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Entry version 155 (02 Dec 2020)
Sequence version 2 (30 Aug 2005)
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Protein

DNA repair endonuclease XPF

Gene

mei-9

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Implicated in recombination events during meiosis, mostly in meiotic exchange. May directly resolve Holliday junctions within recombination intermediates leading to DNA exchange. Also required for the repair of mismatches within meiotic heteroduplex DNA and for nucleotide excision repair.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair, Meiosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5696395, Formation of Incision Complex in GG-NER
R-DME-5696400, Dual Incision in GG-NER
R-DME-6782135, Dual incision in TC-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair endonuclease XPF (EC:3.1.-.-)
Alternative name(s):
Protein meiotic 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mei-9
ORF Names:CG3697
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002707, mei-9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001988551 – 961DNA repair endonuclease XPFAdd BLAST961

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24087

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002707, Expressed in cleaving embryo and 29 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q24087, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24087, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer (By similarity).

Interacts with hdm.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
57890, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q24087, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070624

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q24087

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini697 – 777ERCC4Add BLAST81

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0442, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002265_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24087

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHKILQA

Database of Orthologous Groups

More...
OrthoDBi
324863at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q24087

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006166, ERCC4_domain
IPR011335, Restrct_endonuc-II-like
IPR010994, RuvA_2-like
IPR006167, XPF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02732, ERCC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00891, ERCC4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47781, SSF47781, 1 hit
SSF52980, SSF52980, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00596, rad1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q24087-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSCAENAA KGTENERPKE VEASADTVPQ VEEGVEEYLK RKNMVLLDYE
60 70 80 90 100
KQMFLDLVEA DGLLVCAKGL SYDRVVISIL KAYSDSGNLV LVINSSDWEE
110 120 130 140 150
QYYKSKIEPK YVHEVASTAT ERERVYLEGG LQFISTRILV VDLLKQRIPI
160 170 180 190 200
ELISGIIVLR AHTIIESCQE AFALRLFRQK NKTGFVKAFS SSPEAFTIGY
210 220 230 240 250
SHVERTMRNL FVKHLYIWPR FHESVRTVLQ PWKIQSIEMH VPISQNITSI
260 270 280 290 300
QSHILEIMNF LVQEIKRINR TVDMEAVTVE NCVTKSFHKI LQAQLDCIWH
310 320 330 340 350
QLNSQTKLIV ADLKILRSLM ISTMYHDAVS AYAFMKRYRS TEYALSNSGW
360 370 380 390 400
TLLDAAEQIF KLSRQRVFNG QQEFEPEPCP KWQTLTDLLT KEIPGDMRRS
410 420 430 440 450
RRSEQQPKVL ILCQDARTCH QLKQYLTQGG PRFLLQQALQ HEVPVGKLSD
460 470 480 490 500
NYAKESQTRS APPKNVSSNK ELRREEVSGS QPPLAGMDEL AQLLSESETE
510 520 530 540 550
GQHFEESYML TMTQPVEVGP AAIDIKPDPD VSIFETIPEL EQFDVTAALA
560 570 580 590 600
SVPHQPYICL QTFKTEREGS MALEHMLEQL QPHYVVMYNM NVTAIRQLEV
610 620 630 640 650
FEARRRLPPA DRMKVYFLIH ARTVEEQAYL TSLRREKAAF EFIIDTKSKM
660 670 680 690 700
VIPKYQDGKT DEAFLLLKTY DDEPTDENAK SRQAGGQAPQ ATKETPKVIV
710 720 730 740 750
DMREFRSDLP CLIHKRGLEV LPLTITIGDY ILTPDICVER KSISDLIGSL
760 770 780 790 800
NSGRLYNQCV QMQRHYAKPI LLIEFDQNKP FHLQGKFMLS QQTSMANADI
810 820 830 840 850
VQKLQLLTLH FPKLRLIWSP SPYATAQLFE ELKLGKPEPD PQTAAALGSD
860 870 880 890 900
EPTAGEQLHF NSGIYDFLLR LPGVHTRNIH GLLRKGGSLR QLLLRSQKEL
910 920 930 940 950
EELLQSQESA KLLYDILHVA HLPEKDEVTG STALLAASKQ FGAGSHNRFR
960
MAAAASRRGR R
Length:961
Mass (Da):109,519
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00099A7E52B3FC46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
T2FFI3T2FFI3_DROME
FI21265p1
mei-9 DhR1, Dmel\CG3697, DmXPF, MEI-9, Mei-9
961Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC46917 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti115V → G in AAC46917 (PubMed:8647398).Curated1
Sequence conflicti286S → T in AAC46917 (PubMed:8647398).Curated1
Sequence conflicti286S → T in AAN71074 (PubMed:12537569).Curated1
Sequence conflicti318S → T in AAC46917 (PubMed:8647398).Curated1
Sequence conflicti594A → P in AAC46917 (PubMed:8647398).Curated1
Sequence conflicti798A → R in AAC46917 (PubMed:8647398).Curated1
Sequence conflicti853T → M in AAC46917 (PubMed:8647398).Curated1
Sequence conflicti853T → M in AAN71074 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U27181 Genomic DNA Translation: AAC46917.1 Frameshift.
AE014298 Genomic DNA Translation: AAF45938.1
BT001319 mRNA Translation: AAN71074.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S58936

