UniProtKB - Q24120 (CAPU_DROME)

BLAST

>sp|Q24120|CAPU_DROME Protein cappuccino OS=Drosophila melanogaster OX=7227 GN=capu PE=1 SV=2
MALQLGKKLAQVLGSGAGSPLTPGTMEPCAAGSGSPLANGELFNVSKAKKVELQNLSSRF
TAAVTQTPPGVTSSTPNESGVTGPAGPLGATTSSPSLETQSTVIISFKSSQTPVQSQTNS
AASENVEDDTAPLPLPPPPPGFGTPTTPLLSSNVLKKVASFTVEKSSAGNNSSNPPNLCP
TSDETTLLATPCSSSLTVATLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSFAAYEKFE
GQMLIKWLISTMQSNPKSSSGDANQELFNTLALQFCNNLKYVGVLKQISNEHLDCGFSPY
EMYQWTHTEQPTTSLPLTPGKLDKVAAWPFSSTPSGIRALESASLASLGAGGVAGSLATI
ATASTASSDNQKTLQQILKKRLLNCTTLAEVHAVVNELLSSVDEPPRRPSKRCVNLTELL
NASEATVYEYNKTGAEGCVKSFTDAETQTESEDCEGTCKCGQSSTKVSDNESAKEDGEKP
HAVAPPPPPPPPPLHAFVAPPPPPPPPPPPPPPLANYGAPPPPPPPPPGSGSAPPPPPPA
PIEGGGGIPPPPPPMSASPSKTTISPAPLPDPAEGNWFHRTNTMRKSAVNPPKPMRPLYW
TRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPPTAPPATKEIWTEIEETP
LDNIDEFTELFSRQAIAPVSKPKELKVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIEH
AIYHIDTSVVSLEALQHMSNIQATEDELQRIKEAAGGDIPLDHPEQFLLDISLISMASER
ISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRGQ
ADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKEGVHPLEIRLPIPEPADVERAA
QMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEFVEGADKSMAKLHQ
SLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFKDIWKKEITSLLNE
LMKKSKQAQIESRRNVSTKVEKSGRISLKERMLMRRSKN

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History
Entry version 136 (10 Oct 2018)
Sequence version 2 (21 Feb 2001)
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Protein

Protein cappuccino

Gene

capu

Organism

Drosophila melanogaster (Fruit fly)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts as an actin nucleation factor and promotes assembly of actin filaments together with spir. May play a role in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport.1 Publication

GO - Molecular functionⁱ

actin binding
Source: FlyBase
Inferred from sequence or structural similarityⁱ
- 10908588
microtubule binding
Source: FlyBase
Inferred from direct assayⁱ
- 24362037

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament-based process
Source: FlyBase
Inferred from direct assayⁱ
- 16518391
actin filament organization
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 17925229
actin nucleation
Source: FlyBase
Inferred from direct assayⁱ
- 16518391
chorion-containing eggshell formation
Source: FlyBase
Inferred from high throughput mutant phenotypeⁱ
- 1783295
oogenesis
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 24089467
pole plasm assembly
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 2151612
pole plasm oskar mRNA localization
Source: FlyBase
Traceable author statementⁱ
- 11700288
pole plasm RNA localization
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 2151612
protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Developmental protein
Biological process	Protein transport, Stress response, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein cappuccino
Gene namesⁱ	Name:capu ORF Names:CG3399
Organismⁱ	Drosophila melanogaster (Fruit fly)
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome 2L

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0000256 capu

FlyBaseⁱ

FBgn0000256 capu

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	1049	K → A or D: Abolishes interaction with spir. 1 Publication	1
Mutagenesisⁱ	1051	R → A or D: Abolishes interaction with spir. 1 Publication	1
Mutagenesisⁱ	1055	R → A or D: Abolishes interaction with spir. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000194884	1 – 1059	Protein cappuccinoAdd BLAST		1059

Proteomic databases

PaxDbⁱ	Q24120
PRIDEⁱ	Q24120

Expressionⁱ

Gene expression databases

Bgeeⁱ	FBgn0000256 Expressed in 41 organ(s), highest expression level in testis
ExpressionAtlasⁱ	Q24120 baseline and differential
Genevisibleⁱ	Q24120 DM

Interactionⁱ

Subunit structureⁱ

GO - Molecular functionⁱ

actin binding
Source: FlyBase
Inferred from sequence or structural similarityⁱ
- 10908588
microtubule binding
Source: FlyBase
Inferred from direct assayⁱ
- 24362037

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	59814, 12 interactors
IntActⁱ	Q24120, 3 interactors
STRINGⁱ	7227.FBpp0288517

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q24120
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	480 – 560	FH1Add BLAST		81
Domainⁱ	585 – 1032	FH2PROSITE-ProRule annotationAdd BLAST		448

