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Entry version 203 (02 Jun 2021)
Sequence version 1 (01 Nov 1997)
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Protein

Signal transducer and transcription activator

Gene

Stat92E

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1059683, Interleukin-6 signaling
R-DME-1169408, ISG15 antiviral mechanism
R-DME-1251985, Nuclear signaling by ERBB4
R-DME-209228, Formation of the activated STAT92E dimer and transport to the nucleus
R-DME-209394, Transcriptional activtion and repression of REL-68 target genes
R-DME-209405, JAK/STAT pathway
R-DME-210671, Transcriptional repression by nuclear factors
R-DME-210688, Dephosphorylation by PTP61F phosphatases
R-DME-210693, STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol
R-DME-3249367, STAT6-mediated induction of chemokines
R-DME-6783783, Interleukin-10 signaling
R-DME-6785807, Interleukin-4 and Interleukin-13 signaling
R-DME-877300, Interferon gamma signaling
R-DME-877312, Regulation of IFNG signaling
R-DME-8854691, Interleukin-20 family signaling
R-DME-8983432, Interleukin-15 signaling
R-DME-8984722, Interleukin-35 Signalling
R-DME-8985947, Interleukin-9 signaling
R-DME-9008059, Interleukin-37 signaling
R-DME-9020591, Interleukin-12 signaling
R-DME-9020933, Interleukin-23 signaling
R-DME-9020956, Interleukin-27 signaling
R-DME-909733, Interferon alpha/beta signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q24151

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal transducer and transcription activator
Short name:
d-STAT
Alternative name(s):
Protein marelle
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Stat92E
Synonyms:MARE, mrL, Stat
ORF Names:CG4257
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0016917, Stat92E

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies exhibit aberrant expression of the pair rule gene even-skipped at the cellular blastoderm stage, leading to larval segmentation defects.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001824351 – 761Signal transducer and transcription activatorAdd BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei711Phosphotyrosine; by JAK2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated by hopscotch. Phosphorylation is required for DNA-binding activity and dimerization.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24151

PRoteomics IDEntifications database

More...
PRIDEi
Q24151

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q24151

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryonic, larval, pupal, and adult stages, with some decrease in the late embryonic stages. The expression is uniform in unfertilized or just fertilized eggs, suggesting maternally deposited mRNA. At blastoderm stage, expression pattern shows stripes, that are reminiscent of many pair rule genes pattern.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0016917, Expressed in embryo and 71 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q24151, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24151, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a homodimer or a heterodimer with a related family member.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
67407, 63 interactors

Database of interacting proteins

More...
DIPi
DIP-29510N

Protein interaction database and analysis system

More...
IntActi
Q24151, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088489

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q24151

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini594 – 658SH2PROSITE-ProRule annotationAdd BLAST65

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3667, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234663

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24151

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q24151

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR001217, STAT
IPR036535, STAT_N_sf
IPR013800, STAT_TF_alpha
IPR015988, STAT_TF_coiled-coil
IPR013801, STAT_TF_DNA-bd
IPR012345, STAT_TF_DNA-bd_N
IPR013799, STAT_TF_prot_interaction

The PANTHER Classification System

More...
PANTHERi
PTHR11801, PTHR11801, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017, SH2, 1 hit
PF01017, STAT_alpha, 1 hit
PF02864, STAT_bind, 1 hit
PF02865, STAT_int, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00964, STAT_int, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47655, SSF47655, 1 hit
SSF49417, SSF49417, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform F (identifier: Q24151-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLWKRISSH VDCEQRMAAY YEEKGMLELR LCLAPWIEDR IMSEQITPNT
60 70 80 90 100
TDQLERVALK FNEDLQQKLL STRTASDQAL KFRVVELCAL IQRISAVELY
110 120 130 140 150
THLRSGLQKE LQLVTEKSVA ATAGQSMPLN PYNMNNTPMV TGYMVDPSDL
160 170 180 190 200
LAVSNSCNPP VVQGIGPIHN VQNTGIASPA LGMVTPKVEL YEVQHQIMQS
210 220 230 240 250
LNEFGNCANA LKLLAQNYSY MLNSTSSPNA EAAYRSLIDE KAAIVLTMRR
260 270 280 290 300
SFMYYESLHE MVIHELKNWR HQQAQAGNGA PFNEGSLDDI QRCFEMLESF
310 320 330 340 350
IAHMLAAVKE LMRVRLVTEE PELTHLLEQV QNAQKNLVCS AFIVDKQPPQ
360 370 380 390 400
VMKTNTRFAA SVRWLIGSQL GIHNNPPTVE CIIMSEIQSQ RFVTRNTQMD
410 420 430 440 450
NSSLSGQSSG EIQNASSTME YQQNNHVFSA SFRNMQLKKI KRAEKKGTES
460 470 480 490 500
VMDEKFALFF YTTTTVNDFQ IRVWTLSLPV VVIVHGNQEP QSWATITWDN
510 520 530 540 550
AFAEIVRDPF MITDRVTWAQ LSVALNIKFG SCTGRSLTID NLDFLYEKLQ
560 570 580 590 600
REERSEYITW NQFCKEPMPD RSFTFWEWFF AIMKLTKDHM LGMWKAGCIM
610 620 630 640 650
GFINKTKAQT DLLRSVYGIG TFLLRFSDSE LGGVTIAYVN ENGLVTMLAP
660 670 680 690 700
WTARDFQVLN LADRIRDLDV LCWLHPSDRN ASPVKRDVAF GEFYSKRQEP
710 720 730 740 750
EPLVLDPVTG YVKSTLHVHV CRNGENGSTS GTPHHAQESM QLGNGDFGMA
760
DFDTITNFEN F
Length:761
Mass (Da):86,415
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF3A622A29899161
GO
Isoform B (identifier: Q24151-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     699-705: Missing.

