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Entry version 89 (07 Apr 2021)
Sequence version 2 (16 Apr 2014)
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Protein
Submitted name:

Cation channel family protein

Gene

TTHERM_00194370

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.3.2.3, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cation channel family proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TTHERM_00194370Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetrahymena thermophila (strain SB210)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri312017 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009168 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2384 – 2406HelicalSequence analysisAdd BLAST23
Transmembranei2427 – 2449HelicalSequence analysisAdd BLAST23
Transmembranei2534 – 2562HelicalSequence analysisAdd BLAST29
Transmembranei2583 – 2604HelicalSequence analysisAdd BLAST22
Transmembranei2671 – 2694HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 233Ins145_P3_recInterPro annotationAdd BLAST229
Domaini2055 – 2156RIH_assocInterPro annotationAdd BLAST102
Domaini2517 – 2700Ion_transInterPro annotationAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili93 – 120Sequence analysisAdd BLAST28
Coiled coili128 – 148Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3533, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000206_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q23K98

Identification of Orthologs from Complete Genome Data

More...
OMAi
HECKTIC

Database of Orthologous Groups

More...
OrthoDBi
94996at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR013662, RIH_assoc-dom
IPR035910, RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF08454, RIH_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00779, INSP3RECEPTR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q23K98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQVKFGDYI TIQGTLLDKN NTNGAHYGYM CTTGFTNNEI YLEKQSKSIF
60 70 80 90 100
ANTSNQDQQI SQKPEDNVFS IKNYREYVFQ IWPKLDYDAH KKYSKLLEEK
110 120 130 140 150
NQIQKKLKSS KDNIDISEED QERMKEYLNE VREKIKIAKI AKESEKANNL
160 170 180 190 200
KQLESVKGNF VCYGQEIFLM HADSQSFLNG LLQASVSEKS AFMLQVTKFF
210 220 230 240 250
QRGMVFKFQP KYKLRKEGEI IQYKDQISIF NVKQQCWANF VPSNITQQDK
260 270 280 290 300
IIQGPTPTNY YQSIDFQKYQ NRQRVEVFLT KVKEAFWQIH IHSDYIQNQE
310 320 330 340 350
TSIKGGDLIY LYHTELQGAL TADISYDNKK GYSEAYIRKY QGEYELEKYS
360 370 380 390 400
VASIWEIEKD SCFDRGSNIP VSSLSNQDKK STQSFKIRHF LTGKVLSIQQ
410 420 430 440 450
VNQGQYIPCL AKDDLTTLEN SSKIQFVSTQ NDENEIMEDN HCYLIKINDQ
460 470 480 490 500
FIQANSSIQY TVQKHEKNSE NKLNVTDFKD VTENMIYKPI DDSEFEVYRN
510 520 530 540 550
GLTCVDKGST EENAFQVIKL TEEEKQNILY VNSSLNILHK FLQKLRNVPY
560 570 580 590 600
REPLPKKEYI KKVGQILSDL VLFVVKTESK NPLECEGIPI PKRQKIMKDY
610 620 630 640 650
KFIELLVDLL YYPFKTEVYK MKELDQIDPD TVKIFKLCNV LINNSIKEYR
660 670 680 690 700
PNEIYASQWI NLLIFQSEMT EGYCDIGSEE TLTELIDNNK KILETIDEVT
710 720 730 740 750
VNKFLQMLME NQNKKYVKLI RALILCNGQP VHNQELISNY LLSGMDAISN
760 770 780 790 800
DEDETGQVSQ NKVSQVLQRQ VDINKPLIIQ AVKYINGEVW VQSPFKENYG
810 820 830 840 850
KFMLLSKFQE MSTESQENLD KFEYFSEMIG MLSDLCKSRN YTAINQLVHV
860 870 880 890 900
YKRRVCFEIV QNSLFDPYLR RSFVMLIHTM YLDISDFKKF SLPNNIRVWT
910 920 930 940 950
EIEKAKSIVS VYDQQQNLEK VMGLNSFVSP LLYASNHLKV FSIEYIIGIA
960 970 980 990 1000
KSKYMSSLKE PENLLTYSIL QMIQDLVDFG FFDNSDELES LVKNIIKILD
1010 1020 1030 1040 1050
SSLDVGNQNE EEAAEEVVKL LSCRTTISKG NIPQALKKLN HIQISRFTGR
1060 1070 1080 1090 1100
YEHTEDNLIV HECKTICCEI LKKVILIRND MRITQFMKKF KNEFDLITTF
1110 1120 1130 1140 1150
KPMNKNSKKK PSMKPLEIEN PIQQFQRKRN PSDTPNSVNQ SHIQGDKSPL
1160 1170 1180 1190 1200
INEVFSNQLK IEEGIQDVSE QERRQISQAL AKRSQEMLDE IFFQNTIKLR
1210 1220 1230 1240 1250
GCLKVDVVAI FQDLTLYQNS DLVNNSFEIL NMLFTERQEI LNLLQNLQLL
1260 1270 1280 1290 1300
EDHEQIQSYF SMKQIQDNLS EQVEKSENWL FKYEEANIKE AVKVEINLQQ
1310 1320 1330 1340 1350
IVQIQAQKLQ GLPLPVIGIE QGEDTGRLLN QKQDYNQGIR QEAINFIEQL