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1049 – 1059	Important for interaction with spirAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the formin homology family. Cappuccino subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1922 Eukaryota ENOG410XQWC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136417
HOGENOMⁱ	HOG000247006
InParanoidⁱ	Q24120
KEGG Orthology (KO) More...KOⁱ	K02184
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XIA

Family and domain databases

InterProⁱ	View protein in InterPro IPR015425 FH2_Formin IPR001265 Formin_Cappuccino_subfam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02181 FH2, 1 hit
PRINTSⁱ	PR00828 FORMIN
SMARTⁱ	View protein in SMART SM00498 FH2, 1 hit
PROSITEⁱ	View protein in PROSITE PS51444 FH2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show all Align All

Q24120-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALQLGKKLA QVLGSGAGSP LTPGTMEPCA AGSGSPLANG ELFNVSKAKK 
        60         70         80         90        100
VELQNLSSRF TAAVTQTPPG VTSSTPNESG VTGPAGPLGA TTSSPSLETQ 
       110        120        130        140        150
STVIISFKSS QTPVQSQTNS AASENVEDDT APLPLPPPPP GFGTPTTPLL 
       160        170        180        190        200
SSNVLKKVAS FTVEKSSAGN NSSNPPNLCP TSDETTLLAT PCSSSLTVAT 
       210        220        230        240        250
LPPEIAVGAA AGGVAGGAGS RRGSSYVPEK LSFAAYEKFE GQMLIKWLIS 
       260        270        280        290        300
TMQSNPKSSS GDANQELFNT LALQFCNNLK YVGVLKQISN EHLDCGFSPY 
       310        320        330        340        350
EMYQWTHTEQ PTTSLPLTPG KLDKVAAWPF SSTPSGIRAL ESASLASLGA 
       360        370        380        390        400
GGVAGSLATI ATASTASSDN QKTLQQILKK RLLNCTTLAE VHAVVNELLS 
       410        420        430        440        450
SVDEPPRRPS KRCVNLTELL NASEATVYEY NKTGAEGCVK SFTDAETQTE 
       460        470        480        490        500
SEDCEGTCKC GQSSTKVSDN ESAKEDGEKP HAVAPPPPPP PPPLHAFVAP 
       510        520        530        540        550
PPPPPPPPPP PPPLANYGAP PPPPPPPPGS GSAPPPPPPA PIEGGGGIPP 
       560        570        580        590        600
PPPPMSASPS KTTISPAPLP DPAEGNWFHR TNTMRKSAVN PPKPMRPLYW 
       610        620        630        640        650
TRIVTSAPPA PRPPSVANST DSTENSGSSP DEPPAANGAD APPTAPPATK 
       660        670        680        690        700
EIWTEIEETP LDNIDEFTEL FSRQAIAPVS KPKELKVKRA KSIKVLDPER 
       710        720        730        740        750
SRNVGIIWRS LHVPSSEIEH AIYHIDTSVV SLEALQHMSN IQATEDELQR 
       760        770        780        790        800
IKEAAGGDIP LDHPEQFLLD ISLISMASER ISCIVFQAEF EESVTLLFRK 
       810        820        830        840        850
LETVSQLSQQ LIESEDLKLV FSIILTLGNY MNGGNRQRGQ ADGFNLDILG 
       860        870        880        890        900
KLKDVKSKES HTTLLHFIVR TYIAQRRKEG VHPLEIRLPI PEPADVERAA 
       910        920        930        940        950
QMDFEEVQQQ IFDLNKKFLG CKRTTAKVLA ASRPEIMEPF KSKMEEFVEG 
       960        970        980        990       1000
ADKSMAKLHQ SLDECRDLFL ETMRFYHFSP KACTLTLAQC TPDQFFEYWT 
      1010       1020       1030       1040       1050
NFTNDFKDIW KKEITSLLNE LMKKSKQAQI ESRRNVSTKV EKSGRISLKE 

