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Protein

Dorsal-ventral patterning protein Sog

Gene

sog

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative negative growth factor (PubMed:7958919). Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg (PubMed:7958919). Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa (PubMed:11260716).2 Publications

GO - Molecular functioni

  • collagen binding Source: FlyBase
  • growth factor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor
Biological processGrowth regulation

Enzyme and pathway databases

ReactomeiR-DME-201451 Signaling by BMP
R-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Dorsal-ventral patterning protein Sog
Alternative name(s):
Short gastrulation protein
Gene namesi
Name:sog
ORF Names:CG9224
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003463 sog

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 53CytoplasmicSequence analysisAdd BLAST53
Transmembranei54 – 74Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini75 – 1038ExtracellularSequence analysisAdd BLAST964

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27C → S: No change in baseline secretion but eliminates increased secretion normally caused by coexpression with Hip14 and reduces intracellular levels of Sog. 1 Publication1
Mutagenesisi28C → S: No effect on secretion when coexpressed with Hip14. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190891 – 1038Dorsal-ventral patterning protein SogAdd BLAST1038

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi821N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoylated, probably by Hip14.1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ24025
PRIDEiQ24025

Expressioni

Tissue specificityi

Abuts the dorsal dpp-expressing cells in a lateral stripe 14-16 cells wide. Later in embryogenesis it is expressed in neuroectoderm and in the endoderm spaced along the anterior-posterior axis of the developing gut.1 Publication

Developmental stagei

Embryogenesis.1 Publication

Gene expression databases

BgeeiFBgn0003463 Expressed in 42 organ(s), highest expression level in embryo
ExpressionAtlasiQ24025 baseline and differential
GenevisibleiQ24025 DM

Interactioni

Subunit structurei

Component of a complex composed of dpp, sog and tsg (PubMed:11260716). Interacts with palmitoyltransferase Hip14 (PubMed:20599894).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
vkgO184072EBI-184947,EBI-15721782

GO - Molecular functioni

Protein-protein interaction databases

BioGridi58848, 28 interactors
DIPiDIP-20760N
IntActiQ24025, 5 interactors
STRINGi7227.FBpp0304150

Structurei

3D structure databases

ProteinModelPortaliQ24025
SMRiQ24025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 175VWFC 1PROSITE-ProRule annotationAdd BLAST76
Domaini197 – 337CHRD 1PROSITE-ProRule annotationAdd BLAST141
Domaini339 – 471CHRD 2PROSITE-ProRule annotationAdd BLAST133
Domaini474 – 588CHRD 3PROSITE-ProRule annotationAdd BLAST115
Domaini592 – 713CHRD 4PROSITE-ProRule annotationAdd BLAST122
Domaini742 – 804VWFC 2PROSITE-ProRule annotationAdd BLAST63
Domaini830 – 899VWFC 3PROSITE-ProRule annotationAdd BLAST70
Domaini939 – 1020VWFC 4PROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the chordin family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEDE Eukaryota
ENOG410XSBA LUCA
GeneTreeiENSGT00730000110792
InParanoidiQ24025
KOiK04657
OMAiQSWHPSV
OrthoDBiEOG091G11A0
PhylomeDBiQ24025