NCBI Reference Sequences

More...
RefSeqi
NP_001284859.1, NM_001297930.1
NP_525068.1, NM_080329.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070656; FBpp0070624; FBgn0002707
FBtr0343574; FBpp0310174; FBgn0002707

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31373

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3697

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27181 Genomic DNA Translation: AAC46917.1 Frameshift.
AE014298 Genomic DNA Translation: AAF45938.1
BT001319 mRNA Translation: AAN71074.1
PIRiS58936
RefSeqiNP_001284859.1, NM_001297930.1
NP_525068.1, NM_080329.3

3D structure databases

SMRiQ24087
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi57890, 5 interactors
IntActiQ24087, 2 interactors
STRINGi7227.FBpp0070624

Proteomic databases

PaxDbiQ24087

Genome annotation databases

EnsemblMetazoaiFBtr0070656; FBpp0070624; FBgn0002707
FBtr0343574; FBpp0310174; FBgn0002707
GeneIDi31373
KEGGidme:Dmel_CG3697

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31373
FlyBaseiFBgn0002707, mei-9

Phylogenomic databases

eggNOGiKOG0442, Eukaryota
HOGENOMiCLU_002265_1_0_1
InParanoidiQ24087
OMAiFHKILQA
OrthoDBi324863at2759
PhylomeDBiQ24087

Enzyme and pathway databases

ReactomeiR-DME-5696395, Formation of Incision Complex in GG-NER
R-DME-5696400, Dual Incision in GG-NER
R-DME-6782135, Dual incision in TC-NER

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31373, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31373

Protein Ontology

More...
PROi
PR:Q24087

Gene expression databases

BgeeiFBgn0002707, Expressed in cleaving embryo and 29 other tissues
ExpressionAtlasiQ24087, baseline and differential
GenevisibleiQ24087, DM

Family and domain databases

InterProiView protein in InterPro
IPR006166, ERCC4_domain
IPR011335, Restrct_endonuc-II-like
IPR010994, RuvA_2-like
IPR006167, XPF
PfamiView protein in Pfam
PF02732, ERCC4, 1 hit
SMARTiView protein in SMART
SM00891, ERCC4, 1 hit
SUPFAMiSSF47781, SSF47781, 1 hit
SSF52980, SSF52980, 1 hit
TIGRFAMsiTIGR00596, rad1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPF_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24087
Secondary accession number(s): Q8IHB9, Q9W4L3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 30, 2005
Last modified: December 2, 2020
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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