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Protein

Protein similar

Gene

sima

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-8951664 Neddylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein similar
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sima
ORF Names:CG45051
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0266411 sima

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001274441 – 1507Protein similarAdd BLAST1507

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24167

PRoteomics IDEntifications database

More...
PRIDEi
Q24167

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed in the embryo.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By hypoxia.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0266411 Expressed in 33 organ(s), highest expression level in Malpighian tubule

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q24167 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24167 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with Vhl.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
68436, 202 interactors

Database of interacting proteins

More...
DIPi
DIP-21002N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q24167

Protein interaction database and analysis system

More...
IntActi
Q24167, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0084931

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q24167

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q24167

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 125bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini167 – 240PAS 1PROSITE-ProRule annotationAdd BLAST74
Domaini307 – 377PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini381 – 422PACAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni692 – 863ODDAdd BLAST172

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili880 – 908Sequence analysisAdd BLAST29
Coiled coili982 – 1054Sequence analysisAdd BLAST73
Coiled coili1110 – 1162Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 39Poly-SerAdd BLAST14
Compositional biasi577 – 587Pro-richAdd BLAST11
Compositional biasi718 – 725Poly-Ser8
Compositional biasi759 – 763Poly-Gln5
Compositional biasi767 – 776Poly-Gln10
Compositional biasi907 – 918Poly-GlnAdd BLAST12
Compositional biasi945 – 948Poly-Gln4
Compositional biasi990 – 998Poly-Gln9
Compositional biasi1020 – 1038Poly-GlnAdd BLAST19
Compositional biasi1113 – 1126Poly-GlnAdd BLAST14
Compositional biasi1146 – 1162Poly-GlnAdd BLAST17
Compositional biasi1205 – 1208Poly-Gln4
Compositional biasi1277 – 1284Poly-Gln8
Compositional biasi1298 – 1301Poly-Asp4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The oxygen-dependent degradation (ODD) domain is required for cytoplasmic localization in normoxia.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3558 Eukaryota
ENOG410YK57 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169547

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24167

KEGG Orthology (KO)

More...
KOi
K08268

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0486

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q24167

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit
cd00130 PAS, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q24167-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSLIDTIEA AAEKQKQSQA VVTNTSASSS SCSSSFSSSP PSSSVGSPSP
60 70 80 90 100
GAPKTNLTAS GKPKEKRRNN EKRKEKSRDA ARCRRSKETE IFMELSAALP
110 120 130 140 150
LKTDDVNQLD KASVMRITIA FLKIREMLQF VPSLRDCNDD IKQDIETAED
160 170 180 190 200
QQEVKPKLEV GTEDWLNGAE ARELLKQTMD GFLLVLSHEG DITYVSENVV
210 220 230 240 250
EYLGITKIDT LGQQIWEYSH QCDHAEIKEA LSLKRELAQK VKDEPQQNSG
260 270 280 290 300
VSTHHRDLFV RLKCTLTSRG RSINIKSASY KVIHITGHLV VNAKGERLLM
310 320 330 340 350
AIGRPIPHPS NIEIPLGTST FLTKHSLDMR FTYVDDKMHD LLGYSPKDLL
360 370 380 390 400
DTSLFSCQHG ADSERLMATF KSVLSKGQGE TSRYRFLGKY GGYCWILSQA
410 420 430 440 450
TIVYDKLKPQ SVVCVNYVIS NLENKHEIYS LAQQTAASEQ KEQHHQAAET
460 470 480 490 500
EKEPEKAADP EIIAQETKET VNTPIHTSEL QAKPLQLESE KAEKTIEETK
510 520 530 540 550
TIATIPPVTA TSTADQIKQL PESNPYKQIL QAELLIKREN HSPGPRTITA
560 570 580 590 600
QLLSGSSSGL RPEEKRPKSV TASVLRPSPA PPLTPPPTAV LCKKTPLGVE
610 620 630 640 650
PNLPPTTTAT AAIISSSNQQ LQIAQQTQLQ NPQQPAQDMS KGFCSLFADD
660 670 680 690 700
GRGLTMLKEE PDDLSHHLAS TNCIQLDEMT PFSDMLVGLM GTCLLPEDIN
710 720 730 740 750
SLDSTTCSTT ASGQHYQSPS SSSTSAPSNT SSSNNSYANS PLSPLTPNST
760 770 780 790 800
ATASNPSHQQ QQQHHNQQQQ QQQQQQHHPQ HHDNSNSSSN IDPLFNYREE
810 820 830 840 850
SNDTSCSQHL HSPSITSKSP EDSSLPSLCS PNSLTQEDDF SFEAFAMRAP
860 870 880 890 900
YIPIDDDMPL LTETDLMWCP PEDLQTMVPK EIDAIQQQLQ QLQQQHHQQY
910 920 930 940 950
AGNTGYQQQQ QQPQLQQQHF SNSLCSSPAS TVSSLSPSPV QQHHQQQQAA
960 970 980 990 1000
VFTSDSSELA ALLCGSGNGT LSILAGSGVT VAEECNERLQ QHQQQQQQTS
1010 1020 1030 1040 1050
GNEFRTFQQL QQELQLQEEQ QQRQQQQQQQ QQQQQQQQLL SLNIECKKEK
1060 1070 1080 1090 1100
YDVQMGGSLC HPMEDAFEND YSKDSANLDC WDLIQMQVVD TEPVSPNAAS
1110 1120 1130 1140 1150
PTPCKVSAIQ LLQQQQQLQQ QQQQQQNIIL NAVPLITIQN NKELMQQQQQ
1160 1170 1180 1190 1200
QQQQQQQEQL QQPAIKLLNG ASIAPVNTKA TIRLVESKPP TTTQSRMAKV
1210 1220 1230 1240 1250
NLVPQQQQHG NKRHLNSATG AGNPVESKRL KSGTLCLDVQ SPQLLQQLIG
1260 1270 1280 1290 1300
KDPAQQQTQA AKRAGSERWQ LSAESKQQKQ QQQQSNSVLK NLLVSGRDDD
1310 1320 1330 1340 1350
DSEAMIIDED NSLVQPIPLG KYGLPLHCHT STSSVLRDYH NNPLISGTNF
1360 1370 1380 1390 1400
QLSPVFGGSD SSGGDGETGS VVSLDDSVPP GLTACDTDAS SDSGIDENSL
1410 1420 1430 1440 1450
MDGASGSPRK RLSSTSNSTN QAESAPPALD VETPVTQKSV EEEFEGGGSG
1460 1470 1480 1490 1500
SNAPSRKTSI SFLDSSNPLL HTPAMMDLVN DDYIMGEGGF EFSDNQLEQV

