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Entry version 198 (02 Jun 2021)
Sequence version 4 (13 Jun 2012)
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Protein

Protein trachealess

Gene

trh

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct, Malpighian tubules and the posterior spiracles (PubMed:8557189, PubMed:8557198, PubMed:9374395, PubMed:10502111).

It may induce a general fate of branched tubular structures of epithelial origin (PubMed:8557189, PubMed:8557198, PubMed:10502111).

Functions with tgo to regulate expression of btl (PubMed:9374395).

4 Publications

Miscellaneous

Readthrough of the terminator UGA may occur between the codons for 958-Ser and 960-Val.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein trachealess
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trh
ORF Names:CG6883
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0262139, trh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Tube-forming cells of the salivary gland, trachea, and filzkorper fail to invaginate to form tubes and remain on the embryo surface (PubMed:8557189). In embryo Malpighian tubules, cell rearrangement is incomplete and the resulting tubules are wider than normal (PubMed:10502111).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi233I → N: Malpighian tubules empty into a single large sack that is attached to the hindgut and no ureters are evident. Distal segments of the tubules are tubular but fail to elongate or undergo cell rearrangement, resulting in tubules that are shorter and wider than normal. Hindguts are normal in shape but shortened. 1 Publication1
Mutagenesisi579S → A: No effect on phosphorylation by Akt1; no effect on transcriptional activity. 1 Publication1
Mutagenesisi673S → A: Abolishes phosphorylation by Akt1, nuclear localization, and transcriptional activity. 1 Publication1
Mutagenesisi673S → D: Slightly increases transcriptional activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001274761 – 1022Protein trachealessAdd BLAST1022

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei673Phosphoserine; by PKB/Akt11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ser-673 phosphorylation by PKB/Akt1 is required for nuclear targeting and transcriptional activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24119

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q24119

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Trachea, salivary gland ducts, posterior spiracles (Filzkoeper primordia) and a subset of cells in the CNS.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During embryogenesis, first detected in the tracheal placodes at stage 8, and expression continues throughout embryonic and larval development. In the developing salivary gland, expression is observed in the entire gland at stage 9 and by stage 12, expression is confined to the salivary ducts.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0262139, Expressed in embryo and 43 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q24119, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24119, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with tgo.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
63620, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q24119, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0306032

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 139bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini174 – 244PAS 1PROSITE-ProRule annotationAdd BLAST71
Domaini391 – 461PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini465 – 508PACAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 97DisorderedSequence analysisAdd BLAST40
Regioni236 – 292DisorderedSequence analysisAdd BLAST57
Regioni525 – 734DisorderedSequence analysisAdd BLAST210
Regioni779 – 804DisorderedSequence analysisAdd BLAST26
Regioni844 – 896DisorderedSequence analysisAdd BLAST53
Regioni955 – 996DisorderedSequence analysisAdd BLAST42

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi629 – 636Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi83 – 97Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi270 – 292Polar residuesSequence analysisAdd BLAST23
Compositional biasi582 – 596Polar residuesSequence analysisAdd BLAST15
Compositional biasi662 – 680Polar residuesSequence analysisAdd BLAST19
Compositional biasi711 – 734Polar residuesSequence analysisAdd BLAST24
Compositional biasi844 – 862Polar residuesSequence analysisAdd BLAST19
Compositional biasi955 – 971Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3558, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174266