Show »
Length:628
Mass (Da):71,198
Checksum:i841208C04B2A91D0
GO
Isoform C (identifier: Q24151-2) [UniParc]FASTAAdd to basket
Also known as: E, Short

The sequence of this isoform differs from the canonical sequence as follows:
     699-705: Missing.

Show »
Length:754
Mass (Da):85,637
Checksum:iB607B3328A4A4956
GO
Isoform G (identifier: Q24151-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Show »
Length:635
Mass (Da):71,976
Checksum:iA3B0A8FFC32BCCF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KHS7A0A0B4KHS7_DROME
Signal transducer and activator of ...
Stat92E D-STAT, D-Stat, D-stat, d-STAT, Dmel\CG4257
761Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KGE1A0A0B4KGE1_DROME
Signal transducer and activator of ...
Stat92E D-STAT, D-Stat, D-stat, d-STAT, Dmel\CG4257
818Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KGI7A0A0B4KGI7_DROME
Signal transducer and activator of ...
Stat92E D-STAT, D-Stat, D-stat, d-STAT, Dmel\CG4257
811Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KH10A0A0B4KH10_DROME
Signal transducer and activator of ...
Stat92E D-STAT, D-Stat, D-stat, d-STAT, Dmel\CG4257
679Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHS6A0A0B4KHS6_DROME
Signal transducer and activator of ...
Stat92E D-STAT, D-Stat, D-stat, d-STAT, Dmel\CG4257
635Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM11192 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti105S → T in AAB02195 (PubMed:8608596).Curated1
Sequence conflicti648L → H in AAB02195 (PubMed:8608596).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0127521 – 126Missing in isoform B and isoform G. CuratedAdd BLAST126
Alternative sequenceiVSP_006290699 – 705Missing in isoform B and isoform C. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U40070 mRNA Translation: AAC46984.1
U46688 mRNA Translation: AAB02195.1
AE014297 Genomic DNA Translation: AAN14350.2
AE014297 Genomic DNA Translation: AAN14351.2
AE014297 Genomic DNA Translation: AAS65180.1
AE014297 Genomic DNA Translation: AAX52969.1
BT021314 mRNA Translation: AAX33462.1
AY094839 mRNA Translation: AAM11192.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001014643.1, NM_001014643.2 [Q24151-4]
NP_001262757.1, NM_001275828.1 [Q24151-4]
NP_001262762.1, NM_001275833.1 [Q24151-1]
NP_732516.2, NM_169899.3 [Q24151-2]
NP_732517.2, NM_169900.3 [Q24151-3]
NP_996242.1, NM_206520.2 [Q24151-2]
NP_996243.1, NM_206521.2 [Q24151-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089484; FBpp0088487; FBgn0016917 [Q24151-3]
FBtr0089485; FBpp0088488; FBgn0016917 [Q24151-2]
FBtr0089486; FBpp0088489; FBgn0016917 [Q24151-1]
FBtr0089487; FBpp0088978; FBgn0016917 [Q24151-2]
FBtr0100457; FBpp0099882; FBgn0016917 [Q24151-4]
FBtr0334581; FBpp0306648; FBgn0016917 [Q24151-4]
FBtr0334586; FBpp0306653; FBgn0016917 [Q24151-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42428

