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Protein

Non-specific serine/threonine protein kinase

Gene

Pak

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: FlyBase
  • Rac GTPase binding Source: FlyBase
  • Rho GTPase binding Source: FlyBase
  • SH3 domain binding Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • cell adhesion Source: FlyBase
  • dorsal closure Source: FlyBase
  • dorsal closure, spreading of leading edge cells Source: FlyBase
  • ecdysone-mediated induction of salivary gland cell autophagic cell death Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • JNK cascade Source: FlyBase
  • positive regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • Rac protein signal transduction Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of programmed cell death Source: FlyBase
  • regulation of synapse structure or activity Source: FlyBase
  • septate junction assembly Source: FlyBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-376172 DSCAM interactions
R-DME-389359 CD28 dependent Vav1 pathway
R-DME-3928662 EPHB-mediated forward signaling
R-DME-3928664 Ephrin signaling
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-445144 Signal transduction by L1
R-DME-445355 Smooth Muscle Contraction
R-DME-5218920 VEGFR2 mediated vascular permeability
R-DME-5621575 CD209 (DC-SIGN) signaling
R-DME-5627123 RHO GTPases activate PAKs
R-DME-5687128 MAPK6/MAPK4 signaling
SignaLinkiQ24190

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesi
Name:PakImported
ORF Names:CG10295Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0267698 Pak

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiQ24190
PRIDEiQ24190

Expressioni

Gene expression databases

BgeeiFBgn0267698
ExpressionAtlasiQ24190 baseline and differential

Interactioni

GO - Molecular functioni

  • Rac GTPase binding Source: FlyBase
  • Rho GTPase binding Source: FlyBase
  • SH3 domain binding Source: FlyBase

Protein-protein interaction databases

IntActiQ24190, 29 interactors

Structurei

3D structure databases

ProteinModelPortaliQ24190
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 96CRIBInterPro annotationAdd BLAST14
Domaini430 – 681Protein kinaseInterPro annotationAdd BLAST252

Phylogenomic databases

eggNOGiKOG0578 Eukaryota
ENOG410XP4K LUCA
OrthoDBiEOG091G04H8

Family and domain databases

CDDicd01093 CRIB_PAK_like, 1 hit
Gene3Di3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR033923 PAK_BD
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q24190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEEDKPPA PPVRLTSNRG GNERSGGGVG VGGGGLGGGG MGDVPPDMRP
60 70 80 90 100
LPKEPDDSDR KKKTLKSKIK GSKPSHTDSK PNISYPTNFE HTVHVGFDAV
110 120 130 140 150
TGEFTGMPEA WARLLMNSNI SKQEQKKNPQ AVLDVLKWFD NTTKQRPSSK
160 170 180 190 200
YMTNAITTHS GSSLSRVSSS SPSSTPTDSE LHGSNSGGNL IGVQLGSMTL
210 220 230 240 250
GPNANNVAVA GQILGNHYQQ QQQHLLQQQQ PLLHQNHNQH HMGISQSHSY
260 270 280 290 300
NFVGHTVSSS TSQHSSANED DMLGPQHPQQ QPPPPPVASR PERTKSIYTR
310 320 330 340 350
PIEDLQPAII PMPVAPATTP ATPLQNHRTP GGISAPATSP MMHNNATTTL
360 370 380 390 400
DKNKNNANLY TPEPTVAQVS AGGPSSQVAG NQIAVPQAAV APAATPNTRA
410 420 430 440 450
ANAKKKKMSD EEILEKLRTI VSVGDPNRKY TKMEKIGQGA SGTVYTAIES
460 470 480 490 500
STGMEVAIKQ MNLSQQPKKE LIINEILVMR ENKHPNVVNY LDSYLVSEEL
510 520 530 540 550
WVVMEYLPGG SLTDVVTETC MDEGQIAAVC REVLQALEFL HANQVIHRDI
560 570 580 590 600
KSDNILLGLD GSVKLTDFGF CAQISPEQSK RTTMVGTPYW MAPEVVTRKQ
610 620 630 640 650
YGPKVDLWSL GIMAIEMVEG EPPYLNENPL KALYLIATNG KPEIKEKDKL
660 670 680 690 700
SSAFQDFLDQ CLEVEVDRRA SALDLLKHPF LKLARPLASL TPLIMAAKEA

TKGN
Length:704
Mass (Da):76,217
Last modified:November 1, 1996 - v1
Checksum:iB0A0938CE9408C32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49446 mRNA Translation: AAC47094.1

Similar proteinsi

Entry informationi

Entry nameiQ24190_DROME
AccessioniPrimary (citable) accession number: Q24190
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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