Family and domain databases

InterProiView protein in InterPro
IPR016353 Chordin
IPR010895 CHRD
IPR001007 VWF_dom
PfamiView protein in Pfam
PF07452 CHRD, 2 hits
PF00093 VWC, 4 hits
PIRSFiPIRSF002496 Chordin, 1 hit
SMARTiView protein in SMART
SM00754 CHRD, 4 hits
SM00214 VWC, 4 hits
PROSITEiView protein in PROSITE
PS50933 CHRD, 4 hits
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q24025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANKLRKSNA IEWATATGTV PLLERSCCHS EDAALEPQAS KTSHREQAPI
60 70 80 90 100
LRHLSQLSHL LIIAGLLIVC LAGVTEGRRH APLMFEESDT GRRSNRPAVT
110 120 130 140 150
ECQFGKVLRE LGSTWYADLG PPFGVMYCIK CECVAIPKKR RIVARVQCRN
160 170 180 190 200
IKNECPPAKC DDPISLPGKC CKTCPGDRND TDVALDVPVP NEEEERNMKH
210 220 230 240 250
YAALLTGRTS YFLKGEEMKS MYTTYNPQNV VATARFLFHK KNLYYSFYTS
260 270 280 290 300
SRIGRPRAIQ FVDDAGVILE EHQLETTLAG TLSVYQNATG KICGVWRRVP
310 320 330 340 350
RDYKRILRDD RLHVVLLWGN KQQAELALAG KVAKYTALQT ELFSSLLEAP
360 370 380 390 400
LPDGKTDPQL AGAGGTAIVS TSSGAASSMH LTLVFNGVFG AEEYADAALS
410 420 430 440 450
VKIELAERKE VIFDEIPRVR KPSAEINVLE LSSPISIQNL RLMSRGKLLL
460 470 480 490 500
TVESKKYPHL RIQGHIVTRA SCEIFQTLLA PHSAESSTKS SGLAWVYLNT
510 520 530 540 550
DGSLAYNIET EHVNTRDRPN ISLIEEQGKR KAKLEDLTPS FNFNQAIGSV
560 570 580 590 600
EKLGPKVLES LYAGELGVNV ATEHETSLIR GRLVPRPVAD ARDSAEPILL
610 620 630 640 650
KRQEHTDAQN PHAVGMAWMS IDNECNLHYE VTLNGVPAQD LQLYLEEKPI
660 670 680 690 700
EAIGAPVTRK LLEEFNGSYL EGFFLSMPSA ELIKLEMSVC YLEVHSKHSK
710 720 730 740 750
QLLLRGKLKS TKVPGHCFPV YTDNNVPVPG DHNDNHLVNG ETKCFHSGRF
760 770 780 790 800
YNESEQWRSA QDSCQMCACL RGQSSCEVIK CPALKCKSTE QLLQRDGECC
810 820 830 840 850
PSCVPKKEAA DYSAQSSPAT NATDLLQQRR GCRLGEQFHP AGASWHPFLP
860 870 880 890 900
PNGFDTCTTC SCDPLTLEIR CPRLVCPPLQ CSEKLAYRPD KKACCKICPE
910 920 930 940 950
GKQSSSNGHK TTPNNPNVLQ DQAMQRSPSH SAEEVLANGG CKVVNKVYEN
960 970 980 990 1000
GQEWHPILMS HGEQKCIKCR CKDSKVNCDR KRCSRSTCQQ QTRVTSKRRL
1010 1020 1030
FEKPDAAAPA IDECCSTQCR RSRRHHKRQP HHQQRSSS
Length:1,038
Mass (Da):115,515
Last modified:November 1, 1996 - v1
Checksum:iB0E833AFD79A9037
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PH73M9PH73_DROME
Dorsal-ventral patterning protein S...
sog Dm sog, Dmel\CG9224, l(1)G0160, l(1)G0395, l(1)G0479 sog Dm sog, Dmel\CG9224, l(1)G0160, l(1)G0395, l(1)G0479, SOG, Sog, CG9224, Dmel_CG9224
1,038Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18774 mRNA Translation: AAA89117.1
AE014298 Genomic DNA Translation: AAF48481.1
BT053679 mRNA Translation: ACK77594.1
PIRiT13177
RefSeqiNP_001259576.1, NM_001272647.2
NP_001259578.1, NM_001272649.2
NP_476736.1, NM_057388.4
UniGeneiDm.3944

Genome annotation databases

EnsemblMetazoaiFBtr0074063; FBpp0073879; FBgn0003463
FBtr0331760; FBpp0304148; FBgn0003463
FBtr0340346; FBpp0309304; FBgn0003463
GeneIDi32498
KEGGidme:Dmel_CG9224

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18774 mRNA Translation: AAA89117.1
AE014298 Genomic DNA Translation: AAF48481.1
BT053679 mRNA Translation: ACK77594.1
PIRiT13177
RefSeqiNP_001259576.1, NM_001272647.2
NP_001259578.1, NM_001272649.2
NP_476736.1, NM_057388.4
UniGeneiDm.3944

3D structure databases

ProteinModelPortaliQ24025
SMRiQ24025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58848, 28 interactors
DIPiDIP-20760N
IntActiQ24025, 5 interactors
STRINGi7227.FBpp0304150

Proteomic databases

PaxDbiQ24025
PRIDEiQ24025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074063; FBpp0073879; FBgn0003463
FBtr0331760; FBpp0304148; FBgn0003463
FBtr0340346; FBpp0309304; FBgn0003463
GeneIDi32498
KEGGidme:Dmel_CG9224

Organism-specific databases

CTDi32498
FlyBaseiFBgn0003463 sog

Phylogenomic databases

eggNOGiENOG410IEDE Eukaryota
ENOG410XSBA LUCA
GeneTreeiENSGT00730000110792
InParanoidiQ24025
KOiK04657
OMAiQSWHPSV
OrthoDBiEOG091G11A0
PhylomeDBiQ24025

Enzyme and pathway databases

ReactomeiR-DME-201451 Signaling by BMP
R-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-8957275 Post-translational protein phosphorylation

Miscellaneous databases

GenomeRNAii32498
PROiPR:Q24025

Gene expression databases

BgeeiFBgn0003463 Expressed in 42 organ(s), highest expression level in embryo
ExpressionAtlasiQ24025 baseline and differential
GenevisibleiQ24025 DM

Family and domain databases

InterProiView protein in InterPro
IPR016353 Chordin
IPR010895 CHRD
IPR001007 VWF_dom
PfamiView protein in Pfam
PF07452 CHRD, 2 hits
PF00093 VWC, 4 hits
PIRSFiPIRSF002496 Chordin, 1 hit
SMARTiView protein in SMART
SM00754 CHRD, 4 hits
SM00214 VWC, 4 hits
PROSITEiView protein in PROSITE
PS50933 CHRD, 4 hits
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSOG_DROME
AccessioniPrimary (citable) accession number: Q24025
Secondary accession number(s): B7FNI9, Q9VXS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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