1360 1370 1380 1390 1400
FEEDEVKNQY SQELIRNSYL YQQIIDLLNY DANTFTRKRQ EEGINKLNFN
1410 1420 1430 1440 1450
DTSVFIRILR LCYKILGRLV IGNKQNQILL TDQVTDFIFK HMKYLPQSYP
1460 1470 1480 1490 1500
HLLLDPLIEQ NSLLIMHEEI CRKFVKEIFN CINILKSHNI LNLVSCYLDI
1510 1520 1530 1540 1550
LKKIPYVNDI IVKENQTIIM DLLTSKENQN LLSFINFDDP SYKQLIHSSQ
1560 1570 1580 1590 1600
QFQNFVDSGQ EEIIDVPQEL DYFDSLLSLM AAVCDSKNNA TESKAQSYIS
1610 1620 1630 1640 1650
LYQLKELLIK FKNCFYVKRS LYFFFFHVYL DTEKEMSDQL LEIKKFIIQS
1660 1670 1680 1690 1700
IEDDLILITN NLDVQDIQLL NYKGKISLQK IKLEYIFESL FLCVDTILCK
1710 1720 1730 1740 1750
KLLDTSSEKQ FLTQLLESII KVSQLSVLKQ THKRKLKGIL IQLVVRGFTS
1760 1770 1780 1790 1800
IQKLKQHNIN SQIIPNLLEV RQTQKNLQDY FSTTIQISHE STVQLSQKQA
1810 1820 1830 1840 1850
TLLDVIKKLK KSEILQEEIR KEFKNFVDYF TDIKYISLKA FQGLCTIEFS
1860 1870 1880 1890 1900
ELTTAMIKLM VQNRFVNDYD NTQNELEKKR LQVLRQIIEL ENPESNDSID
1910 1920 1930 1940 1950
LWDSLEGFEE EIIKRQNQLI QQGVAEMIVE IIKDPQASSD IKEEAILLGI
1960 1970 1980 1990 2000
ALLIGGNAKT QDEFLKALSS DSNNQFLGVL YDMITRGLLL IKKNMSKLNK
2010 2020 2030 2040 2050
QVEFKLIEEQ KQALDQQINL NDEDFDDKLS DDEAADVMDS QDDDEESQIP
2060 2070 2080 2090 2100
QNVIQEIRRI RRVYRLLQLF CEGHNNQFQN HLRQQIIDQQ ESGKSIDFIM
2110 2120 2130 2140 2150
NTTILFSSAV KYLNIHCIDL IDQILDFLIE SIQGPCVENQ ITMCRGKINE
2160 2170 2180 2190 2200
TCKDLLQKFQ GNQEQNKQYY ILGFDTEENK EELESLISKS FKLLYSLIEG
2210 2220 2230 2240 2250
DPSKDILQQM CQTLDFNHLF QILDDKFKKI LQQLNISFVQ TLNFSDEKIR
2260 2270 2280 2290 2300
KIVDRLDSHF DESLEGVFDI YLLISTLSDK DENVKQLLEN PPDEYVSALK
2310 2320 2330 2340 2350
FFKYNTASIE VVFKNNLIRV YFPIQPICRL LSKNSRATLM EEIPRSTTSE
2360 2370 2380 2390 2400
KIEGLVEATI DLFDEMEHLA FLKKQIFNFS SNRLQALMLI SYTFALAINL
2410 2420 2430 2440 2450
TILFTYKLTF EEFQKAKNYI NPGALTTTVV FGIIQFITVL IIILFYIIIH
2460 2470 2480 2490 2500
GPLIIKRSWH AIQEENEKFK KPQEEERIIE AKYLSLRDAV SVLMTKGPNA
2510 2520 2530 2540 2550
EEFWKSGKRD FGHFFVAFFY YWRNFQTMMR QGSFIYLLFY VIVSAMGLFV
2560 2570 2580 2590 2600
SDITYCLLLL DIIARFPTLQ NVVKAVTTNI RQIGLTTLLG AVLIYIYSIF
2610 2620 2630 2640 2650
AFYFSDQTYK TTEVYGLDGE KGDQNTCTTL FQCYLYTLNQ GLLHAAGIGE
2660 2670 2680 2690 2700
AIAKPSYEDP STFIFRYFFD LSFFMIINIM FLNFIFGIII DTFAQLRDEK
2710 2720 2730 2740 2750
QKKEEDKNNV CFICGLSRNE FDKVPGGFTI HIEKQHQLWY YVYYIYHLKC
2760 2770 2780 2790 2800
KDSTEYNGVE SYIQDLLNKQ QTTWFPLLKA LSLSKSEDQN QESQIENKFE
2810 2820
KLKSGLKDVT SKVEKISSKK IEKKKNK
Length:2,827
Mass (Da):330,286
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AA403AB2F55436D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GG662673 Genomic DNA Translation: EAR96945.2

NCBI Reference Sequences

More...
RefSeqi
XP_001017190.2, XM_001017190.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAR96945; EAR96945; TTHERM_00194370

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7823162

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tet:TTHERM_00194370

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662673 Genomic DNA Translation: EAR96945.2
RefSeqiXP_001017190.2, XM_001017190.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.3.2.3, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Genome annotation databases

EnsemblProtistsiEAR96945; EAR96945; TTHERM_00194370
GeneIDi7823162
KEGGitet:TTHERM_00194370

Phylogenomic databases

eggNOGiKOG3533, Eukaryota
HOGENOMiCLU_000206_1_0_1
InParanoidiQ23K98
OMAiHECKTIC
OrthoDBi94996at2759

Family and domain databases

InterProiView protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR013662, RIH_assoc-dom
IPR035910, RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF08454, RIH_assoc, 1 hit
PRINTSiPR00779, INSP3RECEPTR
SUPFAMiSSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ23K98_TETTS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23K98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 16, 2014
Last modified: April 7, 2021
This is version 89 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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