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Entry version 150 (10 Feb 2021)
Sequence version 3 (16 Jan 2004)
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Protein

Protein big brother

Gene

Bgb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the DNA-binding properties of Runt.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-8878166, Transcriptional regulation by RUNX2
R-DME-8931987, RUNX1 regulates estrogen receptor mediated transcription
R-DME-8934593, Regulation of RUNX1 Expression and Activity
R-DME-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-DME-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8939245, RUNX1 regulates transcription of genes involved in BCR signaling
R-DME-8939246, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-DME-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling
R-DME-8941326, RUNX2 regulates bone development
R-DME-8941858, Regulation of RUNX3 expression and activity
R-DME-8951936, RUNX3 regulates p14-ARF
R-DME-9018519, Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q24040

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein big brother
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bgb
ORF Names:CG7959
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0013753, Bgb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000649201 – 213Protein big brotherAdd BLAST213

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q24040

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0013753, Expressed in central nervous system and 41 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q24040, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q24040, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
63732, 11 interactors

Database of interacting proteins

More...
DIPi
DIP-22891N

Protein interaction database and analysis system

More...
IntActi
Q24040, 11 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072641

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q24040

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CBF-beta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4785, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018132

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_074992_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q24040

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGKVHIK

Database of Orthologous Groups

More...
OrthoDBi
1254153at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q24040

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.250.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003417, CBF_beta
IPR036552, CBF_bsu_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10276, PTHR10276, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02312, CBF_beta, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50723, SSF50723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q24040-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNEAALANM IPYDTIGLYE QPKPRFIFKM PRVVPDQKSK FESDELFRRL
60 70 80 90 100
SRESEVRYTG YRERSIEERQ VRFMNGCREG HTEASFVASG TNLQLVFNAN
110 120 130 140 150
QNPYLHDKEC DFDKEHGKVH IKSYFIMNGV CVRFRGWIDL ERLDGVGCLE
160 170 180 190 200
YDERRAMHED AILRDQIDRY NQRLREFEDT KRAYRDNRQD EMEAVRRGVA
210
SGGIGVGASM WRR
Length:213
Mass (Da):25,177
Last modified:January 16, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FC6156136B362AA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PGT9M9PGT9_DROME
Big brother, isoform B
Bgb 9, bgb, Dmel\CG7959, en(lz)D, rpbeta2
253Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB03676 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8A → S (PubMed:8622696).Curated1
Sequence conflicti24P → K (PubMed:8622696).Curated1
Sequence conflicti141E → D in AAB03676 (PubMed:8622696).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U22177 mRNA Translation: AAB03676.1 Different initiation.
AE014296 Genomic DNA Translation: AAF47533.3
AY058784 mRNA Translation: AAL14013.1

NCBI Reference Sequences

More...
RefSeqi
NP_477065.3, NM_057717.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0072758; FBpp0072641; FBgn0013753

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38198

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7959

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22177 mRNA Translation: AAB03676.1 Different initiation.
AE014296 Genomic DNA Translation: AAF47533.3
AY058784 mRNA Translation: AAL14013.1
RefSeqiNP_477065.3, NM_057717.5

3D structure databases

SMRiQ24040
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi63732, 11 interactors
DIPiDIP-22891N
IntActiQ24040, 11 interactors
STRINGi7227.FBpp0072641

Proteomic databases

PaxDbiQ24040

Genome annotation databases

EnsemblMetazoaiFBtr0072758; FBpp0072641; FBgn0013753
GeneIDi38198
KEGGidme:Dmel_CG7959

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
107447
FlyBaseiFBgn0013753, Bgb

Phylogenomic databases

eggNOGiKOG4785, Eukaryota
GeneTreeiENSGT00390000018132
HOGENOMiCLU_074992_0_1_1
InParanoidiQ24040
OMAiPGKVHIK
OrthoDBi1254153at2759
PhylomeDBiQ24040

Enzyme and pathway databases

ReactomeiR-DME-8878166, Transcriptional regulation by RUNX2
R-DME-8931987, RUNX1 regulates estrogen receptor mediated transcription
R-DME-8934593, Regulation of RUNX1 Expression and Activity
R-DME-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-DME-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8939245, RUNX1 regulates transcription of genes involved in BCR signaling
R-DME-8939246, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-DME-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling
R-DME-8941326, RUNX2 regulates bone development
R-DME-8941858, Regulation of RUNX3 expression and activity
R-DME-8951936, RUNX3 regulates p14-ARF
R-DME-9018519, Estrogen-dependent gene expression
SignaLinkiQ24040

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
38198, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38198

Protein Ontology

More...
PROi
PR:Q24040

Gene expression databases

BgeeiFBgn0013753, Expressed in central nervous system and 41 other tissues
ExpressionAtlasiQ24040, baseline and differential
GenevisibleiQ24040, DM

Family and domain databases

Gene3Di2.40.250.10, 1 hit
InterProiView protein in InterPro
IPR003417, CBF_beta
IPR036552, CBF_bsu_sf
PANTHERiPTHR10276, PTHR10276, 1 hit
PfamiView protein in Pfam
PF02312, CBF_beta, 1 hit
SUPFAMiSSF50723, SSF50723, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBGB_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q24040
Secondary accession number(s): Q95TG4, Q9W0B9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 16, 2004
Last modified: February 10, 2021
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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