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24119

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00130, PAS, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR001610, PAC
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR013655, PAS_fold_3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00989, PAS, 1 hit
PF08447, PAS_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353, HLH, 1 hit
SM00086, PAC, 1 hit
SM00091, PAS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform D (identifier: Q24119-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPYQAAVAM DYAGYQRQPT PGHPGSHMAT MGSLGMPAVP FTHSWMVPTQ
60 70 80 90 100
DLCAMPPYNK MTGHQQPPGA GMHAQQQPLE PGILELRKEK SRDAARSRRG
110 120 130 140 150
KENYEFYELA KMLPLPAAIT SQLDKASIIR LTISYLKLRD FSGHGDPPWT
160 170 180 190 200
REASSSSKLK SAAIRRSPAV DLFEQHQGTH ILQSLDGFAL AVAADGRFLY
210 220 230 240 250
ISETVSIYLG LSQVEMTGSS IFDYIHQADH SEIADQLGLS LTSGGGGGGG
260 270 280 290 300
SSSSGGGGGG AGGGMASPTS GASDDGSGTH GTNNPDVAAS MTQASTSGYK
310 320 330 340 350
GYDRSFCVRM KSTLTKRGCH FKSSGYRASD ATSNCNNGNN ASNNAKNVKN
360 370 380 390 400
PGSNYSVVLL LCKLRPQYTF SHSRKSQPPL LGMVALAIAL PPPSVHEIRL
410 420 430 440 450
ECDMFVTRVN FDLRVAHCEP RVSDLLDYSP EDLVNKSLYS LCHAEDANRL
460 470 480 490 500
RKSHSDLIEK GQVLTGYYRL MNKSGGYTWL QTCATVVCST KNADEQNIIC
510 520 530 540 550
VNYVISNREN ENMILDCCQL EPSPDSIKHE EGLGNDKSSG SPGGDASGEG
560 570 580 590 600
NSHLSAGDMK LNSPKTDSEG HSHRGRGRSA AASHGSSMNS LTMIKDSPTP
610 620 630 640 650
LGVEIDSGVL PTTVATPVPA ATPPVQSTKR KRKTKASQHA EDQGQEQVIS
660 670 680 690 700
EQPLPKLPTM EQRDQQPRSR LPSIVDEQPS SAADSAVKDL EQAMSKHLPS
710 720 730 740 750
PAAVVSVAPP NTDFSADSLL KQQQQQQQLD PNEKSSTIQW IGTPYQQPPA
760 770 780 790 800
PMPATALLRQ LYANRESVIR ATARQTPTGV GPGVFYGDQQ TGPLPTPPGS
810 820 830 840 850
ESSYENQYLQ LHSAASGGHP GGQKTSADAF TNLVSTYGGY HSSIDYHNAM
860 870 880 890 900
TPPSSVSPRD SNQPGKAAPV LASNGGYDYA PDPLRGQYAT SSGDVVPATL
910 920 930 940 950
PLKPQASYTA TMHPSGSTTT EGGVTYSNLD QPQYFAPHSS FHLYHKGSPA
960 970 980 990 1000
SGWYSTPSXV VDDQGQVPPS CQDQYHHHHH HHHHQDGSAG SSASQASERW
1010 1020
DFVGALGKVA RMFFSARKGN PG
Length:1,022
Mass (Da):109,260
Last modified:June 13, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDF4C8CE3FB38E37
GO
Isoform A (identifier: Q24119-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     959-1022: Missing.

Show »
Length:958
Mass (Da):102,242
Checksum:i8F9CF758F1370541
GO
Isoform B (identifier: Q24119-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-356: Missing.
     959-1022: Missing.

Show »
Length:929
Mass (Da):99,332
Checksum:iDA164A0B869F4BAF
GO
Isoform C (identifier: Q24119-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-82: LPYQAAVAMD...HAQQQPLEPG → EHHGSGFVAS...GAAQSSVNAR
     328-356: Missing.
     959-1022: Missing.

Show »
Length:966
Mass (Da):103,568
Checksum:i50144CA76E353D03
GO
Isoform E (identifier: Q24119-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-286: Missing.
     959-1022: Missing.

Show »
Length:952
Mass (Da):101,643
Checksum:i4B539CF8FBE67EA6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PDQ7M9PDQ7_DROME
Trachealess, isoform G
trh 3.1, bHLHe13, BP1081, CG13885, CG6883
923Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBG9M9PBG9_DROME
Trachealess, isoform D
trh 3.1, bHLHe13, BP1081, CG13885, CG6883
1,022Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PE27M9PE27_DROME
Trachealess, isoform F
trh 3.1, bHLHe13, BP1081, CG13885, CG6883
989Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PDI8M9PDI8_DROME
Trachealess, isoform E
trh 3.1, bHLHe13, BP1081, CG13885, CG6883
952Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA96257 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA96754 differs from that shown. Reason: Frameshift.Curated
The sequence AAM11264 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78P → A in AAA96257 (PubMed:8557198).Curated1
Sequence conflicti250G → GG in AAA96754 (PubMed:8557189).Curated1
Sequence conflicti627S → P in ABX00736 (Ref. 5) Curated1
Sequence conflicti703A → T in AAA96257 (PubMed:8557198).Curated1
Sequence conflicti708A → P in AAA96257 (PubMed:8557198).Curated1
Sequence conflicti829A → V in AAA96257 (PubMed:8557198).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0439312 – 82LPYQA…PLEPG → EHHGSGFVASPWAAVLGHHS MASDAGFAAAAAAAHVQNHS MHHPIHSHHHHHSHSHPHPH PHSHPHHHPHLGTAGGMPMD LHVPQGFPYYRYREDALCWG DRKSMEEIGAAQSSVNAR in isoform C. CuratedAdd BLAST81
Alternative sequenceiVSP_043932281 – 286Missing in isoform E. 1 Publication6
Alternative sequenceiVSP_043933328 – 356Missing in isoform B and isoform C. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_043934959 – 1022Missing in isoform A, isoform B, isoform C and isoform E. 4 PublicationsAdd BLAST64