LGWPEIA
Length:1,507
Mass (Da):165,824
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4102939C8FBFB0C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LIX2A0A0B4LIX2_DROME
Similar, isoform D
sima 7951, bHLHe56, CG31031, CG7951, dHIF-1alpha
1,593Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z0S3B7Z0S3_DROME
Similar, isoform B
sima 7951, bHLHe56, CG31031, CG7951, dHIF-1alpha
426Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHI3A0A0B4KHI3_DROME
Similar, isoform C
sima 7951, bHLHe56, CG31031, CG7951, dHIF-1alpha
869Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti38S → A in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti345S → L in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti492A → V in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti588T → I in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti709T → K in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti776Q → QQQQ in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti895Q → QQ in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti902G → S in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti982A → T in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti1125 – 1126Missing in AAC47303 (PubMed:8682312).Curated2
Sequence conflicti1154 – 1157Missing in AAC47303 (PubMed:8682312).Curated4
Sequence conflicti1444F → L in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti1447G → C in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti1451S → N in AAC47303 (PubMed:8682312).Curated1
Sequence conflicti1494D → G in AAC47303 (PubMed:8682312).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U43090 mRNA Translation: AAC47303.1
AE014297 Genomic DNA Translation: AAF57008.2

Protein sequence database of the Protein Information Resource

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PIRi
JC4851

NCBI Reference Sequences

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RefSeqi
NP_524584.2, NM_079845.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.6953

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0344374; FBpp0310747; FBgn0266411

Database of genes from NCBI RefSeq genomes

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GeneIDi
43580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG45051

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43090 mRNA Translation: AAC47303.1
AE014297 Genomic DNA Translation: AAF57008.2
PIRiJC4851
RefSeqiNP_524584.2, NM_079845.4
UniGeneiDm.6953

3D structure databases

ProteinModelPortaliQ24167
SMRiQ24167
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68436, 202 interactors
DIPiDIP-21002N
ELMiQ24167
IntActiQ24167, 4 interactors
STRINGi7227.FBpp0084931

Proteomic databases

PaxDbiQ24167
PRIDEiQ24167

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0344374; FBpp0310747; FBgn0266411
GeneIDi43580
KEGGidme:Dmel_CG45051

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43580
FlyBaseiFBgn0266411 sima

Phylogenomic databases

eggNOGiKOG3558 Eukaryota
ENOG410YK57 LUCA
GeneTreeiENSGT00940000169547
InParanoidiQ24167
KOiK08268
OrthoDBiEOG091G0486
PhylomeDBiQ24167

Enzyme and pathway databases

ReactomeiR-DME-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-8951664 Neddylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
sima fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
43580

Protein Ontology

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PROi
PR:Q24167

Gene expression databases

BgeeiFBgn0266411 Expressed in 33 organ(s), highest expression level in Malpighian tubule
ExpressionAtlasiQ24167 baseline and differential
GenevisibleiQ24167 DM

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
PfamiView protein in Pfam
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIMA_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24167
Secondary accession number(s): Q9VAA5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 21, 2001
Last modified: December 5, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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