RMLMRRSKN

Length:1,059

Mass (Da):113,864

Last modified:February 21, 2001 - v2

Checksum:ⁱ009B0E24F61B6EA5

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q8IQ12	Q8IQ12_DROME	Cappuccino, isoform J Cappuccino, isoform J	capu capp, Capu, CG15420, CG3399, Dmel\CG3399	1,089	Annotation score:
Q9VQV9	Q9VQV9_DROME	Cappuccino, isoform D Cappuccino, isoform D	capu capp, Capu, CG15420, CG3399, Dmel\CG3399	1,207	Annotation score:
B7Z013	B7Z013_DROME	Cappuccino, isoform I Cappuccino, isoform I	capu capp, Capu, CG15420, CG3399, Dmel\CG3399	1,298	Annotation score:
B7Z011	B7Z011_DROME	Cappuccino, isoform F Cappuccino, isoform F	capu capp, Capu, CG15420, CG3399, Dmel\CG3399	1,361	Annotation score:
B7Z010	B7Z010_DROME	Cappuccino, isoform E Cappuccino, isoform E	capu capp, Capu, CG15420, CG3399, Dmel\CG3399	1,280	Annotation score:
B7Z012	B7Z012_DROME	Cappuccino, isoform H Cappuccino, isoform H	capu capp, Capu, CG15420, CG3399, Dmel\CG3399	1,107	Annotation score:
B7Z014	B7Z014_DROME	Cappuccino, isoform G Cappuccino, isoform G (LP14792p)	capu capp, Capu, capu-RG, CG15420, Dmel\CG3399	932	Annotation score:
Q8MRP5	Q8MRP5_DROME	Cappuccino, isoform B Cappuccino, isoform B (GH07742p)	capu capp, Capu, CG15420, Dmel\CG3399, CG3399	1,049	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	260	S → C in AAC46925 (PubMed:7590229).Curated	1
Sequence conflictⁱ	364	S → T in AAC46925 (PubMed:7590229).Curated	1
Sequence conflictⁱ	386	T → S in AAC46925 (PubMed:7590229).Curated	1
Sequence conflictⁱ	471	E → K in AAC46925 (PubMed:7590229).Curated	1
Sequence conflictⁱ	495	H → P in AAC46925 (PubMed:7590229).Curated	1
Sequence conflictⁱ	513	Missing in AAC46925 (PubMed:7590229).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U34258 mRNA Translation: AAC46925.1 AE014134 Genomic DNA Translation: AAF51054.1
PIRⁱ	T13286
NCBI Reference Sequences More...RefSeqⁱ	NP_476966.1, NM_057618.3
UniGeneⁱ	Dm.4776

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0077513; FBpp0077202; FBgn0000256
GeneIDⁱ	33611
KEGGⁱ	dme:Dmel_CG3399
UCSC genome browser More...UCSCⁱ	CG3399-RA d. melanogaster

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q24120	Cappuccino, isoform F		DROME		1361	UniRef100_Q24120

Protein	Similar proteins		Species	Score	Length	Source
Q24120	Cappuccino, isoform F		DROME		1361	UniRef90_Q24120
Uncharacterized protein, isoform E		DROSI		1426
Uncharacterized protein, isoform D		DROSI		1304

Protein	Similar proteins		Species	Score	Length	Source
Q24120	Cappuccino, isoform F		DROME		1361	UniRef50_Q24120
Uncharacterized protein, isoform E		DROSI		1426
Uncharacterized protein, isoform F		DROAN		1422
Uncharacterized protein, isoform E		DROYA		1305
Uncharacterized protein, isoform B		DROER		1339
+45

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U34258 mRNA Translation: AAC46925.1 AE014134 Genomic DNA Translation: AAF51054.1
PIRⁱ	T13286
RefSeqⁱ	NP_476966.1, NM_057618.3
UniGeneⁱ	Dm.4776

3D structure databases

ProteinModelPortalⁱ	Q24120
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	59814, 12 interactors
IntActⁱ	Q24120, 3 interactors
STRINGⁱ	7227.FBpp0288517

Proteomic databases

PaxDbⁱ	Q24120
PRIDEⁱ	Q24120

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0077513; FBpp0077202; FBgn0000256
GeneIDⁱ	33611
KEGGⁱ	dme:Dmel_CG3399
UCSCⁱ	CG3399-RA d. melanogaster

Organism-specific databases

CTDⁱ	33611
FlyBaseⁱ	FBgn0000256 capu

Phylogenomic databases

eggNOGⁱ	KOG1922 Eukaryota ENOG410XQWC LUCA
GeneTreeⁱ	ENSGT00870000136417
HOGENOMⁱ	HOG000247006
InParanoidⁱ	Q24120
KOⁱ	K02184
OrthoDBⁱ	EOG091G0XIA

Miscellaneous databases

ChiTaRSⁱ	capu fly
GenomeRNAiⁱ	33611
Protein Ontology More...PROⁱ	PR:Q24120

Gene expression databases

Bgeeⁱ	FBgn0000256 Expressed in 41 organ(s), highest expression level in testis
ExpressionAtlasⁱ	Q24120 baseline and differential
Genevisibleⁱ	Q24120 DM

Family and domain databases

InterProⁱ	View protein in InterPro IPR015425 FH2_Formin IPR001265 Formin_Cappuccino_subfam
Pfamⁱ	View protein in Pfam PF02181 FH2, 1 hit
PRINTSⁱ	PR00828 FORMIN
SMARTⁱ	View protein in SMART SM00498 FH2, 1 hit
PROSITEⁱ	View protein in PROSITE PS51444 FH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAPU_DROME
Accessionⁱ	Q24120Primary (citable) accession number: Q24120 Secondary accession number(s): Q9VQV8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	February 21, 2001
	Last modified:	October 10, 2018
	This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

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UniProtKB - Q24120 (CAPU_DROME)

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Protein cappuccino

capu

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Other locations

Cytoskeleton

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