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U33427 mRNA Translation: AAA96257.1 Different initiation.
U42699 mRNA Translation: AAA96754.1 Frameshift.
AE014296 Genomic DNA Translation: AAF47386.1
AE014296 Genomic DNA Translation: ABI31226.1
BT031114 mRNA Translation: ABX00736.1
AY094911 mRNA Translation: AAM11264.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_001036575.1, NM_001043110.2 [Q24119-3]
NP_001097461.2, NM_001103991.2 [Q24119-6]
NP_001261207.1, NM_001274278.1 [Q24119-5]
NP_523872.2, NM_079148.3 [Q24119-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0304120; FBpp0293063; FBgn0262139 [Q24119-1]
FBtr0304121; FBpp0293064; FBgn0262139 [Q24119-3]
FBtr0304122; FBpp0293065; FBgn0262139 [Q24119-6]
FBtr0330146; FBpp0303179; FBgn0262139 [Q24119-5]
FBtr0330147; FBpp0303180; FBgn0262139 [Q24119-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
38065

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG42865

UCSC genome browser

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UCSCi
CG6883-RB, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33427 mRNA Translation: AAA96257.1 Different initiation.
U42699 mRNA Translation: AAA96754.1 Frameshift.
AE014296 Genomic DNA Translation: AAF47386.1
AE014296 Genomic DNA Translation: ABI31226.1
BT031114 mRNA Translation: ABX00736.1
AY094911 mRNA Translation: AAM11264.1 Different initiation.
RefSeqiNP_001036575.1, NM_001043110.2 [Q24119-3]
NP_001097461.2, NM_001103991.2 [Q24119-6]
NP_001261207.1, NM_001274278.1 [Q24119-5]
NP_523872.2, NM_079148.3 [Q24119-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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Protein-protein interaction databases

BioGRIDi63620, 8 interactors
IntActiQ24119, 4 interactors
STRINGi7227.FBpp0306032

PTM databases

iPTMnetiQ24119

Proteomic databases

PaxDbiQ24119

Genome annotation databases

EnsemblMetazoaiFBtr0304120; FBpp0293063; FBgn0262139 [Q24119-1]
FBtr0304121; FBpp0293064; FBgn0262139 [Q24119-3]
FBtr0304122; FBpp0293065; FBgn0262139 [Q24119-6]
FBtr0330146; FBpp0303179; FBgn0262139 [Q24119-5]
FBtr0330147; FBpp0303180; FBgn0262139 [Q24119-2]
GeneIDi38065
KEGGidme:Dmel_CG42865
UCSCiCG6883-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7200
FlyBaseiFBgn0262139, trh

Phylogenomic databases

eggNOGiKOG3558, Eukaryota
GeneTreeiENSGT00940000174266
InParanoidiQ24119

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
38065, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Hn, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
38065

Protein Ontology

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PROi
PR:Q24119

Gene expression databases

BgeeiFBgn0262139, Expressed in embryo and 43 other tissues
ExpressionAtlasiQ24119, baseline and differential
GenevisibleiQ24119, DM

Family and domain databases

CDDicd00130, PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR001610, PAC
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR013655, PAS_fold_3
PfamiView protein in Pfam
PF00989, PAS, 1 hit
PF08447, PAS_3, 1 hit
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SM00086, PAC, 1 hit
SM00091, PAS, 2 hits
SUPFAMiSSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRH_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24119
Secondary accession number(s): A8JNH0
, A8WHG8, Q0E8K2, Q24165, Q8SX13, Q9W0Q7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 13, 2012
Last modified: June 2, 2021
This is version 198 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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