; FBpp0302537; FBgn0263740 [Q24208-1]
FBtr0310387; FBpp0302538; FBgn0263740 [Q24208-2]
FBtr0337054; FBpp0307983; FBgn0263740 [Q24208-1]
GeneIDi41843
KEGGidme:Dmel_CG43665

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41843
FlyBaseiFBgn0263740, eIF2gamma
VEuPathDBiVectorBase:FBgn0263740

Phylogenomic databases

eggNOGiKOG0466, Eukaryota
GeneTreeiENSGT00940000172475
OMAiNIGMVGH
PhylomeDBiQ24208

Enzyme and pathway databases

ReactomeiR-DME-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-381042, PERK regulates gene expression
R-DME-382556, ABC-family proteins mediated transport
R-DME-72649, Translation initiation complex formation
R-DME-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702, Ribosomal scanning and start codon recognition
R-DME-72731, Recycling of eIF2:GDP

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
41843, 1 hit in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41843

Protein Ontology

More...
PROi
PR:Q24208

Gene expression databases

BgeeiFBgn0263740, Expressed in egg chamber and 55 other tissues
ExpressionAtlasiQ24208, baseline and differential
GenevisibleiQ24208, DM

Family and domain databases

CDDicd01888, eIF2_gamma, 1 hit
cd03688, eIF2_gamma_II, 1 hit
cd15490, eIF2_gamma_III, 1 hit
Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR004161, EFTu-like_2
IPR015256, eIF2g_C
IPR044127, eIF2g_dom_2
IPR044128, eIF2g_GTP-bd
IPR027417, P-loop_NTPase
IPR000795, T_Tr_GTP-bd_dom
IPR009000, Transl_B-barrel_sf
IPR009001, Transl_elong_EF1A/Init_IF2_C
PfamiView protein in Pfam
PF09173, eIF2_C, 1 hit
PF00009, GTP_EFTU, 1 hit
PF03144, GTP_EFTU_D2, 1 hit
PRINTSiPR00315, ELONGATNFCT
SUPFAMiSSF50447, SSF50447, 1 hit
SSF50465, SSF50465, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51722, G_TR_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF2G_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24208
Secondary accession number(s): Q9VFA7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families
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