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4257

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40070 mRNA Translation: AAC46984.1
U46688 mRNA Translation: AAB02195.1
AE014297 Genomic DNA Translation: AAN14350.2
AE014297 Genomic DNA Translation: AAN14351.2
AE014297 Genomic DNA Translation: AAS65180.1
AE014297 Genomic DNA Translation: AAX52969.1
BT021314 mRNA Translation: AAX33462.1
AY094839 mRNA Translation: AAM11192.1 Different initiation.
RefSeqiNP_001014643.1, NM_001014643.2 [Q24151-4]
NP_001262757.1, NM_001275828.1 [Q24151-4]
NP_001262762.1, NM_001275833.1 [Q24151-1]
NP_732516.2, NM_169899.3 [Q24151-2]
NP_732517.2, NM_169900.3 [Q24151-3]
NP_996242.1, NM_206520.2 [Q24151-2]
NP_996243.1, NM_206521.2 [Q24151-1]

3D structure databases

SMRiQ24151
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi67407, 63 interactors
DIPiDIP-29510N
IntActiQ24151, 4 interactors
STRINGi7227.FBpp0088489

PTM databases

iPTMnetiQ24151

Proteomic databases

PaxDbiQ24151
PRIDEiQ24151

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
42428

Genome annotation databases

EnsemblMetazoaiFBtr0089484; FBpp0088487; FBgn0016917 [Q24151-3]
FBtr0089485; FBpp0088488; FBgn0016917 [Q24151-2]
FBtr0089486; FBpp0088489; FBgn0016917 [Q24151-1]
FBtr0089487; FBpp0088978; FBgn0016917 [Q24151-2]
FBtr0100457; FBpp0099882; FBgn0016917 [Q24151-4]
FBtr0334581; FBpp0306648; FBgn0016917 [Q24151-4]
FBtr0334586; FBpp0306653; FBgn0016917 [Q24151-1]
GeneIDi42428
KEGGidme:Dmel_CG4257

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
42428
FlyBaseiFBgn0016917, Stat92E

Phylogenomic databases

eggNOGiKOG3667, Eukaryota
GeneTreeiENSGT01030000234663
InParanoidiQ24151
PhylomeDBiQ24151

Enzyme and pathway databases

ReactomeiR-DME-1059683, Interleukin-6 signaling
R-DME-1169408, ISG15 antiviral mechanism
R-DME-1251985, Nuclear signaling by ERBB4
R-DME-209228, Formation of the activated STAT92E dimer and transport to the nucleus
R-DME-209394, Transcriptional activtion and repression of REL-68 target genes
R-DME-209405, JAK/STAT pathway
R-DME-210671, Transcriptional repression by nuclear factors
R-DME-210688, Dephosphorylation by PTP61F phosphatases
R-DME-210693, STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol
R-DME-3249367, STAT6-mediated induction of chemokines
R-DME-6783783, Interleukin-10 signaling
R-DME-6785807, Interleukin-4 and Interleukin-13 signaling
R-DME-877300, Interferon gamma signaling
R-DME-877312, Regulation of IFNG signaling
R-DME-8854691, Interleukin-20 family signaling
R-DME-8983432, Interleukin-15 signaling
R-DME-8984722, Interleukin-35 Signalling
R-DME-8985947, Interleukin-9 signaling
R-DME-9008059, Interleukin-37 signaling
R-DME-9020591, Interleukin-12 signaling
R-DME-9020933, Interleukin-23 signaling
R-DME-9020956, Interleukin-27 signaling
R-DME-909733, Interferon alpha/beta signaling
SignaLinkiQ24151

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
42428, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
42428

Protein Ontology

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PROi
PR:Q24151

Gene expression databases

BgeeiFBgn0016917, Expressed in embryo and 71 other tissues
ExpressionAtlasiQ24151, baseline and differential
GenevisibleiQ24151, DM

Family and domain databases

Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR001217, STAT
IPR036535, STAT_N_sf
IPR013800, STAT_TF_alpha
IPR015988, STAT_TF_coiled-coil
IPR013801, STAT_TF_DNA-bd
IPR012345, STAT_TF_DNA-bd_N
IPR013799, STAT_TF_prot_interaction
PANTHERiPTHR11801, PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF01017, STAT_alpha, 1 hit
PF02864, STAT_bind, 1 hit
PF02865, STAT_int, 1 hit
SMARTiView protein in SMART
SM00964, STAT_int, 1 hit
SUPFAMiSSF47655, SSF47655, 1 hit
SSF49417, SSF49417, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAT_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24151
Secondary accession number(s): Q0KI43
, Q24181, Q59DV7, Q5BIB0, Q8IN54, Q8SX55, Q9VDL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 2, 2021
This is version 203 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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